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1
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"In this very interesting study, the authors demonstrated that the combination of thioridazine with lapatinib acts synergistically in suppressing the growth of gastric cancer by inhibiting cell proliferation and facilitating apoptosis. Therefore, this study forms the experimental basis for the use of thioridazine in patients with human epidermal growth factor receptor 2-positive gastric cancer who developed resistance to trastuzumab administration by restoring the sensitivity of cancer cells to trastuzumab both in vivo and in vitro, through inhibition of glycolysis which is mediated by Skp2. Furthermore, at a purely research level; it represents a starting point for future studies on the role of Skp2 inhibitors in several situations. In my opinion, it is an important study that may also find application in the scourge of the era known as breast cancer. "
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Yang ZY, Zhao YW, Xue JR, Guo R, Zhao Z, Liu HD, Ren ZG, Shi M. Thioridazine reverses trastuzumab resistance in gastric cancer by inhibiting S-phase kinase associated protein 2-mediated aerobic glycolysis. World J Gastroenterol 2023; 29(45): 5974-5987 [DOI: 10.3748/wjg.v29.i45.5974]
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2
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"Primary Budd-Chiari syndrome in children is a rare disease that occurs mainly in India. The authors have provided an excellent overview that describes the current state of this urgent problem. Indeed, genetic prothrombotic states underlie the primary Budd-Chiari syndrome in children in most cases. Therefore they may be the target of treatment. Radiological interventions are technically feasible and effective. However, it is obvious that multidisciplinary treatment is required for a good long-term outcome."
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Samanta A, Sen Sarma M, Yadav R. Budd-Chiari syndrome in children: Challenges and outcome. World J Hepatol 2023; 15(11): 1174-1187 [DOI: 10.4254/wjh.v15.i11.1174]
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3
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"This article is a research report on the functional and clinical relevance of the COPS6 gene in various types of tumors. The main findings of the article are as follows:
Differential expression of the COPS6 gene: The article utilizes various databases and analysis tools to compare the expression levels of the COPS6 gene in normal and tumor tissues. It reveals that the COPS6 gene is highly expressed in most types of tumors, while in a few tumor types, it shows low expression or no significant difference.
Prognostic value of the COPS6 gene: Using survival analysis methods, the article assesses the relationship between the expression levels of the COPS6 gene and overall survival, disease-free survival, disease-specific survival, and disease-free interval. It indicates that high expression of the COPS6 gene is generally associated with poor prognosis, while in a few tumor types, it correlates with a favorable prognosis.
Mutation characteristics of the COPS6 gene: Employing the cBioPortal website, the article analyzes the mutation frequency, types, copy number variations, and structural variations of the COPS6 gene in different tumor types. It identifies missense mutations as the predominant mutation type, and the expression level of the COPS6 gene correlates positively with tumor mutation burden and microsatellite instability. However, the mutations in the COPS6 gene do not significantly impact patient prognosis.
Relationship between the COPS6 gene and tumor immune infiltration: Using the TIMER2 website, the article explores the correlation between the expression levels of the COPS6 gene and the infiltration levels of CD8+ T cells, cancer-associated fibroblasts, macrophages, and natural killer cells in the tumor microenvironment. It reveals that the relationship between the COPS6 gene and immune cell infiltration varies in different tumor types, showing positive, negative, or no correlation.
Genes and pathways associated with the COPS6 gene: The article uses GEPIA2 and STRING websites to identify genes related to the COPS6 gene and conducts enrichment analysis. It finds that genes associated with the COPS6 gene are mainly involved in ubiquitin-mediated protein degradation, nucleotide excision repair, human immunodeficiency virus 1 infection, Parkinson's disease, and circadian rhythm pathways. GPS1 and TCEB2 are the two genes most strongly correlated with the COPS6 gene.
The innovation of this article lies in its systematic exploration of the significance of the COPS6 gene in different tumor types, providing a basis for considering COPS6 as a novel tumor biomarker. However, the limitation of the article is that it only conducts simple correlation data analysis. There are a few concerns and points with this study:
1 Ethics: Does the ethical approval form provided by the author meet the requirements?
The data utilized by the authors consist entirely of open-access content sourced from public databases like TCGA, GTEx, CPTAC, etc. It is crucial to note that these datasets have previously acquired ethical approval and are publicly accessible. Consequently, the authors are exempt from the obligation to submit an ethics approval form.
2 Methods: Is the experimental method effective? Can it be repeated by fellow researchers (according to adequate textual/citation content presented)?
The data analysis in this experiment primarily relies on online platforms, with a minimal portion involving local R language data analysis that doesn't employ original or intricate computational methods. The authors furnish an email address for code and data requests. In general, reproducing this study should not pose significant challenges.
3 Results: Are the results true and authentic? Is the theory or hypothesis of universal significance validated or partially validated?
The authors have not provided adequate explanations and interpretations for these discrepancies, which should be addressed in the "Discussion" section.
1) The differential expression analysis of TCGA data indicates that COPS6 exhibits no significant difference in PAAD (Figure 1B). However, in the GTEx online differential analysis (Figure 1C), COPS6 demonstrates a significant upregulation in PAAD tumors.
2) The upregulation or downregulation of COPS6 at the RNA expression and protein levels shows inconsistency. For instance, COPS6 is upregulated at the RNA level in LUAD and UCEC but downregulated at the protein level (Figure 1B, Figure 2A).
