1
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"This study provides key insights into DR pathogenesis, focusing on the lnc-MGC/miR-495-3p/GRP78 axis in regulating ER stress and ferroptosis. Although the results are compelling, reliance on animal and in vitro models limits clinical relevance, and validation in human studies is required. The study effectively integrates past research but could strengthen mechanistic claims with broader pathway analysis and deeper functional validation. Despite these limitations, it identifies promising therapeutic targets for DR treatment. Further downstream effects and interactions may even add to the translational value of this molecule, making this contribution valuable for DR research. Best Wishes"
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Luo YY, Ba XY, Wang L, Zhang YP, Xu H, Chen PQ, Zhang LB, Han J, Luo H. LEF1 influences diabetic retinopathy and retinal pigment epithelial cell ferroptosis via the miR-495-3p/GRP78 axis through lnc-MGC. World J Diabetes 2025; 16(3): 92003 [DOI: 10.4239/wjd.v16.i3.92003]
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2
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"This editorial explained the importance of systemic inflammation index (SII) to predict the recurrence of atrial fibrillation after successful RFCA by referring the retrospective study published in the World Journal of cardiology. This editorial recall the usefulness of SII in various fields in medicine, because SII is easily calculated. All clinicians should calculate this index frequently and will be able to find a clue of the novel study initiation. "
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Berezin AE. Predictive value of the systemic immune inflammation index in recurrence of atrial fibrillation after radiofrequency catheter ablation. World J Cardiol 2025; 17(1): 102981 [PMID: PMC11755125 DOI: 10.4330/wjc.v17.i1.102981]
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3
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"Recent epidemiological data show that despite implementing preventive control programs for the early detection of malignant neoplasms of the digestive tract, their frequency is increasing and is expected to increase further in the coming years. At the same time, the increase in life expectancy, along with more effective therapeutic methods, has resulted in an increase in patient survival. The diagnosis of patients with simultaneous (within three months) detection of a second (or even third) malignant neoplasm is no longer a surprise. Therefore, detecting a malignant neoplasm should not prevent the physician from performing a complete clinical and laboratory examination to investigate the possibility of distant metastases and the possibility of a second simultaneous malignant neoplasm of the same or different system. Failure to detect the second neoplasm promptly will significantly reduce patients' chances of survival. The reviewed article refers to three cases of patients who developed simultaneous cancers. The authors emphasize the fact that all patients with malignant neoplasms of the digestive tract, especially elderly patients, patients with a positive family history of cancer, smokers, people who systematically use alcohol, as well as patients who have undergone radiotherapy in the past, should be carefully and diligently monitored for the possibility of a synchronous or metachronous malignant neoplasm."
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Bi XR, Zhao SY, Ma YQ, Duan XY, Hu TT, Bi LZ, Cai HY. Multiple primary cancers with gastrointestinal malignant tumors as the first manifestation: Three case reports and review of literature. World J Gastroenterol 2025; 31(8): 100146 [DOI: 10.3748/wjg.v31.i8.100146]
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4
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"1 Ethics: This experimental study was approved by the Experimental Ethics Committee of Xi’an Jiaotong University. The ethical approval form provided by the author meet the requirements.
2 Methods: This animal experimental method effective and proper method following guidelines and histopathology methods.
3 Results: The results true and authentic and significance validated that followed the objectives.
4 Figures and tables: The author provide perfect tables and graphic which is good quality and easily understandable.
5 Biostatistics: Yes, the author provide perfect biostatistics data that complied with standard quality.
6 References: Record the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Zhang MM, Shi AH, Muensterer OJ, Uygun I, Lyu Y, Yan XP. Comparative study of cylindrical vs circular ring magnets for colonic anastomosis in rats. World J Gastrointest Surg 2025; 17(2): 94270 [DOI: 10.4240/wjgs.v17.i2.94270]
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5
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" This study explores the incorporation of human β-defensin-1 (hBD-1) into immunoliposomes as a targeted nanotherapeutic strategy for colon cancer, leveraging its ability to induce autophagy and inhibit tumor proliferation. By integrating anti-EGFR antibodies onto the liposomal surface, the study aims to enhance targeted delivery, stability, and bioavailability of hBD-1, addressing its druggability challenges. This approach is promising, as it aligns with nanotechnology-driven advancements in oncology and represents a potential alternative for improving therapeutic efficacy in colorectal cancer.
The article is well-structured and scientifically sound, presenting a rational framework for utilizing immunoliposomes in cancer therapy. It highlights the limitations of hBD-1 as a therapeutic agent, particularly its poor stability, non-specific distribution, and susceptibility to degradation, and proposes a liposomal delivery system to overcome these challenges. However, while the study introduces an innovative concept, several critical aspects remain underexplored.
One major limitation is the lack of in-depth preclinical validation. Although the study proposes a theoretical model, no experimental data are provided to demonstrate the efficacy of hBD-1 immunoliposomes in vitro or in vivo. The absence of key findings, such as tumor growth inhibition, biodistribution, pharmacokinetics, or toxicity profiles, limits the practical applicability of the proposed system. Future studies should include functional assays, such as cell viability, apoptosis induction, autophagy markers (LC3-II, Beclin-1), and EGFR signaling analysis, to validate the effectiveness of this approach.
Furthermore, the immunoliposome formulation details are not thoroughly discussed. While the concept of conjugating anti-EGFR antibodies to liposomes is well-supported, specific parameters such as antibody-liposome conjugation efficiency, encapsulation stability, and release kinetics are not provided. These factors are crucial for ensuring effective tumor targeting and sustained drug delivery. Addressing these concerns with detailed characterization studies would significantly strengthen the credibility of the proposed system.
From a translational perspective, clinical feasibility and potential toxicity of hBD-1 immunoliposomes remain uncertain. While nanocarriers enhance drug delivery, nanotoxicology and immune system interactions must be carefully assessed. The study acknowledges the need for further research before clinical application, but a clear roadmap for preclinical testing and regulatory considerations is lacking. Future investigations should include in vivo biodistribution studies, immune response evaluation, and large-scale manufacturing feasibility to assess the potential for clinical translation.
In conclusion, this article presents a novel and conceptually strong therapeutic approach by integrating hBD-1 into EGFR-targeted immunoliposomes to enhance colon cancer therapy. However, to strengthen its impact and translational potential, future studies should focus on comprehensive preclinical validation, formulation optimization, and safety assessments. If validated through rigorous experimental studies, this strategy could represent a valuable addition to nanotechnology-based cancer therapeutics."
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Huang Y, Wang XY, Huang JY, Huang ZW. Incorporation of human β-defensin-1 into immunoliposomes to facilitate targeted autophagy therapy of colon carcinoma. World J Clin Oncol 2025; 16(3): 101098 [DOI: 10.5306/wjco.v16.i3.101098]
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6
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" This review provides a comprehensive overview of the molecular landscape of lung cancer diagnosis, targeted therapy, and immunotherapy, highlighting key oncogenic drivers such as EGFR, ALK, ROS1, KRAS, and MET, along with the current state and challenges of PD-1/PD-L1 immune checkpoint blockade. Additionally, the article discusses emerging technologies, including liquid biopsy, ctDNA analysis, multi-omics integration, and artificial intelligence (AI), emphasizing their potential role in precision oncology. The breadth of topics covered makes this review highly relevant to both researchers and clinicians seeking insights into the evolving landscape of lung cancer treatment.
