|
1
|
-
"The authors present an interesting clinical case investigating alpha-glutamyl-tryptophan as an adjunctive intervention following Helicobacter pylori eradication in a patient with chronic atrophic gastritis. The topic is relevant to gastroenterology and clinical pharmacology, particularly because therapeutic strategies aimed at gastric mucosal restoration remain an area of considerable clinical interest.
The report has several strengths, including a clearly described treatment regimen, histological and immunohistochemical assessments, endoscopic findings, gastric functional measurements, and a documented follow-up period. The inclusion of written informed consent and the authors' acknowledgment of the limitations inherent in a single-patient observation are also appreciated.
Nevertheless, several methodological and interpretative issues limit the scientific significance and generalizability of the findings.
1. Inability to establish a treatment-specific effect
The principal limitation is the inability to distinguish the effects of alpha-glutamyl-tryptophan from those of H. pylori eradication. All post-treatment evaluations were performed after both interventions. Consequently, the observed improvements in gastric mucosal inflammation, glandular morphology, and functional parameters cannot be independently attributed to alpha-glutamyl-tryptophan. Although the authors acknowledge this limitation, several statements in the Discussion still imply a treatment-specific regenerative effect. These interpretations should remain explicitly hypothesis-generating.
2. Interpretation of histological improvement
The reported increases in gland density and depth, appearance of parietal cells, and reduction in intestinal metaplasia within a relatively short observation period warrant careful interpretation. Gastric intestinal metaplasia may exhibit a heterogeneous distribution, and differences between biopsy samples can influence apparent histological improvement. The reliability of the reported changes would be strengthened by independent pathological assessment, detailed documentation of biopsy-site comparability, and clarification of the quantitative histomorphometric procedures.
Importantly, the Kimura–Takemoto classification remained C1 before and after treatment, suggesting that the reported improvement should not be interpreted as complete resolution of gastric atrophy.
3. Interpretation of gastric functional recovery
The marked reduction in mean intragastric pH from 6.8 to 1.2, accompanied by substantial changes in pepsinogen I and gastrin-17, represents an important observation. However, these findings require cautious interpretation. Information on medication washout, standardization of pH-monitoring conditions, and the underlying recordings would improve the credibility and reproducibility of these measurements. The observed biochemical and functional changes do not independently establish structural regeneration or identify its underlying pharmacological mechanism.
4. Mechanistic evidence and reference accuracy
The discussion attributes the observed effects to modulation of metabotropic glutamate receptors, matrix metalloproteinases, and inflammatory signaling. However, these molecular pathways were not directly investigated in the reported patient.
Furthermore, several cited studies concern compounds that differ chemically from alpha-glutamyl-tryptophan. In particular, references 31 and 33 investigate gamma-glutamyl-containing peptides, while reference 34 concerns alpha-glutamyl-lysine and a zinc-containing formulation. These studies should not be presented as direct evidence for the pharmacological activity of the compound used in this case without appropriate qualification.
A systematic reassessment of the mechanistic claims and their supporting references is warranted.
5. Assessment of eradication success and clinical follow-up
The authors should clarify the timing and conditions of post-treatment H. pylori testing, particularly the interval after antibiotic administration and discontinuation of proton pump inhibitors. These factors are important for interpreting the reliability of eradication confirmation.
Additionally, the proposed endoscopic surveillance interval of three years should be individualized according to the patient's histological stage, extent of gastric atrophy, and other risk factors, rather than presented as a universal consequence of the MAPS III recommendations.
The three-month follow-up is insufficient to establish sustained regression of intestinal metaplasia, long-term clinical benefit, or any reduction in gastric cancer risk.
6. Limited novelty and incremental contribution
The authors have previously contributed to clinical investigations of alpha-glutamyl-tryptophan in chronic atrophic gastritis, including controlled studies evaluating related morphological and functional endpoints. Although the present case provides additional individual-level clinical observations, its incremental scientific contribution beyond the existing literature appears limited. A clearer explanation of the unique clinical insight provided by this case would strengthen its academic value.
7. Statistical interpretation and reporting
As a single-patient case report, the study appropriately provides descriptive observations rather than population-level statistical inference. Nevertheless, the reported numerical changes should not be described as demonstrating treatment efficacy, statistical significance, or a validated therapeutic mechanism. Similarly, the absence of adverse events in one patient cannot establish the safety profile of the intervention.
Overall assessment
This article presents a clinically relevant observation supported by several complementary diagnostic approaches. Its descriptive value is acknowledged, and the authors appropriately recognize some important limitations.
However, the absence of a treatment-specific comparator, uncertainty surrounding the interpretation of rapid histological improvement, limited mechanistic validation, concerns regarding the applicability of selected references, and insufficient long-term follow-up substantially restrict the strength of the conclusions.
The report should primarily be regarded as an exploratory clinical observation that may help generate hypotheses for future investigations. Controlled clinical studies with standardized biopsy mapping, independent histopathological evaluation, predefined outcome measures, and extended follow-up are required to determine whether alpha-glutamyl-tryptophan provides clinically meaningful benefits beyond H. pylori eradication alone."
-
Baryshnikova NV, Gulunov ZK, Uspenskiy YP. Alpha-glutamyl-tryptophan as adjuvant reparative therapy after Helicobacter pylori eradication in chronic atrophic gastritis: A case report and literature review. World J Pharmacol 2026; 15(2): 120862 [DOI: 10.5497/wjp.120862]
|
|
2
|
-
"The article addresses a clinically relevant question regarding early aspirin discontinuation and ticagrelor monotherapy following percutaneous coronary intervention. The authors have synthesized evidence from four randomized clinical trials, and the findings are potentially useful for understanding the balance between bleeding reduction and ischemic protection.
The inclusion of a study-characteristics table, an expanded discussion of clinical heterogeneity, and a supplementary search strategy represents an improvement over the earlier manuscript, as reflected in the published responses to peer reviewers.
Nevertheless, several important methodological and reporting concerns remain unresolved and affect confidence in the quantitative synthesis.
1. Major inconsistencies in the forest plots
Figure 1 contains significant discrepancies. Panel C, labeled as three-point major adverse cardiovascular events (MACE), reproduces the study-level estimates and pooled effect presented in Panel B for major bleeding. Similarly, Panel D, labeled as net adverse clinical events (NACE), reproduces the estimates and statistical results from Panel A for clinically relevant bleeding. These duplicated results are inconsistent with the outcome-specific findings described in the text. The authors should verify the original extraction sheets and statistical outputs, provide corrected forest plots, and determine whether the reported pooled estimates and conclusions require revision.
2. Incorrect total sample size
The abstract and Core Tip state that the meta-analysis included more than 20,000 patients. However, the randomized sample sizes of TWILIGHT (7,119), TICO (3,056), T-PASS (2,850), and ULTIMATE-DAPT (3,400) yield a total of 16,425 participants. This discrepancy should be corrected and reconciled with the underlying study-selection and extraction records.
3. Incomplete risk-of-bias assessment
A transparent assessment of methodological quality is essential for a systematic review of randomized controlled trials. The published article and supplementary material do not provide study-level risk-of-bias judgments. This issue had already been identified during peer review, but the available response does not demonstrate that a complete assessment was performed. The authors should provide outcome-specific RoB 2 evaluations and explain how these judgments affect confidence in the pooled findings.
4. Insufficient statistical reproducibility
The statistical methods require more comprehensive documentation, particularly the derivation of hazard ratios from reported event counts, the random-effects estimation procedure, and the handling of differences in outcome definitions. This concern is particularly relevant to the T-PASS trial and the pooling of clinically heterogeneous NACE outcomes. An outcome-level data extraction table and reproducible analysis outputs would substantially strengthen transparency.
5. Incomplete systematic-review reporting
Although the authors describe independent study screening, the published article does not present a complete PRISMA flow diagram or sufficient numerical details of study identification and exclusion. The review also follows PRISMA 2009 rather than the updated PRISMA 2020 reporting framework. Furthermore, the timing and prospective status of the PROSPERO registration should be clarified, considering the reported registration identifier and the chronology of manuscript submission.
6. Reference accuracy and interpretation
Several in-text references do not correspond to the studies discussed. These should be systematically verified. In addition, the absence of a statistically significant difference in ischemic events should not be interpreted as definitive evidence of equivalence or non-inferiority without appropriate statistical justification. The conclusions should distinguish established bleeding benefits from the remaining uncertainty regarding ischemic safety in specific patient populations.
Overall assessment
The manuscript addresses an important clinical question and incorporates evidence from relevant randomized trials. However, unresolved inconsistencies in the forest plots, incorrect reporting of the total sample size, incomplete risk-of-bias assessment, and insufficient statistical transparency substantially limit confidence in the published synthesis.
