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Publication Name World Journal of Hepatology
Manuscript ID 99092
Country China
Category Oncology
Manuscript Type Prospective Study
Article Title Thyroid hormone, immunoglobin and complements for predicting hepatocellular carcinoma development in patients with hepatitis B virus-related liver cirrhosis
Manuscript Source Unsolicited Manuscript
All Author List Xue-Cheng Tong, Kai Liu, Ze-Yu Huang, Xiu-Jun Zhang and Yuan Xue
Funding Agency and Grant Number
Funding Agency Grant Number
The Research Foundation of Jiangsu Province Administration of Traditional Chinese Medicine No. MS2023088
The Science and Technology Project of Changzhou No. CE20225040
The Research Foundation of Nanjing Medical University Changzhou Medical Center No. CMCC202311
Leading Talent of Changzhou “The 14th Five-Year Plan” High-Level Health Talents Training Project No. 2022CZLJ021
Corresponding Author Yuan Xue, MD, Department of Infectious Diseases, Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, No. 300 Lanling North Road, Changzhou 213000, Jiangsu Province, China. xueyuan80908@163.com
Key Words Thyroid hormone; Immunoglobulin; Complement; Hepatocellular carcinoma; Prediction
Core Tip Hepatocellular carcinoma (HCC) surveillance is crucial for patients with compensated cirrhosis (CC) and decompensated cirrhosis (DC). During a median follow-up duration of 32 months, the incidence of HCC was significantly higher in the DC group compared to the CC group. Total triiodothyronine and total tetraiodothyronine positively correlated with alanine transaminase (ALT), aspartate transaminase (AST), and gamma-glutamyl transpeptidase (GGT). Immunoglobulin (Ig) G positively correlated with IgM, IgA, ALT, and AST, while it negatively correlated with C3 and C4. The predictive value of thyroid hormone, Ig, and complements for HCC development is suboptimal. Multivariable analysis indicated that age, DC, and GGT were independent risk factors for HCC development.
Citation Tong XC, Liu K, Huang ZY, Zhang XJ, Xue Y. Thyroid hormone, immunoglobin and complements for predicting hepatocellular carcinoma development in patients with hepatitis B virus-related liver cirrhosis. World J Hepatol 2025; In press
Received
2024-08-22 06:37
Peer-Review Started
2024-07-13 13:30
To Make the First Decision
Return for Revision
2025-01-03 09:44
Revised
2025-01-06 16:45
Second Decision
2025-01-17 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-01-24 08:10
Articles in Press
2025-01-24 08:10
Publication Fee Transferred
2025-01-08 14:44
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-01-31 16:38
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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