3) The KM analysis in Figure 4 only partially validates the results obtained from the COX analysis in Figure 3.
In summary, the authors' results underscore the significance of COPS6 in pan-cancer; however, the study lacks a thorough investigation, as it tends to focus more on result accumulation than on in-depth analysis and summarization.
4 Figures and tables: Does the author provide perfect tables, line charts and/or graphs? Or, does the author provide figures and tables that are confusing, poorly constructed and/or not well-annotated?
Figure 1B-C illustrates intergroup differences with significant Wilcoxon P-values denoted by a, b, and c. However, the legend incorrectly displays bP|0.01|cP|0.001 and lacks a description for aP.
The main text exclusively mentions the upregulation of COPS6 in hepatocellular carcinoma and clear cell RCC tumor samples, omitting the downregulation of COPS6 in other tumor types. If these boxplots are to be included in the main text, they should be accompanied by textual explanations; otherwise, exclusion may be warranted.
Figure 2C lacks a legend label indicating the corresponding cancer types for the boxplots. Although the figure caption specifies the cancer types as KICH, KIRC, LIHC, and LUAD, the corresponding order remains unclear.
For the COX analysis results in Figure 3C, it is advisable to present them using a comprehensive forest plot, where the significance of P-values is conveyed through asterisks, enhancing figure readability (“***”, “**”, “*”, and “ns” corresponding to P values of 0–0.001, 0.001–0.01, 0.01–0.05, and 0.05–1).
The figure caption for Figure 3A actually refers to both Figure 3A and 3B but lacks explicit indication. Conversely, the abbreviated figure caption in Figure 3B contains information pertinent to Figure 3C.
In Figure 6A, highlighting important cancer types with a purple box obscures text within the figure.
Due to extensive use of online platforms for analysis, some figures exhibit diminished image clarity.
5 Biostatistics: Does the author provide perfect biostatistics data? Or, does the author provide tables and line charts that have mistakes in the data?
The statistical analysis of biological data provided by the authors shows no apparent errors.
6 References: Does the author scientifically and reasonably cite the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study? Or, does the author self-cite, omit, mis-cite and/or over-cite references?
The citations of literature are well-grounded and sensible.
7 Language: Does the language in article correctly, clearly and concisely express the information? Or, does the article have multiple grammatical and spelling mistakes?
The complete name of the COPS6 gene has been previously mentioned in the abstract. Therefore, it is unnecessary to repetitively use the full name in the Figure 1B caption; a more concise approach is recommended. Similarly, the abbreviation TCGA can be directly used in the Figure 1A caption since its full name has already been introduced in the introduction.
The paragraph COPS6 was associated with the prognosis of patients with diverse types of cancer includes too many specific P-values, which hampers readability. It would be advisable to remove most of them, retaining only a few to indicate the significance criterion of P<0.05.
In paragraph COPS6 expression level was associated with the prognosis of patients with diverse types of cancer, the description of the R packages "survival" and "forestplot" used for survival analysis in the Results section can be omitted, as it has already been explained in the Materials section.
8 Caveats or drawbacks: What are the caveats or drawbacks for the results?
The results presented in the pan-cancer analysis article (RNA, protein, staging, OS, DFI, DSS, etc.) reveal a significant correlation of COPS6 with various characteristics across multiple cancers. However, the authors tend to present results in a stacked manner without conducting sufficient analysis and summarization of the findings. Key aspects, such as the proportion of significant correlations and non-correlations within each data type, the preference of COPS6 for specific cancer types, and the consistent performance of COPS6 across different cancer types, lack thorough analysis.
Considering only the correlation with cancer characteristics, many genes exhibit similar associations, which fails to underscore the distinctiveness of COPS6. The authors should enhance the summarization and analysis of the results in the main text, rather than simply presenting them in a stacked format.
"
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Wang SL, Zhuo GZ, Wang LP, Jiang XH, Liu GH, Pan YB, Li YR. Computational exploration of the significance of COPS6 in cancer: Functional and clinical relevance across tumor types. World J Clin Oncol 2023; 14(11): 479-503 [DOI: 10.5306/wjco.v14.i11.479]
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4
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"It is an interesting study on a combination of mitomycin C (MMC) and capecitabine targeting refractory colorectal cancer patients. But, it could be considered that % of hematological adverse events was high when treating the patients. "
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Mullin G, Sternschuss M, Landman Y, Sulkes A, Brenner B. Mitomycin C and capecitabine: An additional option as an advanced line therapy in patients with metastatic colorectal cancer. World J Gastrointest Oncol 2023; 15(11): 1913-1924 [DOI: 10.4251/wjgo.v15.i11.1913]
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5
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"The role of glutamine metabolism in pancreatic cancer was well investigated."
