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1
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"This systematic review highlighted the growing role of hydroxyapatite, β-tricalcium phosphate, and fibrin-based products in bone regeneration. However, this article contains few diagrams and the references are quite outdated. Although this literature provides a detailed account of the application of synthetic biomaterials combined with fibrin derivatives in bone regeneration medicine, there is still a significant lack of research at the molecular level."
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Pagani BT, Rosso MPO, Moscatel MBM, Trazzi BFM, da Cunha MR, Issa JPM, Buchaim DV, Buchaim RL. Update on synthetic biomaterials combined with fibrin derivatives for regenerative medicine: Applications in bone defect treatment: Systematic review. World J Orthop 2025; 16(5): 106181 [DOI: 10.5312/wjo.v16.i5.106181]
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2
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"This review is rich in illustrations and graphics, with appropriate methods and reliable results. Therefore, this article is highly scientific and innovative. The author elaborated in detail on the formation mechanism and progress of neutrophil extracellular traps in common osteoarticular diseases. However, the mechanism of interaction between neutrophil extracellular traps and other cells in osteoarticular diseases has not been fully elucidated, and this should be a direction for future research."
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Sun GJ, Xu F, Jiao XY, Yin Y. Advances in research of neutrophil extracellular trap formation in osteoarticular diseases. World J Orthop 2025; 16(5): 106377 [DOI: 10.5312/wjo.v16.i5.106377]
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3
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"In this manuscript, the authors analyzed the prevalence and incidence of ulcerative colitis and Crohn's disease using large medical record databases from three regions: Hong Kong, Japan, and the United States. In the results, substantial differences were identified among regions in absolute prevalence/incidence, temporal trends, and disease characteristics. Although the authors discussed various potential factors contributing to these differences, it is difficult to accept several explanations, such as the difference in NO2 exposure leading to the different prevalence and incidence of Crohn's disease between Japan and the USA. NO2 exposure at the time point may not differ between Japan and the USA with the magnitude reflected in the different prevalence/incidence of Crohn's disease. It would be ideal for the authors to include a discussion that proposes possible solutions to reduce the prevalence and incidence of inflammatory bowel diseases in each society."
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Zhang Y, Chung H, Fang QW, Xu YR, Zhang YJ, Nakajo K, Wong ICK, Leung WK, Qiu H, Li X. Current and forecasted 10-year prevalence and incidence of inflammatory bowel disease in Hong Kong, Japan, and the United States. World J Gastroenterol 2025; 31(18): 105472 [DOI: 10.3748/wjg.v31.i18.105472]
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4
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"This manuscript employs a bibliometric analysis to map the field of spondylolisthesis research. Using the Web of Science database, the authors identified 1831 relevant articles. The study reveals a dramatic increase in publications post-2010, with the United States leading in contributions. The University of California, San Francisco, emerges as the most prolific institution. Spine is identified as the top journal publishing in this area. Keyword analysis highlights themes in clinical presentation, diagnosis, and treatment. The authors conclude that this work provides a methodological framework to synthesize historical and current trends in spondylolisthesis studies, but the authors acknowledge limitations due to dependence on the web of science collection database."
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Xu JN, Li Y, Zhao TX, Wu WY, Yang XW, Zhang HW, Chen Q, Xia C, Zhang J. Mapping the field of spondylolisthesis: A bibliometric analysis. World J Clin Cases 2025; 13(22): 99221 [DOI: 10.12998/wjcc.v13.i22.99221]
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5
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"This editorial critically analyzes a study by Maranhão et al. investigating pleural adenosine deaminase (P-ADA) as a biomarker for inflammatory pleural effusions. The editorial highlights the clinical relevance of the study, which established a cutoff value for P-ADA to differentiate between inflammatory and non-inflammatory pleural effusions. It emphasizes the study's novelty in providing a standardized P-ADA threshold in a Brazilian population, addressing inconsistencies found in previous studies. The editorial further explores the pathophysiological mechanisms underlying elevated P-ADA, linking it to purinergic signaling pathways and immune cell activation. The editorial acknowledges that using P-ADA leads to early diagnosis, improved treatment stratification and reduction in cost. The limitation is that the cutoff value requires validation across diverse population and the data is retrospective. Overall, the editorial positions P-ADA as a non-invasive, cost-effective biomarker with potential to streamline diagnostics, particularly in resource-limited settings, and calls for future research to prioritize global validation and explore integration with other biomarkers."
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Shi DD, Tian J, Ding J. Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation. World J Clin Cases 2025; 13(22): 106925 [DOI: 10.12998/wjcc.v13.i22.106925]
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6
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Tasneem AA, Luck NH, Mubarak M. Mediastinal lymphadenopathy: Causes, symptoms and factors predicting good yield of endoscopic ultrasound-guided biopsy. World J Clin Cases 2025; 13(22): 105596 [DOI: 10.12998/wjcc.v13.i22.105596]
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7
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Kucukakcali Z, Akbulut S. Role of immature granulocyte and blood biomarkers in predicting perforated acute appendicitis using machine learning model. World J Clin Cases 2025; 13(22): 104379 [DOI: 10.12998/wjcc.v13.i22.104379]
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8
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Abdishakur AE, Ahmed MAA. Adult ileo cecal intussusception as a manifestation of colon carcinoma: A case report. World J Clin Cases 2025; 13(22): 104352 [DOI: 10.12998/wjcc.v13.i22.104352]
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9
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Inoue Y, Yata Y, Yokota Y, Li ZL, Kawabata K. Acute pancreatitis after total aortic arch replacement leading to walled-off necrosis: A case report and review of literature. World J Clin Cases 2025; 13(22): 104165 [DOI: 10.12998/wjcc.v13.i22.104165]
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10
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"This manuscript describes a rare case of walled-off necrosis (WON) after acute pancreatitis following total aortic arch replacement in a 67-year-old man. The case was successfully managed with the endoscopic ultrasound (EUS)-guided drainage of the peripancreatic fluid collection (PFC). The manuscript underscores the feasibility and safety of this endoscopic intervention in this clinical scenario, even though large prospective studies are certainly needed to draw conclusions in this direction."
