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1
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"Although the disease is very rare nowadays, the article's information looks meaningful and informative. I have witnessed this disease in goats but not in humans. The published article has raised very good concerns by picking up this topic. This is the only way to get information about the disease, as it is very rare, or almost never witnessed by several doctors. In the article, the authors have very nicely discussed the pathogenicity and other aspects. "
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Ismail A, Abdelsalam MA, Shahin MH, Ahmed Y, Bahcecioglu IH, Yalniz M, Tawheed A. Hepatobiliary fascioliasis: A neglected re-emerging threat, its diagnostic and management challenges. World J Gastrointest Pathophysiol 2025; 16(2): 107599 [PMID: 40568034 DOI: 10.4291/wjgp.v16.i2.107599]
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2
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"This study innovatively applied ResNet to the hepatic congestion signs in conventional CT, further diagnosing congestive liver diseases, and has clear value for early warning of liver injury in patients with HF. The methodology is rigorous, and it has confirmed that AI can assist in the early identification of TR-related liver injury. In the next step, it is necessary to expand the sample to verify the generalization, and strengthen the clinical transformation design."
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Miida S, Kamimura H, Fujiki S, Kobayashi T, Endo S, Maruyama H, Yoshida T, Watanabe Y, Kimura N, Abe H, Sakamaki A, Yokoo T, Tsukada M, Numano F, Kashimura T, Inomata T, Fuzawa Y, Hirata T, Horii Y, Ishikawa H, Nonaka H, Kamimura K, Terai S. Image analysis of cardiac hepatopathy secondary to heart failure: Machine learning vs gastroenterologists and radiologists. World J Gastroenterol 2025; 31(34): 108807 [PMID: 40937455 DOI: 10.3748/wjg.v31.i34.108807]
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3
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"This article focuses on esophageal GIST, a rare disease type (accounting for only 0.5% of all GIST cases), and systematically reviews the potential of endoscopic resection techniques (ESD/STER/EFTR) to replace the highly invasive esophageal resection surgery. The next supplementary content includes: supplementing with endoscopic image evidence to clarify technical details; adding treatment strategies for special populations (children/immunosuppressed individuals); discussing the potential application of robot-assisted endoscopy."
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Krishnamoorthy A, Griffiths EA. Endoscopic resection of oesophageal gastrointestinal stromal tumours: Promise, pitfalls and the path forward. World J Gastroenterol 2025; 31(34): 110448 [PMID: 40959819 DOI: 10.3748/wjg.v31.i34.110448]
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4
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"This article focuses on the expanded application of the ALBI score in non-malignant liver diseases, systematically reviewing its clinical value as an objective tool for liver function assessment. Its limitations lie in: inability to assess the degree of liver fibrosis; being affected by non-liver factors such as hemolysis and sepsis; and decreased reliability in cases of end-stage liver disease combined with renal failure."
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Demirors B, Shekouhi R, Jimenez PB, Yadav A, Chiriboga G, Mahesh VA, Manaise HK, Bowers J, Merly AA, Gabriel E. Redefining the albumin-bilirubin score: Predictive modeling and multidimensional integration in liver and systemic disease. World J Gastroenterol 2025; 31(34): 110602 [PMID: 40937459 DOI: 10.3748/wjg.v31.i34.110602]
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5
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"This article systematically integrates the latest evidence-based evidence for the imaging assessment of anorectal fistula type Crohn's disease (pCD), and for the first time proposes a multi-modal imaging stratified decision-making pathway, providing individualized solutions for different medical resource scenarios. The possible future directions include: developing an ultrasound scoring system; implementing AI models to adapt to portable ultrasound devices for use at the grassroots level; and remote image monitoring."
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Habeeb H, Chen L, De Kock I, Bhatnagar G, Kutaiba N, Vasudevan A, Srinivasan AR. Imaging in perianal fistulising Crohn’s disease: A practical guide for the gastroenterologist. World J Gastroenterol 2025; 31(34): 110611 [PMID: 40937454 DOI: 10.3748/wjg.v31.i34.110611]
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6
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"This study innovatively applied SR reconstruction to the prediction of liver cancer pathological grading, confirming that SR-MRI can enhance the prediction efficacy of liver cancer pathological grading. The method is rigorous and the conclusion is reliable, providing a new idea for radiomics. However, it is necessary to strengthen the design of clinical transformation pathways and the exploration of biological mechanisms. The next step should focus on prospective validation and multi-omics integration."
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Wang ZZ, Song SM, Zhang G, Chen RQ, Zhang ZC, Liu R. Multiparametric magnetic resonance imaging of deep learning-based super-resolution reconstruction for predicting histopathologic grade in hepatocellular carcinoma. World J Gastroenterol 2025; 31(34): 111541 [PMID: 40937458 DOI: 10.3748/wjg.v31.i34.111541]
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7
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"A transjugular intrahepatic portosystemic shunt (TIPS) is one of the most challenging procedures in interventional radiology. Hepatic and portal venous anatomy can vary greatly, and access to the portal vein, which can be quite difficult even for experienced surgeons, is the most critical step in a TIPS. Despite the fact that there are many techniques for clearly identifying the relevant anatomic structures during TIPS creation, each of them carries a unique set of risks and benefits. Thus, knowledge of these techniques will empower the surgeon in planning and subsequently performing a TIPS and, ultimately, increase the likelihood of a safe and successful procedure."
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Miao L, Ren JL, Zhao H, Li X. Optimal guiding methods for transjugular intrahepatic portosystemic shunt creation: Characteristics of intravascular ultrasound vs other techniques. World J Hepatol 2025; 17(8): 109496 [PMID: 40901582 DOI: 10.4254/wjh.v17.i8.109496]
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8
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"It was with pleasure that I tracked the quality of the following article. Please see my comments below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The figures/tables enhance the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate/up-to-date
7 Language: This is a well-thought out comprehensive manuscript
8 Caveats or drawbacks: None "
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Habeeb H, Chen L, De Kock I, Bhatnagar G, Kutaiba N, Vasudevan A, Srinivasan AR. Imaging in perianal fistulising Crohn’s disease: A practical guide for the gastroenterologist. World J Gastroenterol 2025; 31(34): 110611 [PMID: 40937454 DOI: 10.3748/wjg.v31.i34.110611]
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9
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"This retrospective multicenter study aimed to investigate the type and rate of complications in patients undergoing SBE as well as the risk factors responsible for the occurrence of these complications. The rate of complications (0.4%) was very low and concerned intestinal perforation, which was detected in all cases during the endoscopy. The treatment was surgical in all patients, and the outcome was favorable. The main risk factor for the occurrence of this complication was previous abdominal surgery and excessive abdominal pressure during endoscopy.
