Publication Name	World Journal of Gastroenterology
Manuscript ID	99136
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Construction and validation of a pancreatic cancer prognostic model based on genes related to the hypoxic tumor microenvironment
Manuscript Source	Unsolicited Manuscript
All Author List	Fan Yang, Na Jiang, Xiao-Yu Li, Xing-Si Qi, Zi-Bin Tian and Ying-Jie Guo
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82100581
Corresponding Author	Ying-Jie Guo, MD, Doctor, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, Shandong, China. guoyingjie305@163.com
Key Words	Pancreatic cancer; Hypoxia; Prognostic model; Immune microenvironment; Plasminogen activator urokinase
Core Tip	In this study, a prognostic model based on the expression levels of the hypoxia-related genes CAPN2, PLAU, and CCNA2 was developed for pancreatic cancer. Compared with traditional methods, the model demonstrated superior predictive accuracy, and the model risk score was strongly correlated with clinical features such as cancer stage and tumor size. The risk score was also significantly associated with chemotherapy drug sensitivity and metabolic pathway activity. These findings highlight the model's potential to enhance personalized treatment selection and improve prognosis.
Citation	<p>Yang F, Jiang N, Li XY, Qi XS, Tian ZB, Guo YJ. Construction and validation of a pancreatic cancer prognostic model based on genes related to the hypoxic tumor microenvironment. <i>World J Gastroenterol</i> 2024; 30(36): 4057-4070</p>

Received	2024-07-14 18:59
Peer-Review Started	2024-07-14 18:59
To Make the First Decision
Return for Revision	2024-08-09 22:00
Revised	2024-08-22 16:19
Second Decision	2024-09-05 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-05 06:38
Articles in Press	2024-09-05 06:38
Publication Fee Transferred	2024-09-06 11:10
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-14 05:12

ISSN	1007-9327 (print) and 2219-2840 (online)
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