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Article Quality Tracking-Peer-Review
Publication Name
Article Title
Manuscript ID Reviewer Code
Year Published Author(s)
1
"The minireview "Key players in the breast cancer microenvironment: From fibroblasts to immune cells" by Sacide et al summarizes the role of tumor microenvironment in the immune invasion, therapy resistance and metastasis process in Breast cancer. This understanding will definitely help us to explore the breast cancer progression with new therapeutic approach. The minireview is well written and beautifully presented. The language and grammar is appropriate. The referencing is good. However, a description on role of tumor microenvironment on angiogenesis and angiogenic signaling could have been discussed. Overall The review is good and useful for the scientific community." 
Çakal S, Er Urgancı B, Şimşek S. Key players in the breast cancer microenvironment: From fibroblasts to immune cells. World J Clin Oncol 2025; 16(7): 107339 [DOI: 10.5306/wjco.v16.i7.107339]
2
"This study concerns a consensus reached by a group of experts from the Middle East, who, with the assistance of an internationally recognized German expert, formulated comprehensive guidelines on the treatment of Helicobacter pylori infection in the Middle East. It is well known that the prevalence of Helicobacter pylori infection in these countries is quite high in both adults and children. The development of antibiotic resistance in these countries is another obstacle to the effectiveness of treatment. In this sense, the formulation of these guidelines for treating Helicobacter pylori infection is useful and of practical importance, particularly about the risk of developing gastric cancer. Such activities should also be carried out in other parts of the world (e.g., Africa, Asia)." 
Sharara AI, Alsohaibani FI, Alsaegh A, Al Ejji K, Al Awadhi S, Malfertheiner P, Karam SA, Al-Taweel T. First regional consensus on the management of Helicobacter pylori infection in the Middle East. World J Gastroenterol 2025; 31(27): 107138 [DOI: 10.3748/wjg.v31.i27.107138]
3
"This is very interesting paper about heart failure after TIPS.Heart failure can be a complication after a transjugular intrahepatic portosystemic shunt (TIPS) procedure, particularly in patients with pre-existing heart conditions or those with cirrhotic cardiomyopathy. While post-TIPS heart failure is relatively uncommon, it is crucial to understand the factors that can contribute to its development and to monitor patients closely for signs and symptoms. The author's fig4 EKG, BNP, and echocardiographic evaluations are simple and easy to understand." 
Tomassoni DR, Schildkraut T, Ramachandran V, Cooke JC, Sawhney R. Cardiovascular risk assessment and predictors of cardiac decompensation after transjugular intrahepatic portosystemic shunt in patients with cirrhosis. World J Gastroenterol 2025; 31(27): 107740 [DOI: 10.3748/wjg.v31.i27.107740]
4
"Kwon et al. reported that deep learning-based localization and lesion detection in capsule endoscopy for patients with suspected small-bowel bleeding. It maybe true the AI-based localization and lesion detection is very useful for the discovery of small-bowel bleeding in patients. If possible, authors should distribute these application for everyone examine their figures. If so, everyone could recognize the results of authors." 
Kwon YS, Park TY, Kim SE, Park Y, Lee JG, Lee SP, Kim KO, Jang HJ, Yang YJ, Cho BJ. Deep learning-based localization and lesion detection in capsule endoscopy for patients with suspected small-bowel bleeding. World J Gastroenterol 2025; 31(27): 106819 [DOI: 10.3748/wjg.v31.i27.106819]
5
"Excellently presented study. All points are very well taken. The article provides a comprehensive perspective on all contemporary aspects of variceal hemorrhage management. The article is written so that it is recommended for gastroenterologists, general surgeons, hospitalists, and emergency medicine physicians. The Authors' effort constitutes a major contribution towards updating the current knowledge and understanding of the problem, and provides a foundation for database perfection. " 
Kogilathota Jagirdhar GS, Okafor CC, Hussain M, Elmati PR, Ghumman A, Shah M, Surani S. Decline of the Sengstaken-Blakemore tube: A review of shifting practices in gastrointestinal hemorrhage management. World J Crit Care Med 2025; 14(3): 101856 [DOI: 10.5492/wjccm.v14.i3.101856]
6
"Only three articles examined are very few, the search should be expanded. also missing the PROSPERO membership number and the PRISMA check-list. More detailed information on research should be provided to make it more rigorous. It would also be useful to specify the limitations of the study and what can be done in future studies to improve these limits Finally , a English editing is needed." 
Yousif Mohamed AM, Salih M, Mohamed M, Abbas AE, Elsiddig M, Osama Omar M, Abdelsalam M, Elhag B, Mohamed N, Eisa Ahmed SH, Ahmed S, Mohamed D, Omar D. Comparative efficacy of cementless bipolar hemiarthroplasty and proximal femoral nail anti-rotation in unstable intertrochanteric fractures: A meta-analysis. World J Orthop 2025; 16(7): 107950 [DOI: 10.5312/wjo.v16.i7.107950]
7
"Survival rates following radical surgery for gastric neuroendocrine neoplasms (g-NENs) are low, with high recurrence rates. Liu, et al’s study addressed a critical issue in determining the postoperative prognosis of gastric neuroendocrine tumors by identifying the significance of lymph node ratio. Moreover, the random survival forest model, a machine-learning approach, surpasses traditional Cox proportional hazards models by enhancing predictive accuracy, clinical utility, and overall performance. This model’s ability to stratify patient risks and personalize survival predictions can aid in formulating targeted postoperative strategies, thus realizing an important aspect of personalized “precision medicine”. This paper is indicative for journal readers in this field." 