SBE performed by experienced endoscopists is a remarkably safe method and should be applied in all cases of occult gastrointestinal bleeding. Endoscopists should be particularly careful in patients with previous surgery, in which the application of abdominal pressure is often necessary. In my opinion, this second reason is the most important for the occurrence of this complication. Gastroenterologists-endoscopists should be particularly careful when requesting the application of abdominal pressure during endoscopy. "
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Ullah S, Bai YQ, Wareesawetsuwan N, Cui LL, Danzhu YJ, Wang K, Zhu SS, He X, Cao XG, Guo CQ, Zhang FB. Complications of single-balloon enteroscopy: A nine-year multicenter experience of 2865 procedures. World J Gastroenterol 2025; 31(34): 110548 [PMID: 40950709 DOI: 10.3748/wjg.v31.i34.110548]
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10
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""A total of 179 patients with chronic HF who underwent echocardiography between 2011 and 2020 were included. These patients underwent CT within 1 year before or after echocardiography; blood samples were collected within 6 months of imaging. The severity of right HF was classified into three groups (mild, moderate, and severe) based on a comprehensive echocardiographic assessment. Selected patient's diseases are unclear. Did authors select the patients who have ischemic coronary diseases, congenital heart diseases, or valvular diseases? Methods are new."
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Miida S, Kamimura H, Fujiki S, Kobayashi T, Endo S, Maruyama H, Yoshida T, Watanabe Y, Kimura N, Abe H, Sakamaki A, Yokoo T, Tsukada M, Numano F, Kashimura T, Inomata T, Fuzawa Y, Hirata T, Horii Y, Ishikawa H, Nonaka H, Kamimura K, Terai S. Image analysis of cardiac hepatopathy secondary to heart failure: Machine learning vs gastroenterologists and radiologists. World J Gastroenterol 2025; 31(34): 108807 [PMID: 40937455 DOI: 10.3748/wjg.v31.i34.108807]
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11
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"This is very interesting paper.The hepatic venous pressure gradient serves as a crucial parameter for assessing portal hypertension and predicting clinical decompensation in individuals with cirrhosis. However, owing to its invasive nature, there has been growing interest in identifying noninvasive alternatives. Noninvasive models utilizing SSM, LSM, and SLD are effective in predicting clinical decompensation among patients with viral cirrhosis,
I agree to author's opinion.
"
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Yang LB, Gao X, Xu M, Li Y, Dong L, Huang XD, She X, Zhang DY, Zhang QW, Liu CY, Fan ST, Wang Y. Noninvasive model based on liver and spleen stiffness for predicting clinical decompensation in patients with cirrhosis. World J Gastroenterol 2025; 31(33): 107408 [PMID: 40933462 DOI: 10.3748/wjg.v31.i33.107408]
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12
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"This is a timely, comprehensive, and clinically valuable systematic review of photon-counting CT in oncologic imaging. The manuscript successfully synthesizes evidence across multiple cancer types and highlights both opportunities and limitations of this emerging technology.
Major revisions suggested:
Add a tabular summary of included studies with key characteristics.
Clarify methodological limitations (lack of risk-of-bias assessment, single database).
Explicitly state that ethical approval was not required.
Minor revisions suggested:
Streamline language in highly technical sections.
Expand limitations regarding cost, accessibility, and inter-institutional standardization."
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Perera Molligoda Arachchige AS, Dashiell A, Jesuraj AS, D’Urso AI, Fiore B, Cattaneo M, Pierzynska E, Szydelko S, Centini FR, Verma Y. Applications of photon-counting CT in oncologic imaging: A systematic review. World J Radiol 2025; 17(8): 107732 [PMID: 40901346 DOI: 10.4329/wjr.v17.i8.107732]
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13
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"The manuscript is well-structured, comprehensive, and provides clinically relevant insights that will be highly valuable for both radiologists and clinicians involved in the diagnosis and management of diverticulitis. The content is organized logically, covering epidemiology, classification systems, imaging findings, complications, and emerging directions such as artificial intelligence. The language is generally clear and precise, making the article accessible to its intended audience.
Minor revisions are recommended to further strengthen the paper. Specifically, polishing a few sentences for clarity and conciseness would enhance readability. Since the manuscript is a review and does not involve direct patient data or interventions, it would be appropriate to explicitly state that ethical approval was not required, in order to meet standard publishing practices. In addition, the discussion could be expanded to address potential caveats or limitations, such as interobserver variability in CT interpretation, the ongoing debate regarding conservative versus surgical management, and the challenges in differentiating diverticulitis from malignancy in certain cases. Addressing these points will improve the balance of the manuscript and provide readers with a more nuanced understanding of the topic."
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Simsar M, Yuruk YY, Sahin O, Sahin H. Radiological insights into diverticulitis: Clinical manifestations, complications, and differential diagnosis. World J Radiol 2025; 17(8): 107463 [PMID: 40901353 DOI: 10.4329/wjr.v17.i8.107463]
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14
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"The advent of machine learning has revolutionized gastrointestinal endoscopy. However, many challenges remain to be overcome before its clinical application, including data dilemmas, algorithm complexity, and ethical dilemmas. Further technological innovation and standardization of endoscopic image data are expected to enable AI to perform everything from diagnosis to personalized treatment, across all endoscope manufacturers."
