Publication Name	World Journal of Clinical Cases
Manuscript ID	99558
Country	Ecuador

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Wilson's disease in two siblings from Ecuador: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Enrique Carrera, Jonathan Alvarado, Martina Astudillo and Galo Pillajo
Funding Agency and Grant Number
Corresponding Author	Enrique Carrera, MD, Assistant Professor, Department of Gastroenterology and Hepatology, Hospital de Especialidades Eugenio Espejo, Gran Colombia Avenue and Yaguachi Street, Quito 170136, Pichincha, Ecuador. carreraestupinan.enrique@gmail.com
Key Words	Wilson disease; Kayser-Fleischer rings; Copper chelator; D-penicillamine; Trientine tetrahydrochloride; Case report
Core Tip	Diagnosing and treating Wilson disease (WD) is particularly challenging in developing countries due to limited resources. This case study of two siblings from Ecuador demonstrates why early diagnoses and consistent treatments are crucial. The male sibling showed severe symptoms, whereas an early intervention kept the female sibling asymptomatic. Switching from D-penicillamine to trientine tetrahydrochloride improved their condition. Our cases report emphasizes the need for an effective healthcare infrastructure and WD awareness to manage the condition under resource-limited settings, and our findings suggest that genetic and environmental factors contribute to the disease's variability.
Citation	<p>Carrera E, Alvarado J, Astudillo M, Pillajo G. Wilson's disease in two siblings from Ecuador: Two case reports. <i>World J Clin Cases</i> 2025; 13(3): 99558</p>

Received	2024-07-25 02:52
Peer-Review Started	2024-07-25 02:52
To Make the First Decision
Return for Revision	2024-09-25 06:32
Revised	2024-10-09 01:52
Second Decision	2024-10-29 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-29 10:26
Articles in Press	2024-10-29 10:26
Publication Fee Transferred	2024-10-21 19:03
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-05 02:38

ISSN	2307-8960 (online)
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