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"Summary
In this study, pulsed-wave spectral Doppler ultrasonography was used to measure ophthalmic artery hemodynamic parameters in second-trimester pregnant women. The primary objective was to assess whether these variables could predict the subsequent development of pregnancy-induced hypertension and identify patients at increased risk for preeclampsia. The results demonstrated that an elevated peak ratio was strongly associated with the later onset of preeclampsia, suggesting its potential value of prediction.
Strengths and Limitations
A notable strength of this study is its clear clinical relevance. However, in addition to the limitations acknowledged by the authors, several other issues must be mentioned:
(1) The term "hypertensive disorder" should be further specified—for example, as "pregnancy-induced hypertension" or "hypertensive disorders of pregnancy"—to enhance clarity in context.
(2) The classification of the second trimester as "17–23 weeks of gestation" is inaccurate. According to current obstetrical standards, the second trimester spans from 14 weeks to 27 weeks and 6 days of gestation.
(3) The "Core tip" section does not meet the journal's required criteria, and key contents have missed.
(4) In Figures 1 and 2, the ophthalmic arteries are not properly visualized. In both cases, the insonation angle between the sampling line and the ophthalmic artery exceeds the authors addressed threshold (<20°)(although <60°allowed for some peripheral vessels), and the placement of the angle correction line(orientation) is incorrect. Given that pulsed-wave Doppler-derived hemodynamic values are highly dependent on the aforementioned technical factors, non-standard protocols may compromise the accuracy of the measurements. Consequently, the issues evident in these figures undermine the robustness and validity of the study's results and conclusions. It is worth noting that proper visualization of the ophthalmic artery and adjustment of the insonation angle to within 20°are not technically challenging to achieve.
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Dhiman R, Nayyar N, Takkar P, Sood D, Shukla A. Predictive value of second-trimester ophthalmic artery Doppler for identifying women at risk for preeclampsia. World J Radiol 2026; 18(7): 120995 [DOI: 10.4329/wjr.120995]
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied"
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Karam K, Charro K, Kechaou D, Abarah W, Rakotobe J, Locher C. Rectal mantle cell lymphoma endoscopically mimicking ulcerative proctitis: A case report. World J Clin Cases 2026; 14(21): 120444 [DOI: 10.12998/wjcc.120444]
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"This study analyzed 97 HCC patients and confirmed that PIV demonstrates higher survival predictive power than ALBI or MELD-Na, establishing it as an independent prognostic factor. Patients with high-PIV showed a median survival of 5 months, while those with low-PIV had a median survival of 30 months, demonstrating a significant difference. Along with ECOG, PIV emerged as the most powerful risk indicator, highlighting the prognostic value of inflammation-based biomarkers."
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Karatlı S, Yazılıtaş D, Kaya S, İmamoğlu Gİ, Çelik S, Uyar GC. Prognostic value of pan-immune-inflammation index in hepatocellular carcinoma compared with albumin-bilirubin and model for end-stage liver disease sodium. World J Gastrointest Oncol 2026; 18(7): 121250 [DOI: 10.4251/wjgo.v18.i7.121250]
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"This paper integrated the evaluation of considerations regarding 97 items concerning herbal medicine treatments used in colorectal cancer, comprehensively analyzing the reporting, methodology, and evidence levels. Regarding the explanation of the law of moderation, the herbal law indicates the effects on ORR and KPS improvement. However, since there is methodological margin in most SRs, relatively rational conclusions do not exist, and this paper proposes the value of considerate, high-quality RCTs and SRs."
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Wang HP, Qin XY, Xu BW, Lu TC, Gao RK, Lin M, Li J. Chinese herbal medicine for colorectal cancer: An overview of systematic reviews and evidence map. World J Gastrointest Oncol 2026; 18(7): 120031 [DOI: 10.4251/wjgo.120031]
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"This study developed a diagnostic scoring model to predict liver metastasis in elderly patients with lung and colorectal cancer by combining four seromarkers—ST2, PIVKA-II, CEA, and CA125—with a history of fatty liver. The combination of the four markers demonstrated the highest sensitivity and specificity, and effectively predicts the likelihood of liver metastasis by classifying patients into low, medium, and high-risk groups based on their total score (0–12 points)."
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Cheng Y, Sun YS, He YM. ST2, PIVKA-II, CEA, CA125 and their combinations in elderly liver metastases cancers: Development of a diagnostic scoring model. World J Gastrointest Oncol 2026; 18(7): 118940 [DOI: 10.4251/wjgo.v18.i7.118940]
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"The greatest strength of this paper is that it is the first to integrate the PS-1/β-catenin/p-PTEN axis into a single invasion regulatory network. It identified a novel mechanism in which PS-1 stabilizes β-catenin and induces p-PTEN to promote gastric cancer invasion, and enhanced the reliability of the results through a multi-layered approach encompassing clinical, cell, and animal experiments. Furthermore, it expanded the potential for developing therapeutic targets by suggesting that the co-high expression of the three molecules can serve as a prognostic indicator."
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Xiao S, Song DD, Yu YP, Xu XZ, Tang JF, Zhou CF. Novel regulatory network of PS-1/β-catenin/p-PTEN axis in gastric cancer invasion. World J Gastrointest Oncol 2026; 18(7): 118256 [DOI: 10.4251/wjgo.v18.i7.118256]
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"The strength of this case report lies in the successful completion of curative treatment even in the extremely rare scenario of ruptured liver cancer and colon invasion. After stabilization via early TAE, R0 resection was achieved through simultaneous hepatectomy and colon resection, followed by effective suppression of micrometastasis through multidisciplinary treatment utilizing TACE, lenvatinib, and tislizumab. As a result, an outstanding long-term outcome of 42 months of disease-free survival was achieved."