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Ding JC, Zhang J. Endoscopic image analysis assisted by machine learning: Algorithmic advancements and clinical uses. Artif Intell Gastrointest Endosc 2025; 6(3): 108281 [DOI: 10.37126/aige.v6.i3.108281]
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15
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"Objectivity
The article demonstrates strong objectivity by adopting a balanced "current status-issues" framework, without one-sidedly overstating research progress on glioblastoma multiforme (GBM). It systematically outlines the application value of imaging technologies such as MRI (with T1-weighted contrast enhancement for visualizing tumor necrosis) and PET (with 18F-FET for distinguishing recurrence from radiation necrosis), while also clearly pointing out limitations like the poor soft tissue contrast of CT and the need for a nearby cyclotron for 11C-methylmethionine (11C-MET). When elaborating on the standard "surgery + radiotherapy + temozolomide (TMZ)" regimen, it simultaneously highlights the therapeutic bottleneck that the 5-year survival rate remains only 4.6%-5.6%. Literature screening covers multiple databases including MEDLINE, with studies up to February 2025 included in accordance with PRISMA guidelines, avoiding selective inclusion of positive results. It also maintains a neutral stance when discussing controversies in AI applications (e.g., low proficiency of doctors in operating AI tools) and does not shy away from technical flaws.
Credibility
The credibility is constrained by the peer review results (with scientific quality, innovation, and other indicators all rated Grade D), but there are still supporting elements. The authors are affiliated with the Department of Medical Imaging and Radiation Sciences, University of Sherbrooke, Canada; the corresponding author is a professor and contact information is provided. Literature citations are standardized, including DOI and PMID, and Tables 1-3 clearly summarize key data such as imaging tracers and chemotherapeutic drugs, with a reproducible PRISMA process. However, the single-blind review (involving only one expert from Japan) may lead to a limited perspective, and the article does not mention data replication and verification, which weakens part of its credibility.
Scientific Quality
As a review article, its scientific quality is moderate. Its strengths lie in a clear structure, progressing logically from "epidemiology-imaging-treatment-AI," with each conclusion supported by literature (e.g., citing Zheng et al.’s AI study using 40 million samples). It also compares the advantages and disadvantages of different imaging modalities and treatment regimens, providing references for clinical practice. Nevertheless, there are shortcomings: it fails to quantify key indicators (such as AI segmentation accuracy), describes research data on emerging nanodrugs and PARP inhibitors in a vague manner, and does not analyze diagnostic and therapeutic differences among different molecular subtypes (e.g., IDH-mutant GBM), resulting in insufficient scientific depth.
Resolved Issues
The article clarifies regional differences in GBM epidemiology, applicable scenarios of mainstream imaging and treatment regimens, and constructs an application framework for AI in GBM, providing systematic knowledge for beginners. It also identifies core bottlenecks such as the blood-brain barrier and difficulties in early detection, defining the research scope.
Unresolved and Existing Issues
It does not propose specific biomarkers for early detection (e.g., circulating tumor cells), fails to quantify data on the generalizability of AI models, provides ambiguous solutions for multi-center collaboration and data privacy protection, and does not discuss personalized diagnosis and treatment strategies for different molecular subtypes.
Future Solutions
The authors mention that future efforts should focus on strengthening structured validation and ethical oversight of AI. Specifically, multi-center collaboration can be conducted to establish a standardized imaging database and carry out prospective AI trials; subtype-specific treatment models can be developed by integrating genomic data; and early screening schemes combining "AI + biomarkers" can be explored to fill current research gaps."
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Bentourkia M, Abdo RA. Updates on glioblastoma multiforme: From epidemiology to imaging and artificial intelligence. Artif Intell Med Imaging 2025; 6(2): 108032 [DOI: 10.35711/aimi.v6.i2.108032]
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16
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"Objectivity: The article avoids bias by balancing AI’s strengths and limitations. It details AI’s value (e.g., 3D vascular mapping cutting DIEP flap surgery time, AR navigation improving osteotomy accuracy) while explicitly noting barriers like data variability and surgeon unfamiliarity. Literature selection follows PRISMA, retrieves 4 databases up to Feb 2025, and is PROSPERO-registered (CRD420251008741), with no selective inclusion of positive results.
Credibility: Backed by external single-blind peer review (experts from China, Saudi Arabia, Türkiye) with specific gradings (scientific quality mostly Grade B, novelty Grade A-C). Authors (e.g., Harvard-affiliated Ryan P Cauley) have authoritative backgrounds; citations include DOI/PMID, and the PRISMA flow diagram (104 screened, 64 excluded, 27 included) ensures reproducibility.
Scientific Quality: As a narrative review, it integrates systematic review elements (pre-registration, standardized retrieval). Results are structured by clinical scenarios (preoperative planning, etc.), each supported by studies (e.g., Le et al.’s 2023 deep learning research). The discussion links technical flaws to clinical risks (e.g., sensor inaccuracy causing missed flap ischemia) and compares AI maturity across fields.
Resolved Issues: Clarified AI’s application scope in plastic surgery imaging, established a framework for analyzing AI challenges, and set methodological benchmarks for similar reviews via PRISMA/PROSPERO compliance.
Unresolved Issues: Lacks quantification of data variability, cross-population model validation, plastic surgery-specific AI regulatory paths, and details on surgeon AI training. Also has potential peer-review bias, imbalanced literature timeliness, and insufficient ethical/technical transparency.
Proposed Solutions: The author implies future focus on structured validation and ethical oversight. To address gaps, multi-center standardized databases, collaboration with regulators for tailored frameworks, surgeon training programs, and supplementary technical/ethical materials are needed."
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Yamin MA, Raquepo TM, Tobin M, Posso AN, Cauley RP. Applications and challenges of artificial intelligence in plastic surgery imaging: A narrative review. Artif Intell Med Imaging 2025; 6(2): 108028 [DOI: 10.35711/aimi.v6.i2.108028]
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17
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"The mini-review addresses the multifunctional roles of the CD47/SIRPα pathway, emphasizing its implications in immunity, homeostasis, and cancer therapeutics. The subject is highly relevant to biomedical research and clinical translation, and the manuscript provides an extensive overview of molecular mechanisms, cellular functions, and therapeutic strategies. The article is timely, given the increasing interest in immune checkpoint modulation and anti-CD47 therapies.
The review is well structured, with clear sections covering molecular mechanisms, cellular functions, and clinical implications. The inclusion of schematic figures and summary tables is helpful, though some illustrations could be improved in resolution and annotation to make complex signaling pathways easier to follow. The manuscript successfully integrates both classical and recent literature, including clinical trial data, which strengthens its scientific significance.
