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1
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"The authors express concern about the lack of detailed analysis of the depth of analysis, i.e., tumor miss rates, machine learning model complexity, and dataset quality. They also discuss future directions for the potential of AI in endoscopy training to facilitate skill development and improve the overall proficiency of endoscopists, a crucial area for the future adoption of AI in clinical practice. For AI endoscopy to further develop, we need to work on updating image data and deep learning."
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Fogas CR, Balassone V. Artificial intelligence in gastrointestinal endoscopy: Focus on analytical depth and endoscopist training. Artif Intell Gastrointest Endosc 2025; 6(4): 115140 [DOI: 10.37126/aige.v6.i4.115140]
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2
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"AI is an important milestone for future development in medicine and science. Nonetheless, there are many AI models and each model has its own learning objectives. Incorporation of multiple AI models and training machine/ learning can greatly enhance the accuracy and readiness of using it to help in hepatopathy. Also, there are many hepatopathy and a systematic way to categories them will be a challenging act."
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Sun JR, Sun XN, Lu BJ, Deng BC. Artificial intelligence in hepatopathy diagnosis and treatment: Big data analytics, deep learning, and clinical prediction models. World J Gastroenterol 2025; 31(45): 111176 [DOI: 10.3748/wjg.v31.i45.111176]
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3
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Wu PE, Chen PJ, Su WC, Chang TK, Chen YC. Perforated sigmoid colon diverticulitis initially presenting with pneumoperitoneum, pneumoretroperitoneum, and pneumomediastinum: A case report. World J Clin Cases 2025; 13(34): 112593 [DOI: 10.12998/wjcc.v13.i34.112593]
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4
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Deng X, Lv LY, Jiang SX, Huang JX, Chen XY, Zhang MF, Qi J, Yang M. Low-grade appendiceal mucinous neoplasm: A case report. World J Clin Cases 2025; 13(34): 111668 [DOI: 10.12998/wjcc.v13.i34.111668]
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5
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"With all due respect, this case shouldn't have been accepted for publication. I lacks complete originality and shows lots of contradictions. That is, the title contradicts the case itself. Initially presenting with Pneumoperitoneum and the cases report indicates that the patient had "three (3) days" with lower abdominal pain. Irregardless of that, whatever clinical presentation, this case shows nothing new that has previously been reported. In conclusion this case report lacks complete originality."
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Wu PE, Chen PJ, Su WC, Chang TK, Chen YC. Perforated sigmoid colon diverticulitis initially presenting with pneumoperitoneum, pneumoretroperitoneum, and pneumomediastinum: A case report. World J Clin Cases 2025; 13(34): 112593 [DOI: 10.12998/wjcc.v13.i34.112593]
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6
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"First of all, congratulations on the publication of your paper. I have read it carefully, and I found it to be extremely well written, highly educational, and truly informative for readers. For these reasons, I would like to award this paper the first prize. I hope you will continue to produce such valuable work in the future. Thank you very much."
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Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Recurrence of acyclovir-resistant herpes encephalitis in an immunocompromised patient: A case report. World J Clin Cases 2025; 13(34): 111438 [DOI: 10.12998/wjcc.v13.i34.111438]
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7
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"At the Baveno VII consensus workshop has defined the concept of recompensation of decompensated liver cirrhosis. It implies that after elimination of the etiological factor, there is at least a partial regression of structural and functional disorders in the liver, reduction of portal pressure with a positive effect on portal hypertension related complications. Many studies have shown the efficacy of direct acting antivirals (DAAs) in achieving recompensation of HCV-related decompensated liver cirrhosis. The authors confirmed these data in Egyptian patients."
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Abdel Hafez RS, Semeya AA, Elgamal R, Othman AA. Direct-acting antiviral therapy reduces variceal rebleeding and improves liver function in hepatitis C virus-related cirrhosis: A multicenter retrospective cohort study. World J Hepatol 2025; 17(11): 110638 [DOI: 10.4254/wjh.v17.i11.110638]
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8
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"This is a comprehensive and well-structured review that effectively synthesizes the complex landscape of MASLD in Egypt. The authors have articulated the convergence of risk factors, diagnostic challenges, and management gaps, positioning MASLD as a critical public health priority. The article's strength lies in its contextualization of the problem within Egypt's unique epidemiological and socioeconomic backdrop, particularly the interplay with the legacy of HCV and nutritional transitions. The inclusion of figures illustrating the multifactorial risks enhances the manuscript's clarity and impact.
