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1
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"This Letter to the Editor highlights the importance of monitoring ocular health as a warning sign for leukemia in pediatric patients. It is a concise yet well-written paper, accompanied by a figure summarizing the clinical, diagnostic, and therapeutic flowchart. The references are very recent and in a sufficient number. In my opinion could be very useful for other clinicians to discover promptly leukemia. "
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Ghosh D. Letter to the Editor: Eye as a window to disease burden in pediatric acute leukemia. World J Exp Med 2026; 16(2): 119334 [PMID: 42394785 DOI: 10.5493/wjem.v16.i2.119334]
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2
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"In this manuscript, the authors concluded that phytosterols are a compelling example of multifunctional dietary bioactives with established cardiometabolic utility and prospective, albeit emerging, applications beyond lipid lowering. The authors have illustrated two figures and one table to explain their review, but Figure 1 seems unclear. The explanation of future perspectives is a good point."
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Mohamed D, Ramadan AA, Mabrok HB, Hamed I. Phytosterols in human health: Biochemical mechanisms of action and disease-modulating effects. World J Biol Chem 2026; 17(2): 121685 [PMID: 42273523 DOI: 10.4331/wjbc.v17.i2.121685]
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3
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"The authors reported that measured cell recovery probabilities, phenotype misclassification rates, locus- and cell-type-specific dropout and stutter models, quantified contamination and drop-in rates, validated minimum cell counts for consensus formation, and specified database-upload requirements should all be required for casework submission. It should also demand a clear separation of sub-source reporting and activity-level assertions. If such prerequisites are met, single-cell typing can supplement, rather than replace, bulk STR analysis and probabilistic genotyping in a small but significant number of high-value forensic instances.
The manuscript is just a review, and it is so interesting."
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Evangelou K, Angeli P, Polydorou A, Petropoulou T. Single-cell deoxyribonucleic acid typing for forensic mixtures and trace evidence: Opportunities, validation requirements, and reporting limits. World J Biol Chem 2026; 17(2): 121467 [PMID: 42273528 DOI: 10.4331/wjbc.v17.i2.121467]
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4
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"The review clarified the HBV reactivation process. Following treatment for HBV-related HCC, the effect of immune-based methods and the antivirals lamivudine, entecavir, tenofovir alafenamide, and tenofovir disoproxil fumarate on reactivation was investigated. This review suggests comparing the genome/proteome of blood from overt and relapsed HCC-related chronic HBV patients. This facilitates recognizing the lingering genetic/epigenetic profiles of HBV-resistant variants, allowing for more precise selection of the optimal antiviral treatment and eliminating the potential of viral reactivation."
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Abdulrahman MS, Aboelmagd O, Zhang Y, Zaky S, Johar D. Precore/core mutation relatedness to viral reactivation in patients undergoing targeted therapy for hepatitis B virus-related hepatocellular carcinoma. World J Biol Chem 2026; 17(2): 120297 [PMID: 42273524 DOI: 10.4331/wjbc.v17.i2.120297]
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5
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"The text is an excellently written mini-review that does not need methods or results. Figure 1 illustrates the significance of TREM2-induced activation of pancreatic macrophages in obesity and its metabolic implications. However, at least one more figure is necessary to demonstrate TREM2 ligand identification and signal transduction. All references are essential, and the language is appropriate.
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Zhang AY, Xie CY, Song X, Guo ZH, Shi YR, Wang SY, Yang GH, Liu Y, Xu TC. Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk: Key regulator of obesity pathophysiology and metabolic dysregulation. World J Biol Chem 2026; 17(2): 118705 [PMID: 42273525 DOI: 10.4331/wjbc.v17.i2.118705]
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6
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Awadallah M, Ton L, Thoguluva Chandrasekar V, Yap JEL, Vega KJ. Ascending colon toothpick impaction identified during screening colonoscopy: A case report. World J Clin Cases 2026; 14(19): 121345 [DOI: 10.12998/wjcc.121345]
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7
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"The authors Sharma and Patial, in their study entitled “Protective effects of kaempferol against diet-induced metabolic disorder," which was published in the World Journal of Hepatology 2026, 18(6) [1], stressed the findings of Nair et al. that kaempferol is a significant medication for diet-induced obesity and hepatic steatosis in mice[2]. This interesting study is limited in its experimental findings and focuses specifically on a diet that is restricted to Indian people. The title of the study and the abstract did not mention that this study is an experimental study or mini-review or a letter to the editor. The selection of C57BL/6 mice as an experimental model for studying the effect of kaempferol on hepatic lipids is misleading because this strain of animal is resistant to the medications, has a tendency to drink alcoholic beverages and is susceptible to morphine addiction. The authors did not mention the constituents of the Indian diet or the differences in the prevalence of MASLD between Indian people and people in other countries to claim that the Indian diet is the pathological cause for MASLD. The pharmacokinetics of kaempferol indicate that this natural antioxidant needs specific formulation to produce its effect, and there is no evidence that kaempferol reduces hepatic lipids. These points need to be considered in assessing the article to avoid many pitfalls that limit the importance of the study.
References
[1] Sharma V, Patial V. Protective effects of kempferol against diet-induced metabolic disorder World J Hepatol 2026; 18 (6)
[2] Nair B, Gopalakrishna R, Nath LR. Kaempferol attenuates diet-induced obesity and hepatic steatosis in C57BL/6J mice fed an Indian diet mimicking regimen. World J Hepatol 2026; 18: 115659
Dr. Marwan S. Al-Nimer
Emeritus Professor
Department of Clinical Pharmacology and Therapeutics
College of Medicine, University of Diyala, 32001 Baqubah, Iraq
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Sharma V, Patial V. Protective effects of kaempferol against diet-induced metabolic disorders. World J Hepatol 2026; 18(6): 120789 [DOI: 10.4254/wjh.120789]
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8
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"Dear Authors,
This study develops a rat model of chronic radiation proctitis using single-dose irradiation and follows disease progression with serial endoscopy, histopathology, fibrosis assessment, VEGF staining, and cytoskeletal protein analysis. The results suggest that 20–35 Gy induces persistent mucosal injury, telangiectasia, fibrosis, and chronic rectal damage, whereas lower doses allow recovery. The longitudinal endoscopic monitoring and blinded scoring increase the credibility of the model. Future studies may strengthen these findings by including fractionated irradiation protocols, validating the model in independent cohorts, and clarifying whether early α-tubulin loss is a causal mechanism or a predictive marker of chronic radiation injury."