The references are numerous, updated, and appropriate, reflecting a good command of the field. However, the methodology for literature selection is not described, and this reduces transparency compared to systematic approaches. The language is generally clear and concise, with good readability, although a few sentences could be shortened to improve flow.
The main caveat is that the article tends to be descriptive rather than analytical. In some sections, especially those on therapeutic implications, the review could benefit from a more critical discussion of controversies, limitations, and unresolved challenges, such as on-target toxicity and resistance mechanisms. Explicitly highlighting knowledge gaps would enhance the review’s impact.
Overall, this is a well-prepared review on a clinically relevant topic. It effectively summarizes the multifunctional roles of CD47/SIRPα and provides a useful resource for readers. With minor revisions to strengthen the critical analysis and presentation of figures, the manuscript is suitable for publication and may attract significant interest from the field."
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Bhardwaj N, Chandra H, Singh A, Babu R. CD47/SIRPα pathways: Functional diversity and molecular mechanisms. World J Biol Chem 2025; 16(3): 108045 [PMID: 40933289 DOI: 10.4331/wjbc.v16.i3.108045]
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18
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"The manuscript presents a comprehensive metabolomic analysis of Gardenia jasminoides fruits collected from different provenances in Hunan Province, China. The topic is relevant to natural product chemistry and pharmacognosy, and the use of UHPLC-MS/MS combined with antioxidant assays adds methodological strength. The description of the experimental setup is detailed and generally sufficient to allow reproducibility, which is a positive aspect. The results are well-supported by data, including PCA, HCA, and correlation analyses, and the conclusions appear consistent with the findings.
The figures and tables are informative and mostly well-designed, although some chromatograms and heatmaps could benefit from improved labelling and clarity for international readers. The statistical approaches are appropriate, with adequate use of replicates and validation steps. The interpretation of antioxidant assays is clear, although the biological significance could be expanded beyond correlations with geniposide, crocin, and chlorogenic acid.
The references are adequate but somewhat regionally focused. Including more international comparative studies on plant metabolomics and bioactivity would increase the article’s global relevance. The language is acceptable overall, but there are occasional grammatical issues and awkward expressions that could be improved by careful editing.
Limitations include the fact that only one geographic region was sampled, which may limit generalizability. Moreover, the study is restricted to antioxidant capacity without further validation of pharmacological activity. Addressing these limitations in the discussion would strengthen the article.
In conclusion, this is a valuable contribution to the metabolomics characterization of medicinal plants, with solid methodology and reliable results, though with moderate impact due to its regional scope. The manuscript is suitable for publication after minor language polishing and some improvement in discussion of broader implications."
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Bi WY, He WL, Wang W, Wang XR, Zhou ZJ, Zeng YL. Chemical composition differences in wild Gardenia jasminoides fruits across provenances using metabolomics. World J Biol Chem 2025; 16(3): 105875 [PMID: 40933290 DOI: 10.4331/wjbc.v16.i3.105875]
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19
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"Thank you for pointing to the some key issues remaining unresolved till now in this area of research. Standard clinical trials, a more holistic approach, including epigenetics, the assessment of genetic association analyses are necessary for a thorough understanding of potential pitfalls, including ethnic and/or even cultural differences.
Sand PG, Poeppl TB, Roessler V. Unmet needs in precision psychiatry. World J Psychiatry 2025; 15(9): 108222 [DOI: 10.5498/wjp.v15.i9.108222] "
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Sand PG, Poeppl TB, Roessler V. Unmet needs in precision psychiatry. World J Psychiatry 2025; 15(9): 108222 [PMID: 40933152 DOI: 10.5498/wjp.v15.i9.108222]
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20
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"Dear authors, thank you for this article, it points to a very important topic to open up mentalization based interventions or mindfulness-based stress reduction. Emotional awareness and nonjudgmental present-moment awareness to foster adaptive coping strategies is a very promising parameter for professionals. Further research is very much needed, thank you for opening up this topic in your review.
Zhou RR, Chen LL, Lin LD. Mindfulness-based stress reduction and mental health in department of emergency nurses: A narrative review. World J Psychiatry 2025; 15(9): 107630 [DOI: 10.5498/wjp.v15.i9.107630]"
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Zhou RR, Chen LL, Lin LD. Mindfulness-based stress reduction and mental health in department of emergency nurses: A narrative review. World J Psychiatry 2025; 15(9): 107630 [PMID: 40933167 DOI: 10.5498/wjp.v15.i9.107630]
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21
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"This is a systematic effort to analyze the clinical characteristics, course, and progression of unclassified colitis in a manner that allows for drawing conclusions about patients from a northern European population. The results are interesting and useful in everyday clinical practice. It appeared that in these patients, the course of the disease was not benign, since a significant percentage required surgical treatment, while an estimated percentage of patients received treatment with biological agents. In 1/5 of patients, the disease was ultimately found to be Crohn's disease.
Although the treatment of patients with unclassified IBD does not differ from that of classic IBD, it is important to make a sustained effort to distinguish the underlying IBD (UC or CD), given the prognostic significance of this distinction. Furthermore, the choice of appropriate surgery will largely depend on the type of underlying disease.
This study may provide an opportunity for conducting similar multicenter studies in Southern European countries to determine whether unclassified IBD is indeed a distinct subtype of IBD and to clarify the clinical course and outcomes of the disease in the European population."
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Balogh F, Gonczi L, Angyal D, Golovics PA, Pandur T, David G, Erdelyi Z, Szita I, Ilias A, Lakatos L, Lakatos PL. Incidence, disease course, therapeutic strategies and outcomes of inflammatory bowel disease-unclassified patients in Western Hungary: A population-based cohort. World J Gastroenterol 2025; 31(33): 109800 [PMID: 40933456 DOI: 10.3748/wjg.v31.i33.109800]
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22
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"With interest I tracked the article quality of the following manuscript. Please see my comments below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The figures add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate/up-to-date
7 Language: This is a comprehensive well-written manuscript
8 Caveats or drawbacks: None "
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Malek KK, Kumar B, Ahmad R, Singh A, Basson MD. Focal adhesion kinase: A promising regulator of colitis-associated healing. World J Gastroenterol 2025; 31(33): 105466 [PMID: 40933464 DOI: 10.3748/wjg.v31.i33.105466]
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23
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"This is a good synthesis on nutrients and their different impacts on MASLD, a major health problem worldwide in constant increase. As a fan of epigenetics and since this was mentioned in the title, I was hoping to get more details regarding epigenetics mechanisms involved and non-coding RNAs affected by nutrients."