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Ren LL, Mao T, Meng P, Zhang L, Wei HY, Tian ZB. Glutamine addiction and therapeutic strategies in pancreatic cancer. World J Gastrointest Oncol 2023; 15(11): 1852-1863 [DOI: 10.4251/wjgo.v15.i11.1852]
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6
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"It is an interesting review for ginger's effect on gastrointestinal cancer. "
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Chen GQ, Nan Y, Huang SC, Ning N, Du YH, Lu DD, Yang YT, Meng FD, Yuan L. Research progress of ginger in the treatment of gastrointestinal tumors. World J Gastrointest Oncol 2023; 15(11): 1835-1851 [DOI: 10.4251/wjgo.v15.i11.1835]
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7
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"Early-stage esophageal carcinoma with IGM is rare. Despite the ESD of the primary lesion, IGM may still occur and should be closely monitored after ESD.
the nature of the submucosal eminence can be clarified by combining endoscopic ultrasonography and ultrasonic puncture biopsy. Therefore, enhancing the preoperative and postoperative imaging and endoscopic ultrasonography are beneficial for indicating the existence of IM.
"
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Yang MQ, Sun MJ, Zhang HJ. Mucosal esophageal carcinoma following endoscopic submucosal dissection with giant gastric metastasis: A case report and review of literature. World J Gastroenterol 2023; 29(44): 5935-5944 [DOI: 10.3748/wjg.v29.i44.5935]
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8
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"Epidemiological data concerning variations in the incidence and prevalence of peptic ulcer disease in various countries are of particular interest given the decrease in the incidence of Helicobacter pylori infection in many parts of the world. In an interesting epidemiological study from Korea, the authors did not show a decrease in the total number of peptic ulcer cases in the decade 2010 to 2019, instead, there was an increasing trend in the incidence of peptic ulcer disease. About the etiology, peptic ulcers due to a Helicobacter pylori infection showed a decrease, while on the contrary, peptic ulcers due to side effects of various drugs showed a substantial increase. Also interesting were the findings according to which the so-called idiopathic ulcers occur in an increased proportion of patients with underlying chronic liver diseases. This is a point that should be further investigated in other countries. The conclusion of this study referring to Korean patients highlights the effects of polypharmacy and uncontrolled drug use in the aging population while confirming the reduction in the incidence of peptic ulcer disease due to the presence of Helicobacter pylori infection. However, their results did not confirm the findings of studies demonstrating a reduction in the incidence of peptic ulcers during recent years. The practical conclusion is that physicians and especially general practitioners should place more emphasis on monitoring and sensitizing elderly patients to the fact that they are indeed a population group susceptible to the occurrence of peptic ulcer disease and its accompanying complications."
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Choi YJ, Kim TJ, Bang CS, Lee YK, Lee MW, Nam SY, Shin WG, Seo SI. Changing trends and characteristics of peptic ulcer disease: A multicenter study from 2010 to 2019 in Korea. World J Gastroenterol 2023; 29(44): 5882-5893 [DOI: 10.3748/wjg.v29.i44.5882]
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9
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"In a retrospective study, the authors analyzed the clinicopathological features and prognostic factors of breast cancer brain metastasis. Here are some of my comments on the article.
The statistical method is effective. However, the topic of this article lacks innovation. And the conclusion is quite mediocre. Besides some of the data remain questionable, for example, In Table 1 ”pathological type”, there were two patients with “Noninvasive carcinoma” in the BCBM group. However, in situ carcinoma is impossible to develop brain metastasis as we know if properly diagnosis. Therefore, the accuracy of the data in the article is suspicious. Additionally, the discussion section lacks significative analysis because the authors did not explore the in-depth mechanisms by which these factors contribute to breast cancer susceptibility to brain metastasis. Importantly, the control group for non-brain metastasis should be clearly stated why they were identified as the control group. As most of the patients during the selected period were not with brain metastasis, the molecular pathology subtypes were totally different if matched with another 136 patients cohort. This model the author used significantly affected the final results. The author should clearly state this problem. More importantly, the single center data always had bias, for diagnosis and follow-up treatment. Also the authors should fully address this point.
In general, the authors only conducted a simple statistical analysis of the patient information of breast cancer brain metastases, the content and conclusions are not strong and innovative enough. The figures and tables are fine. References obviously are not enough for containing the latest findings based on related area.
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Chen YR, Xu ZX, Jiang LX, Dong ZW, Yu PF, Zhang Z, Gu GL. Analysis of clinicopathological features and prognostic factors of breast cancer brain metastasis. World J Clin Oncol 2023; 14(11): 445-458 [DOI: 10.5306/wjco.v14.i11.445]
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10
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"This article primarily proposes that converting impaired glucose tolerance (IGT) into a normal condition is critical to prevent the onset of type 2 diabetes. It emphasizes the mechanism of VEGFB effects on insulin-mediated glucagon secretion in impaired glucose tolerance. It is a well-crafted article with valuable insights."
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Li YQ, Zhang LY, Zhao YC, Xu F, Hu ZY, Wu QH, Li WH, Li YN. Vascular endothelial growth factor B improves impaired glucose tolerance through insulin-mediated inhibition of glucagon secretion. World J Diabetes 2023; 14(11): 1643-1658 [DOI: 10.4239/wjd.v14.i11.1643]
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11
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"This article is a huge study with 11699 dementia cases matched to 11699 non-dementia controls.This article has provided significant assistance in our understanding of the treatment of dementia in diabetes using Chinese herbal medicine. It is a piece of research with considerable societal value."