There are several inherent challenges remain unresolved. The review points out that studies evaluating the prevalence of MASLD in Egypt are scarce and often include small numbers, and the prevalence and impact of key genetic variants (e.g., PNPLA3, TM6SF2) in the Egyptian population remain underexplored. The natural history and progression rates of MASLD specifically within the Egyptian population are not well-defined due to the absence of longitudinal cohort studies.
The authors have already laid out a roadmap for future research. They intend to advocate for and potentially lead large-scale, population-based epidemiological studies. The appropriate methodology like a stratified cluster sampling design, and the non-invasive diagnostics like FibroScan, could ensure the accuracy to assess the prevalence and fibrosis stages.
The review by Abdelhamed et al. is a powerful call to action, raising interest in non-communicable disease like MASLD in Egypt, and providing an evidence-based argument for a public health-oriented approach to a complex disease. "
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Abdelhamed W, Amin M, Waked I, El-Kassas M. Metabolic dysfunction-associated steatotic liver disease in Egypt: Epidemiology, risk factors and management challenges. World J Gastroenterol 2025; 31(45): 111643 [DOI: 10.3748/wjg.v31.i45.111643]
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9
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"This manuscript showed the cellular mechanisms of pentadecanoic acid as an odd-number fatty acid. The presented figures are interesting and include valuable information, especially Figure 2, which shows the relation between pentadecanoic acid and cell signaling. In this figure, Mek/ERk and JAK/STAT pathways were shown as the pathways in which pentadecanoic acid was engaged."
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Mercola J. Molecular and cellular mechanisms of pentadecanoic acid. World J Biol Chem 2025; 16(4): 111258 [DOI: 10.4331/wjbc.v16.i4.111258]
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10
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"This manuscript showed biomarkers for Gestational diabetes mellitus, which is an important metabolic disorder in pregnancy. The authors have shown the biochemical parameters of the healthy and diabetic participants. This is a good point. The authors also showed a good agarose electrophoresis of PCR products. In addition, the gene expression of gene variants was studied and proved as biomarkers of
Gestational diabetes mellitus.
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Shamsad A, Gautam T, Singh R, Banerjee M. CD36 fatty-acid-transporter gene variants-CD36 G/A (rs1761667) and CD36 C/T (rs75326924) as biomarkers for risk-prediction in gestational diabetes mellitus. World J Biol Chem 2025; 16(4): 111104 [DOI: 10.4331/wjbc.v16.i4.111104]
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11
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"Laparoscopic hepatectomy is a minimally invasive surgical procedure to remove part of the liver in cases of benign and/or malignant tumors of the organ. Patients benefit from all the advantages of laparoscopic surgery, such as faster recovery, minimal pain, and smaller surgical wounds, compared to open surgery.
Lei ZL et al. in their study entitled “Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study. World J Gastroenterol 2025; 31(45): 111540 demonstrated that, in patients with small hepatocellular carcinoma, laparoscopic hepatectomy significantly prolongs survival compared with tumor destruction. The findings suggest that laparoscopic hepatectomy should be preferred in these patients, provided liver function is adequate. Nevertheless, radiofrequency tumor destruction remains a valuable weapon in our pharmaceutical arsenal, especially in patients at high surgical risk. It is understandable, however, that these surgical procedures must be performed in specialized centers by surgeons with extensive experience in laparoscopic surgery, particularly in liver surgery."
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Lei ZL, Tan ZL, Luo YH, Yang M, Wang JL, Qin Z, Liu YY. Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study. World J Gastroenterol 2025; 31(45): 111540 [DOI: 10.3748/wjg.v31.i45.111540]
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"This mechanism showed an understanding of mechanisms. As a review article, it includes important information about obesity. Figures 1 and 2 were well designed. The therapeutic strategies in Table 1 also included important information. The authors are urged to perform research work on the subject area of this manuscript, especially the concept of the therapeutic strategy.