I recommend that the authors provide the original outcome-level data and analytical outputs for independent verification. The editorial office should assess whether a formal post-publication correction is required and whether the reported conclusions remain supported after verification."
-
Basit A, Aslam MH, Anwar MM, Sarwar MA, Akram A, Ismail Q, Iftikhar A, Haq M. Re-evaluating aspirin in the era of potent P2Y12 inhibitors: Ticagrelor monotherapy after percutaneous coronary intervention. World J Pharmacol 2026; 15(2): 115880 [DOI: 10.5497/wjp.115880]
|
|
3
|
-
"It has long been known that the use of thiopurines (such as azathioprine and 6-mercaptopurine) in patients with IBD is associated with a small, yet statistically significant, increase in the risk of developing lymphoma. Although thiopurines remain a cornerstone for maintaining remission in Crohn’s disease and ulcerative colitis, extensive epidemiological data indicate that this risk is significantly linked both to the duration of treatment and to the concurrent use of two therapeutic agents.
Specifically, major studies involving a large number of patients show that thiopurine monotherapy carries a 2.6-fold higher risk of developing lymphoma compared to patients who have not received thiopurines. However, when thiopurines are administered in combination with anti-TNF-α biological agents, the risk increases to 6.1 times that of individuals who have not received thiopurines. The data from the study under discussion indicate that there is no significant increase in the risk of lymphoma during the first 3 years of treatment; however, the risk rises gradually with prolonged use, particularly after 4 or more years of continuous exposure.
A critical finding for clinical management is that the increased risk appears to be reversible. Upon discontinuation of thiopurine therapy, the risk of lymphoma gradually decreases, potentially returning to near-baseline levels—similar to the risk observed in patients who have not been exposed to these agents.
The conclusion drawn from all existing studies is that the absolute risk of developing lymphoma in patients with IBD is low, and the absolute increase in risk remains small for most patients; furthermore, the clinical benefits of using these medications to control intestinal inflammation outweigh the risk of developing lymphoma.
The study under discussion suggests that patients with IBD who are in long-term remission while on thiopurine therapy should consider discontinuing treatment after the first 5 or 6 years to avoid the risk of developing lymphoma—especially in the current clinical landscape, where newer biological agents (such as vedolizumab and ustekinumab) and JAK inhibitors do not appear to increase the risk of lymphoma, thereby offering safer alternatives for the long-term maintenance of remission.
"
-
Goyal MK, Chowdhary R, Patel M, Landsman M, Arora K, Kalra S, Chowdhary R, Vuthaluru AR, Subhasri Guna SD, Sharma V. Long-term lymphoma risk in thiopurine-treated inflammatory bowel disease: A 15-year propensity-matched cohort study. World J Gastroenterol 2026; 32(45): 120646 [DOI: 10.3748/wjg.120646]
|
|
4
|
-
"This is very interesting paper about TIPS. Transjugular intrahepatic portosystemic shunt (TIPS) is associated with an increased incidence of hepatic encephalopathy (HE). Other Authors aimed to compare the clinical effectiveness of 6-mm and 8-mm TIPS for secondary prophylaxis of variceal bleeding in patients with cirrhosis who were at risk for HE. Among this cohort of patients with cirrhosis who are receiving TIPS for the secondary prevention of variceal bleeding, the use of 6-mm stents results in a higher rate of rebleeding but has a significantly lower risk of overt HE compared with 8-mm stents. The clinical imperative to reduce post-TIPS OHE rates has spurred extensive research into strategies for shunt regulation. Postoperative survival rates may serve as a more critical metric than OHE incidence when evaluating shunt efficacy. Additionally, the choice of underdilation strategy can substantially influence patient outcomes after TIPS. The underdilation technique, especially to smaller diameters (≤ 6 mm), appears to offer a more favorable risk-benefit profile; such strategies may mitigate the adverse events associated with larger stent diameters, thereby improving the survival rates observed in this and other investigations. Author’s data demonstrated that using 8-mm ePTFE-covered stents with TIPS underdilation to ≤ 6 mm vs ≥ 7 mm did not result in significant differences in postoperative rebleeding, shunt dysfunction, or OHE incidence. However, it revealed a substantial reduction in mortality risk for patients with stent underdilation to ≤ 6 mm. This strategy appears to recalibrate the risk-benefit balance associated with TIPS using 8-mm ePTFE-covered stents, yielding superior mid- to long-term survival benefits for patients. 1.Please tell me the reason why it revealed a substantial reduction in mortality risk for patients with stent underdilation to ≤ 6 mm. 2.Discuss the indications for 6 mm and 7 mm diameters in TIPS. 3.Please provide details regarding the causes of death for both groups.
"
-
Zhang WQ, Li KJ, Yang F, Jiang GJ, Zhang L, Jiang H, Guo H, Li SW. Association of smaller-diameter underdilation of transjugular intrahepatic portosystemic shunt stents with improved long-term survival: A propensity score-matched study. World J Gastroenterol 2026; 32(45): 121243 [DOI: 10.3748/wjg.121243]
|
|
5
|
-
"This narrative review focuses on the synergistic dysregulation of the hippocampus-amygdala-prefrontal cortex circuit in anxiety and depressive disorders. The topic is at the cutting edge of psychiatric neuroscience and has promising value for clinical translation. The article systematically reviews the functions of each node within the circuit, distinguishes aberrant circuit patterns in anxiety, depressive disorders, and their comorbid states, and integrates multiple lines of evidence including neuroimaging, meta-analyses, and animal experiments to establish a circuit-based explanatory framework. It maps clinical symptoms to neurobiological mechanisms and offers new insights for biomarker development and therapeutic interventions.
Nevertheless, the review has notable limitations. As a narrative review, it does not perform quantitative data pooling or risk-of-bias assessment. Most human evidence comes from cross-sectional studies, which can only demonstrate correlations rather than causal relationships. The review does not adequately address disease heterogeneity; confounding variables such as medication use, disease duration, and trauma may confound the findings. Macroscale analysis of brain regions overlooks functional differences among subregions, and the translational link between human and animal experimental results is insufficient.
Overall, this review features a logically coherent framework and adequate literature coverage. It can serve the purposes of knowledge synthesis and overview. However, given the limited level of current evidence, its conclusions await further validation by longitudinal cohort and interventional studies."
-
Zhao X, Zhang W, Xu D, Liu XA. Coordinated dysregulation of the hippocampus-amygdala-prefrontal cortex circuit in anxiety and depressive disorders: A narrative review. World J Psychiatry 2026; 16(10): 123719 [DOI: 10.5498/wjp.123719]
|
|
6
|
-
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
-
Cakiroglu OF, Gurbuz J, Taslidere B, Cander B. Posterior gastric wall perforation and acute kidney injury after upper endoscopy with esophageal dilation: A case report. World J Clin Cases 2026; 14(27): 126787 [DOI: 10.12998/wjcc.126787]
|
|
7
|
-
"The manuscript describes a case report of suspected donepezil withdrawal syndrome in an 89-year-old female with Alzheimer’s disease following abrupt discontinuation of long-term donepezil (10 mg/day). The most important finding is the acute onset of severe behavioral and cognitive disturbances including psychomotor agitation, verbal aggression, insomnia, delirium, and new-onset gait instability within 48 hours of discontinuation, which resolved after reintroduction of low-dose donepezil (5 mg/day). The main scientific and clinical contribution of this work is to increase the awareness of clinicians of the acute withdrawal phenomena associated with the use of acetylcholinesterase inhibitors. It provides useful clues for differential diagnosis when elderly dementia patients present with abrupt decompensation during transitions of care or efforts at deprescribing, emphasizing that abrupt cessation requires close clinical monitoring.
Methodologically, the report is strengthened by its clear chronological narrative, structured causality assessment, adherence to validated diagnostic tools (such as CAM and HDS-R), and transparent contextualization with existing literature. Importantly, the author addresses important pharmacokinetic questions regarding the rapidity of symptom onset relative to the elimination half-life of donepezil. Main limitations include the single-patient design and unavoidable clinical confounders such as environmental stress associated with recent nursing home admission, underlying progression of dementia and transient low-dose quetiapine use. Objective pharmacokinetic biomarkers and continuous symptom-severity scales also were not used. However, the author appropriately couches these findings with balanced caution lending practical clinical utility and educational value to the manuscript."
-
Nagamine T. Suspected donepezil withdrawal syndrome in an older woman with Alzheimer disease of abrupt cessation: A case report. World J Clin Cases 2026; 14(27): 128223 [DOI: 10.12998/wjcc.128223]
|
|
8
|
-
"The review is strong because it clearly summarizes key mechanisms driving lymph node metastasis while evaluating the strengths and weaknesses of diagnostic tools including CT, EUS, PET‑CT, sentinel node mapping, biomarkers, and AI models. By integrating clinicopathologic, imaging, and molecular perspectives, it provides a practical framework for risk stratification in early gastric cancer and emphasizes that reliable assessment requires a multimodal approach rather than any single diagnostic method."