As a review article, the structure is clear, and the content is well-organized, effectively summarizing recent advancements. However, several limitations remain that could be addressed to enhance the scientific rigor and impact of the study. First, while the discussion on targeted therapies across different molecular subtypes is extensive, the article lacks quantitative data from large-scale clinical trials, such as progression-free survival (PFS), overall survival (OS), and objective response rates (ORR) across various treatment strategies. Incorporating such comparative data would significantly strengthen the review’s credibility and practical relevance. Furthermore, although the review touches on immune resistance mechanisms, it does not provide an in-depth exploration of T-cell exhaustion, tumor microenvironment influences, or key immune escape pathways, which are crucial to understanding the limitations of immunotherapy.
In terms of data presentation, the existing tables and figures are informative but primarily descriptive. The review would benefit from more comparative analyses or statistical insights, such as Kaplan-Meier survival curves to illustrate the prognostic differences between molecular subtypes. Additionally, while the discussion on AI and multi-omics is timely and important, it lacks a concrete implementation framework. A more detailed explanation of how AI is being integrated into lung cancer diagnostics and treatment decision-making, along with real-world case studies, would enhance the clarity and applicability of this section.
Overall, this review effectively synthesizes current knowledge on lung cancer molecular diagnostics and therapeutic strategies, making it a valuable resource for both clinicians and researchers. However, to further improve its impact, integrating more quantitative data, refining mechanistic discussions, enhancing data visualization, and providing a clearer outlook on future research directions would elevate its scientific contribution and clinical relevance."
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Xiong Y, Cheng L, Zhou YJ, Ge WH, Qian M, Yang H. Diagnosis and treatment of lung cancer: A molecular perspective. World J Clin Oncol 2025; 16(3): 100361 [DOI: 10.5306/wjco.v16.i3.100361]
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7
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" The article presents a compelling case of a HER2-positive, NRAS-mutant metastatic colorectal cancer (mCRC) patient responding favorably to disitamab vedotin-based therapy, highlighting a potential therapeutic option in an otherwise challenging clinical setting. The well-documented treatment course, including biomarker trends and imaging assessments, provides valuable clinical insights. However, as a single-patient case report, the study's applicability remains limited, and the underlying mechanisms of response warrant further exploration.
Despite the known resistance of RAS-mutant tumors to HER2-targeted therapy, the patient exhibited a significant clinical response, raising important questions about the interplay between HER2 and NRAS signaling. The absence of a mechanistic investigation leaves this aspect unexplored, and future studies should aim to elucidate whether this response is mediated through alternative signaling pathways or compensatory mechanisms. Additionally, while CEA reduction and radiological improvement are promising indicators, the study lacks long-term survival data, such as progression-free survival (PFS) and overall survival (OS), which are crucial for assessing the durability of therapeutic efficacy.
To strengthen the study’s impact, a comparative analysis with similar HER2-positive mCRC cases—especially those with and without NRAS mutations—would provide a broader context for evaluating treatment efficacy. Moreover, integrating functional studies to investigate HER2 signaling dynamics in NRAS-mutant tumors could offer mechanistic insights and support the rationale for targeted therapy combinations. A retrospective or multi-patient case series analysis could also enhance statistical robustness and clinical relevance.
Overall, the article adds value by documenting an exceptional clinical response in a patient subgroup typically considered resistant to HER2 inhibition. However, to maximize its scientific contribution, future research should focus on validating these findings in larger cohorts, exploring resistance and response mechanisms at the molecular level, and providing longer follow-up data to assess treatment durability."
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Yan HC, Liu Y, Feng Y, Li JM, Sheng LM, Chen X, Xie YP, Li N. Efficacy of disitamab vedotin-containing therapy in metastatic colorectal cancer: A case report. World J Clin Oncol 2025; 16(3): 99527 [DOI: 10.5306/wjco.v16.i3.99527]
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8
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"The manuscript is well written, concise, easy to read, without spelling or grammatical errors. The references are updated and the main idea of this article is of a great interest regarding this pathology with a rising incidence and also a higher risk of reccurence, so the sclerobanding is indeed a future therapeutic approach. Thank you. "
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Gravante G. Sclerotherapy for hemorrhoidal disease: Recent evolutions of an oldies goldy. World J Gastroenterol 2025; 31(8): 98704 [DOI: 10.3748/wjg.v31.i8.98704]
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9
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"1. The most frequent complication is pain (in 22–32 % of cases), followed by bleeding (18 %), urinary retention (3 perianal fistula (0.5 %), and abscess (0.04 %). Please comment about complication after sclerotheraphy
2. Various sclerosants have been injected, including aluminum potassium sulfate tannic acid (ALTA),5 % phenol in almond oil,and 1–3 % liquid or foam Lauromacrogol, with 3 % foam proving more effective than 3 % liquid. Please comment about the superiority of polidocanol foam compared to other various sclerosants.
"
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Gravante G. Sclerotherapy for hemorrhoidal disease: Recent evolutions of an oldies goldy. World J Gastroenterol 2025; 31(8): 98704 [DOI: 10.3748/wjg.v31.i8.98704]
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10
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"The study provides valuable insights into the immunosuppressive mechanisms in GC, highlighting the potential role of the CSF3/CSF3R pathway in promoting immune evasion. The use of multiple methodologies, including transcriptome sequencing, immunohistochemistry, and quantitative reverse transcriptase-polymerase chain reaction, strengthens the validity of the findings. The identification of hnRNPH1 as a regulatory factor adds depth to the understanding of CSF3-mediated effects. However, further research is needed to explore the functional implications of these findings and to validate them in larger cohorts."
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Wang L, Wu Q, Zhang ZW, Zhang H, Jin H, Zhou XL, Liu JY, Li D, Liu Y, Fan ZS. Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer. World J Gastrointest Oncol 2025; 17(2): 97858 [DOI: 10.4251/wjgo.v17.i2.97858]
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11
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"The study provides valuable insights into the clinical characteristics and prognosis of pancreatic PNETs. The use of a comprehensive dataset and multiple analytical methods strengthens the validity of the findings. The identification of lymph node metastasis as a key prognostic factor is particularly noteworthy, offering potential targets for improving patient outcomes. However, the study's retrospective nature and limited sample size may affect the generalizability of the results. Further research with larger cohorts and prospective designs is needed to confirm these findings and develop effective treatment strategies."