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Rodriguez S, Dahlem MLF, Rossoni C, Marroni NP, Marroni CA, Fernandes SA. Nutrients as epigenetic modulators in metabolic dysfunction-associated steatotic liver disease. World J Hepatol 2025; 17(8): 108182 [PMID: 40901607 DOI: 10.4254/wjh.v17.i8.108182]
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24
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"Authors have present case in learning mode for readers.
IO in pregnancy is always challenging to manage as reflected in this case.
Subtle Clinical manifestations in this IO in pregnancy often overlook these as masked by pregnancy symptoms
Adhesion obstruction aggravating during pregnancy having hormonal role is debatable
Gravid uterus compression may be precipitaing factor.
Conservative management is choice unless conditions desperately demand surgical intervention.
"
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Omullo FP, Anyango OS, Mutua BM, Odoyo MO, Gogo HM, Obung'a VO. Fatal small bowel perforation complicating intestinal obstruction in pregnancy: A case report. World J Clin Cases 2025; 13(29): 109406 [PMID: 40933936 DOI: 10.12998/wjcc.v13.i29.109406]
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25
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Omullo FP, Anyango OS, Mutua BM, Odoyo MO, Gogo HM, Obung'a VO. Fatal small bowel perforation complicating intestinal obstruction in pregnancy: A case report. World J Clin Cases 2025; 13(29): 109406 [PMID: 40933936 DOI: 10.12998/wjcc.v13.i29.109406]
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26
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"Estrogen has receptors for (ERα) and (ERβ), each of which is distributed in different tissues and has diverse physiological effects. ERα plays an important role in the reproductive organs, bones, and mammary glands, while ERβ functions in skeletal muscles, the nervous system, and the immune system. The authors' data suggests that in liver cancer, ERα is involved in the growth of liver cancer, while the expression of ERβ may control the development and progression of liver cancer. This is very interesting data."
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Groover S, Addison S, Nicks S, Mwangi M, Brooks A, Kaul A, Kaul R. Sex based relative expression of estrogen receptors and tumor necrosis factor-alpha in liver affects hepatitis C virus viral pathogenesis. World J Gastroenterol 2025; 31(32): 104277 [PMID: 40900774 DOI: 10.3748/wjg.v31.i32.104277]
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27
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"This is a well- written and presented rarely case report about Invasive inflammatory fibrotic polyp of the duodenum.This manuscript gives additional new knowledge to the existing literature. This interesting and rare case report has certain guiding significance for clinicians. I think that this manuscript is suitable and worth to publication."
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Zhang FM, Ning LG, Wang JJ, Zhu HT, Feng MB, Chen HT. Invasive inflammatory fibrotic polyp of the duodenum: A case report. World J Gastrointest Surg 2025; 17(8): 107558 [PMID: 40949391 DOI: 10.4240/wjgs.v17.i8.107558]
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28
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"The ethical approval meets requirements. The data obtained from the CCORD/ACCORDION trials (ClinicalTrials.gov identifier: NCT00000620). The methods are effective and can be repeated by fellow researchers. The inclusion and exclusion criteria are clear. The authors conducted a study of 10251 participants aged 40-79 years diagnosed T2DM who were followed up for nearly 10 years to investigate the association of METS-IR with incidence of adverse cardiovascular (CVD) events. The main results and tables of this study are authentic, reliable and validate the initial hypothesis. By using the Cox proportional hazards models, restricted cubic spline, stratified subgroup analyses, and C-statistic analyses, the positive association of METS-IR with incidence of adverse CVD events and enhanced risk assessment and prediction of CVD events by adding METS-IR were observed. The statistical analyses were correct. The graphs and figures were constructed and annotated well. One suggestion and confusion should be noted. (1) Suggestion: MACEs, CVD mortality and other outcomes should not be presented in the Table 1. (2) Confusion: In the Data collection and outcomes section, the MACEs was defined as a composite of cardiovascular mortality, nonfatal myocardial infarction (MI), and non-fatal stroke. So, I assumed that the number of MACEs should be equal to the sum of CVD mortality, non-fatal MI, and non-fatal stroke. However, in the Table 1, the number of MACEs was less than the sum of them. The authors should explain this. Authors have cited key references to support the pathophysiological mechanisms and prior epidemiological relationship, as well as the recent references. The language is generally clear, concise, and logically structed. One mistake should be written. The sentence “Further studies have indicated that biological aging the effects of METS-IR on all-cause and CVD mortality” is not fluent."
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Xin Y, Peng NL, Xin CY, Liao JR, Hu XQ, Dong YH, Zhang XY. Metabolic score for insulin resistance is associated with adverse cardiovascular events in patients with type 2 diabetes. World J Diabetes 2025; 16(8): 108671 [PMID: 40837345 DOI: 10.4239/wjd.v16.i8.108671]
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29
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"This review explores the possible role of SARS-CoV-2 infection in the development of malignant neoplasms of the gastrointestinal system. The proposed mechanisms, as is the case in almost all types of malignant neoplasms, are related to chronic inflammatory processes, disturbances in cellular homeostasis, and possibly the integration of the virus into host cells. The significance of these observations is obvious, since if they are proven to be true, measures will need to be taken to systematically monitor patients who have contracted SARS-CoV-2.
In their very interesting review, the authors also present some thoughts on the reliability of published studies linking SARS-CoV-2 infection with the development of digestive cancer. I would like to add one more doubt. Medical students learn that cancer is a multistage process with multiple causes on the one hand and a time-consuming process on the other. I am struck by the fact that the scientific community almost immediately adopts clinical or experimental evidence of carcinogenesis from a particular cause despite the generally accepted views I mentioned above. In any case, this subject is an extremely interesting subject worth consideration. I believe that in the near future, a number of epidemiological and basic research studies should be conducted to better understand whether this virus is really oncogenic and to further clarify possible mechanisms of carcinogenesis."