-
Xia MT, Zhou Q, Han H, Zhang D, Fan X. Lymph node metastasis in early gastric cancer: A review of risk stratification and surgical decision-making. World J Gastrointest Oncol 2026; 18(10): 123261 [DOI: 10.4251/wjgo.123261]
|
|
9
|
-
"The study is well‑designed because it uses a robust retrospective cohort of 124 patients, applies standardized 16S rRNA sequencing to characterize gut microbiota dysbiosis, and integrates clinical, pathological, metabolic, and survival analyses to demonstrate clear associations between microbial imbalance and tumor aggressiveness, chemotherapy response, and long‑term prognosis. The authors further strengthen reliability through balanced baseline characteristics between groups, rigorous statistical methods including multivariate Cox regression, and consistent findings across TNM and driver‑gene subgroups, resulting in a comprehensive and clinically meaningful investigation into the prognostic value of gut microbiota in advanced colorectal cancer."
-
Wang Y, Dong YW, Wang Y, Jin YY, Zhou YX, Li Y. Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(10): 122497 [DOI: 10.4251/wjgo.122497]
|
|
10
|
-
"The study is well‑executed because it combines multi‑database analyses with rigorous validation using clinical samples, cell‑based assays, and animal models, presents a clear mechanistic link between PARVA, FBXO15, and PI3K/AKT signaling supported by rescue experiments, and maintains a coherent logical flow from biomarker identification to functional and mechanistic confirmation, resulting in a robust and persuasive research design."
-
Lu X, Li J, Wang ML, Wang HZ, Li YX. PARVA promotes gastric cancer progression through FBXO15-related PI3K/AKT signaling. World J Gastrointest Oncol 2026; 18(10): 121827 [DOI: 10.4251/wjgo.121827]
|
|
11
|
-
"Cholestatic liver diseases (CLDs) arise from impaired bile secretion or flow, resulting in accumulation of hepatotoxic bile constituents and progressive hepatic injury. Ursodeoxycholic acid (UDCA), a naturally occurring hydrophilic bile acid is a well-established hepatoprotective agent used in the management of multiple cholestatic and hepatocellular disorders. UDCA exerts pleiotropic effects including enhancement of hepatobiliary secretion, expansion of the hydrophilic bile acid pool, stabilisation of hepatocellular membranes and anti-apoptotic, antioxidant and immunomodulatory actions. By shifting bile composition toward less toxic bile acids, UDCA mitigates cholestatic injury, improves biochemical parameters and supports favourable clinical outcomes. However, in recent years, it has been reported that emodin, a Chinese herbal compound, is effective against cholestatic liver injury (CLI). a natural red-orange plant compound found in rhubarb, knotweed, and various traditional herbs. It belongs to a chemical family called anthraquinones, which are ring-shaped carbon compounds produced by plants, molds, and fungi. First, please describe bile acid dynamics during CLI. Additionally, explain the mechanism by which emodin improves bile acid dynamics. Furthermore, the authors state that fecal transplantation is an effective treatment for CLI; describe the indications and mechanisms of action. It is attracting attention as a novel therapeutic approach for various liver diseases—including cholestatic liver injury—by correcting gut microbiota imbalances (dysbiosis). • Normalization of microbiota: Transplanting stool from healthy donors restores microbial diversity and beneficial bacteria.
• Reduction of inflammation and fibrosis: Animal experiments and clinical studies have shown that it modulates intestinal immunity and metabolic pathways, thereby alleviating hepatic inflammatory markers and histological damage.
• Tool for therapeutic validation: It is also utilized in research (FMT experiments) to verify the hepatoprotective effects of herbal medicines and probiotics (e.g., *Lactobacillus acidophilus*) by demonstrating that their efficacy depends on the gut microbiota. Please describe the timing, indications, and duration of the effects of fecal microbiota transplantation for SLI.
"
-
Wang CX, Wang LM, Fu ZF, Zhao X, Han LF, Lou YF. Emodin ameliorates cholestatic liver injury by regulating bile acid metabolism and gut microbiota in mice. World J Gastroenterol 2026; 32(44): 117819 [DOI: 10.3748/wjg.117819]
|
|
12
|
-
"This Letter is well written, pointing out the limitations of the referenced article and providing a helpful complementary to the referenced article. The ethics are right. The table and references are adequate. There is one drawback in this Letter that "High resolution colour Doppler guidance". It should be "high resolution colour Doppler guidance ultrasound" or "High resolution ultrasound guidance". The following techniques do not involve resolution: Colour Doppler flow imaging, color Doppler pulsed wave spectrum, colour Doppler continuous wave spectrum, and so on. "
-
Gautam AD, Lal H. Letter to the Editor: Reconsidering relevance of endoscopic ultrasound-guided radiofrequency ablation in pancreatic cancer treatment: Future perspectives on artificial intelligence. World J Radiol 2026; 18(9): 124226 [PMID: 42812976 DOI: 10.4329/wjr.124226]
|
|
13
|
-
"This study was selected for commentary because it concerns a rare benign mesenchymal tumor of the digestive tract; the tumor presents with diverse clinical manifestations—largely dependent on its location within the digestive tube—and poses significant challenges for diagnosis prior to surgery or endoscopic removal. Endoscopic or surgical resection should be preceded by a detailed imaging and serological evaluation to ensure the most accurate differential diagnosis possible. It is highly probable that a gastroenterologist will encounter only one or very few such cases throughout their career. The study under discussion offers an opportunity to gain theoretical familiarity with this clinical entity—a condition the gastroenterologist should consider when faced with cases lacking an obvious diagnosis. Reflecting the commentator's own experience, in one instance, the sole clinical manifestation was iron-deficiency anemia of obscure origin. Particular emphasis should be placed on the modern role of endoscopic resection for these benign lesions, utilizing personalized clinical management strategies tailored to the lesion's anatomical location. Finally, it should be emphasized that immunohistochemical profiling is essential to distinguish IFPs from malignant or other mesenchymal spindle cell neoplasms."
-
Wang CH, Liu F, Ji XH, Li LS, Chai NL. Clinical characteristics and endoscopic management of inflammatory fibroid polyp of the gastrointestinal tract. World J Gastroenterol 2026; 32(42): 120663 [DOI: 10.3748/wjg.120663]
|
|
14
|
-
"Thank you for this investigation. Health and wellbeing systems are often approached as though effective intervention depends chiefly on isolating variables, applying targeted levers, and expecting proportionate results. Yet many contemporary problems arise in adaptive, interdependent settings shaped by feedback, delay, unequal resources, and strategic response, where control-oriented action frequently produces mixed or unstable effects. The scholarship relevant to this problem is substantial but dispersed across systems thinking, resilience research, governance and institutional analysis, public health, integrated care, and selected literatures on uncertainty, stress, and trust. This article offers an integrative overview of these overlapping traditions rather than a new general theory of intervention. Across them, several recurring conditions help explain why intervention succeeds or fails in complex health and wellbeing systems, digital health literacy is one of them, thank you for this contribution! "
-
Zhang SJ, Wang JJ. Mediating effect of digital health literacy between preventive health service utilization and mental health among hospital personnel. World J Psychiatry 2026; 16(9): 120446 [DOI: 10.5498/wjp.120446]
|
|
15
|
-
"Thank you for this important work, showing that several symptoms (increased spending, eating disorders) increased during the corona crisis. These disorders are often hard to treat and request multisystemic transdiciplinary treatment plans, if the burden of disease and the secondary health care costs should be kept adequate. Many efforts are necessary further. It would be valuable to follow this research plan and investigation in long term course, thank you. "
-
Wu HN, Luo FG, Wang JJ, Wu WY, Fang KJ, Xing HY, Yan J. Emotion regulation and mental health in college students during coronavirus pandemic lockdowns. World J Psychiatry 2026; 16(9): 115802 [DOI: 10.5498/wjp.115802]
|
|
16
|
-
"Publication is defensible only as a hypothesis generating pharmacovigilance signal, not as evidence that Plantago major caused liver failure. The authors generally acknowledge this distinction, which is the paper's main strength.
1. Temporality is not securely established
Abdominal pain began approximately two months before hospitalization and before the tea was consumed. The tea was started because symptoms persisted. Without liver tests before tea exposure, the initial abdominal pain could have been a manifestation of an already developing hepatic illness.
Exact calendar dates for tea initiation, discontinuation, jaundice onset, first abdominal liver tests, and encephalopathy are needed.
2. The implicated substance was never established
The plant was not botanically authenticated, the amount of plant material and infusion concentration were unknown, and no sample was tested for contaminants, pesticides, heavy metals, adulterants, or another plant species. Therefore, the case cannot specifically implicated P. major. AASLD guidance emphasizes that herbal product composition and contamination are major obstacles to causality assessment.
