Publication Name	World Journal of Gastroenterology
Manuscript ID	98944
Country	China

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	From traditional Chinese medicine formulations to effective anticancer agents: Insights from Calculus Bovis
Manuscript Source	Invited Manuscript
All Author List	He-Tong Zhao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82204909
Corresponding Author	He-Tong Zhao, Doctor, MD, Doctor, Department of Traditional Chinese Medicine, Navy No. 905 Hospital, Huashan Road, Shanghai 200050, China. zhtzhao@126.com
Key Words	Calculus Bovis; Traditional Chinese medicine; Liver cancer; Tumor microenvironment; M2 tumor-associated macrophages; Wnt/β-catenin pathway
Core Tip	This study elucidates the anticancer potential of traditional Chinese medicine (TCM), focusing on Calculus Bovis (CB), a principal component in Pien Tze Huang, in treating liver cancer. It demonstrates CB’s role in suppressing liver cancer progression by inhibiting M2 macrophage polarization through the Wnt/β-catenin pathway. Key findings emphasize the transition from holistic TCM formulations to the isolation of specific active ingredients, underscoring the necessity for modern scientific methods to dissect these components further. This approach highlights a significant shift towards integrating traditional remedies with contemporary oncological research to develop novel cancer therapies.
Citation	Zhao HT. From traditional Chinese medicine formulations to effective anticancer agents: Insights from Calculus Bovis. World J Gastroenterol 2024; In press

Received	2024-07-13 15:47
Peer-Review Started	2024-07-13 15:47
To Make the First Decision
Return for Revision	2024-08-13 16:21
Revised	2024-08-27 10:32
Second Decision	2024-09-04 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-09-04 06:31
Articles in Press	2024-09-04 06:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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