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Chen KR, Chen ZY, Liu FY, Xie CY, Hu J, Wang SY, Xu B, Xu TC. Macrophage-mediated metabolic dysregulation in the pancreas: Insights from obesity. World J Biol Chem 2025; 16(4): 109509 [DOI: 10.4331/wjbc.v16.i4.109509]
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13
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"This study analyzes RSPO3 rearrangements in advanced colorectal cancer (aCRC) and their clinical implications. Among 73 patients with stage pT4a‑b tumors, RSPO3 fusions were detected in 8% of cases, predominantly in right‑sided or transverse colon cancers. These rearrangements were associated with smaller tumor size, normal carcinoembryonic antigen levels, microsatellite stability, and significantly poorer overall survival. The authors also confirmed through in silico analyses that elevated RSPO3 expression correlates with worse recurrence‑free and overall survival in independent CRC cohorts. Strengths of the work include comprehensive next‑generation sequencing of 50 cancer‑related genes, detailed clonal evolution analysis, and integration of clinical, pathological, and molecular data. Overall, the study highlights RSPO3 fusions as a potential prognostic biomarker and therapeutic target in advanced colorectal cancer."
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Tur R, Abad M, Filipovich E, Rivas MB, Rodriguez M, Montero JC, Sayagués JM. RSPO3 rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics. World J Gastrointest Oncol 2025; 17(11): 112838 [PMID: 41281482 DOI: 10.4251/wjgo.v17.i11.112838]
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14
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"This retrospective study develops and validates a novel nomogram model to predict survival outcomes in advanced HER‑2 negative gastric cancer patients treated with immunochemotherapy. Using data from 200 patients who received sintilimab plus chemotherapy, the authors identified PD‑L1 expression, microsatellite status, TNM stage, tumor differentiation, neutrophil‑to‑lymphocyte ratio, and the C‑reactive protein–albumin–lymphocyte (CALLY) index as independent prognostic factors. The resulting models demonstrated strong discrimination (C‑index 0.78–0.82) and calibration, with high accuracy for progression‑free and overall survival across multiple time points. Strengths of the work include integration of molecular, clinical, and inflammatory markers into a single predictive tool, rigorous statistical validation, and clear demonstration of clinical applicability. Overall, the study provides a robust framework for individualized risk assessment and treatment planning in HER‑2 negative advanced gastric cancer."
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Yao ZY, Bao G, Li GC, Hao QL, Ma LJ, Rao YX, Xu K, Ma X, Han ZX. Survival prognosis in advanced HER-2 negative gastric cancer treated with immunochemotherapy: A novel model. World J Gastrointest Oncol 2025; 17(11): 112981 [PMID: 41281500 DOI: 10.4251/wjgo.v17.i11.112981]
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15
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"This meta‑analysis evaluates the efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy in locally advanced rectal cancer (LARC). Across 15 studies involving 796 patients, the addition of immunotherapy significantly improved major pathological response, pathological complete response, and clinical complete response, particularly in patients with proficient mismatch repair (pMMR) and microsatellite stability. Rates of R0 resection and sphincter‑preserving surgery were also higher, while adverse events such as hematologic toxicity and liver dysfunction remained within acceptable limits. Strengths of the study include comprehensive literature retrieval, rigorous subgroup and sensitivity analyses, and clear reporting of heterogeneity and publication bias. Overall, the findings suggest that integrating immunotherapy into neoadjuvant chemoradiotherapy regimens enhances remission and organ preservation without substantially increasing complications, supporting its consideration as a first‑line strategy for LARC."