Wang HN, An JH, Zong L. Estimating prognosis of gastric neuroendocrine neoplasms using machine learning: A step towards precision medicine. World J Gastrointest Oncol 2024; 16(12): 4548-4552 [PMID: 39678793 DOI: 10.4251/wjgo.v16.i12.4548]
8
"Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths due to late diagnosis and high recurrence rates. Key biomarkers such as enhancer of zeste homolog 2 and fatty acid binding protein 5, along with other genetic biomarkers provide insights into HCC progression and potential therapeutic targets. This paper is indicative for journal readers in this field. " 
Shodry S, Hasan YTN, Ahdi IR, Ulhaq ZS. Gene targets with therapeutic potential in hepatocellular carcinoma. World J Gastrointest Oncol 2024; 16(12): 4543-4547 [PMID: 39678796 DOI: 10.4251/wjgo.v16.i12.4543]
9
"In this Editorial we comment on the interesting article by Liu, et al. The controlling nutritional status (CONUT) score was significantly associated with the prognosis of colorectal cancer patients, as supported by a large body of literature. Compared with other nutritional scores, the CONUT score might be introduced in clinical practice as an optimal prognostic nutritional index to predict patient outcome." 
Berardi R, Chiariotti R, Mentrasti G. Is nutritional status a new indicator to use in clinical practice for colorectal cancer patients? World J Gastrointest Oncol 2024; 16(12): 4537-4542 [PMID: 39678789 DOI: 10.4251/wjgo.v16.i12.4537]
10
"In this Editorial, they highlighted potential pitfalls in the current classification of mixed neuroendocrine non-neuroendocrine neoplasms and commented on challenges in the management of this heterogeneous group of malignancies in light of the paucity of evidence in the field. Improved biological and clinical knowledge were needed to generate robust classification schemes that will in turn provide clarity on the epidemiology of the disease, prognosis of affected patients and guidance for treatment tailoring. This paper is indicative for journal readers in this field." 
Cives M, Porta C, Palmirotta R. Mixed neuroendocrine non-neuroendocrine tumors: The quest for evidence. World J Gastrointest Oncol 2024; 16(12): 4532-4536 [PMID: 39678802 DOI: 10.4251/wjgo.v16.i12.4532]
11
"Gastric cancer remains a formidable global health concern with significant morbidity and mortality rates, despite the fact that numerous advances have been made to improve conventional therapies. This Editorial article integrated network pharmacology insights with rigorous experimental validation to highlight the potential of Xiaojianzhong decoction as a multifaceted therapeutic approach for gastric cancer. This paper is indicative for journal readers in this field." 
Cheng CH, Hao WR, Cheng TH. Exploring Xiaojianzhong decoction's potential in gastric cancer treatment: Integrative insights and experimental validation. World J Gastrointest Oncol 2024; 16(12): 4553-4558 [PMID: 39678804 DOI: 10.4251/wjgo.v16.i12.4553]
12
"Mixed neuroendocrine non-neuroendocrine neoplasms constitute rare tumors that are located mainly in the gastrointestinal tract and have high degrees of malignancy, and the frequency of these tumors has been increasing. The rare but steadily increasing number of gastrointestinal mixed neuroendocrine non-neuroendocrine neoplasms and pure neuroendocrine carcinomas require more radical treatment than slow-growing neuroendocrine neoplasms do and they are related to poor prognosis. They constitute a complicated diagnostic and therapeutic challenge. The current management strategy begins with surgery and is followed by chemotherapy. New chemotherapeutics and novel biological agents for targeted therapy, along with immunotherapy broaden the range of therapeutic options, providing promising outcomes. Effective management should be individualized and multidisciplinary. This paper is indicative for journal readers in this field." 
Pavlidis ET, Galanis IN, Pavlidis TE. Critical considerations for the management of gastrointestinal mixed neuroendocrine non-neuroendocrine neoplasms and pure neuroendocrine carcinomas. World J Gastrointest Oncol 2024; 16(12): 4559-4564 [PMID: 39678788 DOI: 10.4251/wjgo.v16.i12.4559]
13
"Within the intricate milieu of colorectal cancer (CRC) tissues, cancer-associated fibroblasts (CAFs) act as pivotal orchestrators, wielding considerable influence over tumor progression. Their review endeavored to dissect the multifaceted functions of CAFs within the realm of CRC, thereby highlighting their indispensability in fostering CRC malignant microenvironment and indicating the development of CAFs-targeted therapeutic interventions. Through a comprehensive synthesis of current knowledge, their review delineated insights into CAFs-mediated modulation of cancer cell proliferation, invasiveness, immune evasion, and neovascularization, elucidating the intricate web of interactions that sustain the pro-tumor metabolism and secretion of multiple factors. Additionally, recognizing the high level of heterogeneity within CAFs is crucial, as they encompass a range of subtypes, including myofibroblastic CAFs, inflammatory CAFs, antigen-presenting CAFs, and vessel-associated CAFs. Innovatively, the symbiotic relationship between CAFs and the intestinal microbiota is explored, shedding light on a novel dimension of CRC pathogenesis. Despite remarkable progress, the orchestrated dynamic functions of CAFs remain incompletely deciphered, underscoring the need for continued research endeavors for therapeutic advancements in CRC management. This review article is well written, and is informative for journal readers in this field." 