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Chang Y, Sun R, Juan W, Xu Z, Xu HY, Zen K, Xuan J. Establishment of a standardized rat model of chronic radiation proctitis and preliminary evaluation of its association with tubulin. World J Gastroenterol 2026; 32(26): 118923 [DOI: 10.3748/wjg.v32.i26.118923]
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9
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"Dear Authors,
This study investigates CDK5 expression in gastric neuroendocrine carcinoma through immunohistochemical evaluation, survival analysis, and functional cell-line experiments. The association of high CDK5 expression with advanced tumor features, higher Ki-67 index, poorer survival, and independent adverse prognostic value suggests a possible role of CDK5 in aggressive GNEC biology. The blinded pathological assessment and multivariable analysis enhance the credibility of the results. The conclusions could be further strengthened by validation in larger multicenter cohorts and by additional pathway-level studies explaining the biological basis of CDK5 activity, particularly the different effects observed in knockdown and overexpression experiments. These future approaches may clarify whether CDK5 serves only as a prognostic marker or may also represent a therapeutic target in GNEC."
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Sun YQ, Su J, Ye KN, Chen QX, Kang EZ, Lv CB, Lian MQ, Zeng WM, Zhang YB, Cai LS. High cyclin-dependent kinase 5 expression promotes tumor progression in gastric neuroendocrine carcinoma. World J Gastroenterol 2026; 32(26): 119574 [DOI: 10.3748/wjg.v32.i26.119574]
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10
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"Fragos et al. presented a case on CSS with hypothyroidism and dyslipidemia. Such a rare case is very important for clinical practice. The case report is presented according to CHECK criteria, thoroughly and well-documented. The content is easily readable and clear, English is correct. The discussion is fruitful, the conclusions have arisen from the presented text. The future perspective are presented. The references are updated.
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Fragos MN, Toulia I, Grammatikopoulou MG, Savvidou P, Taiganidis I, Zissiadis P, Antachopoulos C, Goulis DG, Tsiroukidou K. De novo ARID1A Coffin-Siris syndrome with hypothyroidism and dyslipidemia: A case report and literature review. World J Clin Cases 2026; 14(19): 120716 [DOI: 10.12998/wjcc.120716]
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"This retrospective study addresses a clinically relevant question—whether long-term outcomes after endoscopic strictuotomy for small bowel strictures differ by etiology and whether a simple biomarker can aid risk stratification. The scientific quality is above average, with several methodological strengths, though important limitations temper the conclusions.
1. The study fully meets ethical standards, with IRB approval and informed consent documented. The methodology is clearly described and reproducible, including well-defined eligibility criteria, a patient flowchart, and detailed procedural specifications. However, key unresolved issues weaken internal validity: the lack of standardized post-procedural medical therapy (especially biologics in Crohn's patients) introduces a major confounder; strictures were classified as fibrosis-dominant based on imaging and endoscopy alone without histopathological confirmation; and reintervention decisions relied on symptom recurrence rather than a validated scoring system, introducing subjectivity.
2. The results are authentic and statistically robust. Tables and figures are well-constructed, though endoscopic images could benefit from annotations. Statistical methods are rigorous: a parsimonious multivariable Cox model avoided overfitting, maximally selected log-rank statistics objectively determined the NLR cutoff, and collinearity was properly managed. Nonetheless, gaps remain—no formal power calculation, no sensitivity analyses, and no interaction test between etiology and NLR to assess whether the biomarker's prognostic value differs between groups.
3. References are comprehensive, current, and relevant.
4. The authors have honestly acknowledged several limitations, including the single-center design, modest sample size, residual confounding, and subjective outcome definition. However, other critical issues remain unresolved: heterogeneity within the non-Crohn's group (radiation, NSAID, ischemic, CMUSE) is unexplored; histopathological fibrosis confirmation is lacking; post-procedural medical protocols are not standardized; and only baseline NLR was assessed.
To address these gaps, future studies should incorporate objective fibrosis assessment (EUS, CLE, or STAR histopathological scoring), enroll larger cohorts for subgroup analyses and interaction testing, use validated symptom scores for reintervention definition, and measure NLR longitudinally. A formal sample size calculation based on the effect sizes observed here would strengthen future prospective, multicenter study designs.
In summary, this study makes a valuable contribution by providing etiology-stratified outcome data and identifying NLR as a practical prognostic marker. The findings suggest that non-Crohn's patients with low NLR are the best candidates for endoscopic strictuotomy, while Crohn's patients with elevated NLR may need intensified medical therapy or earlier surgery. Despite its limitations, the study is methodologically sound and advances the field. "
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Lai WC, Feng XM, Huang ZH, Jiang ZM, Sun T, Yin X, Zhang L, Ning SB, Li BR. Balloon-assisted endoscopic stricturotomy for small bowel fibrostenotic strictures: A comparison of Crohn’s disease-related and non-Crohn’s disease strictures. World J Gastroenterol 2026; 32(26): 118889 [DOI: 10.3748/wjg.118889]
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12
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"Colorectal cancer (CRC) is currently one of the most important causes of morbidity and mortality in all parts of the world. It is very important that the shift in its occurrence to younger ages concerns not only developed but also developing countries. According to other epidemiological data, the incidence of this neoplasm is expected to increase over the next two decades despite the availability of the most effective treatment methods. Preventive screening of the asymptomatic population, aimed at early detection, remains the cornerstone of efforts to increase five-year survival rates. Although in all developed countries preventive screening programs are implemented with varying effectiveness, mainly through colonoscopy, the situation is different in developing countries. The limited resources available for health promotion, socioeconomic disparities, and other factors necessitate the development of a cost-effective screening program tailored to these specific conditions. In these countries, priority should be given to primary screening methods, such as fecal hemoglobin detection, which, if positive, should be followed by colonoscopy. The identification of high-risk groups for mandatory colonoscopy is imperative, in combination with efforts to reduce the influence of other environmental factors (mainly dietary) on carcinogenesis. The review by Wu et al. emphasizes the need to develop optimized risk-stratification algorithms in these countries, as an adaptive, organized screening framework can deliver optimal population-level benefits while increasing residents' willingness to undergo colonoscopy."