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Yang CW, Zhang RX, Zheng XL, Zhu L, Zheng Z, Wu XH. Long-term survival after combined hepatectomy and colectomy for ruptured combined hepatocellular-cholangiocarcinoma with direct colonic invasion: A case report. World J Gastrointest Oncol 2026; 18(7): 118212 [DOI: 10.4251/wjgo.118212]
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"The authors investigated outpatient visit frequency in 800 patients with overlapping non-erosive reflux disease and epigastric pain syndrome and reported that frequent gastroenterology attendance was associated with disease chronicity, psychological distress, demographic characteristics, and complex medication patterns, whereas conventional measures of gastrointestinal symptom severity were not independently associated with visit frequency. However, frequent healthcare use should not automatically be interpreted as a direct surrogate for disease severity, treatment failure, or refractory acid-mediated disease. Repeated consultations may reflect interactions among symptom perception, illness-related concerns, psychological distress, previous treatment experience, healthcare accessibility, and clinician prescribing behaviour. I think that the principal clinical implication of this study is the need to move from repeated symptom-directed escalation toward multidimensional assessment of patients with overlapping upper gastrointestinal syndromes."
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Lv M, Liu X, Huang KY, Xu LS, Che H, Yao MX, Wang FY. Outpatient visit frequency in patients with overlapping non-erosive reflux disease and epigastric pain syndrome: A multicenter study. World J Gastroenterol 2026; 32(28): 119326 [DOI: 10.3748/wjg.119326]
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"A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can accommodate the magnetic ring , and the inner fixing ring can fix the inverted intestinal tissue ; the outer shell can be combined to enclose an annular space, and the magnetic ring and the intestinal tissue can be accommodated in the annular space. The magnetic anastomotic ring of the present invention can significantly shorten the anastomosis time and simplify the operation of the operation. It is particularly suitable for scenes such as rapid treatment of war trauma and laparoscopic intestinal anastomosis. It uses the magnetic squeezing principle for anastomosis, improves the anastomosis quality, shortens the anastomosis time, and improves the patient's prognosis.
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can accommodate the magnetic ring , and the inner fixing ring can fix the inverted intestinal tissue ; the outer shell can be combined to enclose an annular space, and the magnetic ring and the intestinal tissue can be accommodated in the annular space. The magnetic anastomotic ring of the present invention can significantly shorten the anastomosis time and simplify the operation of the operation. It is particularly suitable for scenes such as rapid treatment of war trauma and laparoscopic intestinal anastomosis. It uses the magnetic squeezing principle for anastomosis, improves the anastomosis quality, shortens the anastomosis time, and improves the patient's prognosis.
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can accommodate the magnetic ring , and the inner fixing ring can fix the inverted intestinal tissue ; the outer shell can be combined to enclose an annular space, and the magnetic ring and the intestinal tissue can be accommodated in the annular space. The magnetic anastomotic ring of the present invention can significantly shorten the anastomosis time and simplify the operation of the operation. It is particularly suitable for scenes such as rapid treatment of war trauma and laparoscopic intestinal anastomosis. It uses the magnetic squeezing principle for anastomosis, improves the anastomosis quality, shortens the anastomosis time, and improves the patient's prognosis.
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can accommodate the magnetic ring , and the inner fixing ring can fix the inverted intestinal tissue ; the outer shell can be combined to enclose an annular space, and the magnetic ring and the intestinal tissue can be accommodated in the annular space. The magnetic anastomotic ring of the present invention can significantly shorten the anastomosis time and simplify the operation of the operation. It is particularly suitable for scenes such as rapid treatment of war trauma and laparoscopic intestinal anastomosis. It uses the magnetic squeezing principle for anastomosis, improves the anastomosis quality, shortens the anastomosis time, and improves the patient's prognosis.
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can accommodate the magnetic ring , and the inner fixing ring can fix the inverted intestinal tissue ; the outer shell can be combined to enclose an annular space, and the magnetic ring and the intestinal tissue can be accommodated in the annular space. The magnetic anastomotic ring of the present invention can significantly shorten the anastomosis time and simplify the operation of the operation. It is particularly suitable for scenes such as rapid treatment of war trauma and laparoscopic intestinal anastomosis. It uses the magnetic squeezing principle for anastomosis, improves the anastomosis quality, shortens the anastomosis time, and improves the patient's prognosis.
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
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Zhang MM, Xu SQ, Wu HX, Ren HL, Wan JH, Zhong QY, Chen MY, Zhang QF, Gong RM, Yusif-Zada K, Badarch BI, Shi AH, Lyu Y, Liu XM, Yan XP. Comparison of the anastomotic effects of combined-type and whole-type magnetic rings for gastrointestinal anastomosis in beagles. World J Gastroenterol 2026; 32(28): 118067 [DOI: 10.3748/wjg.118067]
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"This Letter to the Editor highlights the importance of monitoring ocular health as a warning sign for leukemia in pediatric patients. It is a concise yet well-written paper, accompanied by a figure summarizing the clinical, diagnostic, and therapeutic flowchart. The references are very recent and in a sufficient number. In my opinion could be very useful for other clinicians to discover promptly leukemia. "
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Ghosh D. Letter to the Editor: Eye as a window to disease burden in pediatric acute leukemia. World J Exp Med 2026; 16(2): 119334 [PMID: 42394785 DOI: 10.5493/wjem.v16.i2.119334]
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11
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"In this manuscript, the authors concluded that phytosterols are a compelling example of multifunctional dietary bioactives with established cardiometabolic utility and prospective, albeit emerging, applications beyond lipid lowering. The authors have illustrated two figures and one table to explain their review, but Figure 1 seems unclear. The explanation of future perspectives is a good point."