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He YF, Wang HZ, Hu XD, Liu JQ, Li HM, Wang J, Lu SF. Pancreatic primitive neuroectodermal tumors: Clinical features, treatment, and influencing factors. World J Gastrointest Oncol 2025; 17(2): 97298 [DOI: 10.4251/wjgo.v17.i2.97298]
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12
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"The study provides a comprehensive analysis of cell dynamics across different stages of GC, offering valuable insights into the tumor microenvironment. The use of scRNA-seq, along with qRT-PCR and flow cytometry, strengthens the validity of the findings. The identification of key interactions within the tumor microenvironment and the elevated presence of specific cell types provide potential targets for developing novel therapeutic strategies. However, further research is needed to explore the functional implications of these findings and to validate them in larger cohorts."
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Tang XS, Xu CL, Li N, Zhang JQ, Tang Y. Landscape of four different stages of human gastric cancer revealed by single-cell sequencing. World J Gastrointest Oncol 2025; 17(2): 97125 [DOI: 10.4251/wjgo.v17.i2.97125]
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13
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"The study is comprehensive and provides valuable insights into the role of lncRNA PCAT6 in colonic NEC. The use of multiple methodologies, including immunohistochemistry, RT-qPCR, and western blotting, strengthens the validity of the findings. The identification of PCAT6 as a potential therapeutic target is particularly noteworthy, offering new directions for cancer treatment. However, further experimental validation and exploration of PCAT6's role in other cancer types are necessary to fully understand its therapeutic potential."
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Wang F, Mu HF, Wang C, Tang Y, Si MY, Peng J. LncRNA PCAT6 promotes progression and metastasis of colonic neuroendocrine carcinoma via MAPK pathway. World J Gastrointest Oncol 2025; 17(2): 96230 [DOI: 10.4251/wjgo.v17.i2.96230]
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14
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"The study is comprehensive and provides valuable insights into the prognostic factors affecting gastric carcinoma patients. The use of multiple methodologies, including LASSO regression and Cox regression analyses, strengthens the validity of the findings. The development of a web-based nomogram tool enhances the model's clinical utility, allowing for personalized treatment strategies. However, further validation with larger, multicenter studies is necessary to confirm these findings and improve the generalizability of the results."
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Liang GZ, Li XS, Hu ZH, Xu QJ, Wu F, Wu XL, Lei HK. Development and validation of a nomogram model for predicting overall survival in patients with gastric carcinoma. World J Gastrointest Oncol 2025; 17(2): 95423 [DOI: 10.4251/wjgo.v17.i2.95423]
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15
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"The study is comprehensive and provides valuable insights into the role of inflammatory markers in predicting the prognosis of GIST patients. The use of multiple inflammatory markers and the development of a nomogram model enhance the study's validity and practical application. The identification of MLR and PLR as independent risk factors for GIST recurrence is particularly noteworthy, offering new directions for personalized treatment strategies. However, further validation with larger, multicenter studies is necessary to confirm these findings and improve the generalizability of the results."
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Zhao JL, Wang MY, Lv YZ, Zhou YJ. Prognostic value of inflammatory markers in predicting recurrence-free survival in gastrointestinal stromal tumor patients: A nomogram-based approach. World J Gastrointest Oncol 2025; 17(2): 94956 [DOI: 10.4251/wjgo.v17.i2.94956]
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16
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"The study is comprehensive and provides valuable insights into the role of TMEM106C in various cancers. The use of multiple methodologies, including gene set enrichment analysis, chromatin immunoprecipitation sequencing, and functional assays, strengthens the validity of the findings. The identification of TMEM106C as a potential therapeutic target is particularly noteworthy, offering new directions for cancer treatment. However, further experimental validation and exploration of TMEM106C's role in other cancer types are necessary to fully understand its therapeutic potential."
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Li JD, He RQ, Dang YW, Huang ZG, Xiong DD, Zhang L, Du XF, Chen G. Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(2): 92437 [DOI: 10.4251/wjgo.v17.i2.92437]
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17
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"The article provides a compelling summary of minimal change disease (MCD) in adults and highlights its unique features in the broader context of nephrotic syndrome. The reference to zinc fingers and homeobox transcription factors represents a new perspective in elucidating the pathophysiology of MCD. This innovative approach is significant because previous theories have not adequately elucidated all the clinical features or therapeutic implications of MCD. The report suggests that focusing on these transcription factors may allow for a tailored therapy that could improve treatment options for people with this disease.
The strength of this article is that it recognizes the dynamic nature of MCD research and offers a new perspective that could fill existing gaps in understanding. Nevertheless, it would be beneficial if the article further explored how these molecular discoveries can be applied clinically, including potential indicators or treatment targets.
Ethics: All ethical standards are observed.
Methods: The technique is highly effective, with all relevant text and citations clearly and thoroughly articulated.
The author has included well-organized, clear and informative tables, line charts and graphs that illustrate the results and are carefully annotated.
The author has cited the most recent and relevant references and ensured that the citations are scientifically sound, rational, and consistent with the research objectives and hypotheses.
The language of the article is precise, clear and concise and conveys all information in an easily understandable manner without grammatical or spelling errors.
Limitations: Some minor limitations are evident but do not significantly affect the overall validity or significance of the article."
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Govindarajan KK. Current understanding of adult nephrotic syndrome: Minimal change disease. World J Nephrol 2025; 14(1): 101930 [DOI: 10.5527/wjn.v14.i1.101930]
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18
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"End-stage renal disease (ESRD) marks a critical point in the progression of kidney failure where the kidneys can no longer perform their vital functions and patients must undergo renal replacement therapies such as dialysis or transplantation in order to stay alive. While much attention has been paid to the core aspects of renal failure, the gastrointestinal (GI) symptoms that accompany the disease are one of the most common but under-recognized complications.
The pathophysiology of gastrointestinal symptoms in patients with ESRD is far from simple. A combination of factors such as electrolyte imbalance, fluid overload, toxin accumulation and uremia can wreak havoc on the GI system. The medications used in the treatment of ESRD, as well as the lifestyle and dietary restrictions imposed on patients, also contribute to the problem. As if this were not enough, the therapies used to keep these patients alive — especially dialysis — can exacerbate GI problems. Together, these elements create a perfect storm of gastrointestinal distress, often leading to conditions that can be both debilitating and dangerous.
GI complaints in ESRD can be categorized as upper GI, small intestine and lower GI. Each category is associated with specific, often excruciating symptoms. Upper GI problems such as gastroesophageal reflux disease (GERD), nausea, vomiting and dysmotility are common complaints in patients with ESRD. These problems occur when the esophagus and stomach no longer function properly. This phenomenon is often exacerbated by the accumulation of toxins such as urea in the blood. Therefore, patients with kidney failure are prone to stomach ulcers, bleeding in the upper part of the gastrointestinal tract and even rare complications such as angioectasia — a condition in which abnormal blood vessels form in the gastrointestinal tract and increase the risk of bleeding.
Further down the digestive tract, patients with ESRD also have a number of small bowel and lower GI problems. Irritable bowel syndrome (IBS), constipation and mesenteric ischemia (a condition in which blood flow to the intestines is reduced) are common complaints. Diverticular disease, an age-related condition in which pouches can form and become inflamed in the colon, is also more common in these patients. And in patients undergoing peritoneal dialysis, the complications of peritonitis (infection of the peritoneum) and peritoneal stenosis (narrowing of the abdominal cavity) pose a further challenge for the GI.
