Publication Name	World Journal of Diabetes
Manuscript ID	99576
Country	China

Category	Otorhinolaryngology
Manuscript Type	Retrospective Study
Article Title	Therapeutic effectiveness of intratympanic and retroauricular methylprednisolone sodium succinate for refractory sudden sensorineural hearing loss in diabetic patients
Manuscript Source	Unsolicited Manuscript
All Author List	Dong Li, Fei Qiao, Jun Dai, Min Xu, He-Yan Gong, Hui-Ming Yang, Jing-Cheng Li and De Huai
Funding Agency and Grant Number	Funding Agency Grant Number 2023 Science and Technology Innovation Program (Key Laboratory of Sleep Respiratory Disorders) in Huai'an HAP202304
Corresponding Author	Jing-Cheng Li, Department of Otorhinolaryngology, The Affiliated Huai'an Hospital of Yangzhou University (The Fifth People's Hospital of Huai'an), No. 1 Huaihe Road, Huaiyin District, Huai’an 223300, Jiangsu Province, China. jingchengl@126.com
Key Words	Intratympanic injection; Retroauricular injection; Refractory sudden hearing loss; Diabetes mellitus; Therapeutic effectiveness
Core Tip	Studies on the efficacy of combined intratympanic and retroauricular injection for refractory sudden sensorineural hearing loss (RSSHL) complicated with diabetes mellitus (DM) remains limited. Herein, we comprehensively assessed treatment outcomes, adverse effects, blood glucose levels, hearing thresholds across various frequencies, serum biochemical markers, and quality of life. The results indicate that intratympanic injection combined with retroauricular administration of methylprednisolone sodium succinate significantly improves therapeutic efficacy in patients with RSSHL complicated with DM. This approach not only improves blood glucose control and suppresses systemic inflammation but also enhances quality of life without increasing the overall risk of adverse effects. These results provide valuable information and a potential framework for optimizing treatment strategies in this patient population.
Citation	<p>Li D, Qiao F, Dai J, Xu M, Gong HY, Yang HM, Li JC, Huai D. Therapeutic effectiveness of intratympanic and retroauricular methylprednisolone sodium succinate for refractory sudden sensorineural hearing loss in diabetic patients. <i>World J Diabetes</i> 2025; 16(5): 99576</p>

Received	2024-11-13 08:13
Peer-Review Started	2024-11-20 01:46
To Make the First Decision
Return for Revision	2025-01-15 10:01
Revised	2025-02-17 03:46
Second Decision	2025-03-12 09:02
Accepted by Journal Editor-in-Chief	2025-03-12 20:37
Accepted by Executive Editor-in-Chief	2025-03-21 08:40
Articles in Press	2025-03-21 08:40
Publication Fee Transferred	2025-02-23 07:40
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-14 02:44

ISSN	1948-9358 (online)
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