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Inoue Y, Yata Y, Yokota Y, Li ZL, Kawabata K. Acute pancreatitis after total aortic arch replacement leading to walled-off necrosis: A case report and review of literature. World J Clin Cases 2025; 13(22): 104165 [DOI: 10.12998/wjcc.v13.i22.104165]
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11
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"The authors conducted a single-centre retrospective study involving nearly 400 patients with ulcerative colitis and approximately 300 patients with Crohn’s disease, compared with 100 controls. The sample was subsequently resampled using propensity score matching to homogenise the cohorts. The authors assessed 17 serum biomarkers, both as individual and composite markers, evaluating their association with endoscopic activity (measured using the Mayo score for ulcerative colitis and the SES-CD for Crohn’s disease), and constructed a predictive nomogram based on the biomarkers that demonstrated predictive value as independent variables. A subgroup of 100 patients was subsequently re-evaluated to verify the consistency of the analyses with the ensuing endoscopic response. The study has several strengths: a large sample size filtered through propensity score matching; the biomarkers evaluated by the authors are readily available in any laboratory; and the endoscopic outcome is highly relevant, as opposed to surrogate laboratory (e.g. faecal calprotectin) or clinical (e.g. partial Mayo score or HBI) outcomes. The analyses demonstrated a very high AUC for ulcerative colitis (0.93) and a fair AUC for Crohn’s disease (0.78). Nonetheless, several limitations emerged: the single-centre design undermines generalisability, the retrospective nature compromises data robustness, external validity is lacking, follow-up was limited to 14 weeks, and therapeutic heterogeneity was not thoroughly accounted for."
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Liu X, Pan LX, Pei JX, Pu T, Wen HT, Zhao Y. Role of serological biomarkers in evaluating and predicting endoscopic activity in inflammatory bowel disease. World J Gastroenterol 2025; 31(18): 104206 [DOI: 10.3748/wjg.v31.i18.104206]
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12
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"In abstract , it is 5 % of intussusceptions , whereas in in Introduction , it is 6%,which is correct.
After Physical examination , t of the should be capital.
what is 8.5 g/DL.
What surgical resection was done ?
Various treatment options should have been described
References are outdated
There was room for improvement in this case , enhancing its credibility.Literature should have been searched.
Reviewers and editors should have reviewed literature to improve quality of case report for readers"
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Abdishakur AE, Ahmed MAA. Adult ileo cecal intussusception as a manifestation of colon carcinoma: A case report. World J Clin Cases 2025; 13(22): 104352 [DOI: 10.12998/wjcc.v13.i22.104352]
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13
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"This editorial provides a comprehensive interpretation of Maranhão et al. 's study, which establishes a pleural adenosine deaminase (P-ADA) cutoff for inflammatory pleural effusions. The authors successfully highlight the clinical utility of P-ADA in differentiating inflammatory from non-inflammatory effusions and connect this biomarker to broader pathophysiological processes involving purinergic signaling and ADA2 isoforms.
Strengths:
The article clearly emphasizes the practical implications of Maranhão et al. 's findings, especially in resource-limited settings where non-invasive, cost-effective biomarkers are highly needed.
The connection between P-ADA levels and immune modulation through ADA2 isoforms in macrophages and lymphocytes adds valuable biological context.
The editorial effectively highlights the need for global validation studies and standardization of P-ADA cutoffs, a crucial message for the field.
Suggestions for Improvement:
Add a paragraph critically discussing P-ADA's diagnostic overlap with malignant and parapneumonic effusions.
Include practical suggestions for standardizing P-ADA testing across different regions and populations.
Expand on the possible role of P-ADA within multi-marker panels and its integration into current diagnostic workflows.
"
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Shi DD, Tian J, Ding J. Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation. World J Clin Cases 2025; 13(22): 106925 [DOI: 10.12998/wjcc.v13.i22.106925]
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14
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"It was with pleasure that I reviewed the article quality of the following manuscript.
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The figures/tables add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate/up-to-date
7 Language: This is a concise/well written manuscript
8 Caveats or drawbacks: None"
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Dong ZY, Zhu HB. Idiopathic retroperitoneal fibrosis arising from peritoneal space: A case report and review of literature. World J Gastroenterol 2025; 31(18): 105443 [DOI: 10.3748/wjg.v31.i18.105443]
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15
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"Full laparoscopic ALPPS for CRLM is safe and feasible, with the potential for reduced morbidity and mortality. However, due to the technical complexity of this procedure, it cannot be guaranteed that each center can perform successfully and safely. It requires surgeons to be highly experienced with laparoscopic hepatectomy.
What level of laparoscopic hepatectomy skills are required? For example, how many laparoscopic hepatectomy cases?