3. Alternative causes were incompletely documented.
4. The F factor may not represent the initial injury
5. No structured causality result.
The authors appropriately state that RUCAM could not be calculated reliably. However, this leaves the association at a very low evidentiary level. An expert adjudicated qualitative assessment with explicit ratings for the herb, omeprazole, and indeterminate ALF would improve the report.
"
-
Ponte RV, Faria AA, Guedes LR, Yamashiro IS, Macedo ML, Lima MC, Souza PF, Vidigal PV, Penna FG, Sancio JB. Acute liver failure temporally associated with intensive consumption of Plantago major tea: A case report. World J Clin Cases 2026; 14(26): 126744 [DOI: 10.12998/wjcc.126744]
|
|
17
|
-
"It is a well conducted study with meaningful endpoints . As the authors have mentioned in their limitations , it will be interseting to see the correlation between BAL TGF levels and lung involvement, as per CT scan rather than chest x-ray . It will make an interesting future study ."
-
Kandi PN, Iskandar MH, Putrawan HA, Mubin RH, Bakri S, Kasim H, Alimuddin S, Rusman RD, Seweng A. Bacterial load and transforming growth factor-beta: Predicting the extent of lung damage in pulmonary tuberculosis patients. World J Exp Med 2026; 16(3): 120424 [PMID: 42780623 DOI: 10.5493/wjem.120424]
|
|
18
|
-
"The inflammatory microenvironment can promote tumor formation and stimulate tumor progression. In esophageal cancers, bacterial infection and neutrophilia can contribute to a poor prognosis. A large amount of evidences support the role of cyclooxygenase-2 (COX-2) in inflammation and oncogenesis. High expression of COX-2 is significantly associated with cell apoptosis, tumor occurrence, development and invasion . COX-2 inhibition has been shown to suppress tumor growth and lymph node metastasis , and, of importance, is an effective strategy for cancer treatment. Prostaglandin E2 (PGE2), a COX-2 product, can enhance angiogenesis and lymphangiogenesis during chronic inflammation and tumor progression. Therefore, the crucial role of COX-2 in tumor progression highlights the importance of discovering and identifying novel regulators of COX-2. In this study,authors combined streptavidin-agarose pulldown assay and mass spectrum identification criteria to pull down and discover several new COX-2 expression regulators in esophageal cells, and identified hnRNPA2/B1 (heterogeneous nuclear ribonucleoprotein A2/B1) as a specific COX-2 promoter binding protein. However, the precise mechanism of hnRNPA2/B1 involved in the regulation of COX-2 expression and esophageal cancer growth remains unknown.
hnRNPA2/B1 has been supposed to be overexpressed in a variety of cancers, including breast, pancreas, liver, and prostate cancer (Tauler et al., 2010, Torosyan et al., 2010, Katsimpoula et al., 2009, Turck et al., 2004). hnRNPA2/B1 is a protein which ubiquitously participates in RNA-binding and pre-RNA processing, and is involved in the regulation of cancer cell metabolism, migration, invasion, proliferation, survival, and apoptosis (Clower et al., 2010, Moran-Jones et al., 2009, Patry et al., 2003, He et al., 2005, He et al., 2009). It also plays an important role in epithelial–mesenchymal transition (Tauler et al., 2010). hnRNPA2/B1 is not the unique characteristic for esophageal cancer. However, whether hnRNPA2/B1 regulates esophageal cancer growth by modulating inflammatory mediator COX-2 expression in esophageal cancer cells is clear. Esophageal cancer includes both adenocarcinoma (ADC) and squamous cell carcinoma (SCC). While Barrett's esophageal cancer (ADC)caused by duodenal fluid reflux is believed to arise through that specific mechanism, does SCC caused by tobacco and alcohol arise via the same mechanism?
"
-
Lu JQ, Fang XF, Guo XX, Liu M, Lin JH, Zheng HL, Zhong CM, Lin QY, Huang XY, Wang XZ, Tian H, Que JW, Chen FL, Zheng BY. Epitranscriptomic regulation of the COX-2/PGE2 axis by hnRNPA2B1 promotes esophageal squamous cell carcinoma progression. World J Gastroenterol 2026; 32(41): 121890 [DOI: 10.3748/wjg.121890]
|
|
19
|
-
"This is a well-written and presented rare case report on "Microscopic evaluation of giant peritoneal loose body. This manuscript gives additional new knowledge to the existing literature.
However, I believe that an adequate literature review has not been conducted. A similar case report was published by us in 2014 (Coskun A, Eliyatkın N, Yıldırım M, Top OE, Vardar E, Erkan N. Completely free and mobile intra-abdominal tumor. Surgery, 2014; 155(2): 350-352). I think that this manuscript is suitable and worth to be published in the World Journal of Gastrointestinal Surgery.
"
-
Lou YM, Gao TZ, Zheng CZ, Yu H, Hong YY, Liu XS. Microscopic evaluation of giant peritoneal loose body: A case report. World J Gastrointest Surg 2026; 18(9): 121842 [DOI: 10.4240/wjgs.121842]
|
|
20
|
-
"Damage to the digestive tract caused by anticancer treatment (chemotherapy and radiotherapy) is quite significant, profoundly affecting patients' quality of life. In many cases, side effects are severe enough to require the assistance of a gastroenterologist for effective management—sometimes involving the administration of biological agents, such as in cases of colitis induced by immune checkpoint inhibitors. The gastroenterologist plays important role in diagnosing and assessing the severity of the underlying condition through endoscopic procedures and biopsies. I believe that collaboration between the oncologist and the gastroenterologist is absolutely essential today. However, this does not occur in routine clinical practice; consequently, gastroenterologists lack sufficient experience in this field."
-
Nan YL, Sun TH, Ren KJ, Min TH, Ma YY, Xie X, Deng XY, Peng YC, Liu YY, Tong SY, Wang W, Dang CX, Zhang H. Cancer therapy-induced intestinal injury: Mechanisms, clinical manifestations, and management strategies. World J Gastroenterol 2026; 32(41): 120954 [DOI: 10.3748/wjg.120954]
|
|
21
|
-
"1. Evaluation of Objectivity, Credibility, and Scientific Quality
• Objectivity: The study is based on clear medical reasoning. The authors looked at how the disease starts: Crohn’s fistula begins on the inner lining of the bowel and cuts straight through the wall (transmural), whereas a common cryptoglandular fistula starts in the glands between the muscle layers. The two main MRI features checked—wall breakthrough and active inflammation/swelling of the rectum—are straightforward and practical. The doctors reviewing the MRI scans were also kept unaware of the patients’ medical records, which prevented personal bias.
• Credibility: The findings are trustworthy because the authors tested their method on a completely separate group of 168 patients from a second hospital. The model worked just as well in this second group, proving that the results were not just a lucky finding at one hospital. Checking patients from two different years (2021 vs. 2022) also confirmed that the tool remained consistent over time.
• Scientific Quality: The paper is well organized and deals with a major real-world problem: preventing doctors from performing the wrong surgery on an unsuspected Crohn's patient. The authors also made a smart choice to exclude patients with setons already in place, because setons create an artificial hole that could trick the scan.
2. Issues Successfully Resolved by the Authors
• Simple, Usable Signs: Instead of relying on complicated math scores or complex imaging formulas, the authors found two clear signs on standard MRI scans: transmural inflammation and active proctitis.
• High Accuracy: Using either of these two signs caught over 82% of Crohn’s cases (sensitivity) and correctly ruled out over 80% of routine fistula cases (specificity).
• Reliable Regardless of Past Care: These MRI signs worked well even if the patient had already undergone past surgery or was taking biologic medications like anti-TNF drugs.
3. Problems and Limitations That Still Exist
• No Routine Colonoscopy for the Control Group: Patients in the common fistula group did not all get a colonoscopy to confirm that their bowels were completely clear of Crohn's. Doctors ruled it out using only symptoms and blood tests. Because Crohn's disease can stay hidden in the bowel for months or years, a few of these patients might have actually had early Crohn's disease.
• Counting the Same Patient Twice: The authors counted 17 patients who returned to the hospital for failed treatments as brand-new cases. In statistics, counting the same person more than once can slightly skew the results.
• Specialist-Only Reviewers: The scans were read by two colorectal surgeons who each had over 10 years of experience reading pelvic MRIs. It is not yet clear if general radiologists or doctors at smaller community hospitals would get the same high accuracy without special training.
• Overlap from Severe Infections: In severe ordinary fistulas, bad swelling and pus can spill over and irritate the rectal wall. This can sometimes look like Crohn’s inflammation on a scan, causing a false alarm.
4. Next Steps and How to Solve Remaining Problems
• Conducting Prospective Studies: The authors explicitly state that their findings need to be tested forward in time with prospective studies.