The impact of these conditions on the health and well-being of patients with ESRD cannot be overstated. For many, gastrointestinal symptoms are not just a minor inconvenience, but a major factor in the daily struggle with kidney failure. These issues exacerbate the physical burden of dealing with a chronic, life-threatening disease and often lead to malaise, malnutrition and, in some cases, further complications that jeopardize patient outcomes.
Most of the literature on this topic indicates that gastrointestinal symptoms in ESRD patients are under-recognized and under-treated. Although many of these problems are common, they are overshadowed by the immediate and obvious renal problems. There is an urgent need for healthcare providers to take a more holistic approach and proactively treat gastrointestinal symptoms alongside kidney problems. This could include tailored nutritional counseling, more frequent monitoring of gastrointestinal health, and closer examination of the side effects of medications used to treat kidney failure.
In addition, ESRD patients should be made more aware of potential gastrointestinal problems and given resources to manage their symptoms. Such education can encourage patients to seek timely treatment and reduce the stigmatization of gastrointestinal symptoms, which are sometimes simply dismissed as a byproduct of their kidney disease.
In summary, gastrointestinal symptoms in ESRD patients are a complex and often debilitating problem that deserves more attention. From the effects of dialysis to the intricacies of fluid and electrolyte imbalance, the gastrointestinal symptoms faced by these individuals deserve a more comprehensive approach in both clinical care and research. Only by recognizing and addressing these challenges can we hope to improve the quality of life of those embarking on the difficult journey of end-stage renal disease.
The article offers important insights into an aspect of kidney disease that is sometimes overlooked in medical discourse. It promotes a patient-centered treatment strategy and makes an important contribution to the ongoing discourse on improving care for patients with end-stage renal disease.
Ethics: All ethical standards are observed.
Methods: The approach is indeed highly successful, with all relevant text and citations clearly and comprehensively articulated.
Results: The results are indeed substantiated.
The author has supplied well-structured, clear, and instructive tables, line charts, and graphs that elucidate the results and are thoroughly commented.
The author has mentioned the most current and pertinent references, ensuring that the citations are scientifically valid, logical, and consistent with the study questions and hypotheses.
The wording in the article is accurate, straightforward, and succinct, conveying all information in an easily comprehensible manner without any grammatical or spelling issues.
Limitations: Although the results are strong, a few small limitations may be acknowledged; however, these do not substantially undermine the general validity or significance of the study."
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Khan A, Mushtaq M, Movva G, Sohal A, Yang J. Gastrointestinal disease in end-stage renal disease. World J Nephrol 2025; 14(1): 101917 [DOI: 10.5527/wjn.v14.i1.101917]
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19
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"The aging process is an inevitable aspect of life that leads to various changes in the human body. The deterioration of kidney function is a development that can have a profound effect on overall health. As we age, the kidneys' ability to filter waste and control physiological activities decreases, leading to an increased risk of problems. A revealing study from Eskisehir in Turkey attempts to investigate the significant relationship between the filtration rate of the kidneys and the health of older people.
The study examines patients aged 75 years and older admitted to the internal medicine clinic of a tertiary care hospital and highlights the significant impact of kidney function on the quality of life of the elderly. The study uses the Modification of Diet in Renal Disease (MDRD) formula to classify patients' renal filtration rates into six stages to determine kidney health. The aim is not only to investigate the relationship between kidney function and hospitalization rates, but also to understand how this relationship could improve clinical practices and enhance patient care.
This study highlights the complex role of the kidneys in overall health. Kidney disease or impaired kidney function often goes unrecognized until symptoms worsen, especially in older people who are already struggling with other chronic diseases. Detecting and monitoring renal filtration rate in hospitalized elderly patients may allow for more effective therapies, reducing problems and hospitalizations.
Hospitalizations for geriatric patients can be a significant burden — not only on the healthcare system, but also on patients' quality of life. The study underlines the importance of early assessment of kidney function, especially in view of the increasing number of elderly people. Recognizing that impaired kidney function can be associated with increased hospitalization rates and adverse health outcomes could be a critical element in preventative care that could mitigate the severity of diseases such as heart disease, diabetes and hypertension, all of which are related to kidney health.
Nevertheless, the findings underscore the need for a more nuanced approach to treating patients. Although a simple formula such as the MDRD is beneficial for classifying kidney function, it is only one component of the overall assessment. When determining treatment options, it is essential to consider additional aspects such as comorbidities, lifestyle and the specific needs of the patient. The relationship between kidney function and the health of older people is complex and requires a holistic approach for each individual patient.
In addition, the study encourages reflection on how healthcare systems can improve support for aging people. Proactive intervention techniques, regular renal health assessments and tailored care plans are essential to minimize hospitalizations and improve life expectancy and quality of life for older people. This research emphasizes that in old age, one should not only focus on treating symptoms, but on cultivating an environment that allows the elderly to thrive with the support they need.
This work makes an important contribution to the discourse on aging, kidney health and the need for quality healthcare. With an aging global population, this type of research is crucial. Understanding the relationship between kidney function and health outcomes in the elderly is central to improving patient care, informing clinical practice and ensuring that the aging population not only has a long life but also a better quality of life."
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Hamarat H. Glomerular filtration rate and comorbidity factors in elderly hospitalizations. World J Nephrol 2025; 14(1): 98837 [DOI: 10.5527/wjn.v14.i1.98837]
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20
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"It was with pleasure that I reviewed the article quality of the following manuscript.
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The included tables add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate/up-to-date
7 Language: This is a concise/well-written editorial
8 Caveats or drawbacks: None"
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Venkatesan S, Lucke-Wold B. Mind the gut: Navigating the complex landscape of gastroprotection in neurosurgical patients. World J Gastroenterol 2025; 31(8): 102959 [DOI: 10.3748/wjg.v31.i8.102959]
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21
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"Dear Sir,
This is a review that try to review and classify the gastric polyps regarding their malignan potential. The description and the way to study them, which can be sometimes limited due to the actual technology as you stated. More new studies are required to have a more accurate classification, as you stated.
Thank you for letting me review it.
"
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Liao XH, Sun YM, Chen HB. New classification of gastric polyps: An in-depth analysis and critical evaluation. World J Gastroenterol 2025; 31(7): 101467 [DOI: 10.3748/wjg.v31.i7.101467]
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22
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"This study leveraged hospital clinical data to comprehensively evaluate the 5-year overall survival (OS) and disease-free survival (DFS) rates associated with surgical resection and adjuvant therapy, utilizing a Cox model for analysis. The findings provide valuable insights into clinical outcomes and treatment efficacy, making this study highly significant for guiding clinical decision-making and improving patient care."