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Wu YP, Chen M, Wang L. Current colorectal cancer screening in developing countries: Identifying optimal approaches. World J Gastroenterol 2026; 32(26): 118151 [DOI: 10.3748/wjg.118151]
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13
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"This is a well-written and prezented rarely case report about " Pancreatic Schwannoma". Schwannoma can occur anywhere in the body. Pancreatic schwannoma (PS) is an extremly rare mesenchymal tumor.
Technological advancements in cross-sectional imaging such as ultrasonography (USG), computed tomography (CT), and magnetic resonance imaging (MRI), and their increased use have made incidental pancreatic tumors more frequently detectable.
Pancreatic schwannoma is one of these tumors and should be considered in the differential diagnosis.
This manuscript gives additional new knowledge to the existing literature. I think that this manuscript is suitable and worth to be published in the World Journal of Gastrointestinal Surgery."
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Xu SM, Qiu LY. Incidental schwannoma of the pancreatic tail mimicking a solid pseudopapillary tumor: A case report. World J Gastrointest Surg 2026; 18(6): 119246 [DOI: 10.4240/wjgs.119246]
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14
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"This paper explains the immune evasion mechanisms of gastric cancer by integrating spatial structure, metabolic reorganization, microbial interactions, and molecular subtypes. By synthesizing cutting-edge insights derived from spatial transcriptomics, single-cell data, and clinical trials, it presents a comprehensive framework advancing toward ecosystem-level precision immuno-oncology and the development of next-generation biomarkers."
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Yao ZY, Ma LJ, Han ZX, Ji GJ. Evolving landscape of the gastric cancer immune microenvironment: From spatial architecture to precision biomarkers. World J Gastrointest Oncol 2026; 18(6): 119114 [DOI: 10.4251/wjgo.v18.i6.119114]
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15
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"This study presents clinically significant and clear evidence by analyzing 38 cases of non-R0 resected rectal neuroendocrine tumors through long-term follow-up. The consistent absence of residual tumor cells after salvage surgery and during the follow-up period supports the conclusion that salvage surgery may be unnecessary. This study supports conservative treatment by integrating pathological findings, treatment outcomes, and the context of clinical guidelines."
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Lin SY, Li ZH, Xu GL, Weng J, Bai KH. Is salvage surgery necessary for non-R0 endoscopic resection of small rectal neuroendocrine tumors? World J Gastrointest Oncol 2026; 18(6): 118531 [DOI: 10.4251/wjgo.v18.i6.118531]
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16
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"This paper comprehensively presents longitudinal, mechanistic, and immunological evidence to re-establish CD24 as a dynamic regulator of liver cancer development rather than a static biomarker. By integrating animal models, human cohorts, immune checkpoint biology, and spatial single-cell analysis, it provides a comprehensive framework highlighting the diagnostic potential and therapeutic importance of CD24 for hepatocellular carcinoma."
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Ren LN, Liu C, Jin CQ, Zhang XH. From association to intervention: Rethinking CD24’s causal role in hepatocellular carcinogenesis. World J Gastrointest Oncol 2026; 18(6): 117434 [DOI: 10.4251/wjgo.v18.i6.117434]
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17
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"This study provides clear mechanistic insights by demonstrating consistent transcriptional activation of apoptosis-related genes and inhibition of proliferation regulators in gastric and colorectal cancer cells. Through a comparative evaluation including combination therapy with Stolax oil and boron compounds, we present novel comparative data and highlight the synergistic anticancer potential supported by consistent gene expression patterns."
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Er Urganci B, Çakal S, Dogan C, Göçmen S, Şimşek S, Yılmaz S. Storax oil and boron compounds trigger apoptosis and cell cycle arrest in gastric and colorectal cancer. World J Gastrointest Oncol 2026; 18(6): 117252 [DOI: 10.4251/wjgo.v18.i6.117252]
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18
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"This paper synthesizes recent research findings to emphasize that the MAZ/UHRF1/ECRG4 axis is a major mechanism of colorectal cancer metastasis. Through an integrated analysis of transcription, epigenetics, and tumor suppressor gene biology, it clearly explains the mechanisms by which this pathway promotes epithelial-mesenchymal transition and invasion. Furthermore, it effectively presents the potential for developing therapies targeting this regulatory mechanism and their clinical applicability."
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Kunz EM, Schoeller III RJ, Carroll JP, Lucke-Wold B. Translational implications of the MAZ/UHRF1/ECRG4 axis in metastatic colorectal carcinoma. World J Gastrointest Oncol 2026; 18(6): 116858 [DOI: 10.4251/wjgo.v18.i6.116858]
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19
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"This study identified CBX2/CBX7 as potential causative genes for salivary gland cancer by integrating a publicly available transcriptome dataset with functional in vitro analysis. We presented a multilayered approach combining differentially expressed genes, whole-genome sequencing, protein interactions, and pathway analysis, and preliminary mechanism experimental results support their involvement in cell cycle regulation and tumor progression."
