Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	98909
Country	China

Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center
Manuscript Source	Unsolicited Manuscript
All Author List	Nan Chen, Chang-Long Li, Lin Wang, Yun-Feng Yao, Yi-Fan Peng, Tian-Cheng Zhan, Jun Zhao and Ai-Wen Wu
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Municipal Administration of Hospitals Incubating Program PZ2020027 Beijing Talent Incubating Funding 2019-4 National Natural Science Foundation of China 81773214 Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support ZYLX202116 National Key R and D Program of China 2021YFF1201104 2019 Major and Difficult Diseases Chinese and Western Medicine Coordination Capacity Colorectal Cancer Project (2018)275 Science Foundation of Peking University Cancer Hospital-2023 JC202310 Natural Science Project of Chifeng City 2023-114
Corresponding Author	Ai-Wen Wu, MD, PhD, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Center, Unit III, Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. wuaw@sina.com
Key Words	Rectal cancer; Neoadjuvant chemoradiotherapy; Local excision; Prognosis
Core Tip	This retrospective study explores the safety, efficacy, and long-term prognosis of local excision (LE) in patients with middle-low rectal cancer who responded well to neoadjuvant chemoradiotherapy. The findings demonstrate that LE can achieve high rates of organ preservation and favorable oncological outcomes, including a 5-year disease-free survival rate of 88.4% and overall survival rate of 92.9%. Complications were manageable and non-severe. This study supports the potential of minimally invasive treatments in selected patients, highlighting the importance of patient participation in treatment decisions.
Citation	Chen N, Li CL, Wang L, Yao YF, Peng YF, Zhan TC, Zhao J, Wu AW. Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center. World J Gastrointest Oncol 2024; In press

Received	2024-07-23 11:46
Peer-Review Started	2024-07-23 11:46
To Make the First Decision
Return for Revision	2024-08-09 10:54
Revised	2024-08-13 10:23
Second Decision	2024-09-05 02:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-09-05 07:56
Articles in Press	2024-09-05 07:56
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ISSN	1948-5204 (online)
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