Cui JY, Ma J, Gao XX, Sheng ZM, Pan ZX, Shi LH, Zhang BG. Unraveling the role of cancer-associated fibroblasts in colorectal cancer. World J Gastrointest Oncol 2024; 16(12): 4565-4578 [PMID: 39678792 DOI: 10.4251/wjgo.v16.i12.4565]
14
"In their report, they assessed the prognostic value of gamma-glutamyl transpeptidase to platelet ratio (GPR) in early hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. They evaluated the clinical utility of preoperative GPR in predicting outcomes for solitary HBV-related HCC patients using propensity score matching, restricted cubic spline, survival analyses and stratified analyses. Preoperative GPR levels facilitated recurrence monitoring and inform treatment strategies, potentially enhancing the quality of life for HCC patients. Although case report accompanied with some limitations for any conclusions, their report is interesting for journal readers in this field." 
Yang CK, Wei ZL, Shen XQ, Jia YX, Wu QY, Wei YG, Su H, Qin W, Liao XW, Zhu GZ, Peng T. Prognostic utility of gamma-glutamyl transpeptidase to platelet ratio in patients with solitary hepatitis B virus-related hepatocellular carcinoma after hepatectomy. World J Gastrointest Oncol 2024; 16(12): 4579-4596 [PMID: 39678799 DOI: 10.4251/wjgo.v16.i12.4579]
15
"Their developed and validated a promising machine learning architecture for predicting the 3-category survival times (cutoff values of 3 years and 5 years) for four survival times (overall, disease-free, recurrence-free, and distant metastasis-free survival) and screened corresponding important variables. Fivefold cross validation and bootstrap validation were conducted. The models were evaluated with the area under the curve (AUC); moreover, the effectiveness of our variable screening methods was evaluated by comparing the models’ pre- and post-screening AUCs. SHapley Additive exPlanations were used to explain the decision-making process. Nomograms were drawn for various applications. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Ji XL, Xu S, Li XY, Xu JH, Han RS, Guo YJ, Duan LP, Tian ZB. Prognostic prediction models for postoperative patients with stage I to III colorectal cancer based on machine learning. World J Gastrointest Oncol 2024; 16(12): 4597-4613 [PMID: 39678810 DOI: 10.4251/wjgo.v16.i12.4597]
16
"Their retrospective study explores the safety, efficacy, and long-term prognosis of local excision (LE) in patients with middle-low rectal cancer who responded well to neoadjuvant chemoradiotherapy. Their results demonstrated that LE can achieve high rates of organ preservation and favorable oncological outcomes, including a 5-year disease-free survival rate of 88.4% and overall survival rate of 92.9%. Complications were manageable and non-severe. Their study supported the potential of minimally invasive treatments in selected patients, highlighting the importance of patient participation in treatment decisions. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Chen N, Li CL, Wang L, Yao YF, Peng YF, Zhan TC, Zhao J, Wu AW. Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center. World J Gastrointest Oncol 2024; 16(12): 4614-4624 [PMID: 39678786 DOI: 10.4251/wjgo.v16.i12.4614]
17
"Their retrospective analyses spanned a decade (January 1, 2012 to September 30, 2022) and included 5417 patients from Beijing Youan Hospital, Capital Medical University. Using Cox regression and competing risk regression models, they identified several key factors that significantly contributed to the risk of hepatocellular carcinoma in patients with cirrhosis. Specifically, their study underscored the increased association of hepatitis B cirrhosis with hepatocellular carcinoma incidence and highlights other significant risk factors, including male sex, advanced age, viral hepatitis-related cirrhosis, elevated blood ammonia, and lower albumin and platelet levels. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Zhou DQ, Liu JY, Zhao F, Zhang J, Liu LL, Jia JR, Cao ZH. Risk factors for hepatocellular carcinoma in cirrhosis: A comprehensive analysis from a decade-long study. World J Gastrointest Oncol 2024; 16(12): 4625-4635 [PMID: 39678801 DOI: 10.4251/wjgo.v16.i12.4625]
18
"The Esophageal cancer (EC) often occurs in the elderly, with approximately 33% of patients aged ≥ 75 years at the time of diagnosis. Since patients aged 75 years and above are often excluded from many clinical trials of EC, there is a lack of agreement regarding the prognosis and treatment of this population. They retrospectively analyzed the clinical characteristics, toxic reactions, and survival information of elderly patients with EC aged ≥ 75 years who received intensity-modulated radiotherapy. Their analyses aimed to evaluate the prognostic factors affecting overall survival. They found that the Charlson comorbidity index and nutritional risk screening 2002 were independent prognostic factors for overall survival. Their results suggested that when formulating treatment plans for elderly patients with EC, full attention should be given to age-related biological indicators such as comorbidities and nutrition. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Hu LL, Rong F, Liu L, Zhang L, Zhang LL, Yang Q, Xia ZL, Wang H. Prognosis of radiotherapy for esophageal cancer in elderly patients exceeding seventy-five years old. World J Gastrointest Oncol 2024; 16(12): 4636-4649 [PMID: 39678803 DOI: 10.4251/wjgo.v16.i12.4636]
19
"The γ-glutamyl transferase to albumin ratio has been confirmed for the first time to be predictive in hepatocellular carcinoma undergoing transarterial chemoembolization and transarterial chemoembolization combined with systemic therapy in this large-sample multicenter study. A nomogram model for predicting postoperative survival was also established based on γ-glutamyl transferase to albumin ratio, which was empirically demonstrated to have strong predictive ability. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Wu ZY, Li H, Chen JL, Su K, Weng ML, Han YW. Nomogram model based on γ-glutamyl transferase to albumin ratio predicts survival in hepatocellular carcinoma patients with transarterial chemoembolization treatment. World J Gastrointest Oncol 2024; 16(12): 4650-4662 [PMID: 39678787 DOI: 10.4251/wjgo.v16.i12.4650]