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Mohamed D, Ramadan AA, Mabrok HB, Hamed I. Phytosterols in human health: Biochemical mechanisms of action and disease-modulating effects. World J Biol Chem 2026; 17(2): 121685 [PMID: 42273523 DOI: 10.4331/wjbc.v17.i2.121685]
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12
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"The authors reported that measured cell recovery probabilities, phenotype misclassification rates, locus- and cell-type-specific dropout and stutter models, quantified contamination and drop-in rates, validated minimum cell counts for consensus formation, and specified database-upload requirements should all be required for casework submission. It should also demand a clear separation of sub-source reporting and activity-level assertions. If such prerequisites are met, single-cell typing can supplement, rather than replace, bulk STR analysis and probabilistic genotyping in a small but significant number of high-value forensic instances.
The manuscript is just a review, and it is so interesting."
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Evangelou K, Angeli P, Polydorou A, Petropoulou T. Single-cell deoxyribonucleic acid typing for forensic mixtures and trace evidence: Opportunities, validation requirements, and reporting limits. World J Biol Chem 2026; 17(2): 121467 [PMID: 42273528 DOI: 10.4331/wjbc.v17.i2.121467]
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13
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"The review clarified the HBV reactivation process. Following treatment for HBV-related HCC, the effect of immune-based methods and the antivirals lamivudine, entecavir, tenofovir alafenamide, and tenofovir disoproxil fumarate on reactivation was investigated. This review suggests comparing the genome/proteome of blood from overt and relapsed HCC-related chronic HBV patients. This facilitates recognizing the lingering genetic/epigenetic profiles of HBV-resistant variants, allowing for more precise selection of the optimal antiviral treatment and eliminating the potential of viral reactivation."
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Abdulrahman MS, Aboelmagd O, Zhang Y, Zaky S, Johar D. Precore/core mutation relatedness to viral reactivation in patients undergoing targeted therapy for hepatitis B virus-related hepatocellular carcinoma. World J Biol Chem 2026; 17(2): 120297 [PMID: 42273524 DOI: 10.4331/wjbc.v17.i2.120297]
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14
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"The text is an excellently written mini-review that does not need methods or results. Figure 1 illustrates the significance of TREM2-induced activation of pancreatic macrophages in obesity and its metabolic implications. However, at least one more figure is necessary to demonstrate TREM2 ligand identification and signal transduction. All references are essential, and the language is appropriate.
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Zhang AY, Xie CY, Song X, Guo ZH, Shi YR, Wang SY, Yang GH, Liu Y, Xu TC. Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk: Key regulator of obesity pathophysiology and metabolic dysregulation. World J Biol Chem 2026; 17(2): 118705 [PMID: 42273525 DOI: 10.4331/wjbc.v17.i2.118705]
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15
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Awadallah M, Ton L, Thoguluva Chandrasekar V, Yap JEL, Vega KJ. Ascending colon toothpick impaction identified during screening colonoscopy: A case report. World J Clin Cases 2026; 14(19): 121345 [DOI: 10.12998/wjcc.121345]
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16
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"The authors Sharma and Patial, in their study entitled “Protective effects of kaempferol against diet-induced metabolic disorder," which was published in the World Journal of Hepatology 2026, 18(6) [1], stressed the findings of Nair et al. that kaempferol is a significant medication for diet-induced obesity and hepatic steatosis in mice[2]. This interesting study is limited in its experimental findings and focuses specifically on a diet that is restricted to Indian people. The title of the study and the abstract did not mention that this study is an experimental study or mini-review or a letter to the editor. The selection of C57BL/6 mice as an experimental model for studying the effect of kaempferol on hepatic lipids is misleading because this strain of animal is resistant to the medications, has a tendency to drink alcoholic beverages and is susceptible to morphine addiction. The authors did not mention the constituents of the Indian diet or the differences in the prevalence of MASLD between Indian people and people in other countries to claim that the Indian diet is the pathological cause for MASLD. The pharmacokinetics of kaempferol indicate that this natural antioxidant needs specific formulation to produce its effect, and there is no evidence that kaempferol reduces hepatic lipids. These points need to be considered in assessing the article to avoid many pitfalls that limit the importance of the study.
References
[1] Sharma V, Patial V. Protective effects of kempferol against diet-induced metabolic disorder World J Hepatol 2026; 18 (6)
[2] Nair B, Gopalakrishna R, Nath LR. Kaempferol attenuates diet-induced obesity and hepatic steatosis in C57BL/6J mice fed an Indian diet mimicking regimen. World J Hepatol 2026; 18: 115659
Dr. Marwan S. Al-Nimer
Emeritus Professor
Department of Clinical Pharmacology and Therapeutics
College of Medicine, University of Diyala, 32001 Baqubah, Iraq
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Sharma V, Patial V. Protective effects of kaempferol against diet-induced metabolic disorders. World J Hepatol 2026; 18(6): 120789 [DOI: 10.4254/wjh.120789]
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"Dear Authors,
This study develops a rat model of chronic radiation proctitis using single-dose irradiation and follows disease progression with serial endoscopy, histopathology, fibrosis assessment, VEGF staining, and cytoskeletal protein analysis. The results suggest that 20–35 Gy induces persistent mucosal injury, telangiectasia, fibrosis, and chronic rectal damage, whereas lower doses allow recovery. The longitudinal endoscopic monitoring and blinded scoring increase the credibility of the model. Future studies may strengthen these findings by including fractionated irradiation protocols, validating the model in independent cohorts, and clarifying whether early α-tubulin loss is a causal mechanism or a predictive marker of chronic radiation injury."