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Yan WX, Yuan HQ, Xiong ZY, Qin LJ, Wu J, He J, Mu J, Li J, Li N. Meta-analysis of the efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy for locally advanced rectal cancer. World J Gastrointest Oncol 2025; 17(11): 113048 [PMID: 41281473 DOI: 10.4251/wjgo.v17.i11.113048]
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16
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"This study investigates folate receptor–positive circulating tumor cells (FR+ CTCs) as potential biomarkers for hepatocellular carcinoma (HCC). In a retrospective cohort of 128 patients, FR+ CTC counts demonstrated superior diagnostic accuracy compared to alpha‑fetoprotein (AFP), with sensitivity of 90% and specificity of 77%. Elevated FR+ CTC levels correlated with adverse pathological features such as larger tumor size, multiple lesions, macrovascular invasion, and extrahepatic metastasis. Importantly, higher baseline FR+ CTC counts predicted shorter disease‑free survival after hepatectomy, with a cutoff of 12.9 FU/3 mL distinguishing high‑risk patients. Strengths of the work include rigorous methodology using ligand‑target PCR, clear statistical validation with ROC and Cox regression analyses, and demonstration that FR+ CTCs may serve both diagnostic and prognostic roles independent of AFP. These findings provide promising evidence that FR+ CTC quantification could enhance patient stratification, guide treatment evaluation, and improve recurrence prediction in HCC."
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Zhang ZY, Zhou M, Liu JJ, Zhang W. Folate receptor-positive circulating tumor cells might function as potential biomarkers for hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(11): 113431 [PMID: 41281492 DOI: 10.4251/wjgo.v17.i11.113431]
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17
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"This article presents two rare case reports of gastrointestinal stromal tumors (GISTs) driven by novel FGFR2 fusions, expanding the molecular spectrum beyond the well‑known KIT and PDGFRA mutations. Both patients underwent successful surgical resection followed by adjuvant imatinib therapy, achieving sustained remission over more than two years. The study is well executed in several respects: it highlights the importance of comprehensive genomic profiling with next‑generation sequencing to uncover actionable mutations, demonstrates that even non‑canonical alterations may respond to standard tyrosine kinase inhibitors, and underscores the potential of FGFR‑targeted therapies for imatinib‑resistant or advanced disease. By carefully documenting clinical, pathological, and molecular features, the authors provide valuable preliminary evidence that FGFR2 fusions may define a distinct, therapeutically relevant GIST subtype."
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Hong YY, Shou CH, Yang WL, Wang XD, Zhang Q, Liu XS, Yu JR. FGFR2 fusions as novel oncogenic drivers in gastrointestinal stromal tumors: Two case reports and review of literature. World J Gastrointest Oncol 2025; 17(11): 113262 [PMID: 41281483 DOI: 10.4251/wjgo.v17.i11.113262]
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18
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"I read with interest of this article. In spite of there are many similar studies in literature, the findings of this study is still informative. Shear wave elastography (SWE) is a non-invasive ultrasound (US) technique that can quantify tissue stiffness, which can used for assistance of diagnosing focal and diffusive diseases. Establishing reference values in normal tissues or organs in healthy individuals is crucial, since abnormal stiffness is associated with clinically relevant conditions such as tumors, liver fibrosis, and pancreatic disease. In the literature, normal values of stiffness for liver, spleen, and pancreas in healthy individuals are various, and they have not been well established. In this study, the investigators measured the stiffness of the liver, spleen, and pancreas in 50 healthy subjects with p-QElaXto and 2D-QElaXto on Esaote MyLab 9 ultrasound system, compared with 2D-SWE on the SuperSonic Imagine Aixplorer (SSI). Values of measurements of stiffness ranges were analyzed for relationship with clinical and technical factors, and inter-operator variability across the different SWE modalities were studied. The results demonstrated that the liver and spleen stiffness assessment was feasible in > 98% of patients, while pancreas stiffness was measurable in 84%-88% depending on the SWE technique. Mean liver stiffness ranged between 3.9-4.7 kPa across techniques, spleen stiffness ranged from 19.4-23.0 kPa, and pancreas stiffness from 5.2-7.6 kPa. Inter-operator agreement was excellent for liver and good to moderate for spleen and pancreas. Bland-Altman analysis confirmed good correlation but also systematic differences among devices, especially in pancreas measurements. The investigators concluded that the values of stiffness of the liver and spleen matched existing guidelines, and pancreas SWE showed more variability and reduced reproducibility. Stiffness measurements of the pancreatic using shear wave elastography is less reliable than that for liver and spleen.