20
"The deep learning model (DLM) was validated to accurately predict the risk classification of gastrointestinal stromal tumors. The combined DLM outperformed DLM in predicting risk stratification. The combined model has potential to guide and facilitate clinical decision-making. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Li Y, Liu YB, Li XB, Cui XN, Meng DH, Yuan CC, Ye ZX. Deep learning model combined with computed tomography features to preoperatively predicting the risk stratification of gastrointestinal stromal tumors. World J Gastrointest Oncol 2024; 16(12): 4663-4674 [PMID: 39678791 DOI: 10.4251/wjgo.v16.i12.4663]
21
"In their study, patients diagnosed with advanced gastroenteropancreatic neuroendocrine tumors who were treated with the temozolomide and capecitabine regimen exhibited a median overall survival of 49 months, with 42% surviving at 60 months. The regimen was well-tolerated, and most patients experienced stable disease. Their results suggested that this treatment could be viable in settings where standard therapies are unavailable or inaccessible, although further prospective studies were needed for confirmation. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Cruz-Diaz WE, Paitan V, Medina J, Flores R, Haro-Varas J, Mantilla R, Castro-Oliden V. Temozolomide and capecitabine regimen as first-line treatment in advanced gastroenteropancreatic neuroendocrine tumors at a Latin American reference center. World J Gastrointest Oncol 2024; 16(12): 4675-4684 [PMID: 39678797 DOI: 10.4251/wjgo.v16.i12.4675]
22
"Supplementation with 1,25-dihydroxy-vitamin D [1,25(OH)2D3] improved hepatic steatosis and lipid metabolism in nonalcoholic fatty liver disease, linked to its capacity to reverse the proinflammatory M1 polarization of hepatic macrophages, partially by regulating the vitamin D receptor-peroxisome proliferator activated receptor γ pathway. The involvement of 1,25(OH)2D3 in inhibiting fatty-acid-induced proinflammatory M1 polarization of macrophages played a direct role in relieving lipid accumulation and metabolism in hepatocytes. Their results are informative for journal readers in this field." 
Luo WJ, Dong XW, Ye H, Zhao QS, Zhang QB, Guo WY, Liu HW, Xu F. Vitamin D 1,25-Dihydroxyvitamin D3 reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization. World J Gastrointest Oncol 2024; 16(12): 4685-4699 [PMID: 39678811 DOI: 10.4251/wjgo.v16.i12.4685]
23
"Despite advances in therapy for colorectal cancer (CRC), the 5-year survival rate for CRC patients in China remains only 56.9%. Their study explored the effects of matrine on CRC by targeting a newly identified anti-apoptotic protein, Shank-associated RH domain interactor (SHARPIN). SHARPIN was discovered through proteomic analysis and its expression was validated in both the TCGA database and our patient cohort using immunohistochemistry. Inhibiting SHARPIN expression led to increased apoptosis and reduced proliferation, invasion, and migration of CRC cells in vitro. Matrine's ability to inhibit SHARPIN and induce apoptosis highlights its potential as a promising therapeutic agent for CRC. Their results are informative for journal readers in this field." 
Zhou YC, Wang QQ, Zhou GYJ, Yin TF, Zhao DY, Sun XZ, Tan C, Zhou L, Yao SK. Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression. World J Gastrointest Oncol 2024; 16(12): 4700-4715 [PMID: 39678809 DOI: 10.4251/wjgo.v16.i12.4700]
24
"Their study highlighted spermine synthase (SMS) as a pivotal molecule regulating DNA damage and autophagy in cancer cells. SMS promoted DNA repair and activated the mammalian target of rapamycin signaling pathway, resulting in the inhibition of cellular autophagy. Collectively, SMS emerges as a promising therapeutic target to enhance colorectal cancer radiosensitivity, providing novel insights into the development of colorectal cancer treatment strategies. Their results are informative for journal readers in this field." 
Guo YB, Wu YM, Lin ZZ. Enhancing the radiosensitivity of colorectal cancer cells by reducing spermine synthase through promoting autophagy and DNA damage. World J Gastrointest Oncol 2024; 16(12): 4716-4727 [PMID: 39678812 DOI: 10.4251/wjgo.v16.i12.4716]
25
"Their study systematically evaluated the efficacy and safety of transhepatic arterial chemoembolization with drug-loaded microspheres in the treatment of unresectable primary liver cancer. Through a meta-analysis of relevant literature, the effect of this treatment in prolonging survival, relieving symptoms and improving quality of life of patients was discussed, and the incidence of adverse reactions and complications was evaluated, so as to provide more scientific treatment recommendations for clinicians. Their results are interesting." 
Deng J, Mi YH, Xie L, Sun XX, Liu DH, Long HJ, He LY, Wu DH, Shang HC. Efficacy and safety of transhepatic arterial chemoembolization with drug-loaded microspheres in unresectable primary liver cancer. World J Gastrointest Oncol 2024; 16(12): 4728-4737 [PMID: 39678808 DOI: 10.4251/wjgo.v16.i12.4728]
26
"Pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare malignancies affecting the pancreas, recognized by the World Health Organization as neoplasms composed of morphologically recognizable neuroendocrine and non-neuroendocrine components, each constituting ≥ 30% of the tumor volume. However, whether the tumor should be classified as a MiNEN or collision tumor when there is clear divergence in histology and molecular profiles for each component is still debatable. Their case reports a rare case with high grade adenocarcinoma admixed with low grade neuroendocrine tumor in pancreas, which were demonstrated to have distinct molecular profiles. They discussed the potential impacts of tumor classification on staging and clinical management, hoping to encourage more discussions and studies on this rare entity. Although case report accompanied with some limitations for any conclusions, their report is interesting for journal readers in this field." 