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Xie QF, Long LS, Luo YY, Lu MT, Ming WK, Zhao LY, Liu H. Long-term survival outcomes of duodenal adenocarcinoma: A cohort study with 15-year single-center experience. World J Gastrointest Surg 2025; 17(2): 101365 [DOI: 10.4240/wjgs.v17.i2.101365]
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23
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"This case underscores the vital importance of conducting a thorough and detailed evaluation for patients presenting with abnormal masses, such as an inguinal mass. Such assessments play a crucial role in identifying and understanding potential metastatic conditions, ultimately contributing to accurate diagnosis, effective treatment, and improved patient outcomes. This case holds significant clinical value."
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Hao JQ, Hu SY, Zhuang ZX, Zhang YJ, Zhang JW, He FJ, Zhuang W, Wang MJ. Distant metastasis in the right inguinal area from gastric cancer: A case report. World J Gastrointest Surg 2025; 17(2): 100244 [DOI: 10.4240/wjgs.v17.i2.100244]
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24
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"Ethics
The ethical approval form provided meets the standard requirements and appropriately addresses the ethical considerations for this study. The compliance with ethical guidelines enhances the credibility of the research.
Methods
The experimental methods are clearly described and appear to be reproducible by fellow researchers. However, additional details regarding [specific steps or techniques] could further strengthen the reliability and replicability of your methods. Please consider providing more in-depth explanations or citing relevant protocols for these steps.
Results
The results are presented in a structured and logical manner. The data supports the proposed hypothesis, and the conclusions drawn are consistent with the findings. Nevertheless, a deeper discussion on how the results relate to existing studies in the field would increase the universal significance of your findings.
Figures and Tables
The figures and tables are well-constructed, clear, and adequately annotated. However, Figure X could benefit from a more detailed legend, particularly explaining [specific aspect]. Improving the contrast in Graph Y might also help readers interpret the data more easily.
Biostatistics
The biostatistical analysis is robust and appropriate for the study objectives. The presentation of statistical tests and p-values is comprehensive. Nonetheless, I recommend clarifying the rationale for using [specific statistical method] to ensure that the choice aligns with the study's design.
References
The references cited are relevant and up-to-date, reflecting the current state of research in this field.
Language
The language is clear, concise, and professional. There are only minor grammatical errors, such as [specific example, if any]. Addressing these will further enhance the readability and quality of the manuscript.
Caveats or Drawbacks
While the study provides significant insights, one notable drawback is [specific limitation]. Acknowledging this in the discussion section and proposing methods to address it in future research would improve the manuscript's overall objectivity and credibility.
Conclusion
Overall, the manuscript presents a valuable contribution to the field. Addressing the mentioned suggestions will improve its quality further. Specifically, I recommend enhancing the discussion of results, refining the figures and tables, and ensuring a balanced citation approach. I look forward to seeing the revised version of this work and its potential impact on the discipline."
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Chen SS, Dong ZB, Xiang HT, Chen ZW, Chen TC, Huang JR, Liang C, Yu WM. Analysis of risk factors for dysphagia in patients after laparoscopic radical gastrectomy. World J Gastrointest Surg 2025; 17(2): 98535 [DOI: 10.4240/wjgs.v17.i2.98535]
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"Gallbladder carcinoma is the most common biliary tree cholangiocarcinoma. It is a relatively unusual, aggressive, lethal malignancy related to poor prognosis. The 5-year overall survival fluctuates between 7% and 20%. GB carcinoma is interwoven with gallstone disease (90%) and specifically with large gallstones (more than 2.5 cm-3 cm) from a long time ago (at least 15-20 years). It is discovered incidentally in removed gallbladder biopsies in half of the cases. Early diagnosis offers a unique therapeutic chance after surgery. Other adjuvant therapies include modern chemotherapy, stereotactic radiotherapy, immunotherapy, vaccines, and targeted gene therapy. Multimodality treatment is required for advanced-stage disease. Thus a prediction model for diagnosis and prognosis is valuable. Several nomograms and radiomics have been developed based on multiple parameters combined with artificial intelligence and algorithms. Artificial intelligence may analyze computerized imaging, while radiomics is a sophisticated method of imaging analysis machine learning. I believe that AI will open new promising horizons regarding precise diagnosis and prognosis for survival and potential recurrence. Early recurrence after radical resection predicts worse prognosis, while therapeutic surgical intervention is impossible in 70% of patients. Thus future research must be focused on this novel innovation.
Congratulations to authors!"
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Mayer NR, Ehrenpreis ED. Modeling post-operative survival in patients with gallbladder cancer resections: The road to improved patient care? World J Gastrointest Surg 2025; 17(2): 101553 [DOI: 10.4240/wjgs.v17.i2.101553]
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26
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"Overall, this article possesses both notable strengths and areas ripe for enhancement. The experimental methodologies are exhaustively described, encompassing processes from tissue chip handling to cell-based assays such as CCK8, transfection, and western blot. These procedures are sufficiently detailed to allow fellow researchers to replicate the experiments. The results appear credible and authenticate the hypothesis that OCT4 influences pancreatic cancer cell behavior. The figures and tables are generally well-structured and clearly convey the data, albeit with some figure legends that could benefit from further elaboration. The biostatistical data seems appropriate, utilizing suitable statistical tests.
However, a significant limitation lies in the absence of a thorough exploration of the clinical implications. Furthermore, the study's generalizability might be constrained due to the utilization of only one cell line (BxPC-3). Additionally, the lack of in-vivo validation represents a notable drawback."
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Pang YY, Chen ZY, Zeng DT, Li DM, Li Q, Huang WY, Li B, Luo JY, Chi BT, Huang Q, Feng ZB, He RQ. Checkpoint kinase 1 in colorectal cancer: Upregulation of expression and promotion of cell proliferation. World J Clin Oncol 2025; 16(3): 101725 [DOI: 10.5306/wjco.v16.i3.101725]
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27
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"Upon evaluating the article, it becomes evident that the author has taken several commendable steps to ensure the ethical integrity of the research, as evidenced by the provided ethical approval, although the inclusion of an approval number would further strengthen transparency. The experimental method described is effective and detailed enough to allow for replication by fellow researchers, which is crucial for the validation of scientific findings. The results presented are credible, partially validating the theory or hypothesis proposed. The figures and tables are well-constructed and annotated, facilitating easy comprehension of the data. Furthermore, the biostatistical analysis adheres to standard practices, ensuring the accuracy of the conclusions drawn. However, despite these strengths, the study has some drawbacks. Notably, the research is somewhat basic, lacking an in-depth exploration of the underlying mechanisms. To enhance the contribution of the study, the author could consider incorporating additional experiments or analyses to delve deeper into these mechanisms. Overall, while the article demonstrates a solid foundation in terms of methodology and results, further development is needed to address the existing gaps and elevate the research to a higher level of significance."
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Li J, Wang ZY, Jin Y, Xu J, Ya YJ, Wan TQ, Li X, Wang X. Transmembrane channel-like 5 drives hepatocellular carcinoma progression by regulating epithelial-mesenchymal transition. World J Clin Oncol 2025; 16(3): 94091 [DOI: 10.5306/wjco.v16.i3.94091]
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28
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"This editorial provides a timely and insightful discussion on how ChatGPT and other AI tools could transform diabetes management. It effectively highlights their potential in patient education, dietary guidance, and clinical decision support while also acknowledging critical ethical and accuracy concerns. The discussion on diabetic retinopathy screening, obesity assessment, and AI-generated treatment recommendations is particularly relevant, showing the growing role of AI in healthcare.
