Publication Name	World Journal of Diabetes
Manuscript ID	99075
Country	Saudi Arabia

Category	Endocrinology & Metabolism
Manuscript Type	Editorial
Article Title	Glucagon-like peptide-1 agonists: The gut role in hypoglycemia unawareness, and the rationale in type 1 diabetes
Manuscript Source	Invited Manuscript
All Author List	Hyder O Mirghani
Funding Agency and Grant Number
Corresponding Author	Hyder O Mirghani, MD, Professor, Internal Medicine, University of Tabuk, Prince Fahd Bin Sultan, Tabuk 51941, Tabuk, Saudi Arabia. s.hyder63@hotmail.com
Key Words	Glucagon-like peptide-1 receptor agonists; Glucagon response; Hypoglycemia unawareness; Gut; Type 1 diabetes
Core Tip	Poor glycemic control, nonadherence to insulin, vascular complication, and obesity remain major challenges in type 1 diabetes management. Glucagon-like peptide-1 receptor (GLP-1) agonists were shown to address the above without significant hypoglycemia. The rationale for GLP-1 use was based on the shared pathophysiology of type 1 and type 2 diabetes. The recent evidence of the gut involvement in GLP-1 agonists induced hypoglycemia unawareness and glucagon dysregulation is of great concern and the emerging role of GLP-1 agonists in the gut microbiota dysregulation and diversity could change diabetes management including type 1 diabetes. The use of GLP-1 agonists is better individualized.
Citation	Mirghani HO. Glucagon-like peptide-1 agonists: The gut role in hypoglycemia unawareness, and the rationale in type 1 diabetes. World J Diabetes 2024; In press

Received	2024-07-12 13:13
Peer-Review Started	2024-07-12 13:13
To Make the First Decision
Return for Revision	2024-08-26 03:21
Revised	2024-08-30 10:54
Second Decision	2024-09-05 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-05 08:13
Articles in Press	2024-09-05 08:13
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-09-06 11:20
Typeset the Manuscript

ISSN	1948-9358 (online)
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