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Chang Y, Sun R, Juan W, Xu Z, Xu HY, Zen K, Xuan J. Establishment of a standardized rat model of chronic radiation proctitis and preliminary evaluation of its association with tubulin. World J Gastroenterol 2026; 32(26): 118923 [DOI: 10.3748/wjg.v32.i26.118923]
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"Dear Authors,
This study investigates CDK5 expression in gastric neuroendocrine carcinoma through immunohistochemical evaluation, survival analysis, and functional cell-line experiments. The association of high CDK5 expression with advanced tumor features, higher Ki-67 index, poorer survival, and independent adverse prognostic value suggests a possible role of CDK5 in aggressive GNEC biology. The blinded pathological assessment and multivariable analysis enhance the credibility of the results. The conclusions could be further strengthened by validation in larger multicenter cohorts and by additional pathway-level studies explaining the biological basis of CDK5 activity, particularly the different effects observed in knockdown and overexpression experiments. These future approaches may clarify whether CDK5 serves only as a prognostic marker or may also represent a therapeutic target in GNEC."
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Sun YQ, Su J, Ye KN, Chen QX, Kang EZ, Lv CB, Lian MQ, Zeng WM, Zhang YB, Cai LS. High cyclin-dependent kinase 5 expression promotes tumor progression in gastric neuroendocrine carcinoma. World J Gastroenterol 2026; 32(26): 119574 [DOI: 10.3748/wjg.v32.i26.119574]
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"Fragos et al. presented a case on CSS with hypothyroidism and dyslipidemia. Such a rare case is very important for clinical practice. The case report is presented according to CHECK criteria, thoroughly and well-documented. The content is easily readable and clear, English is correct. The discussion is fruitful, the conclusions have arisen from the presented text. The future perspective are presented. The references are updated.
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Fragos MN, Toulia I, Grammatikopoulou MG, Savvidou P, Taiganidis I, Zissiadis P, Antachopoulos C, Goulis DG, Tsiroukidou K. De novo ARID1A Coffin-Siris syndrome with hypothyroidism and dyslipidemia: A case report and literature review. World J Clin Cases 2026; 14(19): 120716 [DOI: 10.12998/wjcc.120716]
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20
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"This retrospective study addresses a clinically relevant question—whether long-term outcomes after endoscopic strictuotomy for small bowel strictures differ by etiology and whether a simple biomarker can aid risk stratification. The scientific quality is above average, with several methodological strengths, though important limitations temper the conclusions.
1. The study fully meets ethical standards, with IRB approval and informed consent documented. The methodology is clearly described and reproducible, including well-defined eligibility criteria, a patient flowchart, and detailed procedural specifications. However, key unresolved issues weaken internal validity: the lack of standardized post-procedural medical therapy (especially biologics in Crohn's patients) introduces a major confounder; strictures were classified as fibrosis-dominant based on imaging and endoscopy alone without histopathological confirmation; and reintervention decisions relied on symptom recurrence rather than a validated scoring system, introducing subjectivity.
2. The results are authentic and statistically robust. Tables and figures are well-constructed, though endoscopic images could benefit from annotations. Statistical methods are rigorous: a parsimonious multivariable Cox model avoided overfitting, maximally selected log-rank statistics objectively determined the NLR cutoff, and collinearity was properly managed. Nonetheless, gaps remain—no formal power calculation, no sensitivity analyses, and no interaction test between etiology and NLR to assess whether the biomarker's prognostic value differs between groups.
3. References are comprehensive, current, and relevant.
4. The authors have honestly acknowledged several limitations, including the single-center design, modest sample size, residual confounding, and subjective outcome definition. However, other critical issues remain unresolved: heterogeneity within the non-Crohn's group (radiation, NSAID, ischemic, CMUSE) is unexplored; histopathological fibrosis confirmation is lacking; post-procedural medical protocols are not standardized; and only baseline NLR was assessed.
To address these gaps, future studies should incorporate objective fibrosis assessment (EUS, CLE, or STAR histopathological scoring), enroll larger cohorts for subgroup analyses and interaction testing, use validated symptom scores for reintervention definition, and measure NLR longitudinally. A formal sample size calculation based on the effect sizes observed here would strengthen future prospective, multicenter study designs.