There were some potential limitations of this study, as had been addressed in the article, especially the relatively small sample size compromises the soundness and robust of the results.
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Viceconti N, Paratore M, Del Zompo F, Zocco MA, Ainora ME, Esposto G, Gasbarrini A, Pompili M, Riccardi L, Garcovich M. Shear wave elastography in healthy patients: Pancreatic stiffness is less reliable than liver and spleen measurements. World J Radiol 2025; 17(11): 111651 [PMID: 41356758 DOI: 10.4329/wjr.v17.i11.111651]
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19
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"This review was well written. The subject was meaningful. The objective of this study was to analyse the utility of point-of-care ultrasound-measured optic nerve sheath diameter for early identification of raised intracranial pressure in non-traumatic headache patients, aiming to guide clinicians in integrating this technique into early headache evaluation for better patient outcomes. Point-of-care ultrasound measurement of optic nerve sheath diameter is a convenient, non-invasive method with high sensitivity and specificity for detecting elevated intracranial pressure. Its use can expedite diagnosis, guide urgent management, and reduce unnecessary imaging, especially in outpatient and resource-limited settings. To ensure reliability and accuracy of measurement, comprehensive training programs and standardized protocols for ultrasound operator are required.
Emerging artificial intelligence(AI)-assisted measurement promises to enhance its reliability by reducing operator-dependent variability, and this will broaden its clinical impact. AI-assisted interpretation and automated measurement tools will be the future direction.
One thing must mention, the word “decline” in the sentence that “A good example of the potential value of POCUS is a patient with an acute neurological decline” should be “deficit”."
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Tlaiss Y, Tarchichi A, Atallah K, Al Mashtoub E, Zalzali I, Chokor Z, Fassih I, Harb N, Kassas J, Hamze H. Point-of-care ultrasonography for detecting raised intracranial pressure through optic nerve sheath diameter in non-traumatic headache patients. World J Radiol 2025; 17(11): 113012 [PMID: 41356762 DOI: 10.4329/wjr.v17.i11.113012]
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20
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"In patients with troponin elevation at ER, distinguishing ACS is crucial, but troponin often rises for reasons other than ACS. PSVT is one such cause, but diagnosis is difficult if the episode has already terminated by the time the ER ECG is taken. This is because troponin is only positive in 30-50% of PSVT cases. Even if sinus rhythm is present at presentation, troponin may still be positive after PSVT has stopped.
For example, in patients who experienced palpitations. Therefore, I would also like to see criteria indicating in which PSVT cases troponin will be positive.
Elevated troponin due to paroxysmal supraventricular tachycardia (PSVT) does not merely indicate the presence of ischemic heart disease. It is associated with a high heart rate, prolonged duration, chest pain, and in many cases, causes mild to moderate transient troponin elevation. Conversely, in the absence of obvious organic heart disease, it does not directly correlate with worsened clinical prognosis. The degree of troponin elevation is primarily associated with the heart rate during the episode (risk increases at 165 bpm or higher) and the duration of the episode. Particularly in clinically stable cases, there appears to be limited justification for invasive evaluation based solely on troponin elevation. Further validation through large-scale prospective studies is desired in the future.
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Özlek B, Tanık VO, Barutçu S. Troponin elevation in supraventricular tachycardia: A narrative review. World J Cardiol 2025; 17(11): 113411 [PMID: 41356591 DOI: 10.4330/wjc.v17.i11.113411]
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21
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"Lymphangiomas occur in various parts of the body, most commonly in the head and neck region, but rarely in the gastrointestinal tract. Esophageal lymphangioma is an exceedingly rare benign submucosal tumor. Lymphangiomas are usually asymptomatic and incidentally found on endoscopic evaluation.
This is a well- written and presented rarely case report. This manuscript gives additional new knowledge to the existing literature. Ithink that this manuscript is worth to publication."