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Miteva DG, Gulinac M, Peruhova M, Velikova T. Exploring the oncogenic potential of SARS-CoV-2 in the gastrointestinal tract. World J Gastroenterol 2025; 31(31): 105665 [PMID: 40901683 DOI: 10.3748/wjg.v31.i31.105665]
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30
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"Good article on an important topic. Well researched. Will act as a reference point for future articles on this subject. Use of Artificial intelligence to improve patient outcomes is the future. Author has taken good reference points and has written an unbiased article. More such articles and editorials are welcome."
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Tasci B, Dogan S, Tuncer T. Artificial intelligence in gastrointestinal surgery: A systematic review. World J Gastrointest Surg 2025; 17(8): 109463 [PMID: 40949399 DOI: 10.4240/wjgs.v17.i8.109463]
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31
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"An interesting article on tissue engineering with a good set of modern methods incl. immunochemistry and valuable data on ligament regeneration using MSC seeded fibrous scaffolds.
1 Ethics: The ethical approval form provided by the author meets the requirements.
2 Methods: The experimental method effective and can be repeated.
3 Results: The results are true and authentic.
4 Figures and tables: The authors provide perfect tables, line charts and/or graphs.
5 Biostatistics: The authors provide perfect biostatistics data.
6 References: The authors scientifically and reasonably cite the latest references which are important in this field.
7 Language: The language in article correctly, clearly and concisely expresses the information? "
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Yang CW, Zhang YQ, Chang H, Gao R, Chen D, Yao H. Aligned nanofiber scaffolds combined with cyclic stretch facilitate mesenchymal stem cell differentiation for ligament engineering. World J Stem Cells 2025; 17(8): 107124 [PMID: 40951703 DOI: 10.4252/wjsc.v17.i8.107124]
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32
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"A good review with general information about MSCs and artificial intelligence and specific information about the application of artificial intelligence in MSCs therapy.
1 Ethics: The ethical approval form provided by the author meets the requirements.
2 Methods: The experimental method effective and can be repeated.
3 Results: The results are true and authentic.
4 Figures and tables: The authors provide perfect tables, line charts and/or graphs.
5 Biostatistics: The authors provide perfect biostatistics data.
6 References: The authors scientifically and reasonably cite the latest references which are important in this field.
7 Language: The language in article correctly, clearly and concisely expresses the information?
"
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Choudhery MS, Arif T, Mahmood R. Applications of artificial intelligence in stem cell therapy. World J Stem Cells 2025; 17(8): 106086 [PMID: 40951704 DOI: 10.4252/wjsc.v17.i8.106086]
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33
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"A good informative review with valuable general information in the Introduction and 2 first sections and specific information on clinical cases about MSC therapy for lupus nephritis.
Liu L, Behera TR, Wang QJ, Shen QQ. Advances in mesenchymal stem cell therapy for lupus nephritis. World J Stem Cells 2025; 17(8): 104930 [DOI: 10.4252/wjsc.v17.i8.104930].
1 Ethics: The ethical approval form provided by the author meets the requirements.
2 Methods: The experimental method effective and can be repeated.
3 Results: The results are true and authentic.
4 Figures and tables: The authors provide perfect tables, line charts and/or graphs.
5 Biostatistics: The authors provide perfect biostatistics data.
6 References: The authors scientifically and reasonably cite the latest references which are important in this field.
7 Language: The language in article correctly, clearly and concisely expresses the information? "
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Liu L, Behera TR, Wang QJ, Shen QQ. Advances in mesenchymal stem cell therapy for lupus nephritis. World J Stem Cells 2025; 17(8): 104930 [PMID: 40951714 DOI: 10.4252/wjsc.v17.i8.104930]
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34
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"This is very interesting paper about gastrointestinal cancer after covid19 infection.After Covid 19 infection, an increase in gastrointestinal cancer has been reported due to factors such as a weakened immune system,changes in the intestinal flora and a weakened gut barrier.If so, please tell me what kind of gastrointestinal cancer are most popular."
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Miteva DG, Gulinac M, Peruhova M, Velikova T. Exploring the oncogenic potential of SARS-CoV-2 in the gastrointestinal tract. World J Gastroenterol 2025; 31(31): 105665 [PMID: 40901683 DOI: 10.3748/wjg.v31.i31.105665]
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35
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"1. Non operative treatment failure can be different in age groups 9 pediatric vs adult), types of appendicitis (complicated vs non complicated).
2. In case of appendicolith, the need for follow up visit and imaging considerations may inflate the health expenditure, cautioning the approach of neglecting the role of appendicolith in management strategies
3. Conclusion can avoid citations as it pertains to the manuscript discussion and represents the author's opinion as a take-home message
"
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Tian J. Appendicolith in non-operative management of acute appendicitis: Implications for recurrence and future directions. World J Clin Cases 2025; 13(28): 109664 [PMID: 40881013 DOI: 10.12998/wjcc.v13.i28.109664]
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36
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"1. The Magnetic resonance cholangiopancreatography (MRCP) image is not available and can be included for correlation
2. A diagram illustrating the surgical findings may be helpful in understanding the patient's anatomy better
3. Imaging on sonography (multiple gall stones) and intra op findings (single large 4 cm stone) appear to stand in contrast.
"
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Gupta AK, Surendranath A. Cholecysto-biliary fistula mimicking type 1 Mirizzi syndrome: A case report. World J Clin Cases 2025; 13(28): 108437 [PMID: 40881011 DOI: 10.12998/wjcc.v13.i28.108437]
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37
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"1. The airway difficulty is not clearly described. The xray spine was normal. The intubation was not prolonged and was carried out smoothly.
2. In children with complex cervical spine lesions such as Klippel Feil syndrome, the intubation is more challenging due to the short neck and restricted neck mobility
3. Were other options such as sedation / local block / LMA considered?"
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Lin XN, Chan WS, Lu CW. Airway management strategies in a pediatric patient with MURCS association: A case report. World J Clin Cases 2025; 13(28): 106852 [PMID: 40881014 DOI: 10.12998/wjcc.v13.i28.106852]
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38
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"Cardiovascular complications and mortality remain the leading causes of death in T2DM.