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Liao HH, Livneh H, Huang HL, Hung JY, Lu MC, Guo HR, Tsai TY. Reduced risk of dementia in patients with type 2 diabetes mellitus using Chinese herbal medicine: A nested case-control study. World J Diabetes 2023; 14(11): 1632-1642 [DOI: 10.4239/wjd.v14.i11.1632]
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12
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"This article holds certain value and significance in researching and exploring diabetes and obesity. However, its content could benefit from further enhancement."
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Guo YC, Cao HD, Lian XF, Wu PX, Zhang F, Zhang H, Lu DH. Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development. World J Diabetes 2023; 14(11): 1621-1631 [DOI: 10.4239/wjd.v14.i11.1621]
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13
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"This article adheres to ethical standards, employing reasonable and commendable methods. The obtained results possess significant value and practical relevance. The vivid and comprehensible visual representations in the form of charts enhance the overall clarity. The data processing is methodologically sound, and the article exhibits minimal grammatical errors."
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Wang T, Wang YY, Shi MY, Liu L. Mechanisms of action of natural products on type 2 diabetes. World J Diabetes 2023; 14(11): 1603-1620 [DOI: 10.4239/wjd.v14.i11.1603]
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14
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"1. The type of article is not clear - review / topic update / expert opinion?
2. The article can include discussion as a separate section
3. Relevant images can enhance the understanding of AI in Dentistry"
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Heboyan A, Yazdanie N, Ahmed N. Glimpse into the future of prosthodontics: The synergy of artificial intelligence. World J Clin Cases 2023; 11(33): 7940-7942 [DOI: 10.12998/wjcc.v11.i33.7940]
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15
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"1. To minimise the physiological variation, both hands of the same pt could have been chosen as case / control
2. The technicians involved in blood collection using the pippete could introduce bias as the sample collection may vary
3. How does the heel prick method compare against the finger ?"
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Luo L, Qin WL, Huang HM, Ou ZH, Peng ZH. Fever glove hand-shake method safe blood collection from children's fingertips in COVID-19 fever clinic. World J Clin Cases 2023; 11(33): 7965-7971 [DOI: 10.12998/wjcc.v11.i33.7965]
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16
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"1. Innovative study design with acknowledgement of limitations
2. Data tabulated, analysed appropriately
3. Language / scientific writing / overall presentation good"
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Zhang XD, Zhang K. Comparative analysis of conventional ultrasound and shear wave elastography features in primary breast diffuse large B-cell lymphoma. World J Clin Cases 2023; 11(33): 7994-8002 [DOI: 10.12998/wjcc.v11.i33.7994]
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17
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"1. The study methodology is not clear - prospective / retrospective?, randomised / not? Minimal access/ open? adjuvant therapy use/not?
2. Were the observers meauring the parameters blinded?
3. Study limitations can be included
"
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Yu KY, Kuang RK, Wu PP, Qiang GH. Subcutaneous fat thickness and abdominal depth are risk factors for surgical site infection after gastric cancer surgery. World J Clin Cases 2023; 11(33): 8013-8021 [DOI: 10.12998/wjcc.v11.i33.8013]
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18
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"1. Differentials with respect to imaging / clinical features to highlight the GCTB can be helpful
2. Operative details can be elaborate with a postop image
3. Representative histopathology image would be useful"
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Yan J. Granular cell tumor of the breast: A case report and review of literature. World J Clin Cases 2023; 11(33): 8044-8049 [DOI: 10.12998/wjcc.v11.i33.8044]
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19
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"1. The operative procedure details can be outlined separately - incision, identification of muscle complex, positioning the bowel within the muscle complex
2. The image can include the postop result similar to the view in A
3. Excision of the dilated bowel, positioning within the muscle complex and complete separation of the bowel from the Vagina achieving reasonable cosmesis are the surgical principles"
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Wang J, Zhang XY, Chen JH, Jin HY. Treatment of adult congenital anal atresia with rectovestibular fistula: A rare case report. World J Clin Cases 2023; 11(33): 8065-8070 [DOI: 10.12998/wjcc.v11.i33.8065]
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20
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"1.Ethical approval needed.
2.No
3.yes
4.Provided
5.not needed.
6.ok
7.minor correction needed
8.none"
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Liu DL, Pan JY, Huang TC, Li CZ, Feng WD, Wang GX. Isolated traumatic gallbladder injury: A case report. World J Gastrointest Surg 2023; 15(11): 2639-2645 [DOI: 10.4240/wjgs.v15.i11.2639]
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21
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"Primary pulmonary meningiomas (PPM) and minute pulmonary meningothelial-like nodules (MPMN) are rare lesions of lung. It is hard to distinguish PPM and MPMN from other pulmonary nodule diseases, or distinguish between benign and malignant PPM through imaging alone. The main method for diagnosing PPM and MPMN is still pathological biopsy. Increasing the understanding of features of MPMNs and PPMs and elucidating their pathogenesis are helpful to accurately distinguish PPM and MPMN and improve clinical application."
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Ruan X, Wu LS, Fan ZY, Liu Q, Yan J, Li XQ. Pathological diagnosis and immunohistochemical analysis of minute pulmonary meningothelial-like nodules: A case report. World J Clin Cases 2023; 11(33): 8022-8029 [DOI: 10.12998/wjcc.v11.i33.8022]
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22
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"This article emphasized the role of Ruxolitinib is the treatment of intermediate and high-risk patients with Myelofibrosis and Polycythemia vera. Ruxolitinib inhibites JAK1 and JAK2, and helps control excessive PMN cells production and reduce splenomegaly. Meanwhile, its use carries the risk of opportunistic infections and HBV reactivation. The authors concluded that precise follow up of patients with liver function testing in appropriate intervals might reduce the harmful outcomes of HBV reactivation when receiving Ruxolitinib.