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Huang YH, Liu XL, Yang Z. Evaluating the efficacy of interventional hepatocellular carcinoma via dynamic contrast-enhanced magnetic resonance imaging: A retrospective study. World J Gastrointest Oncol 2026; 18(6): 116770 [DOI: 10.4251/wjgo.v18.i6.116770]
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20
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Milionis C, Zoumakis E, Ilias I. Letter to the Editor: Endocrine determinants of diabetic ketoacidosis outcomes in type 2 diabetes and insights into Gymnema sylvestre actions. World J Exp Med 2026; 16(2): 121192 [PMID: 42394775 DOI: 10.5493/wjem.v16.i2.121192]
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21
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Desai R, Patel D, Prasad A, Mandalapu N, Nagarajan J, Guddeti A, Khatri S, Shahnawaz W, Aleem A, Mohammed AS, Yasmeen U, Ghani MU. Genetic and biological determinants of pulmonary embolism: Insights from Mendelian randomization studies. World J Exp Med 2026; 16(2): 121046 [PMID: 42394776 DOI: 10.5493/wjem.v16.i2.121046]
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22
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Savvidis C, Thomopoulos C, Ilias I. Melatonin supplementation, hyperprolactinemia, and incident heart failure: A proposed prolactin-mediated pathway for cardiovascular risk. World J Exp Med 2026; 16(2): 120754 [PMID: 42394777 DOI: 10.5493/wjem.v16.i2.120754]
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23
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Khalil MAM, Sadagah NM, Mahmood HHK, Alrowaie F, Almansour AM, Alghamdi RMH, Alghamdi L, A Al-Ghamdi R, Elgadi A, Al-Qurashi SH. Forgotten compartment: Impact of tubulointerstitial inflammation and damage on renal outcomes in lupus nephritis from Saudi Arabia. World J Exp Med 2026; 16(2): 119440 [PMID: 42394784 DOI: 10.5493/wjem.v16.i2.119440]
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24
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Ghosh D. Letter to the Editor: Eye as a window to disease burden in pediatric acute leukemia. World J Exp Med 2026; 16(2): 119334 [PMID: 42394785 DOI: 10.5493/wjem.v16.i2.119334]
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25
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Pandey S, Aravaanan ASK, Bhaskar E, Silambanan S. Detection of intracellular bacterial communities and biofilms in urinary tract infections with Escherichia coli using staining protocols. World J Exp Med 2026; 16(2): 119306 [PMID: 42394778 DOI: 10.5493/wjem.v16.i2.119306]
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26
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Şengel N, Köksal Z, Küçük A, Sezen ŞC, Güneş I, Atlı M, Kip G, Gökgöz Acar S, Özer A, Kavutçu M, Arslan M. Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury. World J Exp Med 2026; 16(2): 118828 [PMID: 42394782 DOI: 10.5493/wjem.118828]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Deshmukhe SM, Vyawahare CR, Suryawanshi PV, Ratnaparkhi MM, Gandham NR. Unveiling the antibiotic resistance pattern in Staphylococcus aureus: A systematic review (2013-2024). World J Exp Med 2026; 16(2): 118252 [PMID: 42394783 DOI: 10.5493/wjem.v16.i2.118252]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Chhokar A, Joshi U, Tripathi T, Gupta B, Mudassir M, Janjua D, Chaudhary A, Yadav J, Aggarwal N, Jaggi VK, Bharti AC. Quantitative assessment of STAT3 and HPV16 E6 transcripts using Flow-FISH approach for early detection of progressive cervical lesions. World J Exp Med 2026; 16(2): 118250 [PMID: 42394774 DOI: 10.5493/wjem.v16.i2.118250]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Ahmed AEA, Hassan MH, Hamdan RS, Sakhr HM. Evaluation of growth hormone provocative tests in Egyptian children with growth hormone-related short stature. World J Exp Med 2026; 16(2): 117853 [PMID: 42394781 DOI: 10.5493/wjem.v16.i2.117853]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Xing WL, Liu T. Beyond distance and heart rate: Reading 6-minute walk test via blood pressure variability in chronic heart failure. World J Exp Med 2026; 16(2): 116315 [PMID: 42394780 DOI: 10.5493/wjem.v16.i2.116315]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Wishahi M, Badawy M. Letter to the Editor: Urinary infection in European guidelines 2025 vs microbiology culture results in the management of urinary infection. World J Exp Med 2026; 16(2): 115894 [PMID: 42394779 DOI: 10.5493/wjem.v16.i2.115894]
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"Congratulate ！The high-quality article performs well in terms of objectivity, credibility, and scientific quality. Thank you for your support of World Journal of Experimental Medicine. Looking forward to your next originality and innovativeness.Impact Factors of Baishideng Series of Journals released in 2024:
World Journal of Gastroenterology (2024 released IF: 4.3, Quartile: Q1; CiteScore: 7.8)
World Journal of Diabetes (2024 released IF: 4.2, Quartile: Q1)
World Journal of Psychiatry (2024 released IF: 3.9, Quartile: Q1)
World Journal of Gastrointestinal Oncology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.2)
World Journal of Hepatology (2024 released IF: 2.5, Quartile: Q3; CiteScore: 4.1)
World Journal of Orthopedics (2024 released IF: 2.0, Quartile: Q2; CiteScore: 3.1)
World Journal of Gastrointestinal Surgery (2024 released IF: 1.8, Quartile: Q2)
World Journal of Stem Cells (2024 released IF: 3.6, Quartile: Q3; CiteScore: 7.8)
World Journal of Clinical Oncology (2024 released IF: 2.6, Quartile: Q3)
World Journal of Cardiology (2024 released IF: 1.9, Quartile: Q3; CiteScore: 3.3)
World Journal of Radiology (2024 released IF: 1.4, Quartile: Q3)
World Journal of Gastrointestinal Endoscopy (2024 released IF: 1.4, Quartile: Q4)"
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Savvidis C, Ilias I. Letter to the Editor: Circadian and microbial misalignment in metabolic dysfunction-associated steatotic liver disease - mechanistic insights and chronotherapeutic potential. World J Exp Med 2026; 16(2): 118228 [PMID: 42394773 DOI: 10.5493/wjem.v16.i2.118228]
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"Nice commentary on a published paper. It is an excellent piece of work for the readers and for better understand the commented manuscript. it highlights strenghts and limitations of the discussed paper, also pointing out some practical implications for physicians and the era of precision / tailored medicine. Best regards"
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Yang YH. Transcatheter arterial chemoembolization plus lenvatinib toward precision prognostication for unresectable hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(6): 116250 [DOI: 10.4251/wjgo.v18.i6.116250]
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"This is very interesting paper. In chemotherapy for pancreatic cancer, the presence of sarcopenia (age-related or disease-related loss of muscle mass and strength) significantly impacts treatment continuity and prognosis. Sarcopenia increases the likelihood of severe side effects from anticancer drugs, potentially necessitating dose reduction, temporary discontinuation, or complete cessation of treatment. As a result, patients may not achieve sufficient therapeutic effects, leading to a shorter survival time. Appropriate nutritional management: Under the guidance of a cancer specialist dietitian or physician, supplementation of often-deficient calories and protein is provided. Light exercise (resistance training): Within the limits permitted by the attending physician, gentle strength training and walking are performed to maintain muscle stimulation. Symptom control: Pain, nausea, loss of appetite, and other distressing symptoms are alleviated with medication to facilitate eating. Preventing and improving sarcopenia reduces the side effects of chemotherapy and increases the likelihood of completing treatment as planned. 1. Please describe the rehabilitation for sarcopenia at your hospital. 2. Please also describe the evaluation of sarcopenia in the iliopsoas muscle using CT, as well as the evaluation using conventional SARC-F/SARC-Calf, DXA, and BIA.
