Publication Name	World Journal of Transplantation
Manuscript ID	98509
Country	Greece

Category	Transplantation
Manuscript Type	Review
Article Title	Immunotherapy and liver transplantation for hepatocellular carcinoma: Current and future challenges
Manuscript Source	Invited Manuscript
All Author List	Theodoros Pettas, Sofia Lachanoudi, Filippos F Karageorgos, Ioannis A Ziogas, Asimina Fylaktou, Vassilios Papalois, Georgios Katsanos, Nikolaos Antoniadis and Georgios Tsoulfas
Funding Agency and Grant Number
Corresponding Author	Georgios Tsoulfas, MD, PhD, Professor, Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University of Thessaloniki, School of Medicine, 49 Konstantinoupoleos Street, Thessaloniki 54642, Greece. tsoulfasg@gmail.com
Key Words	Hepatocellular carcinoma; Immunotherapy; Liver transplantation; Neoadjuvant and adjuvant immunotherapy; Immune checkpoint inhibitors; Vaccine therapies; Oncolytic viruses; Adoptive cell therapy; Antigen-targeting antibodies; Diagnostic biomarkers
Core Tip	Hepatocellular carcinoma is a prevalent condition nowadays. The increasing number of new cases worldwide requires intensive research and innovative curative options. Cancer immunotherapy constitutes a constantly growing field in terms of treatment of the disease, as well as potential tumor downstaging with an eye to liver transplantation. There are two approaches regarding immunotherapy for hepatocellular carcinoma: Boosting the existing immune response and stimulating the de novo immune response.
Citation	<p>Pettas T, Lachanoudi S, Karageorgos FF, Ziogas IA, Fylaktou A, Papalois V, Katsanos G, Antoniadis N, Tsoulfas G. Immunotherapy and liver transplantation for hepatocellular carcinoma: Current and future challenges. <i>World J Transplant</i> 2025; 15(2): 98509</p>

Received	2024-08-14 02:39
Peer-Review Started	2024-06-27 15:37
To Make the First Decision
Return for Revision	2024-09-19 22:01
Revised	2024-10-03 17:10
Second Decision	2024-11-07 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-07 09:34
Articles in Press	2024-11-07 09:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-11-21 19:08
Typeset the Manuscript	2024-11-28 07:59

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com