In summary, this study makes a valuable contribution by providing etiology-stratified outcome data and identifying NLR as a practical prognostic marker. The findings suggest that non-Crohn's patients with low NLR are the best candidates for endoscopic strictuotomy, while Crohn's patients with elevated NLR may need intensified medical therapy or earlier surgery. Despite its limitations, the study is methodologically sound and advances the field. "
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Lai WC, Feng XM, Huang ZH, Jiang ZM, Sun T, Yin X, Zhang L, Ning SB, Li BR. Balloon-assisted endoscopic stricturotomy for small bowel fibrostenotic strictures: A comparison of Crohn’s disease-related and non-Crohn’s disease strictures. World J Gastroenterol 2026; 32(26): 118889 [DOI: 10.3748/wjg.118889]
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"Colorectal cancer (CRC) is currently one of the most important causes of morbidity and mortality in all parts of the world. It is very important that the shift in its occurrence to younger ages concerns not only developed but also developing countries. According to other epidemiological data, the incidence of this neoplasm is expected to increase over the next two decades despite the availability of the most effective treatment methods. Preventive screening of the asymptomatic population, aimed at early detection, remains the cornerstone of efforts to increase five-year survival rates. Although in all developed countries preventive screening programs are implemented with varying effectiveness, mainly through colonoscopy, the situation is different in developing countries. The limited resources available for health promotion, socioeconomic disparities, and other factors necessitate the development of a cost-effective screening program tailored to these specific conditions. In these countries, priority should be given to primary screening methods, such as fecal hemoglobin detection, which, if positive, should be followed by colonoscopy. The identification of high-risk groups for mandatory colonoscopy is imperative, in combination with efforts to reduce the influence of other environmental factors (mainly dietary) on carcinogenesis. The review by Wu et al. emphasizes the need to develop optimized risk-stratification algorithms in these countries, as an adaptive, organized screening framework can deliver optimal population-level benefits while increasing residents' willingness to undergo colonoscopy."
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Wu YP, Chen M, Wang L. Current colorectal cancer screening in developing countries: Identifying optimal approaches. World J Gastroenterol 2026; 32(26): 118151 [DOI: 10.3748/wjg.118151]
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22
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"This is a well-written and prezented rarely case report about " Pancreatic Schwannoma". Schwannoma can occur anywhere in the body. Pancreatic schwannoma (PS) is an extremly rare mesenchymal tumor.
Technological advancements in cross-sectional imaging such as ultrasonography (USG), computed tomography (CT), and magnetic resonance imaging (MRI), and their increased use have made incidental pancreatic tumors more frequently detectable.
Pancreatic schwannoma is one of these tumors and should be considered in the differential diagnosis.
This manuscript gives additional new knowledge to the existing literature. I think that this manuscript is suitable and worth to be published in the World Journal of Gastrointestinal Surgery."
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Xu SM, Qiu LY. Incidental schwannoma of the pancreatic tail mimicking a solid pseudopapillary tumor: A case report. World J Gastrointest Surg 2026; 18(6): 119246 [DOI: 10.4240/wjgs.119246]
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"This paper explains the immune evasion mechanisms of gastric cancer by integrating spatial structure, metabolic reorganization, microbial interactions, and molecular subtypes. By synthesizing cutting-edge insights derived from spatial transcriptomics, single-cell data, and clinical trials, it presents a comprehensive framework advancing toward ecosystem-level precision immuno-oncology and the development of next-generation biomarkers."
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Yao ZY, Ma LJ, Han ZX, Ji GJ. Evolving landscape of the gastric cancer immune microenvironment: From spatial architecture to precision biomarkers. World J Gastrointest Oncol 2026; 18(6): 119114 [DOI: 10.4251/wjgo.v18.i6.119114]
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"This study presents clinically significant and clear evidence by analyzing 38 cases of non-R0 resected rectal neuroendocrine tumors through long-term follow-up. The consistent absence of residual tumor cells after salvage surgery and during the follow-up period supports the conclusion that salvage surgery may be unnecessary. This study supports conservative treatment by integrating pathological findings, treatment outcomes, and the context of clinical guidelines."
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Lin SY, Li ZH, Xu GL, Weng J, Bai KH. Is salvage surgery necessary for non-R0 endoscopic resection of small rectal neuroendocrine tumors? World J Gastrointest Oncol 2026; 18(6): 118531 [DOI: 10.4251/wjgo.v18.i6.118531]
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"This paper comprehensively presents longitudinal, mechanistic, and immunological evidence to re-establish CD24 as a dynamic regulator of liver cancer development rather than a static biomarker. By integrating animal models, human cohorts, immune checkpoint biology, and spatial single-cell analysis, it provides a comprehensive framework highlighting the diagnostic potential and therapeutic importance of CD24 for hepatocellular carcinoma."
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Ren LN, Liu C, Jin CQ, Zhang XH. From association to intervention: Rethinking CD24’s causal role in hepatocellular carcinogenesis. World J Gastrointest Oncol 2026; 18(6): 117434 [DOI: 10.4251/wjgo.v18.i6.117434]
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"This study provides clear mechanistic insights by demonstrating consistent transcriptional activation of apoptosis-related genes and inhibition of proliferation regulators in gastric and colorectal cancer cells. Through a comparative evaluation including combination therapy with Stolax oil and boron compounds, we present novel comparative data and highlight the synergistic anticancer potential supported by consistent gene expression patterns."
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Er Urganci B, Çakal S, Dogan C, Göçmen S, Şimşek S, Yılmaz S. Storax oil and boron compounds trigger apoptosis and cell cycle arrest in gastric and colorectal cancer. World J Gastrointest Oncol 2026; 18(6): 117252 [DOI: 10.4251/wjgo.v18.i6.117252]
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"This paper synthesizes recent research findings to emphasize that the MAZ/UHRF1/ECRG4 axis is a major mechanism of colorectal cancer metastasis. Through an integrated analysis of transcription, epigenetics, and tumor suppressor gene biology, it clearly explains the mechanisms by which this pathway promotes epithelial-mesenchymal transition and invasion. Furthermore, it effectively presents the potential for developing therapies targeting this regulatory mechanism and their clinical applicability."
