Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	99122
Country	China

Category	Immunology
Manuscript Type	Editorial
Article Title	Early identification and multidisciplinary management of immune checkpoint inhibitors associated colitis can improve patient outcomes
Manuscript Source	Invited Manuscript
All Author List	Liang Wang, Sheng-Mei Zhang and Xiao-Qian Chen
Funding Agency and Grant Number	Funding Agency Grant Number 2021 Key Topic of Qinghai Provincial Health System–Guiding Plan Topic No. 2021-WJZDX-43
Corresponding Author	Xiao-Qian Chen, Department of Gastrointestinal Oncology Surgery, The Affiliated Hospital of Qinghai University, The Affiliated Cancer Hospital of Qinghai University, No. 29 Tongren Road, Xining 810000, Qinghai Province, China. cxq925@163.com
Key Words	Immune checkpoint inhibitors; Immune-related adverse events; Immune checkpoint inhibitor-associated colitis; Immunotherapy; Multidisciplinary management
Core Tip	The application of various immune checkpoint inhibitors (ICIs) in treating various malignant tumors has yielded remarkable clinical efficacy, significantly improving patient prognosis. However, while ICIs strengthen anti-tumor immunity, they can also induce autoimmune damage and immune-related adverse events (irAEs), with immune checkpoint inhibitor (ICI)-associated colitis being relatively common. This condition may lead to treatment interruptions, drug discontinuation, and reduced treatment efficacy. Severe irAEs can even be life-threatening. Thus, vigilance for ICI-associated colitis is essential when patients exhibit symptoms like diarrhea and abdominal pain during or after ICI treatment. Early identification, multidisciplinary management, and continuous monitoring are critical to improving patient outcomes.
Citation	Wang L, Zhang SM, Chen XQ. Early identification and multidisciplinary management of immune checkpoint inhibitors associated colitis can improve patient outcomes. World J Gastrointest Surg 2024; In press

Received	2024-07-15 05:44
Peer-Review Started	2024-07-14 10:16
To Make the First Decision
Return for Revision	2024-10-28 07:50
Revised	2024-11-09 12:34
Second Decision	2024-11-26 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-26 07:09
Articles in Press	2024-11-26 07:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-30 02:54

ISSN	1948-9366 (online)
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