Investigating TyG-BMI (a composite index combining triglyceride-glucose index with BMI) is highly relevant, as it may better capture the combined impact of insulin resistance and obesity compared to TyG or BMI alone. While TyG has been studied, TyG-BMI is a relatively novel marker, and this research adds unique insights into its predictive role for cardiovascular outcomes and mortality.
Authors reported that that TyG-BMI improved discriminative performance beyond TyG or BMI alone and it provided important evidence for clinical risk stratification."
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Liu MJ, Xiang SM, Hu XQ. Triglyceride glucose-body mass index is associated with cardiovascular outcomes and overall mortality in type-2 diabetes mellitus patients. World J Diabetes 2025; 16(8): 108839 [PMID: 40837332 DOI: 10.4239/wjd.v16.i8.108839]
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39
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"The use of an RCT design is the gold standard for evaluating therapeutic interventions. Randomization minimizes allocation bias and balances potential confounders between groups, thereby strengthening internal validity. This is particularly valuable in DFU research, where outcomes are strongly influenced by multiple factors (glycemic control, vascular status, infection history). DFUs are a leading cause of hospitalization, morbidity, and amputation in diabetes. Exploring a low-cost, safe, and easily accessible adjunct therapy like vitamin D addresses an urgent unmet clinical need. The supplementation strategy (2000 IU cholecalciferol daily) is practical, inexpensive, and feasible to implement in most healthcare systems, enhancing translational impact.
Authors didn't limit themselves to only wound size reduction but evaluated multiple endpoints such as infection incidence and severity (clinically meaningful, patient-centered outcomes) as primary outcomes and wound healing rate, serum vitamin D levels, immune biomarkers (cathelicidin, IL-6, TNF-α), and safety monitoring as secondary outcomes. This multidimensional approach allowed the authors to connect clinical outcomes with mechanistic pathways, thereby strengthening biological plausibility. Reduced infection rate, promoted wound healing, and strengthened immune responses in patients with DFUs are reported after vitamin D supplementation. "
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Gao YQ, Gao YH, Xing JH. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers. World J Diabetes 2025; 16(8): 108166 [PMID: 40837342 DOI: 10.4239/wjd.v16.i8.108166]
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40
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"Type 2 diabetes (T2D) is a global health burden, and lifestyle interventions remain foundational. The focus on meal replacements (MRs) addressed an area of growing clinical and research interest, particularly in weight and glycemic control. Authors aimed to provide a comprehensive scoping review, not only summarizing evidence on outcomes but also classifying meal replacement types, dosages, and adverse effects. This approach is clinically useful, as different formulations (low-calorie, diabetes-specific, protein-rich, etc.) may have different impacts. Large initial dataset (53,922 studies) screened down to 133 eligible studies, showing thoroughness. Categorization of interventions provides practical insights for clinicians.
Both benefits (HbA1c reduction, weight loss, BMI changes) and risks (adverse events, tolerability) were reported in the systematic review. Authors concluded that most adverse events were mild (constipation being most frequent) is reassuring for safety considerations."
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Lew LC, Mat Ludin AF, Abdul Manaf Z, Mohd Tohit N, Shahar S. Mapping evidence and identifying risks: A systematic scoping review of meal replacements in type 2 diabetes. World J Diabetes 2025; 16(8): 104371 [PMID: 40837337 DOI: 10.4239/wjd.v16.i8.104371]
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41
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"Carotid atherosclerosis is a major complication of T2DM, and identifying predictors of plaque formation is important for early risk stratification and prevention of cardiovascular events. Authors xamined a broad set of clinical and biochemical parameters (glycemic markers, renal function indices, uric acid, lipid profile, etc.), giving a holistic picture of vascular risk in T2DM. IMT and plaque detection via ultrasound provide objective and clinically relevant endpoints, improving the translational value of the findings. Authors reported modifiable (FPG, HbA1c, SBP, SUA, UACR) and non-modifiable (age) risk factors, which can guide both clinical practice and patient education."
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Shi L, Li NJ. Comprehensive analysis of risk factors associated with carotid plaque in patients with type 2 diabetes mellitus. World J Diabetes 2025; 16(8): 104180 [PMID: 40837341 DOI: 10.4239/wjd.v16.i8.104180]
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42
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"The article provides compelling long-term evidence that challenges traditional assumptions about appendicoliths in acute appendicitis. It highlights that their presence should not be viewed as a definitive predictor of failure in nonoperative management. Instead, it supports individualized, evidence-based clinical decision-making aimed at improving patient outcomes, reducing recurrence risks, and avoiding unnecessary surgical interventions, thereby promoting a more balanced, patient-centered approach to managing uncomplicated cases of acute appendicitis."
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Tian J. Appendicolith in non-operative management of acute appendicitis: Implications for recurrence and future directions. World J Clin Cases 2025; 13(28): 109664 [PMID: 40881013 DOI: 10.12998/wjcc.v13.i28.109664]
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43
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"The study by Ding et al., “TSC22D1 promotes liver sinusoidal endothelial cell dysfunction and induces macrophage M1 polarization in non-alcoholic fatty liver disease,” investigates the role of TSC22D1 in NAFLD, demonstrating its involvement in endothelial dysfunction and macrophage M1 polarization, key factors in disease progression. The authors successfully address the molecular mechanisms underlying NAFLD, providing insights into potential therapeutic targets. However, the study is limited by its in vitro design and does not explore the clinical implications or validate findings in human subjects. Future research should include in vivo studies and clinical investigations to assess the therapeutic potential of targeting TSC22D1. Overall, the study offers significant mechanistic insights that advance the understanding of NAFLD while highlighting directions for future translational research.