• Targeted Endoscopy Workups: The authors propose using these MRI findings as an early warning system: any patient showing these signs should immediately be sent for a full colonoscopy and tissue biopsy before undergoing surgery. Testing this exact workflow in future clinical trials will prove how many unnecessary operations can be prevented.
• Adding Advanced Scans and Stool Tests: Future research can combine these basic MRI signs with advanced MRI sequences (such as DWI or ADC scans) and stool tests (like fecal calprotectin) to tell the difference between temporary swelling and true Crohn's disease.
"
-
Xu ZP, Li L, Sun GD, Wu YY, Cai EW, Wen K, Shao WJ, Chen YG. Magnetic resonance imaging predicts perianal fistula in Crohn’s disease. World J Gastroenterol 2026; 32(40): 116827 [DOI: 10.3748/wjg.116827]
|
|
22
|
-
"The title “Do they have a vested interest?” implies a conclusion of conflict or bias; the manuscript should use more neutral wording unless systematic evidence demonstrates that the guideline recommendations were actually influenced by financial interests.
The authors should clearly distinguish declared industry relationships from demonstrated industry influence on recommendations. A financial conflict of interest does not, by itself, establish that a guideline is biased.
Statements such as “these guidelines will always promote the hernia industry”, “guidelines are meaningless and industry-friendly,” and “industry funding may likely lead to less transparent clinical results” are overly categorical and should be supported by direct evidence or appropriately qualified.
The manuscript should provide a systematic assessment of the HerniaSurge panel's individual conflicts of interest, including the type, magnitude, timing, and relevance of each relationship, rather than making broad statements about “most panel members.”
The claim that industry funding was accepted for the guideline process should be documented with precise evidence, including the source and amount/type of funding, and clarification of whether industry had any role in evidence synthesis or recommendation formulation.
The article should more carefully distinguish guideline recommendations from the authors' interpretation of those recommendations. In particular, claims that the guidelines “promote” mesh or minimally invasive surgery require direct comparison with the actual guideline recommendations.
The discussion of mesh versus non-mesh repair is potentially unbalanced. The authors should acknowledge evidence supporting mesh repair, including recurrence reduction, while separately discussing chronic pain, mesh-related complications, and patient preferences.
The statement that “clear-cut, hard-core level 1 evidence for the best groin hernia technique is still elusive” should be clarified because evidence may support different techniques for different patient groups; absence of a single universally superior technique is not equivalent to absence of high-quality evidence.
The table comparing open, laparoscopic, and robotic repair is useful but oversimplified. Important outcomes such as recurrence, chronic pain, quality of life, complications, learning curve, and long-term follow-up should be supported by references.
The assertion that robotic repair has “no proven superiority in major clinical outcomes” should be referenced to contemporary comparative evidence and should distinguish lack of demonstrated superiority from evidence demonstrating equivalence.
The discussion of cost should incorporate healthcare-system differences and ideally include formal health-economic evidence rather than general statements about operative costs.
The manuscript would benefit from explicitly acknowledging limitations of its own methodology. It appears to be a narrative/opinion-based critique rather than a systematic review, yet some conclusions are presented as established facts.
Several quotations from Bendavid and other sources are rhetorically strong and may give the article an advocacy/opinion-piece character. The authors should ensure that these quotations are balanced by contemporary, objective evidence.
The authors should discuss the 2023 HerniaSurge update in greater detail, including how its methodology addressed conflicts of interest, evidence grading, patient preferences, and multidisciplinary participation.
Rather than concluding that current guidelines are “meaningless,” the authors could make a more scientifically defensible argument that guidelines should be continuously evaluated for transparency, independence, methodological rigor, and applicability to different patient populations.
Overall critique
The manuscript has a relevant and worthwhile subject, but its credibility would improve substantially with a more systematic and balanced evaluation of the HerniaSurge guidelines. The authors should replace allegations and categorical language with documented evidence, quantified conflict-of-interest analysis, transparent methodology, and appropriately cautious conclusions. The central argument—that guideline development should maximize independence, transparency, patient involvement, and rigorous evidence appraisal—is reasonable, but it should be separated clearly from claims that existing HerniaSurge recommendations are actually the product of industry influenc"
-
Bhattacharya K. International guidelines for groin hernia management: Do they have a vested interest? World J Surg Proced 2026; 16(2): 124162 [DOI: 10.5412/wjsp.124162]
|
|
23
|
-
"This case report addresses a clinically relevant and technically challenging problem in the management of choledocholithiasis when conventional ERCP is not feasible.
The manuscript provides a detailed and reproducible description of the laparoscopic transcystic technique and intraoperative fluoroscopic guidance.
The patient's clinical presentation, imaging findings, operative procedure, and postoperative course are generally well documented.
The successful clearance of an 8-mm distal CBD stone demonstrates the technical feasibility of this approach in a carefully selected patient.
The case's novelty is potentially valuable, although the specific contribution should be better supported by a comprehensive review of existing literature.
The discussion appropriately considers alternative approaches, but several statements regarding safety, efficacy, cost-effectiveness, and superiority are stronger than can be supported by a single case.
The reported one-month follow-up is reassuring but insufficient to establish long-term biliary safety or recurrence outcomes.
Important details, including anticoagulation management, laboratory values, and the precise technique of papillary dilation, should be clarified.
The manuscript would benefit from improved adherence to case-report reporting standards and more cautious, evidence-based language throughout the Discussion and Conclusion.
Overall, the report has good clinical and technical value, but substantial revision is recommended to strengthen methodological rigor and ensure that conclusions remain proportionate to the evidence.
CRITICAL REVIEW COMMENTS :
Please moderate claims such as “safe,” “effective,” “least morbid,” and “most efficient,” as these cannot be established from a single case report; “technically feasible” would be more appropriate.
Please provide the actual laboratory values (bilirubin, AST/ALT, ALP/GGT, WBC, CRP, amylase/lipase and coagulation profile) rather than stating that routine investigations were normal.
The statement that the patient was “on anticoagulation” should be clarified, including the drug used, indication, perioperative interruption and resumption.
Please clarify whether the duodenal stricture was definitively diagnosed as benign/peptic, since biopsies were deferred and the stated etiology appears presumptive.
The terminology and technical details of ampullary balloon dilation/biliary sphincteroplasty should be described more precisely, including balloon position, diameter, pressure and duration.
Please distinguish clearly between technical infeasibility of ERCP and an absolute contraindication to ERCP.
The criteria stated for transcystic clearance (e.g., stones <10 mm and fewer than 10 stones) should be supported by appropriate references or presented as suggested selection criteria rather than definitive recommendations.
Table 1 should provide more consistent information regarding study populations, definitions of stone-clearance success, complications and follow-up, because the included studies are heterogeneous.
Please substantiate the claim that the specific use of an infant feeding tube is novel, preferably through a more comprehensive literature search.
The one-month follow-up should be acknowledged as a limitation, particularly regarding recurrent stones, biliary stricture and delayed complications.
Statements such as “essential reference for surgeons” should be removed or rephrased in neutral scientific language.
Consider adding a CARE-style timeline to make the sequence of diagnostic evaluation, failed ERCP access, surgery, stone clearance and follow-up clearer.
The conclusion should emphasize technical feasibility in a selected patient, rather than implying general safety or superiority over established alternatives."
-
Bhandarkar S, Dotor N, Bendapudi N, Kamat N, Parekh S, Vora S, Maydeo A. Transcystic laparoscopic common bile duct stone clearance facilitated by intraoperative fluoroscopy guided cholangiography: A case report. World J Surg Proced 2026; 16(2): 122292 [DOI: 10.5412/wjsp.122292]
|
|
24
|
-
"Patients with Crohn's disease frequently develop anal fistulas, and the presence of a fistula is often the initial sign leading to a diagnosis of Crohn's disease. Regarding the relationship between Crohn's disease and anal fistulas: High incidence of co-occurrence—approximately half of Crohn's disease patients exhibit painful, purulent anal lesions. Predominance in younger populations—onset often occurs in the teens and twenties, and the condition is characterized by being refractory to treatment. Differences from ordinary hemorrhoids—fistulas associated with Crohn's disease tend to involve complex inflammation; surgical treatment for standard fistulas often results in poor wound healing or the successive formation of new fistulas. MRI is highly useful for accurately mapping the course of complex anal fistulas (perianal fistulas) and the extent of abscesses associated with Crohn's disease, thereby aiding in the determination of treatment strategies. MRI reveals the following: Fistula tract course—where the tunnel-like opening begins and how it extends. Branching and secondary extensions—complex branching tunnels or deep tissue extensions. Presence of abscesses—locations and sizes of pus collections. Spatial relationship with sphincter muscles—the position of the lesion relative to the muscles that maintain anal closure (sphincters). Reasons for choosing MRI include: No radiation exposure—safe for repeated imaging and for young patients. High imaging resolution—the use of contrast agents allows for clearer visualization of inflammation and pus collections. Studies have shown that measuring changes in the 3D volume of perianal fistulas in Crohn's disease (CD) patients via MRI may serve as a useful imaging biomarker for predicting clinical outcomes. Specifically, it was found that a reduction of 16% or more in the volume of the active fistula component predicts clinical remission with high sensitivity and specificity. These findings were published in the *United European Gastroenterology Journal* on July 18, 2025. Based on the above, I believe that MRI analysis for anal fistulas is indeed useful, as the authors state.