"
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Zheng ZY, Zhang L, Li WL, Dong SY, Song JL, Zhang DW, Huang XM, Pan WD. Laparoscopic associating liver partition and portal vein ligation for staged hepatectomy for colorectal liver metastases: A single-center experience. World J Gastroenterol 2025; 31(18): 105530 [DOI: 10.3748/wjg.v31.i18.105530]
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16
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"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this paper is of high value because the research methods used to confirm the original hypotheses regarding the topic, as well as the results, analysis methods, and evaluation methods, all appear to be valid."
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Guo X, Guo L, Lu QZ, Xie H, Chen J, Su WL, Tian Y, Li XH, Miao HL, Zhang Y, Yang Y, Liao C, Deng JY, Yang YH, Tang CL, Liu HJ. Effect of electroacupuncture combined with Tuina therapy on gut microbiota in patients with knee osteoarthritis. World J Gastroenterol 2025; 31(18): 105495 [DOI: 10.3748/wjg.v31.i18.105495]
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17
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"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this paper is of high value because the research methods used to confirm the original hypotheses regarding the topic, as well as the results, analysis methods, and evaluation methods, all appear to be valid."
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Kamimura K, Terai S. Importance of understanding a diagnostic-treatment algorithm for primary hyperparathyroidism-induced acute pancreatitis during pregnancy. World J Gastroenterol 2025; 31(18): 105866 [DOI: 10.3748/wjg.v31.i18.105866]
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18
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"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this paper is of high value because the research methods used to confirm the original hypotheses regarding the topic, as well as the results, analysis methods, and evaluation methods, all appear to be valid."
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Zhang Y, Chung H, Fang QW, Xu YR, Zhang YJ, Nakajo K, Wong ICK, Leung WK, Qiu H, Li X. Current and forecasted 10-year prevalence and incidence of inflammatory bowel disease in Hong Kong, Japan, and the United States. World J Gastroenterol 2025; 31(18): 105472 [DOI: 10.3748/wjg.v31.i18.105472]
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"The authors conducted a systematic review and meta-analysis to compare the clinical outcomes and safety of TAVR and SAVR in patients with severe AS. The methodology follows PRISMA guidelines, and both inclusion criteria and outcome assessment are clearly defined and presented. Multiple reviewers were involved in data extraction procedure eliminating the risk of selection bias. The authors used the Cochrane Collaboration Tool for assessing the risk of bias in the included studies. However, there are concerns regarding the blinding of participants in some studies which could have led to performance bias.
Statistical methods were appropriately applied making the study reproducible by other researchers. TAVR was associated with significantly lower risk of short-term mortality (1-year-mortality) and reduced complications like AKI, major bleeding and new-onset AF, while it was associated with higher rates of long-term mortality (5-year-mortality), permanent pacemaker implantation and major vascular complications compared to SAVR. The results are strongly supported by tables and forest plots. However, the interpretation of this difference in long-term and short-term mortality rates could be discussed further and explain possible factors. The statistical analysis was conducted using Review Manager which is a well-established software in the field.
References are current and relevant including major clinical trials and systematic reviews. The authors avoid excessive self-citation and provide a solid foundation of current literature. The language used in this manuscript is generally clear but some sentences are overly complex and could be simplified for better understanding. This study has several limitations which are appropriately presented and discussed in the relevant section of this manuscript. However, a major caveat regarding this study is that the analysis did not include several patient-specific factors which could have influenced both selection of treatment and outcomes.
"
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Moradi I, Mustafa MS, Sardar Sheikh J, Shojai Rahnama B, Fredericks M, Kumar Yennam A, Arain M, Saha U, Richard Ma A, Nagendran A, Bin Omer M, Armaghan M, Jaimes DCC, Avinash Bojanki NLSV, Shafique MA. Comparative effectiveness of transcatheter vs surgical aortic valve replacement: A systematic review and meta-analysis. World J Cardiol 2025; 17(4): 104168 [PMID: 40308627 DOI: 10.4330/wjc.v17.i4.104168]
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20
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Chen LQ, Wu CY, Wu SJ, Ye K. Laparoscopic surgical approaches for various locations of gastrointestinal stromal tumours. World J Clin Cases 2025; 13(21): 105559 [DOI: 10.12998/wjcc.v13.i21.105559]
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21
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"In this editorial, the authors discussed an article reporting the significance of the triglyceride-glucose (TyG) index in predicting prognosis and response to immunotherapy. Unfortunately, it is difficult to assess the study’s significance, as the editorial does not provide actual probability for each comparison. Furthermore, the manuscript lacks clarity, as it contains numerous contradictory statements.
In the sections titled “The TyG Index as a Prognostic Factor in GC” and “Exploring the Relationship Between TyG and Immunotherapy Response”, the authors emphasize that a higher TyG index is associated with better outcomes and an improved response to immunotherapy. However, in the subsequent section “Mechanisms Linking TyG to Cancer Progression and Immune Function”, they state that a high TyG index may promote tumor cell proliferation, inhibit apoptosis, and reduce the response rate to immunotherapy.
The authors should revise the manuscript to resolve these inconsistencies and improve overall clarity."