In recent years, ghrelin-like agonists targeting sarcopenia (caxia) have been reported to be effective in increasing lean body mass and improving loss of appetite in patients with gastrointestinal cancers, including pancreatic cancer (2), and are attracting attention as a therapeutic target.
Previous studies on the molecular mechanisms by which sarcopenia promotes pancreatic cancer progression have only been conducted in animal models such as mice, and no studies focusing on the microenvironment in human pancreatic cancer have been conducted. If the molecular mechanisms of sarcopenia in the progression of pancreatic cancer in humans can be elucidated, it may lead to the development of new therapeutic targets.3. Please comment about the molecular mechanisms by which sarcopenia promotes pancreatic cancer progression
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Akazawa Y, Ohtani M, Murata Y, Tanaka T, Nosaka T, Takahashi K, Naito T, Nakamoto Y. Three-dimensional psoas muscle volume and longitudinal changes as predictors of outcomes in older patients with advanced pancreatic cancer. World J Gastroenterol 2026; 32(24): 118757 [DOI: 10.3748/wjg.118757]
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"In this manuscript, the authors investigate the prognostic value of stress hyperglycemia indices; specifically the Stress Hyperglycemia Ratio (SHR) and Admission Glucose-to-Chronic Glycemia Ratio (ACGR) in patients with non-ST elevation myocardial infarction (NSTEMI). The study effectively distinguishes between chronic dysglycemia (HbA1c) and acute metabolic stress. By demonstrating that SHR and ACGR outperform HbA1c in predicting early mortality, the authors provide a more granular understanding of one’s acute metabolic state during an NSTEMI event. The use of a prospective design and the sequential adjustment of multivariable models (incorporating inflammatory and echocardiographic parameters) shows an appropriate and the correct approach to control confounding factors. I believe, the core strength of their work lies in the focus on simply markers available in minutes at the time of initial presentation itself. These indices provide a metabolic snapshot before echocardiographic or invasive data are available, offering a potential window for early risk stratification.
However, while I agree with the authors in regards to the key strengths and impact of this report, the results and conclusions must be taken in totality. With only 25 mortality events, the study is statistically underpowered for robust multivariable modelling. This increases the risk of overfitting, where the model captures noise rather than true signal, limiting the generalizability of the findings. Further, the use of data-driven (Youden index) cut-offs without external validation means these values are hypothesis-generating rather than clinically actionable at this moment of time. While the authors adjusted for several variables, the lack of key hemodynamic data on admission including blood pressure and heart rate, prevented the calculation of validated clinical scores like the GRACE score, which as of now remains the gold standard for NSTEMI risk stratification. Perhaps it will be possible for the authors to go back and have a look at this important data, as such a comparison would make it more relevant and worthy of further investigation.
Overall, my suggestions to the authors going forward will be to validate these findings in an independent, larger cohort. If the same would be challenging in near future, they can consider applying their derived thresholds to a public dataset to demonstrate consistency and validity of their findings. Instead of presenting SHR as a standalone predictor, investigate whether adding SHR to the GRACE score improves its discriminative power and offer additive information. Clinicians like myself are unlikely to use a new, isolated index, but they will be open to adopting a simple marker/ index that improves existing and validated tools. Since the study only looked at admission glucose, consider tracking glucose variability or the change in glucose over the first 48 hours. Early normalization of stress hyperglycaemia might offer some additive information and would be also a good reflection of the metabolic condition of an individual beyond the initial spike.
Nonetheless, the findings are important and deserve attention. It comes as a well-conducted study that highlights the importance of the metabolic stress response in NSTEMI. However, one must wait for more higher quality evidence before adopting these tools in routine clinical practice.
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Becirovic E, Becirovic M, Hodzic J, Becirovic A, Bajric M, Abdic A, Sabanovic F, Begagic E. Stress hyperglycemia and early mortality in non-ST elevation myocardial infarction. World J Cardiol 2026; 18(5): 119429 [DOI: 10.4330/wjc.v18.i5.119429]
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"The manuscript explores a clinically relevant topic. However, its overall scientific contribution remains limited. In review, the authors attempt to discuss the association between type 2 diabetes mellitus and pancreatic neuroendocrine tumors, the paper largely lacking the sufficient depth, critical appraisal, and methodological rigor which offers credibility of that study. The discussion is largely descriptive and relies on selective interpretation of previously published studies without systematically evaluating study quality, sources of bias, or the strength of the available evidence. Important issues were not analysed adequately such as reverse causality, residual confounding, and surveillance bias. In several sections, the conclusions appear more overstating the level of evidence definitive than warranted by the cited literature. Furthermore, the manuscript offers limited novel insights, and the proposed recommendations are largely speculative and insufficiently supported by robust data. The review would have benefited from a more balanced presentation of conflicting findings, a clearer methodological framework, and a stronger focus on evidence-based interpretation. "
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Goyal MK, Hatwal J, Desai R, Sehgal T, Batta A. Glycated hemoglobin and cardiovascular risk in diabetes mellitus: Evolving evidence beyond glycemic control. World J Diabetes 2026; 17(6): 115820 [DOI: 10.4239/wjd.115820]
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"The manuscript is well written, concise and easy to follow. There are no grammatical or spelling errors throughout the text. The topic debated is interestingly and with a relevant clinical impact in practice due to the risc of poor prognosis of this pathology. The references are well chisen and updated. "
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Wei ML, Tan QL. Chronic ulcer diagnosis and perforation risk with oral agent contrast-enhanced ultrasound: A case report and review of literature. World J Gastroenterol 2026; 32(24): 119006 [DOI: 10.3748/wjg.119006]
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"In this review article, the authors systematically identify and analyze the main risk factors for the development of gastric cancer (GC). Furthermore, the article details the current methods of disease detection, comparing the advantages and limitations of each. The review concludes that the development of GC results from the synergistic action of multiple factors, with Helicobacter pylori infection being the most clearly established carcinogen of the category. Gastroscopy remains the gold standard for GC screening. Gastric cancer often develops silently. In my opinion, it could also be characterized as a “silent killer” along with pancreatic cancer. The clear conclusion is that identifying individuals at increased risk of developing GC and detecting precancerous lesions early are crucial prevention and treatment strategies. Most guidelines now emphasize targeted screening of high-risk groups, first by demonstrating Helicobacter pylori infection and precancerous gastric lesions, and then by performing endoscopy to detect early disease. Endoscopic screening, which should be applied to high-risk groups, is considered the most effective way to detect carcinoma early and is also the most effective diagnostic method in areas with a high prevalence of the disease, as well as selected intermediate-risk cases. Primary prevention through H. pylori eradication and lifestyle changes, combined with monitoring of patients with advanced atrophy or intestinal metaplasia, offers the best strategy for reducing the burden of gastric cancer. With future advances in liquid biopsy and endoscopic techniques, it is expected that the early detection rate of GC will improve significantly, mortality rates will decrease, patient prognosis will improve, and the global burden of GC will be mitigated."