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Kunz EM, Schoeller III RJ, Carroll JP, Lucke-Wold B. Translational implications of the MAZ/UHRF1/ECRG4 axis in metastatic colorectal carcinoma. World J Gastrointest Oncol 2026; 18(6): 116858 [DOI: 10.4251/wjgo.v18.i6.116858]
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"This study identified CBX2/CBX7 as potential causative genes for salivary gland cancer by integrating a publicly available transcriptome dataset with functional in vitro analysis. We presented a multilayered approach combining differentially expressed genes, whole-genome sequencing, protein interactions, and pathway analysis, and preliminary mechanism experimental results support their involvement in cell cycle regulation and tumor progression."
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Huang YH, Liu XL, Yang Z. Evaluating the efficacy of interventional hepatocellular carcinoma via dynamic contrast-enhanced magnetic resonance imaging: A retrospective study. World J Gastrointest Oncol 2026; 18(6): 116770 [DOI: 10.4251/wjgo.v18.i6.116770]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Milionis C, Zoumakis E, Ilias I. Letter to the Editor: Endocrine determinants of diabetic ketoacidosis outcomes in type 2 diabetes and insights into Gymnema sylvestre actions. World J Exp Med 2026; 16(2): 121192 [PMID: 42394775 DOI: 10.5493/wjem.v16.i2.121192]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Desai R, Patel D, Prasad A, Mandalapu N, Nagarajan J, Guddeti A, Khatri S, Shahnawaz W, Aleem A, Mohammed AS, Yasmeen U, Ghani MU. Genetic and biological determinants of pulmonary embolism: Insights from Mendelian randomization studies. World J Exp Med 2026; 16(2): 121046 [PMID: 42394776 DOI: 10.5493/wjem.v16.i2.121046]
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31
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Savvidis C, Thomopoulos C, Ilias I. Melatonin supplementation, hyperprolactinemia, and incident heart failure: A proposed prolactin-mediated pathway for cardiovascular risk. World J Exp Med 2026; 16(2): 120754 [PMID: 42394777 DOI: 10.5493/wjem.v16.i2.120754]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Khalil MAM, Sadagah NM, Mahmood HHK, Alrowaie F, Almansour AM, Alghamdi RMH, Alghamdi L, A Al-Ghamdi R, Elgadi A, Al-Qurashi SH. Forgotten compartment: Impact of tubulointerstitial inflammation and damage on renal outcomes in lupus nephritis from Saudi Arabia. World J Exp Med 2026; 16(2): 119440 [PMID: 42394784 DOI: 10.5493/wjem.v16.i2.119440]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Ghosh D. Letter to the Editor: Eye as a window to disease burden in pediatric acute leukemia. World J Exp Med 2026; 16(2): 119334 [PMID: 42394785 DOI: 10.5493/wjem.v16.i2.119334]
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34
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Pandey S, Aravaanan ASK, Bhaskar E, Silambanan S. Detection of intracellular bacterial communities and biofilms in urinary tract infections with Escherichia coli using staining protocols. World J Exp Med 2026; 16(2): 119306 [PMID: 42394778 DOI: 10.5493/wjem.v16.i2.119306]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Şengel N, Köksal Z, Küçük A, Sezen ŞC, Güneş I, Atlı M, Kip G, Gökgöz Acar S, Özer A, Kavutçu M, Arslan M. Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury. World J Exp Med 2026; 16(2): 118828 [PMID: 42394782 DOI: 10.5493/wjem.118828]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Deshmukhe SM, Vyawahare CR, Suryawanshi PV, Ratnaparkhi MM, Gandham NR. Unveiling the antibiotic resistance pattern in Staphylococcus aureus: A systematic review (2013-2024). World J Exp Med 2026; 16(2): 118252 [PMID: 42394783 DOI: 10.5493/wjem.v16.i2.118252]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Chhokar A, Joshi U, Tripathi T, Gupta B, Mudassir M, Janjua D, Chaudhary A, Yadav J, Aggarwal N, Jaggi VK, Bharti AC. Quantitative assessment of STAT3 and HPV16 E6 transcripts using Flow-FISH approach for early detection of progressive cervical lesions. World J Exp Med 2026; 16(2): 118250 [PMID: 42394774 DOI: 10.5493/wjem.v16.i2.118250]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Ahmed AEA, Hassan MH, Hamdan RS, Sakhr HM. Evaluation of growth hormone provocative tests in Egyptian children with growth hormone-related short stature. World J Exp Med 2026; 16(2): 117853 [PMID: 42394781 DOI: 10.5493/wjem.v16.i2.117853]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Xing WL, Liu T. Beyond distance and heart rate: Reading 6-minute walk test via blood pressure variability in chronic heart failure. World J Exp Med 2026; 16(2): 116315 [PMID: 42394780 DOI: 10.5493/wjem.v16.i2.116315]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Wishahi M, Badawy M. Letter to the Editor: Urinary infection in European guidelines 2025 vs microbiology culture results in the management of urinary infection. World J Exp Med 2026; 16(2): 115894 [PMID: 42394779 DOI: 10.5493/wjem.v16.i2.115894]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Savvidis C, Ilias I. Letter to the Editor: Circadian and microbial misalignment in metabolic dysfunction-associated steatotic liver disease - mechanistic insights and chronotherapeutic potential. World J Exp Med 2026; 16(2): 118228 [PMID: 42394773 DOI: 10.5493/wjem.v16.i2.118228]
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"Nice commentary on a published paper. It is an excellent piece of work for the readers and for better understand the commented manuscript. it highlights strenghts and limitations of the discussed paper, also pointing out some practical implications for physicians and the era of precision / tailored medicine. Best regards"
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Yang YH. Transcatheter arterial chemoembolization plus lenvatinib toward precision prognostication for unresectable hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(6): 116250 [DOI: 10.4251/wjgo.v18.i6.116250]
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"This is very interesting paper. In chemotherapy for pancreatic cancer, the presence of sarcopenia (age-related or disease-related loss of muscle mass and strength) significantly impacts treatment continuity and prognosis. Sarcopenia increases the likelihood of severe side effects from anticancer drugs, potentially necessitating dose reduction, temporary discontinuation, or complete cessation of treatment. As a result, patients may not achieve sufficient therapeutic effects, leading to a shorter survival time. Appropriate nutritional management: Under the guidance of a cancer specialist dietitian or physician, supplementation of often-deficient calories and protein is provided. Light exercise (resistance training): Within the limits permitted by the attending physician, gentle strength training and walking are performed to maintain muscle stimulation. Symptom control: Pain, nausea, loss of appetite, and other distressing symptoms are alleviated with medication to facilitate eating. Preventing and improving sarcopenia reduces the side effects of chemotherapy and increases the likelihood of completing treatment as planned. 1. Please describe the rehabilitation for sarcopenia at your hospital. 2. Please also describe the evaluation of sarcopenia in the iliopsoas muscle using CT, as well as the evaluation using conventional SARC-F/SARC-Calf, DXA, and BIA.