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Zhao CF, Liu XL, Wu NB, Xu ZF. Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research. World J Gastroenterol 2025; 31(17): 104794 [DOI: 10.3748/wjg.v31.i17.104794]
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22
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"Helicobacter pylori is still a significant health problem in developed and developing countries. Its presence is associated with several important consequences. Its eradication is, therefore, an essential objective in cases where its presence has been demonstrated. It is well known that inhibiting gastric acid secretion is necessary for the combination of antibiotics used for its eradication to be effective. In recent years, a new drug with a strong antisecretory effect has been introduced into our pharmaceutical quiver, Vonoprazan (VPZ), which is a member of the potassium competitive acid blockers. In the commented study (Ozercan M et al., Vonoprazan and proton pump inhibitors: which is superior for Helicobacter pylori eradication? World J Gastroenterol 2025; 31(17): 103156), the authors commented on the safety and efficacy of VPZ with the safety and effectiveness of proton pump inhibitors (PPIs), in the eradication of Helicobacter pylori. By reviewing the relevant studies, they found that VPZ administration had a higher rate of efficacy and a lower rate of side effects compared to PPIs. They concluded that despite its higher cost, VPZ is an economically and medically superior therapeutic strategy compared to PPIs. Helicobacter pylori eradication therapy may be a significant problem in daily clinical practice in some proportion of patients, particularly in patients over 60 years of age, for whom the avoidance of the side effects of treatment should be a key objective. This task could be achieved by using fewer antibiotics combined with VPZ, e.g. only amoxicillin plus VPZ which is an important alternative therapy shortly.
The paper by Ozercan M et al. is a comprehensive but clear review of the data on the usefulness of VPZ in the treatment of Helicobacter pylori infection, providing clear guidelines for the use of the drug in daily clinical practice. "
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Ozercan M, Tawheed A, Ismail A, Amer MS, El-Kassas M. Vonoprazan and proton pump inhibitors: Which is superior for Helicobacter pylori eradication? World J Gastroenterol 2025; 31(17): 103156 [DOI: 10.3748/wjg.v31.i17.103156]
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23
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"This is the first United Kingdom study to report the frequency of death in patients presenting with paracetamol overdose-related acute hepatic failure.Paracetamol overdose (POD) is the most common cause of acute hepatic failure (AHF) in the United Kingdom. Without urgent orthotopic liver transplant (OLT), mortality is high. Indeed, Paracetamol overdose (POD) is the most common cause of acute hepatic failure (AHF) in the United Kingdom. Without urgent orthotopic liver transplant (OLT), mortality is high.
This is an 18-year single-centre retrospective cohort study based in a national liver transplant centre. 524 participants were identified from a departmental database and included if they had AHF from suspected POD and received a psychiatric assessment for OLT.Among 524 patients undergoing psychiatric assessment for OLT, there were 102 in-episode deaths (19.5%). This indicates a need for ongoing assessor training and support, and (inter) national comparisons of practice"
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Impey ORE, Baker JD, Smyth RS, Potts SG. Death after psychiatric contraindications to urgent liver transplant for paracetamol overdose. World J Transplant 2025; 15(3): 101865 [DOI: 10.5500/wjt.v15.i3.101865]
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24
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"Paediatric liver transplantation (PLT) is a life-saving procedure for children with advanced liver disease or hepatoblastoma. The number of available grafts is limited in relation to the number of children on PLT waiting list. One of the limitations is the donor obesity. Donors’ obesity is strongly associated with hepatic steatosis which can affect graft function by impairing microcirculation and maximizing the potential of ischemia-reperfusion injury. This important study faces this problem and offers a possible solution. New strategies to optimize the grafts before PLT such as normothermic regional perfusion and ex vivo liver perfusion can potentially mitigate the risk of using grafts from obese donors.The study in particular treats new strategies to optimize the grafts before PLT such as normothermic regional perfusion and ex vivo liver perfusion can potentially mitigate the risk of using grafts from obese donors.
"
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Alnagar A, Amgad A, Grammatikopoulos T, Kyrana E. Impact of donor obesity on paediatric liver transplantation; current evidence and potentials for graft pool expansion. World J Transplant 2025; 15(3): 103015 [DOI: 10.5500/wjt.v15.i3.103015]
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25
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"Very important study on the management of patients with doner-specific antibodies detected
by Luminex pre-transplantation. Pretransplant low-level donor-specific antibodies (DSAs) detected by the Luminex platform are associated with favorable graft outcomes after 1 year and 10 years in kidney transplant recipients. This study highlighted the appropriate immunosuppressive induction and maintenance protocols. These patients experienced low rates of acute rejection and sustained satisfactory long-term graft function and survival.
"
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Abbas K, Mubarak M, Musharraf W, Hafeez AR, Aziz T, Zafar MN. Impact of low-level pretransplant donor-specific antibodies detected by the Luminex platform on acute rejection and long-term graft survival. World J Transplant 2025; 15(3): 104308 [DOI: 10.5500/wjt.v15.i3.104308]
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26
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"Very interesting study on a critical point involving transplantatio. Indeed,Fertility preservation and pregnancymanagement are critical considerations for patients undergoing organtransplantation.
This mini-review explores advancements in cryopreservationtechniques, pre-conception counseling, and multidisciplinary strategies forsafe pregnancies post-transplantation. Emphasis is placed on balancing maternalhealth, graft function, and fetal outcomes. Fertility preservation and pregnancymanagement are critical considerations for patients undergoing organtransplantation."
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Lazarov V, Naseva E, Miteva DG, Tomov LP, Shumnalieva R, Peruhova M, Velikova T. Advances in fertility preservation and pregnancy care for transplant patients. World J Transplant 2025; 15(3): 103958 [DOI: 10.5500/wjt.v15.i3.103958]
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27
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"Heart transplantation is a life-saving procedure for many people throughout the world. However, organ availability remains a major limiting factor affecting transplant volume. This mandates that innovation must take place to increase the supply of donor organs. This study outline several of the proposed strategies, including splitting the donor heart to provide multiple partial heart transplants, domino partial heart transplantation, changes in legislation including opt-out legislation, and xenotransplantation.