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Jiang JJ, Chen K, Weng T, Hong JM, Qin WY. Early screening and risk factors for gastric cancer. World J Gastroenterol 2026; 32(24): 119127 [DOI: 10.3748/wjg.119127]
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"Dear authors, the article provides a perfect overview of current findings and optimizes therefore the opportunities to set up further reserarch questions. External validation, clinical and practice oriented research, as well as integration of neurological, psychiatric, psychological, biological disciplines and translational research is needed. Therefore it could be helpful to integrate affective neurosciences, primary emotional systems with their neuromorpholocial and biochemical neuromodulating systems into care pathways and calculation. Attaching emotional systems to relational components would be the next steps, that could be conceptualized for preventive strategies.
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Gu JX, Liu CQ, Chen GX, Yao T, Sun ZX, Wang Y. Post-stroke depression update 2025: Mechanisms, prediction, and management. World J Psychiatry 2026; 16(6): 115996 [DOI: 10.5498/wjp.v16.i6.115996]
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"This review discusses recent advances in the pathogenesis and clinical spectrum of IgG4-DSD, as well as the importance of assessing various disease-related biomarkers. The clinician should suspect the disease, especially in cases of painless jaundice. The determination of IgG4 levels in these cases should be done anyway since there is no other way to demonstrate the disorder. The clinician should also keep in mind the possibility of false-positive results. New biomarkers promise greater sensitivity and specificity in accurately diagnosing the syndrome. Early diagnosis is essential, allowing the implementation of personalized therapeutic strategies. As mentioned above, clinical suspicion and timely detection of the disease will play an important role. It constitutes a new chapter in modern gastroenterology, with diverse manifestations that modern gastroenterologists should be familiar with."
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Pan Y, Jiang YZ. Clinical features and biomarker research advances in immunoglobulin 4-related digestive system disorders. World J Gastroenterol 2026; 32(23): 118782 [DOI: 10.3748/wjg.v32.i23.118782]
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Excess fat tissue is involved in the pathophysiology of MASLD. Yet there is no definite method for accurately estimating body fat tissue. Right now BMI and waist circumference are accepted anthropometric tools in this regard. The limitations of these parameters in determining lean-body fatty liver patients declare that new methods are needed.
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Moriyama K. Rethinking noninvasive steatosis indices: Structural limitations and misclassification across the body mass index spectrum. World J Hepatol 2026; 18(5): 118804 [DOI: 10.4254/wjh.v18.i5.118804]
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"This is very interesting paper.Gallbladder cancer is geographically unevenly distributed, with Chile, Bolivia, South Korea, Laos, and Japan having the highest incidence. While numerous epidemiological studies have investigated who is more susceptible to gallbladder cancer, the clear etiology remains unclear in most cases, making prevention difficult. Literature suggests that advanced age, female gender, family history of gallbladder cancer, co-existing gallstones, obesity, smoking, multiple pregnancies, oral contraceptive use, and red pepper consumption are risk factors; however, having these factors does not dramatically increase the risk of biliary tract cancer.
Gallbladder cancer often shows no symptoms until it is quite advanced. Currently, it is frequently discovered during routine ultrasound examinations as an irregular thickening of the gallbladder wall, or incidentally during pathological examinations following cholecystectomy for gallstones or polyps. Because the gallbladder wall is thin, what appears to be early-stage cancer often turns out to be surprisingly deep and advanced upon pathological examination. Therefore, rather than identifying a high-risk population and carefully following them up, as is the case with hepatocellular carcinoma, it is more practical to aim for early detection and treatment. Regular ultrasound examinations during health checkups and screenings are considered useful for screening for gallbladder cancer. Gallbladder cancer often shows no symptoms until it has progressed considerably. Therefore, in most cases, it is discovered incidentally during pathological examinations following a cholecystectomy for conditions such as gallstones or gallbladder polyps, either as an irregular thickening of the gallbladder wall during a routine ultrasound examination. Because the gallbladder wall is thin, what appears to be early-stage cancer often turns out to be surprisingly deep and advanced upon pathological examination. Therefore, rather than identifying a high-risk population and carefully following them, as is the case with hepatocellular carcinoma, early detection and treatment are more practical approaches for gallbladder cancer. Regular ultrasound examinations during health checkups and screenings are considered useful for screening for gallbladder cancer. How about my opinion for gallbladder cancer?
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Tsukanov VV, Vasyutin AV, Kasparov EV, Tonkikh JL. Gallbladder cancer: Is significant attention to this pathology justified? World J Gastroenterol 2026; 32(23): 118199 [DOI: 10.3748/wjg.v32.i23.118199]
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"For an editorial, the evaluation should focus more on scholarly perspective, balance of arguments, relevance, originality of insights, and contribution to the field rather than methodology or statistical analysis.
This editorial addresses a highly relevant and contemporary topic and provides a thoughtful, balanced, and well-articulated perspective on the subject. The author has successfully synthesized current evidence and expert opinion into a coherent narrative that is both informative and engaging for the readership.
The article demonstrates a high degree of objectivity and scientific credibility. The arguments are logically developed, appropriately referenced, and supported by the available literature. The author presents the topic in a balanced manner, acknowledging existing challenges and areas of uncertainty while highlighting important advances and future opportunities within the field.