In recent years, ghrelin-like agonists targeting sarcopenia (caxia) have been reported to be effective in increasing lean body mass and improving loss of appetite in patients with gastrointestinal cancers, including pancreatic cancer (2), and are attracting attention as a therapeutic target.
Previous studies on the molecular mechanisms by which sarcopenia promotes pancreatic cancer progression have only been conducted in animal models such as mice, and no studies focusing on the microenvironment in human pancreatic cancer have been conducted. If the molecular mechanisms of sarcopenia in the progression of pancreatic cancer in humans can be elucidated, it may lead to the development of new therapeutic targets.3. Please comment about the molecular mechanisms by which sarcopenia promotes pancreatic cancer progression
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Akazawa Y, Ohtani M, Murata Y, Tanaka T, Nosaka T, Takahashi K, Naito T, Nakamoto Y. Three-dimensional psoas muscle volume and longitudinal changes as predictors of outcomes in older patients with advanced pancreatic cancer. World J Gastroenterol 2026; 32(24): 118757 [DOI: 10.3748/wjg.118757]
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"In this manuscript, the authors investigate the prognostic value of stress hyperglycemia indices; specifically the Stress Hyperglycemia Ratio (SHR) and Admission Glucose-to-Chronic Glycemia Ratio (ACGR) in patients with non-ST elevation myocardial infarction (NSTEMI). The study effectively distinguishes between chronic dysglycemia (HbA1c) and acute metabolic stress. By demonstrating that SHR and ACGR outperform HbA1c in predicting early mortality, the authors provide a more granular understanding of one’s acute metabolic state during an NSTEMI event. The use of a prospective design and the sequential adjustment of multivariable models (incorporating inflammatory and echocardiographic parameters) shows an appropriate and the correct approach to control confounding factors. I believe, the core strength of their work lies in the focus on simply markers available in minutes at the time of initial presentation itself. These indices provide a metabolic snapshot before echocardiographic or invasive data are available, offering a potential window for early risk stratification.
However, while I agree with the authors in regards to the key strengths and impact of this report, the results and conclusions must be taken in totality. With only 25 mortality events, the study is statistically underpowered for robust multivariable modelling. This increases the risk of overfitting, where the model captures noise rather than true signal, limiting the generalizability of the findings. Further, the use of data-driven (Youden index) cut-offs without external validation means these values are hypothesis-generating rather than clinically actionable at this moment of time. While the authors adjusted for several variables, the lack of key hemodynamic data on admission including blood pressure and heart rate, prevented the calculation of validated clinical scores like the GRACE score, which as of now remains the gold standard for NSTEMI risk stratification. Perhaps it will be possible for the authors to go back and have a look at this important data, as such a comparison would make it more relevant and worthy of further investigation.
Overall, my suggestions to the authors going forward will be to validate these findings in an independent, larger cohort. If the same would be challenging in near future, they can consider applying their derived thresholds to a public dataset to demonstrate consistency and validity of their findings. Instead of presenting SHR as a standalone predictor, investigate whether adding SHR to the GRACE score improves its discriminative power and offer additive information. Clinicians like myself are unlikely to use a new, isolated index, but they will be open to adopting a simple marker/ index that improves existing and validated tools. Since the study only looked at admission glucose, consider tracking glucose variability or the change in glucose over the first 48 hours. Early normalization of stress hyperglycaemia might offer some additive information and would be also a good reflection of the metabolic condition of an individual beyond the initial spike.
Nonetheless, the findings are important and deserve attention. It comes as a well-conducted study that highlights the importance of the metabolic stress response in NSTEMI. However, one must wait for more higher quality evidence before adopting these tools in routine clinical practice.