However, some key gaps remain. First, there is no clear evaluation of how well ChatGPT actually performs in diabetes care compared to existing tools or human experts. More studies testing its accuracy and reliability in real-world scenarios are needed. Second, while the paper mentions challenges like data privacy and AI errors, it does not propose specific solutions. Future research should explore ways to fine-tune AI models using diabetes-specific data and ensure medical supervision of AI recommendations. Finally, a broader comparison of ChatGPT with other AI models like Google Bard and Microsoft Bing would add depth to the discussion.
Going forward, research should focus on validating AI tools in clinical practice, ensuring they improve patient outcomes rather than just providing information. More AI models specialized in diabetes could also help make these tools safer and more reliable. Overall, while this editorial is a valuable contribution, it would benefit from a more structured analysis of AI’s real-world effectiveness and ethical safeguards."
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Sridhar GR, Gumpeny L. Prospects and perils of ChatGPT in diabetes. World J Diabetes 2025; 16(3): 98408 [DOI: 10.4239/wjd.v16.i3.98408]
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29
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"Authors studied the role of serum retinol-binding protein (RBP) as a potential biomarker for lower limb atherosclerosis in individuals with type 2 diabetes mellitus (T2DM). RBP, a primary transport protein for vitamin A, has been implicated in metabolic and inflammatory processes, yet its association with diabetes-related vascular complications, particularly lower limb atherosclerosis, remains unclear. Authors reported a linear correlation between RBP levels and lower limb atherosclerosis risk.
The inclusion of 4,428 patients enhances the statistical power and generalizability of the findings. Identification of serum RBP as a biomarker for lower limb atherosclerosis may guide risk stratification and early intervention in T2DM patients.
However, several limitations were notable:
- The absence of follow-up data precludes the assessment of changes in RBP levels over time and their impact on disease progression.
- The study’s retrospective nature limits its ability to establish causal relationships between serum RBP levels and atherosclerosis.
- The study does not explore interactions between RBP and other biomarkers or pathways involved in atherosclerosis.
- Authors did not evaluate interventions to modulate RBP levels or their impact on atherosclerosis risk reduction.
"
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Zhang YL, Peng GL, Leng WL, Lian Y, Cheng LQ, Li X, Wang YL, Zhou L, Long M. Association between serum retinol-binding protein and lower limb atherosclerosis risk in type 2 diabetes mellitus. World J Diabetes 2025; 16(3): 98590 [DOI: 10.4239/wjd.v16.i3.98590]
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30
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"This study identifies key risk factors for diabetic foot (DF) in hospitalized patients with type 2 diabetes and develops a predictive model with strong discrimination (AUC = 0.797). Notably, it reveals a U-shaped relationship between fasting plasma glucose (FPG) and DF and highlights serum albumin as a protective factor. However, the model lacks external validation and is limited to a single-center dataset, raising concerns about generalizability. Missing data on HbA1c and medication use may affect the comprehensiveness of the findings, and further prospective, multicenter studies are needed to confirm causality. Despite these limitations, the study provides valuable insights that could guide early risk assessment and prevention strategies for DF in clinical practice."
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Li MZ, Tang F, Liu YF, Lao JH, Yang Y, Cao J, Song R, Wu P, Wang YB. Risk factors and a predictive model of diabetic foot in hospitalized patients with type 2 diabetes. World J Diabetes 2025; 16(3): 95644 [DOI: 10.4239/wjd.v16.i3.95644]
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31
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"Authors studied the role of LEF1 and related RNAs in the pathogenesis of diabetic retinopathy (DR), focusing on their regulatory effects on endoplasmic reticulum (ER) stress, inflammation, and ferroptosis in retinal cells. By elucidating the molecular mechanisms underlying DR progression, the study aims to identify potential therapeutic targets. Authors found that streptozotocin-induced diabetic rats showed improvement in retinal health with LEF1 knockdown, as observed in reduced retinal damage (via HE staining) and inflammation.
The study relies solely on cellular and animal models, which may not fully replicate human DR pathology. Moreover, impact of LEF1 knockdown on long-term DR progression and retinal function remains unaddressed. In addition, authors identified potential targets, but they did not comment on the feasibility, safety, or efficacy of translating LEF1 knockdown or related interventions into clinical treatments.
Authors focused on GRP78 but did not explore other key players in ER stress pathways, which may also influence DR progression."
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Luo YY, Ba XY, Wang L, Zhang YP, Xu H, Chen PQ, Zhang LB, Han J, Luo H. LEF1 influences diabetic retinopathy and retinal pigment epithelial cell ferroptosis via the miR-495-3p/GRP78 axis through lnc-MGC. World J Diabetes 2025; 16(3): 92003 [DOI: 10.4239/wjd.v16.i3.92003]
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32
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"1. The narration of sequence of events after trauma is not easily understandable. Details regarding presentation and imaging findings can help in better understanding.
2. Was the cause for peritonitis identified during the first surgery?
3. The dense adhesions probably dveeloped after the bowel involvement followed by sepsis which resulted in adhesions which were dense
4. The stoma non functioning was probably due to adhesive bowel obstruction secondary to bands, fibrosis and sequelae.
5. Preventive aspect may include early diagnosis, elimination of sepsis and aggressive lavage to prevent adhesion formation"
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Xu R, Sun LX, Chen Y, Ding C, Zhang M, Chen TF, Kong LY. Stoma occlusion caused by abdominal cocoon after abdominal abscess surgery: A case report. World J Clin Cases 2025; 13(15): 98608 [DOI: 10.12998/wjcc.v13.i15.98608]
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33
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"1. Were other differentials for postop hypoventilation considered? List includes incomplete reversal of neuromuscular blocking agents, opioid use, Acetyl choline esterase deficiency, background respiratory insufficiency, etc
2. Uncommon factors can include multifactorial causes such as viral, drug induced, neuromuscular disorders.
3. Metabolic disorders, storage disorders, late presenting neuropathy / myopathy, acquired progressive musculoskeletal disorders are other disorders to consider in the evaluation.