Zhao X, Bocker Edmonston T, Miick R, Joneja U. Mixed pancreatic ductal adenocarcinoma and well-differentiated neuroendocrine tumor: A case report. World J Gastrointest Oncol 2024; 16(12): 4738-4745 [PMID: 39678795 DOI: 10.4251/wjgo.v16.i12.4738]
27
"They presented a case of primary signet-ring cell carcinoma of the colon in a 10-year-old girl. Pediatric signet-ring cell carcinoma was an exceptionally rare condition with atypical clinical symptoms, making early diagnosis challenging. The absence of specific clinical manifestations and the disease’s concealed location often resulted in oversight by both clinicians and parents. Therefore, when a child presented with persistent abdominal pain, unexplained intestinal obstruction, or refractory ascites, clinicians should strongly consider the possibility of a malignant tumor. Prompt abdominal computed tomography and contrast-enhanced computed tomography scans, along with colonoscopy if indicated, were essential for early detection and timely intervention. Although case report accompanied with some limitations for any conclusions, their report is interesting for journal readers in this field." 
Lv L, Song YH, Gao Y, Pu SQ, A ZX, Wu HF, Zhou J, Xie YC. Signet-ring cell carcinoma of the transverse colon in a 10-year-old girl: A case report. World J Gastrointest Oncol 2024; 16(12): 4746-4752 [PMID: 39678790 DOI: 10.4251/wjgo.v16.i12.4746]
28
"Hepatocellular carcinoma (HCC) was the fifth most common cancer worldwide and the third most common cause of cancer-related death, accounting for approximately 8% of overall cancer deaths. For patients with initially unresectable HCC (uHCC), transarterial chemoembolization was being evaluated associated with systemic treatments including immune checkpoint inhibitors and antiangiogenics. The synergism of these strategies could improve outcomes for patients deemed unresectable and ineligible for transplantation. In this article, they discussed a very interesting combination evaluated in uHCC patients, and highlighted new studies and trials coming forward. This letter is indicative." 
Centrone N, Serrano Uson Junior PL. Combinations of lenvatinib and immune checkpoint inhibitors plus transarterial chemoembolization, is it the prime time for unresectable hepatocellular carcinoma? World J Gastrointest Oncol 2024; 16(12): 4753-4756 [PMID: 39678805 DOI: 10.4251/wjgo.v16.i12.4753]
29
"Hepatic arterial infusion chemotherapy (HAIC) was shown to be a highly effective and safer treatment for advanced hepatocellular carcinoma. Despite its success in Asia, HAIC was underutilized in western countries. Further research and clinical trials in diverse populations were essential to validate HAIC’s benefits and integrate it into global oncology practices. This letter is indicative." 
Caliskan Yildirim E, Ergun Y. Advancing hepatocellular carcinoma treatment with hepatic arterial infusion chemotherapy. World J Gastrointest Oncol 2024; 16(12): 4757-4761 [PMID: 39678807 DOI: 10.4251/wjgo.v16.i12.4757]
30
"This article discussed the case study by Kakinuma, et al, which highlighted the successful diagnosis and treatment of UAP in a 48-year-old primiparous woman. This article emphasized the importance of rapid diagnosis and effective management of uterine artery pseudoaneurysm (UAP) following hysteroscopic surgery, as highlighted in the case study by Kakinuma, et al. Advanced imaging techniques, such as transvaginal ultrasound and contrast-enhanced computed tomography, were crucial for early detection of UAP, preventing severe hemorrhage and potential mortality. The successful treatment of UAP with uterine artery embolization demonstrated the efficacy and safety of this minimally invasive procedure, particularly for patients desiring fertility preservation. Clinicians should maintain high vigilance for UAP in patients presenting with abnormal uterine bleeding post-surgery and promptly initiate appropriate imaging studies to confirm the diagnosis. This letter is indicative." 
Byeon H. Timely identification and treatment of uterine artery pseudoaneurysm after hysteroscopic procedures. World J Gastrointest Oncol 2024; 16(12): 4762-4765 [PMID: 39678800 DOI: 10.4251/wjgo.v16.i12.4762]
31
"Newer systemic therapies for hepatocellular carcinoma (HCC) have led to growing interest in combining hepatic arterial infusion chemotherapy (HAIC) with systemic treatments. To evaluate the effectiveness and safety of HAIC and combination therapies in treating advanced HCC, a network meta-analysis was conducted by Zhou, et al. Their meta-analysis provided a valuable and comprehensive evaluation of hepatic arterial infusion chemotherapy (HAIC) and its combination therapies for advanced hepatocellular carcinoma. Compared to other treatments including transarterial chemoembolization, HAIC showed favorable outcomes including response rate and survival. Furthermore, based on the findings, combination of HAIC with antiangiogenics and even immune checkpoint inhibitors seems to improve efficacy when compared to HAIC alone. This letter is indicative." 