Triple panel screening should be used before starting immunosuppression. In patients who are immunocompromised, HBV viral load testing is a crucial issue. Even if the primary screening is negative for HBV, continued regular screening for HBV in high-risk individuals is recommended.
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Adesola AA, Cozma MA, Chen YF, Srichawla BS, Găman MA. Risk of hepatitis B reactivation in patients with myeloproliferative neoplasms treated with ruxolitinib. World J Hepatol 2023; 15(11): 1188-1195 [DOI: 10.4254/wjh.v15.i11.1188]
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23
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"The title reflect the main subject of the manuscript. The abstract summarize and reflect the work described in the manuscript. The key words reflect the focus of the manuscript. The manuscript describe methods in adequate detail. In my opinion it is a very good article, well written , novelty with high impact."
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Ryou SH, Shin HD, Kim SB. Hepatocellular carcinoma presenting as organized liver abscess: A case report. World J Clin Cases 2023; 11(33): 8078-8083 [DOI: 10.12998/wjcc.v11.i33.8078]
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24
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"Ethics: The ethical approval form is provided by the authors and meets the requirements.
Methods: The experimental method is effective. It be repeated by fellow researchers (according to adequate textual/citation content presented).
Results: The results look true and authentic. The theory or hypothesis is of universal significance. Due to a case report, it is not validated. Only multicentric studies on the subject can validate the theory.
Figures and tables: The authors provide perfect tables, line charts and/or graphs.
Biostatistics: This is a case report without biostatistics.
References: Does the author scientifically and reasonably cite the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study?
Language: The language in the article correctly, clearly, and concisely express the information.
Caveats or drawbacks: Nothing new or novel."
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Ryou SH, Shin HD, Kim SB. Hepatocellular carcinoma presenting as organized liver abscess: A case report. World J Clin Cases 2023; 11(33): 8078-8083 [DOI: 10.12998/wjcc.v11.i33.8078]
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25
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"Downs children are particularly predisposed to develop early and severe pulmonary hypertension which remains one of the most important predictor of future morbidly and mortality in these patients. The case report by the authors highlight the serious impact that pulmonary hypertension has on referral for surgical correction. Indeed these patients are also infrequently considered for cardiac transplant highlighting the gap between recommendations and actual clinical practice. The report however is not novel and highlights most of the facts which are already well established when it comes to downs syndrome and congenital heart diseases."
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Kong MW, Li YJ, Li J, Pei ZY, Xie YY, He GX. Down syndrome child with multiple heart diseases: A case report. World J Cardiol 2023; 15(11): 615-622 [DOI: 10.4330/wjc.v15.i11.615]
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"Need for PPM post TAVR remains the most frequent and clinically relevant challenge. Naturally, identifying risk factors which predispose an individual to develop advanced conduction blocks is important. Various factors have been described and linked to need for PPM and are being refined everyday as newer evidence is available. Amongst them prolnged baseline QRS irrespective of the type of conduction block seems to be one of the strongest risk factor. The index study by Nwaedozie S et al. highlight that patients requiring PPM post TAVR had greater odds of having a baseline QRS >120 ms and were more likely to be having diabetes mellitus that those who did not.
The potential of artificial intelligence in generating a personalised risk assessment tool should be explored to identify and validate the emerging predictors. "
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Nwaedozie S, Zhang H, Najjar Mojarrab J, Sharma P, Yeung P, Umukoro P, Soodi D, Gabor R, Anderson K, Garcia-Montilla R. Novel predictors of permanent pacemaker implantation following transcatheter aortic valve replacement. World J Cardiol 2023; 15(11): 582-598 [DOI: 10.4330/wjc.v15.i11.582]
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27
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"Since the policy of “diagnostic ESD” has been commonly implemented recently, especially when accurate prediction of the depth of EGC invasion before ESD is impossible. This manuscript deals with the quality indicators of ESD of EGCs some extent. This review is innovative and can somewhat guide the next direction of clinical research. "
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Kim GH. Endoscopic submucosal dissection for early gastric cancer: It is time to consider the quality of its outcomes. World J Gastroenterol 2023; 29(43): 5800-5803 [DOI: 10.3748/wjg.v29.i43.5800]
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28
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"- Ethics: The authors state that they obtained written informed consent from all patients and that the study was approved by the Ethics Committee of the Nantong Third People’s Hospital.
- Methods: The authors describe the experimental method of hemihepatectomy and the determination of SRLV and LSM values in detail.
- Results: The authors report the results of their logistic regression analysis, ROC curve analysis, and comparison of the new assessment model with the Child-Pugh score. They claim that LSM values and SRLV are independent risk factors for liver dysfunction after hemihepatectomy, and that the new assessment model has a higher accuracy than the Child-Pugh score in predicting postoperative liver function..
- Figures and tables: The authors provide four figures and six tables to illustrate their results. The figures are clear and well-labeled.
- Biostatistics: The authors use IBM SPSS Statistics 25.0 for their biostatistical analysis.