"
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Alexander B, Javed H, Furrukh A, Joshi K, Steen L, Rajab TK. Innovative strategies to increase cardiac donor availability. World J Transplant 2025; 15(3): 102768 [DOI: 10.5500/wjt.v15.i3.102768]
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28
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"The impact of major cardiovascular events on the outcomes of kidney transplant patients is extremely important. In this original study, the authors report the role of the blood levels of uric acid on the frequency of MACEs. the statitstical analysi here reported i well done and relevant. MACEs occurred in 145 of 545 (26.6%) KT recipients. The most prevalent comorbidities were hypertension (87%), dyslipidemia (78%), secondary hyperparathyroidism (68%), HU (63%) and anemia (33%). In the multivariate logistic regression model, the most significant factors associated with MACEs were previous CV events [odds ratio (OR) = 70.6, 95%CI: 24.9–200.1], left ventricular hypertrophy (LVH) (OR = 12.6, 95%CI: 2.7– 58.3), HU treatment (OR = 4.3, 95%CI: 2.4–7.6), and anemia (OR = 5.3, 95%CI: 2.9–9.8). Effect modification by the presence of HU revealed that independent factors associated with MACEs were age (OR = 1.03, 95%CI: 1.0–1.1), previous CV events (OR = 41.7, 95%CI: 13.6–127.6), LVH (OR = 15.3, 95%CI: 2.0–116.6), HU treatment (OR = 2.5, 95%CI: 1.3–4.6) and anemia (OR = 5.4, 95%CI: 2.8–10.5). Effect modification by UA levels dichotomized at 475 μmol/L (very high level of UA) revealed that HU treatment was not associated with MACEs in groups with or without very high UA levels.
"
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Junk E, Tzivian L, Folkmane I, Folkmanis K, Jushinskis J, Strazda G, Folkmanis V, Kuzema V, Petersons A. Major adverse cardiovascular events and hyperuricemia as an effect-modifying factor in kidney transplant recipients. World J Transplant 2025; 15(3): 102287 [DOI: 10.5500/wjt.v15.i3.102287]
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29
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"Even this is a case report, its importance is due to the rarity of the problematis exposed and the treatment succesful. Despite numerous challenges, the patient achieved a successful recovery with satisfactory graft function and was free from lymphorrhea/lymphedema in her left lower limb 3 years post-transplantation. This case underscores the importance of robust infection control during both the pre- and post-transplantation phases and highlights the potential of LVA as a treatment option for managing lymphorrhea and infections in patients with liver cirrhosis.
"
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Wu TW, Hou TY, Yang JCS, Wang CC. First report of successful liver transplantation following supermicrosurgical lymphaticovenous anastomoses for lymphorrhea with intractable infection: A case report. World J Transplant 2025; 15(3): 101496 [DOI: 10.5500/wjt.v15.i3.101496]
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30
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" De novo malignancies (DNMs) are a major concern, accounting for 20%-25% of deaths in LT recipients surviving beyond the early post-transplant period. Non-melanoma skin cancers, particularly squamous cell carcinoma are the most prevalent DNMs. Other significant malignancies include Kaposi's sarcoma, post-transplant lymphoproliferative disorders, and various solid organ cancers, including head and neck cancers.
This is a very interesting paper over the issue of cancers de novo in liver transplant patients
"
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Singh A, Singh C, Dhaliwal A, Singh N, Kumar V, Sohal A, Schneider J. Incidence, screening, and management of de novo malignancies in liver transplant patients: A review. World J Transplant 2025; 15(3): 101046 [DOI: 10.5500/wjt.v15.i3.101046]
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31
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"A rather good paoer as many others on the same issue. the paper stresses the impact of covid 19 on the transplanted patients or on the patients waiting to be transplanted. important paper for the physicians dealing with transplantation. the recommendation offered by the authors should be carefully followed to reduce the impact of covid 19 over the transplant activity"
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Bozkurt HB, Özdemir Ö. Changes regarding solid organ transplantation during the COVID-19 pandemic. World J Transplant 2025; 15(3): 100591 [DOI: 10.5500/wjt.v15.i3.100591]
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32
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"The article adheres to the ethical standards of the institutional and national research committees, as well as with the 1964 Helsinki Declaration and its later amendments or equivalent ethical guidelines. The study methods are robust, using a large national database based on retrospective data, and appropriate statistical analysis, allowing reproducibility. Results are authentic and statistically validated, offering meaningful insights into cardiovascular risks among metabolically healthy obese postmenopausal women. Tables and figures are clear, well-constructed, and support the data effectively. References are up-to-date and relevant to the field. The manuscript is written clearly and concisely. Language throughout the article is clear, academic, and concise. However, the study acknowledges limitations due to retrospective design and database reliance. Furthermore, the study lacks detailed BMI distribution data, and, as noted by the authors, it does not explore the potential impact of lifestyle factors on MACCE outcomes. No long-term follow-up data is recorded and the study population is exclusively composed of postmenopausal women who required hospitalization, which may limit the generalizability of the findings to the broader outpatient population."