Dias E Silva D, Borad M, Uson Junior PLS. Current efficacy of hepatic arterial infusion chemotherapy in hepatocellular carcinoma. World J Gastrointest Oncol 2024; 16(12): 4766-4769 [PMID: 39678794 DOI: 10.4251/wjgo.v16.i12.4766]
32
"Liver cancer seriously affects the physical and mental health of human beings. Traditional Chinese medicine (TCM) is an important part of a comprehensive treatment plan, due to its multi-component and multi-target therapeutic characteristics and its known clinical efficacy. However, its mechanism of action is unclear. As science and technology progress and in-depth research leads to the creation of new drugs, many novel treatments for liver cancer have been developed. The research and development of TCM with anti-tumor effects is a hot spot in clinical treatment. Bezoars and bezoar preparations in TCM are known to regulate the immune microenvironment in liver cancer and inhibit the progression of liver cancer through various mechanisms. Targeting these mechanisms through the development of TCM anti-tumor agents, such as nano-bezoars, is the focus of future research. This letter is indicative." 
Li DH, Wen QE, Feng RQ, Qiao C, Tian XT. Use of traditional Chinese medicine bezoars and bezoar-containing preparations in hepatocarcinoma. World J Gastrointest Oncol 2024; 16(12): 4770-4777 [PMID: 39678798 DOI: 10.4251/wjgo.v16.i12.4770]
33
"The expression of cyclin-dependent kinase 9 (CDK9) was correlated with elevated autophagy levels in colon cancer, and high expression of CDK9 indicates a poor prognosis in colorectal cancer (CRC). The incidence of autophagy and the expressions of Beclin 1 and ATP binding cassette transporter G2 were different between left and right colon cancer. The roles of CDK9, ATP binding cassette transporter G2 and Beclin 1 in CRC were clarified, underlining the linkages among them and providing potential therapeutic targets of CRC. This letter is indicative." 
Shao ZB, He K, Su YB, Shi Z. Crosslink among cyclin-dependent kinase 9, ATP binding cassette transporter G2 and Beclin 1 in colorectal cancer. World J Gastrointest Oncol 2024; 16(12): 4778-4781 [PMID: 39678806 DOI: 10.4251/wjgo.v16.i12.4778]
34
"Cholangiocarcinoma is a highly aggressive cancer with limited treatment options. The recent study by Wang, et al highlights the prognostic value of the PEA3 subfamily genes (ETV1, ETV4, and ETV5), especially ETV4, as key indicators of poor survival. Elevated ETV4 expression is linked to aggressive tumor behavior and worse outcomes. Their results offered potential for personalized treatment strategies, but further large-scale validation was required to integrate ETV4 as a prognostic biomarker and therapeutic target in clinical practice, particularly in high-incidence regions. This letter is indicative." 
Okpete UE, Byeon H. Elevated ETV4 expression in cholangiocarcinoma is linked to poor prognosis and may guide targeted therapies. World J Gastrointest Oncol 2024; 16(11): 4528-4531 [PMID: 39554735 DOI: 10.4251/wjgo.v16.i11.4528]
35
"In their study, the clinical data of patients with colorectal cancer (CRC) from a single center were retrospectively analyzed. A high neutrophil-to-lymphocyte ratio and low hemoglobin levels were independent predictive risk factors for poor prognosis in patients with peritoneal metastasis (PM) of CRC. The established nomogram including CA 19-9 levels and patient age accurately predicted the overall survival of patients having PM, indicating its usefulness as a valuable prognostic tool for this patient cohort. This letter is indicative." 
Sforzin I, Borad M, Uson Junior PLS. Are preoperative inflammatory and nutritional markers important for the prognosis of patients with peritoneal metastasis of colorectal cancer? World J Gastrointest Oncol 2024; 16(11): 4522-4527 [PMID: 39554733 DOI: 10.4251/wjgo.v16.i11.4522]
36
"Their article reviewed the integration of novel combined therapies and biomarker identification in hepatocellular carcinoma (HCC) management. The studies by Zhang, et al and Li, et al explored the efficaciousness of a triple therapy involving transarterial chemoembolization, tyrosine kinase inhibitors, and PD-1 inhibitors, and the prognostic value of protein tyrosine phosphatase non-receptor II (PTPN2), respectively. These investigations underscored the significance of PTPN2 as a potential therapeutic target and highlighted the promise of synergistic treatment strategies in enhancing HCC patient outcomes. This letter is indicative." 
Kong MW, Yu Y, Wan Y, Gao Y, Zhang CX. From biomarker discovery to combined therapies: Advancing hepatocellular carcinoma treatment strategies. World J Gastrointest Oncol 2024; 16(11): 4518-4521 [PMID: 39554736 DOI: 10.4251/wjgo.v16.i11.4518]
37
"In their article, an article published in the World Journal of Gastrointestinal Oncology, which focuses on whether the expression of programmed death-ligand 1 affects the effectiveness of chemotherapy regimens, including bevacizumab, in treating patients with colorectal cancer. In the management of colorectal carcinoma, bevacizumab wields its therapeutic impact via the neutralization of vascular endothelial growth factor (VEGF), a paramount mediator of intratumoral angiogenesis. This inhibitory action on VEGF obstructs neovascularization, consequently sequestering the essential sustenance of nutrients and oxygen requisite for tumoral proliferation and viability. Contrarily, the interaction between programmed death-ligand 1 and VEGF receptor 2 catalyzes the genesis of novel vasculature that sustains and nurtures the neoplasm, thereby potentiating angiogenic processes. This letter is indicative." 