The revised version reflects careful consideration of reviewer and editorial feedback. The clarity of presentation, organization of content, and overall readability have been improved. The key messages are clearly conveyed, and the discussion effectively places the topic within the broader context of current clinical practice and ongoing scientific developments.
One of the major strengths of this editorial is its ability to stimulate critical thinking and encourage further discussion among clinicians, researchers, and policymakers. The perspectives offered are timely, relevant, and likely to attract considerable interest from readers. The manuscript successfully highlights important unmet needs and identifies potential directions for future research and development.
Although editorials are inherently opinion-based and not intended to provide exhaustive systematic analyses, the author has maintained an appropriate balance between expert interpretation and evidence-based discussion. Any remaining limitations are minor and do not detract from the overall value of the article.
Overall, this is a well-written, insightful, and scientifically credible editorial that makes a meaningful contribution to the literature. It provides valuable perspectives on an important issue, is likely to enhance reader engagement, and may help stimulate future research and academic discourse within the discipline. I commend the author for this excellent contribution and support its publication.
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Sessa C, Gembillo G, Morale W. Rethinking chronic kidney disease risk after liver transplantation. World J Transplant 2026; 16(2): 115035 [PMID: 42281854 DOI: 10.5500/wjt.v16.i2.115035]
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"It is an important study with important data. The authors concluded that the role of oxidative stress in the pathophysiology of T2DM. The authors concluded that there is an important role of oxidative stress in the pathophysiology of T2DM. Unfortunately, the authors measured only catalase as an antioxidant enzyme but neglected the others, such as SOD and GPX. The title showed "antioxidant enzyme" but not "antioxidant enzymes." "
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Ojong EW, Nyake Mbu Akime LB, Tambe AB, Seukep AJ, Ofon EA, Akwa TC, Sawah CN. Glycemic status, antioxidant enzyme and lipid peroxidation among patients with diabetes mellitus in Buea Regional Hospital in Cameroon. World J Biol Chem 2026; 17(2): 118440 [PMID: 42273527 DOI: 10.4331/wjbc.v17.i2.118440]
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"It is a nice work with a lot of assays and experiments:
Strength:
The units are expressed correctly, and the enzyme activities are specific.
Weakness:
1) Figures 2, 3, and 4 show examples of similar figures that are not integrated into a single figure with panels.
2) Too many tables. Some tables could be consolidated into a single table to reduce the number of tables."
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Boro A, Jothi Dheivasikamani A, Prabhu Jeyabal Philomenathan A, Manivannan J, Krishnaswamy S, Palanisamy S, Arumugam VA. Study of Tinospora cordifolia stem and Senna siamea leaf and pods: An in vitro therapeutic approach for leukemia. World J Biol Chem 2026; 17(2): 113144 [PMID: 42273526 DOI: 10.4331/wjbc.v17.i2.113144]
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"Proton pump inhibitors (PPIs) are acid-suppressive agents that irreversibly bind to the gastric mucosa’s H+/K+ ATPase proton pump. They are the first-line treatment for various gastrointestinal conditions, including peptic ulcers and gastroesophageal reflux disease, demonstrating superior efficacy compared to traditional acid-suppressive therapies. PPIs have become one of the most widely prescribed long-term medications globally, however, an increasing number of adverse effects have been reported. Numerous studies have confirmed PPIs’ extensive and significant impact on the gut microbiota from the oral cavity to the rectum. Gut dysbiosis is a significant adverse effect of PPIs, potentially exceeding the microbiota-altering impact of antibiotics. While gastric acid suppression plays an important role, PPIs also affect the gut microbiota through multiple mechanisms. Several studies have identified a potential association between PPIs and IBD, suggesting that PPIs may influence the onset, progression, and treatment efficacy of IBD. Although the underlying mechanisms remain unclear, many researchers speculate that dysbiosis induced by PPIs plays a critical role, given the similarities in gut microbiota changes observed in PPIs users and IBD patients. Authors concluded that this association may be influenced by study design, age differences, and protopathic bias, thereby limiting causal inference. Clinicians should interpret this association cautiously, and future prospective studies with rigorous bias control are needed to determine whether PPI use contributes to inflammatory bowel disease pathogenesis. I agree to authors’ opinion.
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Gao M, Yin RR, Mao X, Shao ZX, Shi YY. Association between proton pump inhibitor use and the risk of inflammatory bowel disease: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(22): 116469 [DOI: 10.3748/wjg.v32.i22.116469]
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"1. Overall assessment
Ethics approval, study registration, and funding disclosure are complete, and the study generally complies with international ethical standards for medical research. The work is based on a 499-patient multi-centre retrospective cohort and uses OS together with 3- and 5-year cumulative survival rates as primary endpoints; Kaplan-Meier survival analysis and Cox proportional-hazards modelling are used to evaluate prognostic factors, and the overall analytical framework is consistent with common analytical approaches in oncology prognostic research. Statistical procedures, including survival time definition, censoring handling, and baseline comparison, are reported relatively completely, and the figures and baseline characteristics are presented clearly. In the context of relatively limited real-world long-term survival evidence on ICWM in CRLM, this study provides a useful foundation for future research.
Although the research question is clinically valuable and the cohort size is reasonable, several methodological limitations may affect causal interpretation; the findings are therefore more appropriately regarded as hypothesis-generating evidence.
2. Major methodological concerns
(a) Immortal time bias
The study defines cohort A by "continuous TCM >=3 months" and uses the date of initial diagnosis as the OS time origin. This combination of exposure definition and survival time origin may introduce immortal time bias, because patients have to survive long enough to qualify for cohort A. The reclassification of some patients from cohort B to cohort A during follow-up also points to a potential time-dependent exposure issue. A landmark analysis (e.g., a 3- or 6-month landmark) or modelling TCM as a time-dependent covariate would help reduce this risk of bias.
(b) Residual confounding
The grouping is not randomized, and the choice of TCM may be related to factors such as adherence, socioeconomic status, family support, and treatment tolerability. These unmeasured variables may also influence survival, and Cox regression alone may not fully address residual confounding. Propensity-score-based approaches (e.g., PSM or IPTW) could be considered to improve covariate balance. If these unmeasured data cannot be retrospectively extracted, this should be explicitly listed as a study limitation in the Discussion.