4. Inclusion of an algorithm / table would enhance the understanding
"
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Park SY, Hong SM, Lee HY, Kim MY, Lee HK, Han JY, Cho HJ, Oh SI, Lee H. Mitochondrial myopathy revealed postoperative acute respiratory failure: A case report. World J Clin Cases 2025; 13(15): 102691 [DOI: 10.12998/wjcc.v13.i15.102691]
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34
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"There are many causes of acute pancreatitis, but the three major causes are alcohol-related, biliary tract disease, and idiopathic pancreatitis of unknown etiology. In Japan, these account for 20.4%, 26.6%, and 40.0% of cases, respectively.5) Other causes are rare, and the proportion of cases caused by hyperparathyroidism is also extremely low. The mechanism by which primary hyperparathyroidism causes acute pancreatitis is as follows: 1. Hypercalcemia causes pancreatic stones to form in the pancreatic duct, causing blockage, and the pancreas becomes inflamed. 1. The theory that high calcium ions promote the activation of intrapancreatic trypsinogen to trypsin, which causes pancreatitis. 2. The theory that high calcium ions promote the activation of intrapancreatic trypsinogen to trypsin, which causes pancreatitis. 3. The theory that excessive secretion of parathyroid hormone directly causes pancreatitis. However, none of these theories can explain everything, Especially during pregnancy., How old were the patients in question? Which of the above mechanisms is most likely to cause pancreatitis?
"
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Luong TV, Le LD, Nguyen NVD, Dang HNN. Persistent challenges in the diagnosis of acute pancreatitis due to primary hyperparathyroidism during pregnancy. World J Gastroenterol 2025; 31(7): 100973 [DOI: 10.3748/wjg.v31.i7.100973]
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35
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"Thank you for the opportunity of appraising the quality of the following manuscript:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The tables/figures add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The included references are appropriate and up to date
7 Language: This is a concise/well-written review
8 Caveats or drawbacks: None
"
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Liao XH, Sun YM, Chen HB. New classification of gastric polyps: An in-depth analysis and critical evaluation. World J Gastroenterol 2025; 31(7): 101467 [DOI: 10.3748/wjg.v31.i7.101467]
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36
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"Important study, but a little bit general and not very distinctive. I would have tried to find time ranges and limits within which treatments of specific kinds in particular populations with regard to the etiology of the obstruction would have given best results, and types and rates of morbidities that would be expected at any time point. This gives a good guide to the clinician to choose the best approach in different conditions."
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Gembillo G, Spadaro G, Santoro D. Link between obstructive uropathy and acute kidney injury. World J Nephrol 2025; 14(1): 99120 [DOI: 10.5527/wjn.v14.i1.99120]
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37
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"Pancreatic primitive neuroectodermal tumors: Clinical features, treatment, and influencing factors
World J Gastrointest Oncol 2025; 17(2): 97298
[DOI: 10.4251/wjgo.v17.i2.97298]
The topic of this manuscript is crucial to the readers of this journal and those interested in pancreatic tumours. However, I have a few comments to the authors
The paper is not clearly written, The abstract aim is not consistent with the methods. You need to explain why you searched the literature if you have mentioned the aim to analyse 30 patients. Later, I realised that this was a mini literature review. The authors must very early state that this is a mini-review of the literature, and when you refer to 30 patients, you must state that 30 patients were reported in the literature as case reports. The title should also indicate that it is a mini-review. It cannot fulfil the criteria of a Systematic Review.
You should, in the introduction, show a comparison between pancreatic neuroendocrine tumours and primary neuroectodermal tumours of the pancreas. The inclusion of the Ewings tumours in the table is not well justified and can be debated. These two cases should have been excluded.
Also, I have concern about the number given for PRESPERO registration it is not functioning and typing the tumour type also does not show your protocol or any related matters.
The aims and the methods section should state that this is a mini-review, The country of each case should be stated in the table. The language of the manuscript needs editing.
"
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He YF, Wang HZ, Hu XD, Liu JQ, Li HM, Wang J, Lu SF. Pancreatic primitive neuroectodermal tumors: Clinical features, treatment, and influencing factors. World J Gastrointest Oncol 2025; 17(2): 97298 [DOI: 10.4251/wjgo.v17.i2.97298]
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38
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"Prognostic value of inflammatory markers in predicting recurrence-free survival in gastrointestinal stromal tumor patients: A nomogram-based approach
World J Gastrointest Oncol 2025; 17(2): 94956
[DOI: 10.4251/wjgo.v17.i2.94956]
I congratulate the authors on publishing the above-titled manuscript. The authors are targeting an important research question in gastrointestinal oncology, and they used several biomarkers to provide an answer to their research question. I have three comments-
1. Introduction- The justification from the literature for selecting the inflammatory-driven tumourigenesis / biomarkers should have been explained in-depth, showing the scientific grounds for selecting each and their accuracy, sensitivity, specificity, PPV, and NPP as per published studies.
The statement, " and in other malignant diseases," needs a reference.
2. More details in the method section under Blood Sample and analysis should be provided. Only Ref 11 was given. Methods of measurement should be stated.
3.It would be ideal to compare this method with another method published in the literature. However, maybe in a retrospective study, such a comparison is difficult. If the authors plan for another non-retrospective, they may compare this method with a method published in the literature and compare the parameters for each. "
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Zhao JL, Wang MY, Lv YZ, Zhou YJ. Prognostic value of inflammatory markers in predicting recurrence-free survival in gastrointestinal stromal tumor patients: A nomogram-based approach. World J Gastrointest Oncol 2025; 17(2): 94956 [DOI: 10.4251/wjgo.v17.i2.94956]
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39
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"1. Why was the child formula fed? Was it formula / cow milk?
2. Did the child have any abnormal facies on examination?
3. Esoinophils can be expressed as part of the differential count or absolute eosinophil count for better understanding
4. The history taking to include the type / volume / nature of feeds as a routine
5. Learning point also can include feeding which can aid in the diagnosis, especially in atypical clinical features not co relating with the overall suspicion and diagnosis"
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Jiang HH, Tang Q, Huang L, Yun X, Shan QW, Chen XQ. Severe upper gastrointestinal hemorrhage due to milk protein allergy: A case report. World J Clin Cases 2025; 13(14): 104039 [DOI: 10.12998/wjcc.v13.i14.104039]
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40
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"1. In the history, "tender lymphadenopathy with draining lymph nodes" points to atypical features not fitting with the picture of Inflammatory Bowel Disease
2. Atypical history combined with non classical scopy findings probably to raise suspicion and point to a different diagnosis
3. The occupation is not mentioned. It may be relevant, given the final diagnosis.
4. Marital status is probably another indirect clue.
5. The history to consider inclution of the above relevant details to avoid misdiagnosis
"
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Khoury KM, Jradi A, Karam K, Fiani E. Lymphogranuloma venereum proctosigmoiditis misdiagnosed as inflammatory bowel disease: A case report. World J Clin Cases 2025; 13(14): 102791 [DOI: 10.12998/wjcc.v13.i14.102791]
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41
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"1. The title can include recipient extubation for clarity
2. The operating time appears to be different for both the groups. Did prolonged surgical time have a bearing on extubation?