- References: The authors cite 28 references, most of which are recent and relevant to their study topic.
- Language: The language in the article is generally clear and concise.
- Caveats or drawbacks:
- The sample size of the study is small (35 patients), which may limit the generalizability and reliability of the results.
- The study is retrospective and observational, which may introduce selection bias, confounding factors, and causal inference problems.
- The study does not compare the new assessment model with other existing models, which may have different advantages and disadvantages in predicting liver function after hemihepatectomy.
- The study does not evaluate the long-term outcomes or survival rates of the patients after hemihepatectomy, which may be affected by other factors besides liver function, such as tumor recurrence, infection, or complications.
"
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Yue ZQ, Zhang P, Yan S, Ju LL, Wang HX, Yuan LX, Chen L, Wu JZ, Cao YL. Clinical study of standard residual liver volume and transient elastography in predicting poor prognosis of patients after hemihepatectomy. World J Clin Oncol 2023; 14(11): 459-470 [DOI: 10.5306/wjco.v14.i11.459]
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29
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"1. Ethics: The ethical approval form provided by the author meets the requirements. The author has obtained the informed consent from all the patients and has followed the ethical principles of the Declaration of Helsinki.
2. Methods: The author has described the inclusion and exclusion criteria, the data collection process, and the statistical methods in detail.
3. Results: The results are true and authentic. The author has validated the hypothesis that some clinical and molecular factors are associated with the risk and prognosis of BCBM. The author has also presented the results in a clear and logical way, using tables and figures to illustrate the main findings. However, the author should also discuss the possible mechanisms and biological implications of the results, and compare them with the existing literature.
4. Figures and tables: The author has provided perfect tables, line charts and graphs. The figures and tables are well-constructed and well-annotated. They are easy to understand and interpret.
5. Biostatistics: The author has provided perfect biostatistics data. The author has used appropriate statistical methods and tests to analyze the data and report the results. The author has also provided the confidence intervals and p-values for the main outcomes.
6. References: The author has scientifically and reasonably cited the latest references that are important in this field and related to the scientific problems and research hypotheses addressed in the study. The author has also followed the citation style and format of the journal.
7. Language: The language in the article correctly, clearly and concisely expresses the information.
8. Caveats or drawbacks: The caveats or drawbacks for the results are as follows:
The study is a retrospective study, which may have some limitations in terms of the data quality, the selection bias, and the causal inference.
The study is a single-center study, which may have some limitations in terms of the generalizability, the representativeness, and the external validity of the results.
The study has a relatively small sample size, which may have some limitations in terms of the statistical power, the precision, and the reliability of the results.
The study does not explore the underlying mechanisms and biological implications of the results, which may limit the understanding and interpretation of the results."
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Chen YR, Xu ZX, Jiang LX, Dong ZW, Yu PF, Zhang Z, Gu GL. Analysis of clinicopathological features and prognostic factors of breast cancer brain metastasis. World J Clin Oncol 2023; 14(11): 445-458 [DOI: 10.5306/wjco.v14.i11.445]
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30
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"good paper. "
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Sakamoto A, Noguchi T, Matsuda S. System describing surgical field extension associated with flap reconstruction after resection of a superficial malignant soft tissue tumor. World J Clin Oncol 2023; 14(11): 471-478 [DOI: 10.5306/wjco.v14.i11.471]
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31
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"SRLV and LSM values can be used to evaluate the safety of hemihepatectomy. Anticipate validation in prospective trial."
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Yue ZQ, Zhang P, Yan S, Ju LL, Wang HX, Yuan LX, Chen L, Wu JZ, Cao YL. Clinical study of standard residual liver volume and transient elastography in predicting poor prognosis of patients after hemihepatectomy. World J Clin Oncol 2023; 14(11): 459-470 [DOI: 10.5306/wjco.v14.i11.459]
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32
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"HER2-overexpressing, triple-negative BC, late tumor stage and lung metastasis are risk factors of BM. The presence of neurological symptoms, bone metastasis, and molecular type are influencing prognosis factors of BCBM. This is an interesting article on the prediction of brain metastasis"
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Chen YR, Xu ZX, Jiang LX, Dong ZW, Yu PF, Zhang Z, Gu GL. Analysis of clinicopathological features and prognostic factors of breast cancer brain metastasis. World J Clin Oncol 2023; 14(11): 445-458 [DOI: 10.5306/wjco.v14.i11.445]
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33
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"Please tell me the independent risk factor of bleeding and perforation."
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Kim GH. Endoscopic submucosal dissection for early gastric cancer: It is time to consider the quality of its outcomes. World J Gastroenterol 2023; 29(43): 5800-5803 [DOI: 10.3748/wjg.v29.i43.5800]
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34
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"The data mentioned in the Editorial are not only true, but also particularly important in daily clinical practice, both for the patient and for the health system. The author proposes quality indicators for the outcome of ESD performed in a number of endoscopy departments worldwide, which are increasing by leaps and bounds. The quality indicators proposed are correct and could be modified through a special international scientific meeting devoted to this purpose. To reduce the rate of non-curative resection of gastric cancer after therapeutic ESD I propose that the "licensing" criteria for endoscopists performing ESD should now be made stricter. Perhaps in this way, the success rate of these invasive endoscopic procedures will be improved."