(c) Exposure heterogeneity and treatment-intensity imbalance
The TCM exposure in cohort A includes individualized decoctions together with several patent medicines (Anteke, Pingxiao, Compound Cantharidin, Xihuang, Weimaining). These patent medicines may differ in mechanism and potential efficacy, and combining them under a single “TCM exposure” may weaken interpretability. Additional variation across treatment stages may further increase within-exposure heterogeneity. In addition, the manuscript states only that patients received "best available treatment according to guidelines," without reporting treatment-intensity indicators such as chemotherapy lines, biologic agent use rate, or relative dose intensity (RDI). Stratified sensitivity analyses by patent-medicine category or by decoction-only exposure, together with reporting of systemic treatment intensity, would be useful additions.
3. Statistical and reporting considerations
Covariate adjustment in the Cox model
The multivariable Cox model includes only four covariates: primary tumour site, RAS/BRAF status, local treatment of liver metastases, and cohort assignment. For CRLM survival analysis, prognostic models generally need to cover key dimensions such as patient status, tumour biology, disease burden, and treatment intensity in a relatively comprehensive way. The variables currently included are concentrated on selected treatment factors and molecular features, while several well-recognized prognostic factors have not yet been entered into the model. For example, age differs significantly between the two groups (62.47 vs 58.51 years, P<0.01) but is not adjusted for; ECOG/KPS is used only as an inclusion criterion (0-2) rather than as a covariate; and liver metastatic burden indicators (such as number of metastases, maximum lesion diameter, synchronous vs metachronous status, and extrahepatic disease) are also not included. Treatment-intensity indicators such as chemotherapy lines and RDI are not reported.
Multiplicity and subgroup analyses
Figure 2 presents multiple subgroup analyses (age, sex, primary site, gene status, local treatment, treatment lines, and metastasis location, among others), but the manuscript does not address the multiple-comparisons issue. A large number of subgroup tests may increase the risk of false-positive findings; we suggest that the authors interpret subgroup results cautiously and consider reporting adjusted P values for key subgroups in order to reduce the likelihood of false-positive findings.
Proportional-hazards assumption
Follow-up in this study is relatively long (up to 132 months), and time-varying treatment effects are plausible. Formal assessment of the Cox proportional-hazards assumption (e.g., Schoenfeld residuals) would strengthen confidence in the reported hazard ratios.
Safety reporting
The methods section notes that major adverse reactions would be tracked during follow-up, but the manuscript does not report a safety comparison between the two cohorts, nor does it present indicators such as HILI, myelosuppression, or hepatic/renal function. Given that ICWM is evaluated as a long-term treatment exposure, additional safety data would help support a more comprehensive assessment of its clinical value. If these data cannot be systematically obtained, this limitation should be further clarified in the Discussion.
References
The reference base broadly covers CRLM epidemiology, local liver-directed therapies, and TCM-related mechanisms, and is reasonably current and on-topic. Incorporating the most recent systematic reviews or meta-analyses on integrative medicine in advanced colorectal cancer, where available, would further strengthen the literature base.
4. Language and interpretation
The manuscript is clearly structured and well organized, and on the whole follows standard reporting conventions for observational cohort studies. However, causal and associative language are mixed in places. For example, the title uses verbs with a more causal connotation such as "prolong," and the Discussion contains expressions such as "reduced the risk of death by 35%" and "protective factors," whereas the Abstract Conclusion is phrased associatively as "is associated with longer OS." Maintaining greater consistency in the use of associative rather than causal language throughout the manuscript would better match the evidence level of a retrospective observational design.
5. Conclusion
Overall, this study addresses a clinically relevant question and contributes useful real-world evidence regarding ICWM in CRLM. The findings are best interpreted as hypothesis-generating. Addressing the methodological limitations identified above, particularly immortal time bias, residual confounding, and limited covariate adjustment, in future studies would strengthen causal inference and improve the interpretability of the results.
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Bian JY, Sun YX, Wang LF, He WT, Liu CB, Wang XQ, Zhang T. Integrated Chinese and Western medicine prolong survival in colorectal cancer with liver metastasis: A retrospective cohort study. World J Clin Oncol 2026; 17(5): 118265 [DOI: 10.5306/wjco.v17.i5.118265]
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"Post-stroke depression (PSD) is a frequent complication that worsens recovery and quality of life. Clinicians should prioritize early screening of PSD, especially in patients with cognitive impairment, severe disability, or social isolation. Biological markers such as inflammation and neurotransmitter imbalance may guide risk stratification, while predictive models can support monitoring. Management requires a multimodal approach: antidepressants, psychotherapy, and rehabilitation programs, complemented by family and social support. If integrated into routine stroke care, these strategies enable timely intervention, reduces complications, and promote fast functional recovery."
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Gu JX, Liu CQ, Chen GX, Yao T, Sun ZX, Wang Y. Post-stroke depression update 2025: Mechanisms, prediction, and management. World J Psychiatry 2026; 16(6): 115996 [DOI: 10.5498/wjp.v16.i6.115996]
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"This study is methodologically rigorous, employing a large sample size, LASSO regression, and dual validation to ensure robust results. The dynamic online nomogram enhances clinical usability and identifies clear risk factors, including cognition, albumin, and surgical parameters. Limitations include its single‑institution scope, short validation period, and the need for prospective testing of clinical impact. Overall, it provides a solid foundation and meaningful step toward proactive management of emergence delirium in older adults."
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Xin Y, He B, Wei XH, Yan YL, Huang C, Gao CY, Wang S, Zhang GM, Li R, Wu Y. Construction and validation of a predictive model for the risk of emergence delirium in older adult patients. World J Psychiatry 2026; 16(6): 115839 [DOI: 10.5498/wjp.v16.i6.115839]
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"This is a well-written and presented a rare case report on "Clinical management of porcelain gallbladder: A case report". This manuscript gives additional new knowledge to the existing literature.Porcelain gallbladder is a rare clinical entity that should always be considered due to its well-established association with gallbladder carcinoma. I think that this manuscript is worth to be published in the World Journal of Gastrointestinal Surgery."
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Chen SJ, Chen S, Hu AY, Li QS, Fan Y, Chen YG, Tian S, Li HL, Peng CJ, Han M. Clinical management of porcelain gallbladder: A case report. World J Gastrointest Surg 2026; 18(5): 116359 [DOI: 10.4240/wjgs.v18.i5.116359]
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