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Pingili A, Desai R, Vempati R, Vemula M, Lakkimsetti M, Madhavaram H, Nanjundappa A, Singh S, Sunkara P, Gummadi J. Prevalence and impact of metabolically healthy obesity on cardiovascular outcomes in postmenopausal women and disparities: An age-matched study. World J Cardiol 2025; 17(4): 105842 [PMID: 40308624 DOI: 10.4330/wjc.v17.i4.105842]
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"1. Is the patient's age compatible with the diagnosis of congenital renal arteriovenous fistula? What is the common age group for a typical congenital RAVF?
2. Instead of summarising the details of the case under the conclusion, a 'take home' message including when to suspect, what to do can be helpful for the reader."
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Lv SP, Qin LL, Mou H, Huang T, Wang KQ. Multimodal imaging techniques for the diagnosis of congenital left renal arteriovenous fistula: A case report. World J Clin Cases 2025; 13(21): 104062 [DOI: 10.12998/wjcc.v13.i21.104062]
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34
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"1. The introduction section is lengthy and packed with information. The purpose of the introduction is to inform the reader about the background, which can be a brief overview rather than an exhaustive one.
2. The discussion can include the cost and other potential limitations of circulating tumor DNA.
3. The likely future prospects such as need for a multicentre / institutional prospective randomised trial can be included in the discussion. "
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Zhou XY, Jiang YJ, Guo XM, Han DH, Liu Y, Qiao Q. Application of circulating tumor DNA liquid biopsy in nasopharyngeal carcinoma: A case report and review of literature. World J Clin Cases 2025; 13(21): 105066 [DOI: 10.12998/wjcc.v13.i21.105066]
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35
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"1. The order of the case report can be changed to bring clarity and understanding in the following manner. Chief complaints to be followed by other history (past, present, family), physical examination, laboratory findings, imaging in a sequence so that the reader can appreciate the methodical work up.
2. The conclusion can include the importance of imaging (MRI > US) in avoiding unnecessary surgery"
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Ali S, Anjum A, Nasir KM, Khalid AR, Shahzad F, Nashwan AJ. Ovarian vein thrombosis mimicking acute appendicitis: A case report. World J Clin Cases 2025; 13(21): 103525 [DOI: 10.12998/wjcc.v13.i21.103525]
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36
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"1. The title does not indicate the study type. To include the type of article (descriptive review)
2. General principles of Gastro Intestinal Stromal Tumor resection can be outlined (minimal handling, avoiding tumor rupture, maintaining surgical margins, etc)
3. The management can be summarised in a table/algorithm format
4. Inclusion of more figures can be helpful in better understanding"
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Chen LQ, Wu CY, Wu SJ, Ye K. Laparoscopic surgical approaches for various locations of gastrointestinal stromal tumours. World J Clin Cases 2025; 13(21): 105559 [DOI: 10.12998/wjcc.v13.i21.105559]
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37
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"In this editorial, the authors emphasize the importance of Creeping Fat (CF) as a predictor indicating poor prognosis in Crohn's disease. The authors speculate that CF is associated with specific characteristics of small bowel Crohn's disease and present several reports to support this hypothesis. However, their description is more narrative than statistical. To strengthen their speculation, it would be better to include numerical data. Overall, while the editorial raises interesting points about CF, it would benefit from more quantitative evidence."
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Wei H, Mai ZL, Ma BT, Chang B. Creeping fat: A promising radiological predictor in small bowel Crohn’s disease. World J Gastroenterol 2025; 31(16): 105186 [PMID: 40308808 DOI: 10.3748/wjg.v31.i16.105186]
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38
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"In addition to the discussion focusing on the morphalogy and volume of the pituitary neuroendocrine tumor in the editorial, the function status of a pituitary neuroendocrine tumor, target organs response, relevant homones, permissive action of hormone, and other factors should be addressed. Some tumors are large in size, but their functions are weak and secret less hormones, result in mild or moderate hazard; vice versa. "
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Yang JS. Prognosis value of pituitary neuroendocrine tumor volume. World J Radiol 2025; 17(4): 106186 [PMID: 40309474 DOI: 10.4329/wjr.v17.i4.106186]
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39
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"Using four-dimensional flow magnetic resonance imaging technique for the evaluation of vascular flow hemodynamics is novel attempt. The reviewer compliments this editorial for its rich content. Adverse the weaknesses of it are not neglected, as following:
It’s a study of small sample, so it’s results and conclusion had better not be expressed as promising. The author commented on the study by Leesmidt et al should focus on the feasibility. Leesmidt et al said that superior and inferior mesenteric arteries were investigated and using Duplex ultrasound as a control.In fact, color Doppler ultrasound can measure the diameter and flow velocity of superior mesenteric artery reliable and conveniently, but it’s challenging to measure the diameter and flow velocity of inferior mesenteric artery. It’s hard to visualize the inferior mesenteric artery(vein). Measurement of the diameter and flow velocity of superior mesenteric vein is not so easy as that for the superior mesenteric artery.
The author of this editorial did not raise inquiry of this. In this editorial, the author said“Duplex ultrasound is a non-radiative tool for obtaining vascular flow velocity information but has limitations in larger patients due to reduced acoustic windows and operator dependency.”. It should be specific, the evaluation of superior mesenteric artery is almost not handicapped by acoustic windows and operator dependency. It’s hard to follow that“The study provides valuable insights into the hemodynamics of abdominal vessels in children.”in this editorial. The “Conclusion”should focus on the additional role of four-dimensional flow magnetic resonance imaging for blood vessels and hemodynamics.