Qin Y, Ma FY, Zhang Z, Zhao CH, Huang B. Vascular endothelial growth factor pathway’s influence on bevacizumab efficacy in metastatic colorectal cancer treatment. World J Gastrointest Oncol 2024; 16(11): 4514-4517 [PMID: 39554750 DOI: 10.4251/wjgo.v16.i11.4514]
38
"Patient-derived tumor organoids have been demonstrated to improve the efficacy of conversion therapy by identifying individual-targeted effective drugs. They described a patient with hepatocellular carcinoma (HCC) who achieved pathologic complete response to conversion therapy guided by the patient-derived organoid (PDO) drug sensitivity testing. This typical case suggested that PDO-based drug sensitivity testing contributes to screening sensitive drugs for HCC patients to realize the personalized treatment and to improve the efficacy of conversion therapy, which may change the previous experiential therapy and serve as a novel treatment mode in liver cancer. Although case report accompanied with some limitations for any conclusions, their report is interesting for journal readers in this field." 
He YG, Wang Z, Li J, Xi W, Zhao CY, Huang XB, Zheng L. Pathologic complete response to conversion therapy in hepatocellular carcinoma using patient-derived organoids: A case report. World J Gastrointest Oncol 2024; 16(11): 4506-4513 [PMID: 39554753 DOI: 10.4251/wjgo.v16.i11.4506]
39
"Breast cancer gene (BRCA)1 and BRCA2 mutations affect 4%-7% of pancreatic cancer patients and influence their response to therapies such as platinum chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors such as olaparib. A bibliometric analysis of 196 publications highlights growing global research interest, with China and the United States leading. The key contributors included O'Reilly EM's team and Memorial Sloan-Kettering, whereas the Journal of Clinical Oncology stands out for citations. Future trends point toward increased use of PARP inhibitors and combination therapies, offering valuable insights for advancing olaparib research in pancreatic cancer. This paper is indicative." 
Feng X, Chai YH, Jiang KX, Jiang WB, Chen WC, Pan Y. Bibliometric analysis of olaparib and pancreatic cancer from 2009 to 2022: A global perspective. World J Gastrointest Oncol 2024; 16(11): 4489-4505 [PMID: 39554747 DOI: 10.4251/wjgo.v16.i11.4489]
40
"Their study systematically evaluated the relationship between neutrophil to lymphocyte ratio (NLR) and prognosis in patients with gastric cancer (GC) receiving neoadjuvant chemotherapy (NAC). This is ameta-analysis to evaluate the association between NLR and prognosis in patients with NAC for GC. In summary, NLR levels are highly correlated with the prognosis of GC patients receiving NAC, and NLR can be used as an effective biomarker for prognosis assessment of GC patients. This review article is well written, and is informative for journal readers in this field." 
Wei ZH, Tuo M, Ye C, Wu XF, Wang HH, Ren WZ, Liu G, Xiang T. Prognostic value of neutrophil-to-lymphocyte ratio in gastric cancer patients undergoing neoadjuvant chemotherapy: A systematic review and meta-analysis. World J Gastrointest Oncol 2024; 16(11): 4477-4488 [PMID: 39554738 DOI: 10.4251/wjgo.v16.i11.4477]
41
"The incidence and mortality of intestinal cancer is increasing year by year. Due to the limited therapeutic means and low survival rate of advanced patients, and the easy development of drug resistance to chemotherapy, targeting and immunotherapy, they have found that spleen-healthy anticancer formula can play an anti-tumor role through the extracellular-signal-regulated kinase/mitogen-activated protein kinase signaling pathway and inhibit the expression of matrix metalloproteinase 2 and c-myc. Their results are informative for journal readers in this field." 
Wang W, Wang J, Ren XX, Yue HL, Li Z. Effects of invigorating-spleen and anticancer prescription on extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway in colon cancer mice model. World J Gastrointest Oncol 2024; 16(11): 4468-4476 [PMID: 39554742 DOI: 10.4251/wjgo.v16.i11.4468]
42
"Their study investigates the anticancer effects of dioscin on colorectal cancer cells (HCT116). Their results revealed that dioscin inhibits cell viability, promotes apoptosis, and suppresses migration and invasion by modulating the Notch1 signaling pathway. These results highlight the potential of dioscin as a therapeutic agent against colorectal cancer. Their results are informative for journal readers in this field." 
Cai XX, Huang ZF, Tu FY, Yu J. Impact and mechanism study of dioscin on biological characteristics of colorectal cancer cells. World J Gastrointest Oncol 2024; 16(11): 4456-4467 [PMID: 39554744 DOI: 10.4251/wjgo.v16.i11.4456]
43
"Their study discovered that the overexpression of BIRC3 leads to the stimulation of phosphoinositide 3-kinase-Akt phosphorylation and activation. Consequently, this enhanced the proliferation of human epidermal growth factor receptor 2-positive tumor cells and inhibits apoptosis, resulting in resistance to trastuzumab. Their results are informative for journal readers in this field." 