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Kim GH. Endoscopic submucosal dissection for early gastric cancer: It is time to consider the quality of its outcomes. World J Gastroenterol 2023; 29(43): 5800-5803 [DOI: 10.3748/wjg.v29.i43.5800]
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35
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"Exosomes contribute to cancer occurrence, proliferation, metastasis, angiogenesis, pre-metastatic environment remodeling, drug resistance and immunity for ESCC.
Good data have been reported regarding the diagnosis, treatment, prognosis, and drug resistance of Exosomes for ESCC, but how about Exosomes for Esophageal adenocarcinoma?
"
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Ning XY, Ma JH, He W, Ma JT. Role of exosomes in metastasis and therapeutic resistance in esophageal cancer. World J Gastroenterol 2023; 29(42): 5699-5715 [DOI: 10.3748/wjg.v29.i42.5699]
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36
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"Although this is a case of diabetes type 1 with a diagnosis of severe microvascular complications with details on pancreas, laboratory and family history, she refused educational and therapeutic assistance which can be related to complications progression and this is a limitation of the study."
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Huret P, Lopes P, Dardari R, Penfornis A, Thomas C, Dardari D. Rapid correction of hyperglycemia: A necessity but at what price? A brief report of a patient living with type 1 diabetes. World J Diabetes 2023; 14(11): 1710-1716 [DOI: 10.4239/wjd.v14.i11.1710]
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37
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"This is a review regarding gestacional diabetes mellitus that include information of 79 articles.
There are several strategies for preventing this disorder based on usual risk factors and the main important preventive strategies considered on this review were physical activity and diet. Treatment of gestacional diabetes should be also important issue.
"
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Lim PQ, Lai YJ, Ling PY, Chen KH. Cellular and molecular overview of gestational diabetes mellitus: Is it predictable and preventable? World J Diabetes 2023; 14(11): 1693-1709 [DOI: 10.4239/wjd.v14.i11.1693]
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38
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"The authors have described a mechanism of GA on diabetic nephropathy based on database, western blot and flow cytometry for analysing the apoptosis and insulin receptor pathway. Although it was an interesting issue, the authors performed the mechanisms on cells and a preclinical animal model might improve the quality of the article. "
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Meng FD, Yuan L, Xu DJ, Che MY, Hou SZ, Lu DD, Liu WJ, Nan Y. Exploring the targets and molecular mechanism of glycyrrhetinic acid against diabetic nephropathy based on network pharmacology and molecular docking. World J Diabetes 2023; 14(11): 1672-1692 [DOI: 10.4239/wjd.v14.i11.1672]
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39
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"This is an interesting issue regarding diabetic cardiomyopathy. The authors performed bioinformatic tools which can help to understand mechanisms and pharmacological drugs. However, a validation with mechanistic studies will improve the quality of the article. "
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Wang YJ, Wang YL, Jiang XF, Li JE. Molecular targets and mechanisms of Jiawei Jiaotai Pill on diabetic cardiomyopathy based on network pharmacology. World J Diabetes 2023; 14(11): 1659-1671 [DOI: 10.4239/wjd.v14.i11.1659]
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40
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"The authors have described the important role of epigenetic changes on obesity and diabetes.
Although this issue has gained special attention to the scientific readers, the review might be more complete."
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Guo YC, Cao HD, Lian XF, Wu PX, Zhang F, Zhang H, Lu DH. Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development. World J Diabetes 2023; 14(11): 1621-1631 [DOI: 10.4239/wjd.v14.i11.1621]
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41
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"This is a review for understanding the role of effectiveness of natural products on diabetes. They foccused the role on inflammatory and oxidative stress modulation.Although this mechanism might reduce the diabetes progression, new pharmacological drugs are also important for reducing cardiovascular events and/or mortality.
"
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Wang T, Wang YY, Shi MY, Liu L. Mechanisms of action of natural products on type 2 diabetes. World J Diabetes 2023; 14(11): 1603-1620 [DOI: 10.4239/wjd.v14.i11.1603]
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42
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"This is an exhaustive review regarding mesenchymal stem cells activity on diabetic foot. This is an important issue on diabetic patients that has to improve and new knowledge with advantages, characteristics of these mesenchymal stem cells wil help us to look for new therapeutic strategies."
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Zhang HM, Yang ML, Xi JZ, Yang GY, Wu QN. Mesenchymal stem cells-based drug delivery systems for diabetic foot ulcer: A review. World J Diabetes 2023; 14(11): 1585-1602 [DOI: 10.4239/wjd.v14.i11.1585]
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43
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"This is a case-control study (with/out dementia) for evaluating the herbal medicine effects on dementia in patients with type 2 diabetes. This is a huge study with 11699 dementia cases matched to 11699 non-dementia controls. This cohort of patients will help us to understand the main causes of dementia on type 2 diabetes.