"
-
Xu ZP, Li L, Sun GD, Wu YY, Cai EW, Wen K, Shao WJ, Chen YG. Magnetic resonance imaging predicts perianal fistula in Crohn’s disease. World J Gastroenterol 2026; 32(40): 116827 [DOI: 10.3748/wjg.116827]
|
|
25
|
-
"This study demonstrated superiority of Infliximab at a dose of 5mg/Kg BW in patients with moderate to severe ulcerative colitis compared to 40-60 mg methypredizolone or 300-400mg hydrocortisone in divided doses. The authors demonstrated superiority of the biological agent in all parameters investigated compared to methylprednisolone and hydrocortisone.
In the study design, one could make the following observations
Methylprednisolone (up to 60mg, equivalent to 75 mg prednisolone) was used in the study. However, doses of prednisolone greater than 50- 60 mg have not been shown to increase the therapeutic effect.
Hydrocortisone, like other synthetic corticosteroids, has failed therapeutically in IBD and is not used.
These factors probably contributed to the difference in the results.
I am impressed by the long follow-up and the comparison of the two groups with these two regimens. Corticosteroids are not used as a maintenance treatment for IBD with the exception of budesonide (Cortiment tab 9mg) in some cases of ulcerative colitis.
In daily clinical practice, corticosteroids have proven their immediate and dramatic effect. For this reason, gastroenterologists widely use them in selected cases as a first-line treatment, and I strongly believe this reflects the view of most gastroenterologists involved in IBD treatment."
-
Elsaadany HM, Abd El-Hamid B, Elewesy EA, Mansour MI, Abdelghany WM, Shoukeer MAH, Khalaf M, Eid SM, Almaghraby MT. Long-term comparative effectiveness of first-line infliximab vs corticosteroids in ulcerative colitis: Remission and colectomy risk. World J Gastroenterol 2026; 32(38): 121333 [DOI: 10.3748/wjg.121333]
|
|
26
|
-
"It is well prepared and written article.
The authors concluded that TGFβ2 may have differing effects on cancer cells and CAFs in the development of GC. TGFβ2 may promote cancer cell proliferation and invasion, but not in CAFs. High TGFβ2 levels on cancer cells and low levels of CAF or other factors may indicate a favorable prognosis for GC patients."
-
Imanishi D, Nishikubo H, Ma D, Sano T, Fan C, Sakuma T, Yashiro M. Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma. World J Biol Chem 2026; 17(3): 121664 [PMID: 42707849 DOI: 10.4331/wjbc.121664]
|
|
27
|
-
"This manuscript is a review article with one figure and three tables. It is a nice review.
In this manuscript, the authors stated that calcification progresses from microcalcifications in the intima to more fragmented, sheet-like, or nodular deposits. Although widespread calcification frequently indicates stable plaque, some patterns, such as patchy calcification and eruptive calcified nodules, are associated with plaque susceptibility and thrombotic events. PCI in calcified lesions is technically difficult because calcium inhibits balloon expansion, stent delivery, and optimum stent deployment, increasing the risk of under-expansion and unfavorable results. Intracoronary imaging using intravascular ultrasound and optical coherence tomography allows for thorough calcium characterisation and guides lesion preparation. This study highlights the processes, prevalence, risk factors, clinical outcomes, and current treatment of calcified coronary artery disease."
-
Ktenopoulos N, Apostolos A, Theodoropoulou T, Karakasis P, Iliakis P, Tsiamis N, Milaras N, Skalidis I, Evdaimon K, Sagris M, Drakopoulou M, Synetos A, Latsios G, Tsioufis K, Toutouzas K. Calcified coronary artery disease: Mechanisms, risk factors and clinical consequences. World J Biol Chem 2026; 17(3): 121278 [PMID: 42707870 DOI: 10.4331/wjbc.121278]
|
|
28
|
-
"This work confirms that RNAlater consistently enables high-quality RNA extraction from biopsies, addressing a gap in pancreas-specific evidence. Implementing this procedure may allow for more precise evaluation of graft injury, increase biomarker development, and facilitate high-quality biobanking of human pancreas samples for future investigations.
I have the following and important comment:
The title of the y axis of Figures 2 and 3 B should be RNA level, but not concentration. It have to be corrected and expressed per mg. What is mg? Isit protein or tissue.
This journal have to take care with units."
-
Pook RR, Hearne A, Botting RA, Tingle SJ, Honkanen-Scott M, Shaw JAM, Ali S, Scott III WE. Improved stabilisation of human pancreas biopsies: Comparative evaluation of RNA preservation methods. World J Biol Chem 2026; 17(3): 121018 [PMID: 42707486 DOI: 10.4331/wjbc.121018]
|
|
29
|
-
"This evidence review addresses an important and evolving topic in gynecologic oncology and provides a useful overview of sentinel lymph node biopsy (SLNB) across cervical, endometrial, vulvar, and ovarian cancers. The discussion incorporates major studies including SENTICOL, SENTIX, FIRES, GROINS-V, SELLY, and SENTOV, and the summary table facilitates comparison of key evidence. The references are generally relevant and include recent publications.
As a review without patient recruitment or new experimental data, specific ethical approval and original biostatistical analysis are not applicable. However, the methodology of evidence identification could be described more clearly. Although PubMed was used, the search strategy, dates, eligibility criteria, and process for selecting studies are not provided, which limits reproducibility and raises the possibility of selection bias.
The conclusions are broadly consistent with the evidence presented, but some statements regarding SLNB as standard of care or its oncologic safety should be more carefully qualified according to cancer type, disease stage, patient selection, mapping technique, and maturity of survival evidence. The limitations of the review itself should also be explicitly acknowledged.
This is a clinically relevant and informative review with good educational value. Future updates would benefit from a more systematic literature-search methodology and incorporation of emerging prospective trial results and evolving international guidelines.
"
-
Singh P. Sentinel lymph node biopsy in gynecologic cancers. World J Obstet Gynecol 2026; 15(2): 120261 [DOI: 10.5317/wjog.120261]
|
|
30
|
-
"This multicenter cross-sectional study addresses an important maternal and child health issue and provides useful evidence regarding breastfeeding techniques among primiparous mothers in Northeast Ethiopia. Ethical approval and informed consent are appropriately reported. The methodology is generally sound and reproducible, with systematic sampling, an adequate sample size, observational assessment of breastfeeding technique, and appropriate multivariable logistic regression. The tables and figures adequately present the main findings, and the references are generally relevant and reasonably current.
The principal limitation is the cross-sectional design, which permits identification of associations but not causal relationships. Therefore, terms such as “predictors” or “determinants” should be interpreted cautiously and preferably replaced by “associated factors.” The strong association between absence of breast problems and effective breastfeeding technique also requires cautious interpretation because the temporal relationship cannot be established. Facility-based recruitment from a limited geographic area, potential self-report and observer bias, and limited generalizability should also be recognized.
Overall, the article is scientifically credible and clinically relevant, with generally appropriate methods and statistical analysis. Future longitudinal or interventional studies would be valuable to determine whether structured breastfeeding education can causally improve breastfeeding technique and subsequent maternal and infant outcomes.
"
-
Bogale M, Cherie N, Abeje G, Dagnew SB, Abate AW, Agidew MM. Breastfeeding techniques and associated factors among primiparous mothers: A multicenter health facility-based cross-sectional study in Northeast Ethiopia. World J Obstet Gynecol 2026; 15(2): 119451 [DOI: 10.5317/wjog.119451]
|
|
31
|
-
"This case report describes a rare and clinically important occurrence of ileosigmoid knotting with bowel gangrene and shock in a postpartum woman. The case has educational value because it highlights the diagnostic difficulty of acute abdominal conditions in the postpartum period and the importance of timely surgical intervention. The clinical course, operative findings, management, and follow-up are generally well documented, and written informed consent for publication is reported.
The major strength of the article is the direct operative confirmation of the diagnosis and the description of successful emergency surgical management. The figures, laboratory data, and discussion of previous literature support the clinical presentation. Formal biostatistical analysis is not applicable to a single case report.
