Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	98909
Country	China

Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center
Manuscript Source	Unsolicited Manuscript
All Author List	Nan Chen, Chang-Long Li, Lin Wang, Yun-Feng Yao, Yi-Fan Peng, Tian-Cheng Zhan, Jun Zhao and Ai-Wen Wu
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Municipal Administration of Hospitals Incubating Program PZ2020027 Beijing Talent Incubating Funding 2019-4 National Natural Science Foundation of China 81773214 Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support ZYLX202116 National Key R and D Program of China 2021YFF1201104 2019 Major and Difficult Diseases Chinese and Western Medicine Coordination Capacity Colorectal Cancer Project (2018)275 Science Foundation of Peking University Cancer Hospital-2023 JC202310 Natural Science Project of Chifeng City 2023-114
Corresponding Author	Ai-Wen Wu, MD, PhD, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Center, Unit III, Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. wuaw@sina.com
Key Words	Rectal cancer; Neoadjuvant chemoradiotherapy; Local excision; Prognosis
Core Tip	This retrospective study explores the safety, efficacy, and long-term prognosis of local excision (LE) in patients with middle-low rectal cancer who responded well to neoadjuvant chemoradiotherapy. The findings demonstrate that LE can achieve high rates of organ preservation and favorable oncological outcomes, including a 5-year disease-free survival rate of 88.4% and overall survival rate of 92.9%. Complications were manageable and non-severe. This study supports the potential of minimally invasive treatments in selected patients, highlighting the importance of patient participation in treatment decisions.
Citation	<p>Chen N, Li CL, Wang L, Yao YF, Peng YF, Zhan TC, Zhao J, Wu AW. Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center. <i>World J Gastrointest Oncol</i> 2024; 16(12): 4614-4624</p>

Received	2024-07-23 11:46
Peer-Review Started	2024-07-23 11:46
To Make the First Decision
Return for Revision	2024-08-09 10:54
Revised	2024-08-13 10:23
Second Decision	2024-09-05 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-05 07:56
Articles in Press	2024-09-05 07:56
Publication Fee Transferred	2024-10-05 02:53
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-14 00:39

ISSN	1948-5204 (online)
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