3. Diffcult anatomy / reconstruction - was it given consideration during the analysis?
4. Was the surgeon factor considered across the groups - senior / junior?
5. What about the anesthesia team - was it the same across the groups?
6. Limiting factors - non randomisation / surgeon / anesthetist factors"
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Jeon S, Lim DG, Kim H, You SB, Kim HJ, Yoon JP, Yang K, Park SJ, Ri HS. Relevant clinical factors for early extubation in living-donor liver transplantation: A single-center retrospective cohort study. World J Clin Cases 2025; 13(14): 102693 [DOI: 10.12998/wjcc.v13.i14.102693]
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42
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"Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma
World J Gastrointest Oncol 2025; 17(2): 92437 [DOI:10.4251/wjgo.v17.i2.92437]
I congratulate the authors on publishing the above-titled manuscript. The authors are targeting an important research question, and they used several tools to provide an answer from the 34 cancers they tested, including hepatocellular carcinoma. I have three comments-
The title is not clear - "From pan-cancers to hepatocellular carcinoma"- it showed be instead testing 34 cancers, including hepatocellular carcinoma". We use "pan-cancer analysis", not from ..to, as stated.
These 34 cancers should be stated in the introduction or the methods. I see some mentioned in the note under Figures 1 and 2. Informing the readers about them early is crucial. also, why they were selected.
There is a bias in selecting references. Nearly most references (total 37) are by Chinese authors, may be you need to look into the broader English literature and include references from the USA, the UK, Canada, Europe, Japan, South Korea, Australia and New Zealand. Thank you."
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Li JD, He RQ, Dang YW, Huang ZG, Xiong DD, Zhang L, Du XF, Chen G. Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(2): 92437 [DOI: 10.4251/wjgo.v17.i2.92437]
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43
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"Cost-effective treatment strategies for liver fibrosis/cirrhosis are limited. Many clinical trials have shown that stem cells might be a potential therapeutic approach here. This study presented the first bibliometric analysis of stem cell therapy for liver fibrosis/cirrhosis. This is useful information for future research on problems and trends in stem cell therapy for liver fibrosis/cirrhosis.
"
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Zhu WY, Li X, Xie JL, Lu Q, Ma YJ, Zhu ZJ, Liu J. Hotspots and trends in stem cell therapy for liver fibrosis and cirrhosis: A bibliometric analysis. World J Hepatol 2025; 17(1): 96105 [PMID: PMC11736489 DOI: 10.4254/wjh.v17.i1.96105]
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44
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"Fecal transplantation appears to be effective for refractory Crohn's disease, but please mention the intestinal flora before and after the procedure, and the short-chain fatty acids lactic acid, butyric acid, and acetic acid. Also, please describe contraindications for fecal transplantation for refractory Crohn's disease.How long do the effects of fecal transplants last?"
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Ozbey D, Saribas S, Kocazeybek B. Gut microbiota in Crohn’s disease pathogenesis. World J Gastroenterol 2025; 31(6): 101266 [DOI: 10.3748/wjg.v31.i6.101266]
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45
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"1 Ethics: Yes, the ethical approval form provided by the author that meets the requirements
2 Methods: Experimental method effective and well described by authors
3 Results: Yes, the results true and authentic. it is validated very well.
4 Figures and tables: Good quality and well constructive
5 Biostatistics: Yes, validated and perfect biostatistics data
6 References: Recent and relevant to the topic
7 Language: Good quality of language in article correctly, clearly and concisely without any grammatical and spelling mistakes.
8 Caveats or drawbacks: No obsvious caveats or drawbacks for the results noted"
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Ba MQ, Zheng WL, Zhang YL, Zhang LL, Chen JJ, Ma J, Huang JL. Construction of a nomogram prediction model for early postoperative stoma complications of colorectal cancer. World J Gastrointest Surg 2025; 17(1): 100547 [PMID: PMC11757204 DOI: 10.4240/wjgs.v17.i1.100547]
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46
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"1 Ethics: Yes, the ethical approval form provided by the author that meets the requirements
2 Methods: Experimental method effective and well described by authors
3 Results: Yes, the results true and authentic. it is validated very well.
4 Figures and tables: Good quality and well constructive
5 Biostatistics: Yes, validated and perfect biostatistics data
6 References: Recent and relevant to the topic
7 Language: Good quality of language in article correctly, clearly and concisely without any grammatical and spelling mistakes.
8 Caveats or drawbacks: No obsvious caveats or drawbacks for the results noted"
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Ling YT, Yao F, Li SJ, Cao CX, Chen ZW, Qiu M, Li BZ, Hu BW, Zhong SY, Hu GL, Li JH. Microbiota in patients with cefuroxime resistance and anal fistula revealed by 16S ribosomal DNA. World J Gastrointest Surg 2025; 17(1): 100790 [PMID: 39872785 DOI: 10.4240/wjgs.v17.i1.100790]
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47
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"1 Ethics: Not applicable
2 Methods: Not applicable
3 Results: Not applicable
4 Figures and tables: Good quality and constructive
5 Biostatistics: No applicable
6 References: Recent and relevant to the topic
7 Language: The language in article correctly, clearly and concisely accordingly. No obvious grammatical and spelling mistakes?
8 Caveats or drawbacks: No caveats or drawbacks"
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Li MY, Han Z, Wang H, Wang YY, Zhao ZR. Multiple jejunal diverticula with repeated gastrointestinal bleeding: A case report. World J Gastrointest Surg 2025; 17(1): 101623 [PMID: PMC11757187 DOI: 10.4240/wjgs.v17.i1.101623]
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48
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"1. What about urine VMA / metanephrine levels?
2. What were the sonography findings?
3. What were the differential diagnosis based on the clinical and imaging findings?
4. Was a MIBG scan considered in the evaluation?
5. What was the Blood Pressure on examination?
6. What were the histopathology findings? The same can be described. A relevant photomicrograph can be included for better understanding and educational purpose."
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Zhou JL, Xie F. Precision en-bloc retroperitoneal paraganglioma resection performed laparoscopically: A case report. World J Clin Cases 2025; 13(12): 98721 [DOI: 10.12998/wjcc.v13.i12.98721]
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49
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"1. Did the pain abdomen relate to the food type? Was the pain increased or decreased after intake of different foods like solid / liquid?
2. Any ball rolling movements in the upper abdomen reported in history. On examination any visible gastric peristalsis noted? With air instillation through nasogastric tube or large bolus fluid intake examination for visible gastric peristalsis can be looked for.
3. A calibre change of the duodenum between D1 / D2 or other parts of duodenum would help in suspecting the web .
4. Differentials include stenosis / stricture / duodenal duplication / intraluminal mass"
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Chen KQ, Jiang WQ, Li XR. Diagnostic value of upper gastrointestinal imaging for duodenal webbing in adults: A case report. World J Clin Cases 2025; 13(12): 101443 [DOI: 10.12998/wjcc.v13.i12.101443]
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50
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"1. Both rehabilitation and palliation are actually two sides of the same coin in cancer care. Tailoring them to the individual needs of the patient is not a simple task
2. Physical, mental and social issues as discussed require to be identified, evaluated by the interdisciplinary team keeping the individual needs in focus.
3. Holistic approach with integration of spiritual needs requires consideration
4. Charts / algorithms would help in better understanding"
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Swarnakar R, Yadav SL. Integration of rehabilitation and palliative care in cancer management: A futuristic model. World J Clin Cases 2025; 13(12): 102326 [DOI: 10.12998/wjcc.v13.i12.102326]
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