"
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Ding W, Xu XQ, Wu LL, Wang Q, Wang YQ, Chen WW, Tan YL, Wang YB, Jiang HJ, Dong J, Yan YM, Xu XZ. TSC22D1 promotes liver sinusoidal endothelial cell dysfunction and induces macrophage M1 polarization in non-alcoholic fatty liver disease. World J Gastroenterol 2025; 31(31): 109605 [PMID: 40901684 DOI: 10.3748/wjg.v31.i31.109605]
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44
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"The article by Li and Zhai, “Insights into a machine learning-based prediction model for colorectal polyp recurrence after endoscopic mucosal resection,” presents a machine learning model designed to predict colorectal polyp recurrence following EMR using clinical and pathological data. The study successfully addresses the need for individualized risk assessment, offering potential improvements over traditional prediction methods. However, its retrospective design limits causal inference, and the model’s generalizability to diverse populations remains untested. Future work should include prospective multicenter validation, integration of additional predictive variables such as genetic markers, and incorporation into clinical decision support systems. Overall, the study provides a valuable foundation for advancing predictive tools in gastroenterology, though further validation is needed to confirm its clinical utility.
"
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Li GY, Zhai LL. Insights into a machine learning-based prediction model for colorectal polyp recurrence after endoscopic mucosal resection. World J Gastroenterol 2025; 31(31): 109389 [PMID: 40901692 DOI: 10.3748/wjg.v31.i31.109389]
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45
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"The article by Zhang et al., “Age- and gender-specific dynamics and next-generation reference intervals for pepsinogen in northern China,” provides updated reference intervals for pepsinogen levels, accounting for age and gender in a northern Chinese population. The study successfully addresses the need for region-specific reference data, offering a comprehensive dataset that can improve the interpretation of pepsinogen in clinical practice. However, it does not explore the direct clinical implications of these findings or establish causative links between pepsinogen levels and gastric diseases. Future research should include prospective studies to assess clinical outcomes, integrate the reference intervals into decision support systems, and validate them in diverse populations. Overall, the study contributes valuable foundational data to gastroenterology, while further work is needed to fully translate these results into clinical practice.
"
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Zhang MM, Zhu D, Zhao HB, Zhao XY. Age- and gender-specific dynamics and next-generation reference intervals for pepsinogen in northern China. World J Gastroenterol 2025; 31(31): 108977 [PMID: 40901694 DOI: 10.3748/wjg.v31.i31.108977]
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46
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"The study by Qi et al. developed the SIALF nomogram, a dynamic model to predict sepsis risk in patients with acute liver failure using simple clinical variables. Validated both internally and externally, the model outperformed traditional scores like SOFA and SIRS and showed strong clinical applicability through calibration and decision curve analyses. While the study addresses a key gap in sepsis prediction, limitations include its retrospective design and dependence on specific datasets, with generalizability still uncertain. Prospective multicenter validation and integration into clinical decision support systems are recommended to confirm its effectiveness. Overall, SIALF represents a significant and practical contribution to clinical practice in managing acute liver failure.
"
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Qi R, Wang X, Kuang ZD, Shang XY, Lin F, Chang D, Mu JS. Dynamic nomogram predicts sepsis risk in patients with acute liver failure: Analysis of intensive care database with external validation. World J Gastroenterol 2025; 31(31): 105229 [PMID: 40901690 DOI: 10.3748/wjg.v31.i31.105229]
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47
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"The article “Exploring the oncogenic potential of SARS-CoV-2 in the gastrointestinal tract” is a minireview that innovatively discusses the possible mechanisms through which SARS-CoV-2 may contribute to oncogenesis in the gastrointestinal tract. Although it does not present original data, the review is relevant as it addresses an emerging topic, integrates recent findings, and raises hypotheses that encourage further research. Published in open access, it fulfills the role of updating the scientific community and promoting the advancement of medical knowledge. Thus, it meets the criteria of the Baishideng Distinguished Award in the Review category, representing a significant contribution to science.
"
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Miteva DG, Gulinac M, Peruhova M, Velikova T. Exploring the oncogenic potential of SARS-CoV-2 in the gastrointestinal tract. World J Gastroenterol 2025; 31(31): 105665 [PMID: 40901683 DOI: 10.3748/wjg.v31.i31.105665]
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48
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"This well-designed observational study provides compelling evidence that modifiable lifestyle factors—such as physical activity, healthy diet, smoking cessation, and sleep quality—significantly influence disease progression in patients with colorectal polyps and early-stage cancer, underscoring the value of personalized lifestyle interventions in clinical management. The integration of behavioral science with clinical oncology offers a practical and impactful pathway for improving patient outcomes through non-invasive, cost-effective strategies."
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Lin FF, Ye JT, Mao XY, Mao XJ, Ye HH. Association between lifestyle factors and disease progression in patients with colorectal polyps and early-stage cancer. World J Gastrointest Oncol 2025; 17(8): 108452 [PMID: 40837747 DOI: 10.4251/wjgo.v17.i8.108452]
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49
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"This comprehensive review thoughtfully addresses the technical and clinical challenges of implementing cell-free DNA (cfDNA) in colorectal cancer screening and prognostication, while offering innovative solutions that could transform early detection and personalized care. The authors’ integration of molecular biology, diagnostic technology, and clinical strategy reflects a forward-looking approach that could significantly advance non-invasive cancer diagnostics."
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Chua MWE, Chan DKH. Challenges and proposed solutions to the adoption of cell free DNA in screening, detecting and prognosticating colorectal cancer. World J Gastrointest Oncol 2025; 17(8): 106663 [PMID: 40837751 DOI: 10.4251/wjgo.v17.i8.106663]
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50
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"This comprehensive 10-year multicenter study offers valuable insights into pancreatic cancer treatment patterns across China, revealing that combination chemotherapy regimens significantly improve survival outcomes compared to monotherapy, while also underscoring the importance of early diagnosis and surgical precision. The scale, regional diversity, and robust statistical analysis make this study a meaningful contribution to global pancreatic cancer research and a strong foundation for future clinical guidelines."
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Sun WY, Zhang SS, Zhang SK, Qin RY, Zhou B, Liu J, Li SP, Chen RF, Wang CF, Fan JH. Treatment options in patients with pancreatic cancer: A 10-year multicenter epidemiological investigation in China. World J Gastrointest Oncol 2025; 17(8): 106447 [PMID: 40837749 DOI: 10.4251/wjgo.v17.i8.106447]
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