"
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Liao HH, Livneh H, Huang HL, Hung JY, Lu MC, Guo HR, Tsai TY. Reduced risk of dementia in patients with type 2 diabetes mellitus using Chinese herbal medicine: A nested case-control study. World J Diabetes 2023; 14(11): 1632-1642 [DOI: 10.4239/wjd.v14.i11.1632]
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44
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"This is a mechanistic study for describing the effect of vascular endothelial growth factor B on glucose intolerance. The authors have included different preclinical models (animal and cells). They have demonstrated the role of VEGFB on insulin secretion by pancreatic islets. This study is a therapeutic advance against insulin resistance. "
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Li YQ, Zhang LY, Zhao YC, Xu F, Hu ZY, Wu QH, Li WH, Li YN. Vascular endothelial growth factor B improves impaired glucose tolerance through insulin-mediated inhibition of glucagon secretion. World J Diabetes 2023; 14(11): 1643-1658 [DOI: 10.4239/wjd.v14.i11.1643]
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45
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"This paper aimed to establish and characterize a new extrahepatic cholangiocarcinoma sarcoma cell line, namely CBC2T-2. The challenges that the reliability of CBC2T-2 still needs to be verified by a large amount of experimental data. Finally, it highlighted that CBC2T-2, as a research model, has a high clinical value and would facilitate the understanding of the pathogenesis of cholangiocarcinoma sarcoma."
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Jiang NZ, Bai MZ, Huang CF, Ma ZL, Zhong RY, Fu WK, Gao L, Tian L, Mi NN, Ma HD, Lu YW, Zhang ZA, Zhao JY, Yu HY, Zhang BP, Zhang XZ, Ren YX, Zhang C, Zhang Y, Yue P, Lin YY, Meng WB. First report on establishment and characterization of the extrahepatic cholangiocarcinoma sarcoma cell line CBC2T-2. World J Gastroenterol 2023; 29(41): 5683-5698 [DOI: 10.3748/wjg.v29.i41.5683]
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46
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"This paper aimed to assess physical activity (PA) levels and barriers in a southern Italian inflammatory bowel diseases (IBD) population. The paper also discussed the challenges that the data were from a single-centre experience, and future multicentre evidence would be desirable. Finally, it highlighted that using validated and feasible questionnaires (e.g., IPAQ) could be a strategy to weigh patient-reported PA levels and get an initial idea about which patients have insufficient PA levels."
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Gravina AG, Pellegrino R, Durante T, Palladino G, D’Onofrio R, Mammone S, Arboretto G, Auletta S, Imperio G, Ventura A, Romeo M, Federico A. Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity: The “BE-FIT-IBD” study. World J Gastroenterol 2023; 29(41): 5668-5682 [DOI: 10.3748/wjg.v29.i41.5668]
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47
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"This paper aimed to compare the psychiatric (depression and anxiety) and colorectal motility (colonic transit and anorectal motility and sensation) characteristics between FC and IBS-C patients in an Eastern Chinese population. The paper also discussed the challenges that deeper and wider psychosocial studies should also be performed in the future. Finally, it highlighted our comprehension of the intricate pathophysiological mechanisms underlying FC and IBS-C and could potentially guide the formulation of more precise diagnostic protocols and personalized treatment methodologies."
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Lv CL, Song GQ, Liu J, Wang W, Huang YZ, Wang B, Tian JS, Yin MQ, Yu Y. Colorectal motility patterns and psychiatric traits in functional constipation and constipation-predominant irritable bowel syndrome: A study from China. World J Gastroenterol 2023; 29(41): 5657-5667 [DOI: 10.3748/wjg.v29.i41.5657]
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48
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"This paper provided an overview of long-term efficacy and predictors of pembrolizumab-based regimens in patients with advanced esophageal cancer. The paper also discussed the challenges that low baseline NLR, dNLR and PLR showed a trend for OS benefit, but a statistically significant difference was not observed. Finally, it highlighted that pembrolizumab combined with chemotherapy or radiotherapy resulted in a favorable long-term survival outcome in patients with locally advanced and metastatic esophageal cancer."
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Wang HC, Huang X, Chen J, Li Y, Cong Y, Qu BL, Feng SQ, Liu F. Long-term efficacy and predictors of pembrolizumab-based regimens in patients with advanced esophageal cancer in the real world. World J Gastroenterol 2023; 29(41): 5641-5656 [DOI: 10.3748/wjg.v29.i41.5641]
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49
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"This paper provided an overview of application of extended criteria donor grafts in liver transplantation for acute-on-chronic liver failure. The paper also discussed the challenges in the boundary of ECD in clinical practice. Finally, it highlighted that ECD grafts are associated with a higher risk of EAD than non-ECD grafts but can be safely used in ACLF recipients as they do not affect post-LT survival."
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Gong JL, Yu J, Wang TL, He XS, Tang YH, Zhu XF. Application of extended criteria donor grafts in liver transplantation for acute-on-chronic liver failure: A retrospective cohort study. World J Gastroenterol 2023; 29(41): 5630-5640 [DOI: 10.3748/wjg.v29.i41.5630]
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50
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"This paper reviewed the impact of the patient’s dietary pattern on the inflammatory process of IBD through the interaction of food, intestinal microbiota, and epigenome. The impact of diet on the epigenetic process of microbiota modulation is clear. Finally, it highlights that further clinical trials involving diets, supplements, and epigenetic and inflammatory markers are still needed."
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Marangoni K, Dorneles G, da Silva DM, Pinto LP, Rossoni C, Fernandes SA. Diet as an epigenetic factor in inflammatory bowel disease. World J Gastroenterol 2023; 29(41): 5618-5629 [DOI: 10.3748/wjg.v29.i41.5618]
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