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Becirovic E, Becirovic M, Hodzic J, Becirovic A, Bajric M, Abdic A, Sabanovic F, Begagic E. Stress hyperglycemia and early mortality in non-ST elevation myocardial infarction. World J Cardiol 2026; 18(5): 119429 [DOI: 10.4330/wjc.v18.i5.119429]
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"The manuscript explores a clinically relevant topic. However, its overall scientific contribution remains limited. In review, the authors attempt to discuss the association between type 2 diabetes mellitus and pancreatic neuroendocrine tumors, the paper largely lacking the sufficient depth, critical appraisal, and methodological rigor which offers credibility of that study. The discussion is largely descriptive and relies on selective interpretation of previously published studies without systematically evaluating study quality, sources of bias, or the strength of the available evidence. Important issues were not analysed adequately such as reverse causality, residual confounding, and surveillance bias. In several sections, the conclusions appear more overstating the level of evidence definitive than warranted by the cited literature. Furthermore, the manuscript offers limited novel insights, and the proposed recommendations are largely speculative and insufficiently supported by robust data. The review would have benefited from a more balanced presentation of conflicting findings, a clearer methodological framework, and a stronger focus on evidence-based interpretation. "
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Goyal MK, Hatwal J, Desai R, Sehgal T, Batta A. Glycated hemoglobin and cardiovascular risk in diabetes mellitus: Evolving evidence beyond glycemic control. World J Diabetes 2026; 17(6): 115820 [DOI: 10.4239/wjd.115820]
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"The manuscript is well written, concise and easy to follow. There are no grammatical or spelling errors throughout the text. The topic debated is interestingly and with a relevant clinical impact in practice due to the risc of poor prognosis of this pathology. The references are well chisen and updated. "
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Wei ML, Tan QL. Chronic ulcer diagnosis and perforation risk with oral agent contrast-enhanced ultrasound: A case report and review of literature. World J Gastroenterol 2026; 32(24): 119006 [DOI: 10.3748/wjg.119006]
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"In this review article, the authors systematically identify and analyze the main risk factors for the development of gastric cancer (GC). Furthermore, the article details the current methods of disease detection, comparing the advantages and limitations of each. The review concludes that the development of GC results from the synergistic action of multiple factors, with Helicobacter pylori infection being the most clearly established carcinogen of the category. Gastroscopy remains the gold standard for GC screening. Gastric cancer often develops silently. In my opinion, it could also be characterized as a “silent killer” along with pancreatic cancer. The clear conclusion is that identifying individuals at increased risk of developing GC and detecting precancerous lesions early are crucial prevention and treatment strategies. Most guidelines now emphasize targeted screening of high-risk groups, first by demonstrating Helicobacter pylori infection and precancerous gastric lesions, and then by performing endoscopy to detect early disease. Endoscopic screening, which should be applied to high-risk groups, is considered the most effective way to detect carcinoma early and is also the most effective diagnostic method in areas with a high prevalence of the disease, as well as selected intermediate-risk cases. Primary prevention through H. pylori eradication and lifestyle changes, combined with monitoring of patients with advanced atrophy or intestinal metaplasia, offers the best strategy for reducing the burden of gastric cancer. With future advances in liquid biopsy and endoscopic techniques, it is expected that the early detection rate of GC will improve significantly, mortality rates will decrease, patient prognosis will improve, and the global burden of GC will be mitigated."
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Jiang JJ, Chen K, Weng T, Hong JM, Qin WY. Early screening and risk factors for gastric cancer. World J Gastroenterol 2026; 32(24): 119127 [DOI: 10.3748/wjg.119127]
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"Dear authors, the article provides a perfect overview of current findings and optimizes therefore the opportunities to set up further reserarch questions. External validation, clinical and practice oriented research, as well as integration of neurological, psychiatric, psychological, biological disciplines and translational research is needed. Therefore it could be helpful to integrate affective neurosciences, primary emotional systems with their neuromorpholocial and biochemical neuromodulating systems into care pathways and calculation. Attaching emotional systems to relational components would be the next steps, that could be conceptualized for preventive strategies.
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Gu JX, Liu CQ, Chen GX, Yao T, Sun ZX, Wang Y. Post-stroke depression update 2025: Mechanisms, prediction, and management. World J Psychiatry 2026; 16(6): 115996 [DOI: 10.5498/wjp.v16.i6.115996]
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"This review discusses recent advances in the pathogenesis and clinical spectrum of IgG4-DSD, as well as the importance of assessing various disease-related biomarkers. The clinician should suspect the disease, especially in cases of painless jaundice. The determination of IgG4 levels in these cases should be done anyway since there is no other way to demonstrate the disorder. The clinician should also keep in mind the possibility of false-positive results. New biomarkers promise greater sensitivity and specificity in accurately diagnosing the syndrome. Early diagnosis is essential, allowing the implementation of personalized therapeutic strategies. As mentioned above, clinical suspicion and timely detection of the disease will play an important role. It constitutes a new chapter in modern gastroenterology, with diverse manifestations that modern gastroenterologists should be familiar with."
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Pan Y, Jiang YZ. Clinical features and biomarker research advances in immunoglobulin 4-related digestive system disorders. World J Gastroenterol 2026; 32(23): 118782 [DOI: 10.3748/wjg.v32.i23.118782]
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Excess fat tissue is involved in the pathophysiology of MASLD. Yet there is no definite method for accurately estimating body fat tissue. Right now BMI and waist circumference are accepted anthropometric tools in this regard. The limitations of these parameters in determining lean-body fatty liver patients declare that new methods are needed.
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Moriyama K. Rethinking noninvasive steatosis indices: Structural limitations and misclassification across the body mass index spectrum. World J Hepatol 2026; 18(5): 118804 [DOI: 10.4254/wjh.v18.i5.118804]
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