Several issues, however, limit the scientific quality of the report. Most importantly, there appears to be an inconsistency in the classification of ileosigmoid knotting. Table 2 defines Type I as the ileum wrapping around the sigmoid colon and Type II as the sigmoid colon wrapping around the ileum, whereas the patient's condition is described as Type II despite the ileum reportedly twisting around the sigmoid colon. This should be clarified or corrected. In addition, the diagnosis of septic shock would be more convincing if supported by detailed objective parameters such as serum lactate, acid-base status, urine output, and evidence of organ dysfunction. The absence of CT imaging is appropriately explained by lack of availability but remains a diagnostic limitation.
The literature cited is generally relevant; however, because the article is presented as a case report and review of the literature, the method used to identify and select the reviewed literature could be described more clearly. The manuscript would also benefit from further language editing and more explicit acknowledgment of the limitations of drawing general conclusions from a single case.
Overall, the article provides a useful contribution concerning a rare postpartum surgical emergency, but greater consistency in disease classification, more precise documentation of shock, and cautious interpretation of conclusions would improve its scientific credibility. Future studies or case series should systematically document diagnostic, hemodynamic, operative, and outcome parameters to strengthen the evidence regarding ileosigmoid knotting in pregnancy and the postpartum period.
"
-
Dereje WM, Zegeye ML, Wulolgn D, Tamene BA, Kassie MT. Ileosigmoid knotting causing gangrenous bowel obstruction in a postpartal mother presented with septic shock: A case report and review of literature. World J Obstet Gynecol 2026; 15(2): 118869 [DOI: 10.5317/wjog.118869]
|
|
32
|
-
"The article presents two interesting cases of patients with virus-related decompensated cirrhosis who were treated with TIPS and antiviral therapy and subsequently had favorable long-term outcomes. A major strength of the article is the more than 10-year follow-up period and the use of multiple assessment methods, including clinical, laboratory, hemodynamic, imaging, and histological parameters. The findings are particularly interesting, especially the normalization of portal pressure and the significant regression of liver fibrosis.
From a writing perspective, the article is well written, clear, and coherent, with a logical structure and appropriate medical terminology. The grammar and terminology are accurate, and the information is presented in a professional and easy-to-follow manner. Overall, I consider the article to be of good quality, addressing a relevant topic and presenting findings that deserve further investigation in larger studies.
"
-
Tie J, Yuan XL, Niu J, Xu J, Shi YQ. Transjugular intrahepatic portosystemic shunt combined with viral suppression reverses decompensated cirrhosis: Two case reports. World J Gastroenterol 2026; 32(37): 120860 [DOI: 10.3748/wjg.120860]
|
|
33
|
-
"The conclusions are clinically relevant and highlight important dietary characteristics associated with glycemic control in patients with T2DM. However, the observed association between higher total energy intake and poor glycemic control should be interpreted cautiously, particularly given the cross-sectional nature of the analysis and the potential for reverse causality. The authors should further clarify the clinical implications of these findings and avoid overstating causality when discussing personalized dietary interventions."
-
Tang YB, Du J, Zhou HP, Guo YM, Shen LS, Jiang XH, Huang S. Nutritional intake characteristics and glycemic control in patients with type 2 diabetes mellitus. World J Diabetes 2026; 17(9): 122163 [DOI: 10.4239/wjd.122163]
|
|
34
|
-
"The authors provide an interesting observation that elevated TNF-α levels may promote pancreatic islet β-cell apoptosis through the Bax/Bcl-2/caspase-3 pathway, with this process correlating with the severity of inflammation. However, the therapeutic implications of these findings remain insufficiently explored. The authors should further evaluate whether modulation of this pathway can attenuate β-cell apoptosis and improve glucose metabolism in acute pancreatitis-associated AGM.
"
-
Qi FF, Zhang Y, Liu CQ, Chen HJ, Wang AF. Pancreatic injury and glucose metabolism dysfunction: The central role of inflammatory signaling and islet β-cell apoptosis. World J Diabetes 2026; 17(9): 117159 [DOI: 10.4239/wjd.117159]
|
|
35
|
-
"This is a methodologically sound, transparent, and clinically oriented retrospective cohort study that develops an interpretable machine-learning (ML) model for early (first-trimester) risk stratification of gestational diabetes mellitus (GDM). The authors compare eight ML algorithms under four class-imbalance handling strategies, report performance on an independent hold-out test set, and support interpretation with SHAP analysis and patient-level heatmaps. The study is well reported (STROBE statement), ethically complete, and internally consistent. Its principal contribution is the demonstration that routinely collected first-trimester clinical, ultrasound, and placental biomarkers can support a 'rule-out' (high negative predictive value, NPV 0.940) approach to GDM risk. The main limitations—single-center design, absence of external validation, heterogeneity of GDM diagnostic criteria, and test-set-based model selection—limit the generalizability and the strength of the causal/clinical claim. The study is a solid, incremental extension of the authors’ earlier logistic-regression work, but it does not deliver a new biological mechanism or a fully validated, practice-ready tool. Authors may add a head-to-head benchmark against a conventional multivariable logistic-regression model on the same cohort/features, and explicitly quantify the incremental AUC (ΔAUC), net reclassification improvement (NRI), and decision-curve net benefit over both no-screening and universal screening."
-
Hung SM, Chen CP, Sun FJ, Chen YY, Wang LK, Chen CY. Early risk stratification of gestational diabetes using interpretable machine learning with first-trimester screening parameters. World J Diabetes 2026; 17(9): 123276 [DOI: 10.4239/wjd.123276]
|
|
36
|
-
"This paper evaluates the status of artificial intelligence (AI) implementation in the field of gastrointestinal endoscopy across six defined domains: evidence maturity, regulatory and healthcare system approval processes, clinical adoption status, potential for workflow integration (practicality), governance and monitoring, and generalizability. Computer-aided detection (CADe) for colonoscopy is classified as "Tier 1," while computer-aided diagnosis (CADx) for optical polyp characterization falls under "Tier 2." Also classified as "Tier 2" are second-observer systems for the upper gastrointestinal tract, AI-assisted procedural quality control systems, reading support tools for capsule endoscopy, and *Helicobacter pylori* infection prediction using endoscopic images. Cholangioscopy AI, therapeutic endoscopy assistance, and pancreatic lesion analysis using endoscopic ultrasound (EUS) are positioned at "Tier 3." The framework and checklist presented in this paper are noteworthy for enabling researchers designing trials, regulatory bodies evaluating submissions, and endoscopy departments deciding on implementation to apply these criteria in practice."
-
Boppana SH, Chandrashekar A, Sunkesula V. From hype to clinical translation: A tiered, readiness-based framework for artificial intelligence in gastrointestinal endoscopy. Artif Intell Gastrointest Endosc 2026; 7(2): 121109 [DOI: 10.37126/aige.121109]
|
|
37
|
-
"Lee HY et al. presented an interesting case of an extensive multiple calcinosis in seronegative limited cutaneous scleroderma (CREST variant). The paper is written according to CARE criteria. The text is fluent and easy understandable. The figures are clearly visible and correctly marked. English is used according to scientific standards. Such unusual disease presentation is very important for everyday clinical practice. "
-
Lee HY, Lee SK, Kim H, Kang SW. Extensive multiple calcinosis cutis in seronegative limited cutaneous scleroderma (CREST variant): A case report. World J Clin Cases 2026; 14(25): 123670 [DOI: 10.12998/wjcc.123670]
|
|
38
|
-
"The authors presented an interesting case of disseminated Cryptococcus infection (central nervous system and skin) in HIV-negative patient. The paper is written according to CARE criteria. The text is fluent and easy understandable. The figures are clearly visible and correctly marked. English is used according to scientific standards. Such unusual disease presentation is very important for everyday clinical practice. "
-
Walia H, Mehta H, Rahi S, Singh I, McKee PH. Beyond the usual suspects - disseminated cryptococcosis presenting as molluscoid skin lesions: A case report. World J Clin Cases 2026; 14(25): 119033 [DOI: 10.12998/wjcc.119033]
|
|
39
|
-
"This is a nice, short review of the von Hippel-Lindau (VHL) protein by Kanno H and Nakahara K. Figure 1 summarizes the article content with impressive data. The authors concluded that VHL is a multifaceted regulator of neuronal differentiation and regeneration whose activity is heavily environment-dependent. Under normal oxygen conditions, VHL promotes neuronal development by suppressing JAK2/STAT and Notch signaling and activating proneural bHLH factors. In hypoxic settings, HIF-1α stabilization enhances glial differentiation and NSC survival and migration. The BC-box motif in VHL serves as a portable neural induction module, and the Daam2-VHL-Nedd4 axis promotes oligodendrocyte development and remyelination. Together, these pathways make VHL a promising target for regenerative therapeutics in neurodegenerative diseases, CNS injury, and demyelinating disorders."