Noteably, the reviewer checked the original article, and found that there is no involving of the inferior mesenteric artery(vein) in that article.
"
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Yang JS. Promising four-dimensional flow magnetic resonance imaging technique for vascular flow analysis in children. World J Radiol 2025; 17(4): 106185 [PMID: 40309473 DOI: 10.4329/wjr.v17.i4.106185]
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40
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"Strengths: A clinical issue orientation study, having practical significance.
A better study design should avoid or reduce background confounder, e.g., to compare (NIC of tumor-NIC of normal tissue)/NIC of normal tissue and (NIC of lymph node-NIC ofof normal tissue)/NIC of normal tissue and obtain ratio. There was only TD+ and TD-, no golden reference. Expect the largest lmpha node, other size of lmpha nodes should be selected added to make the results more sound and rigorous."
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Lai YF, Liang ZM, Li JF, Zhang JY, Xu DH, Dai HY. Spectral computed tomography parameters of primary tumors and lymph nodes for predicting tumor deposits in colorectal cancer. World J Radiol 2025; 17(4): 103359 [PMID: 40309472 DOI: 10.4329/wjr.v17.i4.103359]
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41
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"Compared with nondiabetic subjects, T2D patients had increased risks of cirrhosis of the liver, HCC, hepatic-related complications, and mortality, irrespective of age or sex. Coexisting obesity, hypertension, and dyslipidemia worsened these risks, but regular exercise could ameliorate these outcomes. Diabetologists should be aware of the excessive risks of harmful hepatic outcomes in T2D patients, and a comprehensive medical evaluation with a meticulous assessment of the risks, improvement of associated metabolic dysfunctions, and enhancement of diabetes self-management education emphasizing the importance of regular physical activity are mandatory to reduce the hazards of hepatic-related diseases and mortality in T2D patients."
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Chen HF, Chang YY, Chen P, Shen XH, Chang CH, Hsu WL. Risks of liver cirrhosis, hepatocellular carcinoma, hepatic-related complications, and mortality in patients with type 2 diabetes in Taiwan. World J Diabetes 2025; 16(5): 104576 [DOI: 10.4239/wjd.v16.i5.104576]
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42
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"This study highlights the critical role of systemic inflammation, as reflected by SII, in the progression of early kidney damage in children with newly diagnosed T1DM. The findings underscore the potential of SII as a reliable and practical biomarker for identifying at-risk individuals. Future longitudinal research with extended follow-up and expanded biomarker panels will be essential to validate these findings and advance our understanding of diabetic nephropathy pathogenesis."
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Cao LF, Xu QB, Yang L. Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children. World J Diabetes 2025; 16(5): 104482 [DOI: 10.4239/wjd.v16.i5.104482]
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43
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"The study advances the investigation of the safety of food supplements by exploring the effects of different doses of L-Arg on patients with type 2 diabetes, thereby clarifying the complexity and limitations of L-Arg supplementation. L-Arg is the substrate of eNOS and can generate NO. As a key signaling molecule, NO plays roles in vasodilation, antioxidation, and anti-inflammation in the body. Additionally, NO can protect the heart from damage by inhibiting myocardial hypertrophy and fibrosis. However, when high doses of L-Arg are ingested, NO reacts with superoxide anions to form peroxynitrite, a strong oxidant that can cause cell damage, and the accumulation of superoxide anion exacerbates oxidative stress, leading to cardiomyocyte damage and cardiac dysfunction. Excess L-Arg may increase the production of ROS by activating pathways such as NADPH oxidase, which can attack lipids, proteins, and DNA, leading to cellular dysfunction and tissue damage. L-Arg can enhance cellular antioxidant capacity by activating the Nrf2 pathway, increasing the expression of antioxidant enzymes such as glutathione peroxidase and SOD, thereby exerting a protective effect on the heart, and high doses of L-Arg can lead to cardiomyocyte damage, fibrosis, and cardiac remodeling, further aggravating cardiac dysfunction . Over 0.5 g/kg L-Arg is not safe for daily administration. It may aggravate myocardial damage by increasing blood glucose levels, the oxidative stress response, inflammatory mediator levels, and cardiac remodeling. L-Arg supplementation has shown some potential in clinical and experimental studies, especially in areas such as cardiovascular health, immune regulation, and athletic performance improvement. However, the effects of L-Arg were found to be dose-dependent, with low doses exerting a protective effect by generating NO, while high doses may lead to tissue damage by increasing oxidative stress and inflammatory responses. However, there are still some issues to be addressed in future studies, including further optimization of human studies, accurate improvement of the maximum safe treatment dose for patients with type 2 diabetes, and further investigations of the frequency of daily intake of L-Arg in patients with type 2 diabetes and the effects of different doses of L-Arg on patients with type 1 diabetes."
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Chen Y, Dai MT, Gong GH. L-arginine overdose is a potential risk factor for myocardial injury in patients with type 2 diabetes. World J Diabetes 2025; 16(5): 104409 [DOI: 10.4239/wjd.v16.i5.104409]
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44
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"This study provides preliminary insights into the potential role of Nrf2 in the wound healing process of DFUs treated with NPWT. Our findings indicate that NPWT may enhance wound healing, possibly through the upregulation of Nrf2. This upregulation may activate antioxidant defense mechanisms, promote angiogenesis, and reduce inflammation, although further research is needed to confirm these effects."