Li SL, Wang PY, Jia YP, Zhang ZX, He HY, Chen PY, Liu X, Liu B, Lu L, Fu WH. BIRC3 induces the phosphoinositide 3-kinase-Akt pathway activation to promote trastuzumab resistance in human epidermal growth factor receptor 2-positive gastric cancer. World J Gastrointest Oncol 2024; 16(11): 4436-4455 [PMID: 39554734 DOI: 10.4251/wjgo.v16.i11.4436]
44
"Their results showed that larger diameter, the presence of multiple polyps, pedunculated or semi-pedunculated shape, and specific background gastric mucosa were risk factors for neoplastic transformation. Furthermore, age > 65 years and male sex were important indicators for predicting the risk of malignant transformation of gastric hyperplastic polyps. Their results suggested that for polyps with the abovementioned endoscopic and pathological features, clinicians should be alert to the possibility of neoplastic transformation to improve the diagnosis rate of the neoplastic transformation of gastric hyperplastic polyps. Additionally, our study showed that Helicobacter pylori infection was not associated with the risk. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Zhang DX, Niu ZY, Wang Y, Zu M, Wu YH, Shi YY, Zhang HJ, Zhang J, Ding SG. Endoscopic and pathological features of neoplastic transformation of gastric hyperplastic polyps: Retrospective study of 4010 cases. World J Gastrointest Oncol 2024; 16(11): 4424-4435 [PMID: 39554740 DOI: 10.4251/wjgo.v16.i11.4424]
45
"The characteristics of aggressive primary gastrointestinal non-Hodgkin lymphoma (PGINHL) with or without severe gastrointestinal complications (GICs) were explored in this study. The relationship between GICs and clinicopathological features of aggressive PGINHL patients, such as primary site, histological type, tumor size, depth of gastrointestinal invasion and other factors, was investigated by statistical analysis. The aim of their study was to summarize the risk factors and treatment strategies for aggressive PGINHL patients with or without GICs and to provide evidence-based evidence for clinical decision-making and individualized treatment strategies. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Liu XH, Chen G, Cao DD, Liu H, Ke XK, Hu YG, Tan W, Ke D, Xu XM. Comparison of clinical features of patients with or without severe gastrointestinal complications in aggressive gastrointestinal lymphomas. World J Gastrointest Oncol 2024; 16(11): 4409-4423 [PMID: 39554739 DOI: 10.4251/wjgo.v16.i11.4409]
46
"Endoscopic submucosal dissection (ESD) application in patients with early gastric cancer (EGC) can significantly promote the recovery of gastrointestinal function, improve nutritional status, and reduce complications. Their study confirmed the effectiveness of ESD in promoting the recovery of gastrointestinal function by observing the changes in gastrointestinal function and nutritional status in patients with EGC. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Xu QD, Liu H, Zhang HW, Gao XM, Li YG, Wu ZY. Effect of endoscopic submucosal dissection on gastrointestinal function and nutritional status in patients with early gastric cancer. World J Gastrointest Oncol 2024; 16(11): 4402-4408 [PMID: 39554754 DOI: 10.4251/wjgo.v16.i11.4402]
47
"A retrospective analysis encompassing 104 patients diagnosed with large hepatocellular carcinoma (≥ 5 cm), focused on comparing the efficacy and safety of two treatment modalities, which were the triple combination therapy of drug-eluting beads transarterial chemoembolization (D-TACE), programmed cell death 1 inhibitor, and lenvatinib (D-TACE-P-L) and the triple therapy consisting of conventional TACE, programmed cell death protein 1 inhibitor, and lenvatinib. Progression-free survival, tumor response, and adverse events were compared between the two groups, and the findings revealed that D-TACE-P-L demonstrated significantly superior median progression-free survival and objective response rate, while maintaining comparable toxicity profiles. Based on these outcomes, their study proposed that the D-TACE-P-L therapy served as a preferential treatment option for individuals suffering from large hepatocellular carcinoma. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Yang H, Qiu GP, Liu J, Yang TQ. Drug-eluting beads chemoembolization combined with programmed cell death 1 inhibitor and lenvatinib for large hepatocellular carcinoma. World J Gastrointest Oncol 2024; 16(11): 4392-4401 [PMID: 39554745 DOI: 10.4251/wjgo.v16.i11.4392]
48
"Their investigation was the largest real-world study comparing colorectal cancer surgery patterns and overall survival (OS) in a Chinese tertiary university hospital. A total of 5141 colorectal cancer patients who underwent primary surgical resection between 2008 and 2013 were evaluated, 1748 (34.0%) of these by a colorectal surgeon (CS). The percentage of minimally invasive procedures in the CS group showed an increasing trend. They found that surgeon specialization is associated with improved OS after primary surgery in stage III rectal patients. An appropriate surgical technique, perioperative program and adjuvant therapy may contribute to survival benefit in these patients. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field." 
Zhu DX, Chen M, Xu DH, He GD, Xu PP, Lin Q, Ren L, Xu JM. Pattern of colorectal surgery and long-term survival: 10-year experience from a single center. World J Gastrointest Oncol 2024; 16(11): 4383-4391 [PMID: 39554737 DOI: 10.4251/wjgo.v16.i11.4383]
49
"Gastric cancer (GC) is the leading common malignancy in China. Their review summarized the study design and the clinical or translational research focued to explore the state-of-the-art and development trends in Chinese GC cancer surgery studies. This review article is well written, and is informative for journal readers in this field." 
Zhang S, Hu RH, Cui XM, Song C, Jiang XH. Current clinical trials on gastric cancer surgery in China. World J Gastrointest Oncol 2024; 16(11): 4369-4382 [PMID: 39554743 DOI: 10.4251/wjgo.v16.i11.4369]
50
"Their paper focuses on how colorectal cancer stem cells affect the tumor immune microenvironment through immune escape, immunosuppression and microenvironment remodeling, and analyzes their key functions in tumor progression and metastasis. In addition, this paper also summarized potential therapeutic strategies for colorectal cancer stem cells, aiming to inhibit their cancer-promoting effects and provide new targets and ideas for the treatment of colorectal cancer. This review article is well written, and is informative for journal readers in this field." 
Deng RZ, Zheng X, Lu ZL, Yuan M, Meng QC, Wu T, Tian Y. Effect of colorectal cancer stem cells on the development and metastasis of colorectal cancer. World J Gastrointest Oncol 2024; 16(11): 4354-4368 [PMID: 39554751 DOI: 10.4251/wjgo.v16.i11.4354]
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