-
Kanno H, Nakahara K. Regenerative potential of von Hippel-Lindau tumor suppressor protein. World J Biol Chem 2026; 17(3): 119936 [PMID: 42707860 DOI: 10.4331/wjbc.119936]
|
|
40
|
-
"The manuscript explains good scientific quality, novelty, innovation, and clinical significance.
It provides a timely and well-structured synthesis of the emerging gut–ocular axis, integrating immunological, metabolic, neuroimmune, and barrier mechanisms across several ocular diseases.
Its inclusion of a transparent literature-search methodology, an evidence hierarchy, clinical-trial findings, and translational research priorities strengthen its value.
The review appropriately recognizes that most mechanistic evidence comes from animal models, while human evidence is largely observational, heterogeneous, and vulnerable to dietary, geographic, medication-related, and methodological confounding.
Clinical evidence for probiotics, dietary interventions, and fecal microbiota transplantation remains sparse and is insufficient to guide routine ophthalmic practice.
Accordingly, therapeutic claims should remain cautious and emphasize biological plausibility rather than proven clinical efficacy.
Overall, the manuscript offers a useful and clinically relevant overview, provided that the gut–ocular axis is presented as an emerging hypothesis requiring validation through prospective studies and adequately powered randomized controlled trials."
-
Paul RS, Samanta A. Gut-ocular axis: An emerging strategy to treat ocular diseases. World J Clin Cases 2026; 14(25): 124172 [DOI: 10.12998/wjcc.124172]
|
|
41
|
-
"The manuscript shown moderate scientific quality and significance.
Its use of a large national cohort and propensity-score matching provides value; however, its retrospective design, residual confounding, use of prescription records, and broad two-year outcome window limit causal interpretation.
The research topic has moderate novelty, while the study’s creativity and methodological innovation are limited because it applies established database and propensity-matching methods to a previously studied clinical association.
Overall, the conclusions are generally supported when interpreted cautiously, although further prospective research using clinically defined postoperative intervals, morphine-milligram equivalents, and actual medication use is warranted."
-
Wu KA, Mai E, Warburton CS, Dhanjani S, Choudhury A, Docters F, Wong L, Prabhat A, Raza M, Maayan O, Song J, Shatkin M, Moucha CS, Hayden BL. Obesity and postoperative opioid utilization after total knee arthroplasty: A propensity-matched analysis. World J Clin Cases 2026; 14(25): 125054 [DOI: 10.12998/wjcc.125054]
|
|
42
|
-
"This review summarizes how gastric cancer spreads to the peritoneum by integrating key mechanisms such as genetic mutations, EMT activation, ECM remodeling, hypoxia-driven signaling, anoikis resistance, and immunosuppressive microenvironment interactions. It explains how tumor cells detach, survive, adhere, invade, proliferate, and induce angiogenesis within the peritoneal cavity, highlighting the coordinated roles of stromal cells, immune cells, and metabolic reprogramming. Overall, it provides a clear molecular framework that identifies promising biomarkers and therapeutic targets for improving early diagnosis and treatment of peritoneal metastasis."
-
Yan HQ, Lai QQ, Huang MW, Wang TA, Wu LC, Qin YZ. Advances in molecular mechanism of gastric cancer peritoneal metastasis. World J Gastrointest Oncol 2026; 18(8): 121799 [DOI: 10.4251/wjgo.v18.i8.121799]
|
|
43
|
-
"This review explains the need for liquid biopsy in CRC screening, summarizes key circulating biomarkers and how they complement each other, and highlights that multi‑analyte panels can improve early detection accuracy despite challenges in standardization and validation. Liquid biopsy ultimately offers a pathway toward earlier and more precise CRC diagnosis."
-
Bai XZ, Bao SCL, Zhang XQ, Yang ZN. Liquid biopsies in colorectal cancer screening and diagnosis. World J Gastrointest Oncol 2026; 18(8): 120332 [DOI: 10.4251/wjgo.120332]
|
|
44
|
-
"The study shows that MCM10 overexpression is strongly associated with aggressive HCC and poor prognosis. It provides consistent mechanistic evidence that MCM10 promotes tumor growth through cyclin D1–CDK4/6 activation across cell, animal, and patient samples. Overall, it highlights MCM10 combined with cyclin D1 as a meaningful biomarker pair for HCC progression."
-
Chen YR, Wang G, He LJ, Ye HW, Wang LF, Zou DD, Wang MQ, Xie HW, Zhu SL, Wang XY. MCM10 promotes hepatocellular carcinoma progression through cyclin D1 regulation. World J Gastrointest Oncol 2026; 18(8): 119834 [DOI: 10.4251/wjgo.119834]
|
|
45
|
-
"The article clearly identifies a novel RHEB-CSF1R interaction as a driver of EMT in pancreatic cancer and supports this with coherent molecular, autophagy‑related, and functional evidence. It integrates in‑vitro and in‑vivo data to demonstrate mechanistic consistency across experimental models. Overall, the study provides a concise and compelling mechanistic framework that strengthens the biological relevance of targeting this pathway."
-
Xing YR, Wang SF, Dai JJ, Xu XG, Mao WJ. Unlocking the metastatic switch: The RHEB-CSF1R complex ignites epithelial-mesenchymal transition in pancreatic cancer by autophagy. World J Gastrointest Oncol 2026; 18(8): 119680 [DOI: 10.4251/wjgo.v18.i8.119680]
|
|
46
|
-
"The case report clearly presents a rare CRC brain‑only metastasis with well‑documented imaging and pathology. It concisely describes coordinated multidisciplinary management across neurosurgery, oncology, and colorectal surgery. The discussion effectively contextualizes the case within existing literature, highlighting its clinical relevance. Overall, the report provides a clear and informative example of how early symptom recognition can guide timely multidisciplinary intervention."
-
Xu JL, Ge ZW, Wu CW, Wang YH, Mao JD. Multidisciplinary care for colorectal cancer brain metastases with headache as initial symptom: A case report and literature review. World J Gastrointest Oncol 2026; 18(8): 119679 [DOI: 10.4251/wjgo.119679]
|
|
47
|
-
"This meta‑analysis is clearly structured, follows PRISMA standards, and uses high‑quality retrospective studies to synthesize evidence on NLR and malignant IPMN. The statistical method, including subgroup and leave‑one‑out sensitivity analyses, are rigorous and transparently reported. Overall, the article provides a coherent, well‑supported conclusion that elevated NLR is an adjunctive marker for malignant IPMN."
-
Dong WW, Zhou LL, Yang DJ, Lu HM. Association between preoperative neutrophil-to-lymphocyte ratio and malignant intraductal papillary mucinous neoplasms: A systematic review and meta-analysis. World J Gastrointest Oncol 2026; 18(8): 119432 [DOI: 10.4251/wjgo.119432]
|
|
48
|
-
"The study clearly demonstrates that Streptococcus anginosus is most abundant in gastrointestinal tumors and rigorously links its load to inflammation, invasion depth, and tumor progression using both human samples and a controlled rat model. It integrates molecular, immunologic, and pathological data to show consistent pro‑tumorigenic effects, including elevated IL‑6/TNF‑α and increased immune‑cell infiltration. Overall, it provides strong, multi‑layered evidence that S. anginosus is a meaningful microbial driver and potential therapeutic target in gastric cancer."
-
Huang DB, Chen BS, Wang AP, Hu XZ, Xu YJ. Polymerase chain reaction detection of Streptococcus anginosus in digestive diseases and its immunomodulation in rat gastric cancer model. World J Gastrointest Oncol 2026; 18(8): 119026 [DOI: 10.4251/wjgo.119026]
|
|
49
|
-
"The editorial clearly highlights how patient‑derived organoids overcome the limitations of traditional models and better preserve patient‑specific biology. It synthesizes recent mechanistic and translational findings into a coherent narrative that clarifies their relevance to gastric intestinal metaplasia. It also provides forward‑looking insight by emphasizing organoid‑based drug screening as a promising direction for future therapeutic development."
-
Deng JY, Du HB, Zao XB. Patient-derived organoids: A new platform for mechanism research and drug development of gastric intestinal metaplasia. World J Gastrointest Oncol 2026; 18(8): 118750 [DOI: 10.4251/wjgo.v18.i8.118750]
|
|
50
|
-
"The study clearly states its clinical question, applies a structured comparative design with balanced baseline characteristics, and reports statistically consistent advantages of amlodipine without added toxicity. Safety outcomes are systematically presented using CTCAE criteria, and the authors transparently acknowledge methodological limitations. Overall, the article demonstrates clarity, methodological rigor, and responsible scientific reporting."
-
Lou HC, Liu XH, Jin P, Wang JM, Liu B. Interaction between calcium channel blockers and capecitabine in colorectal cancer patients with hypertension. World J Gastrointest Oncol 2026; 18(8): 118698 [DOI: 10.4251/wjgo.118698]
|