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Sun HJ, Si SW, Ma YM, Liu XK, Geng HF, Liang J. Role of nuclear factor erythroid 2-related factor 2 in negative pressure wound therapy for diabetic foot ulcers. World J Diabetes 2025; 16(5): 104350 [DOI: 10.4239/wjd.v16.i5.104350]
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45
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"RCD of pancreatic β-cells plays a pivotal role in the onset and progression of DM, as the loss of functional β-cells leads to impaired insulin secretion and disrupted glucose homeostasis. Targeting RCD of β-cells has therefore emerged as a promising therapeutic strategy for DM. PMS, a bioactive compound derived from TCM, is characterized by its versatility, safety and suitability for industrial synthesis, exhibiting diverse pharmacological properties through multiple pathways, such as inhibiting autophagy and apoptosis in different diseases. Although current research on the regulation of RCD such as ferroptosis, PANoptosis, and cuproptosis by PMS in DM is limited, the ongoing investigation is highly likely to uncover additional RCD pathways influenced by PMS. By specifically targeting the RCD of β-cells, PMS presents a potentially novel therapeutic strategy with a multitarget approach for improving DM management. However, there is still a lack of large-scale clinical trials assessing the effects of PMS in humans, and much of the existing preclinical data remains preliminary. While the molecular mechanisms discussed in the aforementioned research appear promising, the translation of PMS from bench to bedside remains a significant challenge, further investigation is warranted to comprehensively elucidate PMS pharmacological effects and evaluate its clinical applications."
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Liu N, Yan WT, Xiong K. Plantamajoside: A potentially novel botanical agent for diabetes mellitus management. World J Diabetes 2025; 16(5): 104311 [DOI: 10.4239/wjd.v16.i5.104311]
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46
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"Treatment of diabetic neuropathy is often limited by side effects. Aucubin, an iridoid glycoside derived from natural plants, exhibits notable anti-inflammatory and antioxidant properties. This study provides a crucial theoretical foundation for developing new therapeutic approaches for DNP. Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in DNP via aldose reductase."
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Zheng XZ, Yu HY, Chen YR, Fang JS. Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in diabetic neuropathic pain via aldose reductase. World J Diabetes 2025; 16(5): 103915 [DOI: 10.4239/wjd.v16.i5.103915]
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47
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"Interactions between the MTNR1B rs10830963 and CHEMERIN rs4721 SNPs play a significant role in the development of GDM, whereas SNPs involved in folate metabolism do not show such a correlation. In addition, no significant gene-gene or gene-environment interactions involving the studied SNPs and GDM were identified. These findings are valuable for early screening and precise intervention for GDM in pregnant women, which could ultimately improve maternal and child health."
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Zheng TT, Liu JH, Huang WT, Hong B, Wang D, Liu CY, Zhang J, Li SS, Wu SW, Wang Q, Chen L, Jin L. Single-nucleotide polymorphisms in genes involved in folate metabolism or selected other metabolites and risk for gestational diabetes mellitus. World J Diabetes 2025; 16(5): 103602 [DOI: 10.4239/wjd.v16.i5.103602]
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48
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"The study confirmed the significant potential of SZF in ameliorating renal injury in DN mice. The primary pathway through which SZF mitigates renal injury appears to be the modulation of CYP450-mediated AA metabolism, which contributes to its anti-inflammatory and antioxidant effects (Figure 6). However, this investigation serves as a preliminary study on the effects and mechanisms of SZF. To comprehensively explore the mechanisms underlying SZF's treatment of DN, it must combine the findings with multiple validation methods, including in vitro experiments and single-cell RNA sequencing. This approach will provide reliable support for the clinical application of SZF."
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Zhang ZY, Wang YM, Wang N, Wang YS, Zhang H, Wang D, Wang LX, Cui HT, Wen WB, Lv SQ, Cao YJ. Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism. World J Diabetes 2025; 16(5): 103511 [DOI: 10.4239/wjd.v16.i5.103511]
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49
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"The sample size of this study is relatively small, with only 78 cases included. Each surgery has specific indications and contraindications, and compared to pharmacological treatments, fewer patients may be suitable for this procedure. This study primarily reviews the relevant indicators at 3 and 6 months post-surgery, which limits the ability to assess the long-term effects of the surgery on T2DM complications. Furthermore, the study did not adequately address the enhancement of patients' quality of life and their satisfaction with the subjective experience of treatment. Nonetheless, the study provides a valuable new perspective on the treatment of T2DM. Jejunoileal side-to-side anastomosis may offer new hope for patients with T2DM. Further in-depth and longer-term retrospective studies are needed to fully evaluate its long-term efficacy and impact."
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Shao MQ, Liao JB, Zhai MY, Wan QQ, Jiang LJ, Cui HT. Jejunoileal side-to-side anastomosis: New hope for patients with type 2 diabetes? World J Diabetes 2025; 16(5): 103447 [DOI: 10.4239/wjd.v16.i5.103447]
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50
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"This comprehensive analysis supports the potential association between prediabetes and the risk of CRC. These results highlight the significance of identifying and addressing hyperglycemia as early as possible to possibly prevent CRC and stress the necessity for customized prevention and screening approaches in individuals with prediabetes, although further interventional studies are needed for validation. Additional investigation is necessary to understand the underlying mechanisms of the association between prediabetes and the risk of CRC."
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Wang N, Zhao TY, Ma X. Increased colorectal cancer risk in prediabetes: A meta-analysis. World J Diabetes 2025; 16(5): 103403 [DOI: 10.4239/wjd.v16.i5.103403]
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