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Zheng XL, Yu XX. Esophageal lymphangioma: A case report and review of literature. World J Gastrointest Surg 2025; 17(11): 111148 [PMID: 41357658 DOI: 10.4240/wjgs.v17.i11.111148]
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22
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"This study proposes that the tumor-suppressive functions of these proteases are contingent upon the stage of cancer progression or metastatic conditions, and may be activated or suppressed in response to cues from the tumor microenvironment. The proposition that the functional role of tumors—either promoting or inhibiting cancer—can be dynamically regulated by the tumor microenvironment is a noteworthy conceptual advancement. Indeed, cancer is increasingly recognized as a complex pathological ecosystem. Within this framework, genes and mutations are not primary causal drivers of carcinogenesis—as posited by the prevailing somatic mutation theory—but rather represent one of many events occurring throughout tumor evolution. A more comprehensive understanding therefore requires the integration of genetic and mutational dynamics within broader ecological and evolutionary contexts (https://pubmed.ncbi.nlm.nih.gov/40443342/)."
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Palacios Serrato EG, Medina-Abreu KH, Oropeza-Martínez E, Jacinto-Alemán LF, Macías-Silva M, Tecalco-Cruz AC. ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role. World J Clin Oncol 2025; 16(11): 110202 [PMID: 41355923 DOI: 10.5306/wjco.v16.i11.110202]
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23
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"• This is very interesting paper about pancreatic cyst. Pancreatic cysts are diagnosed through imaging tests like CT, MRI, and endoscopic ultrasound (EUS). These tests help characterize the cyst's size, structure, and relationship to the pancreas. An EUS can also be used to collect fluid or tissue samples for lab analysis to check for cancer cells, while other factors like symptoms, patient history, and risk factors are also considered to make a final diagnosis. Fluid and tissue analysis: If a sample is collected through EUS-FNA, the fluid is analyzed for specific markers like carcinoembryonic antigen (CEA), which can help identify cancer. The diagnostic process involves a combination of medical history review, various imaging tests, and sometimes fluid analysis/biopsy to determine the cyst's type and its potential for malignancy.
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Shumka N, Karagyozov PI. Cystic tumors of the pancreas: Current perspectives on diagnosis and management. World J Gastroenterol 2025; 31(43): 111393 [PMID: 41358177 DOI: 10.3748/wjg.v31.i43.111393]
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24
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"The article is well written and well conducted.
I particularly appreciated the discussion, which is rich and full of interesting comments.
Unfortunately, the study is retrospective. The addition of other parameters, such as the precence of left ventricular noncompaction and serum electrolyte values, would likely have further differentiated the two populations studied."
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Kaddoura R, Al-Tamimi H, Pieles GE. Racial disparities in electrical and structural cardiac adaptation among adolescent athletes: A systematic review and meta-analysis. World J Cardiol 2025; 17(11): 107835 [PMID: 41356586 DOI: 10.4330/wjc.v17.i11.107835]
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25
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Park YE. Gastric Crohn’s disease presenting as a subepithelial tumor: A case report. World J Clin Cases 2025; 13(33): 113312 [PMID: 41356089 DOI: 10.12998/wjcc.v13.i33.113312]
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26
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Bergeron E, Gologan A. Abdominal compartment syndrome with colonic hypoganglionosis and massive colonic distension in a young adult: A case report. World J Clin Cases 2025; 13(33): 112684 [PMID: 41356083 DOI: 10.12998/wjcc.v13.i33.112684]
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27
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"1. Ethics
It is a review article thus ethics approval form is not required
2. Methods
As a narrative/invited review, the “methods” section is not a detailed primary experimental protocol. The paper describes construction methods of gastric organoids, modeling steps, mechanisms, limitations and future directions.
The methods are adequate in describing the topic and background rather than reporting new experimental workflows.
3. Results
The results are summary of published work rather than original data. The authors summaries how gastric organoids can model atrophic gastritis → intestinal metaplasia → dysplasia → gastric cancer, and discuss mechanisms and propose that gastric organoids are a “promising model” for the inflammation-cancer transition.
4. Figures and Tables
Figures shows the multiple schematic figures. Annotation/Quality of the figures is good and are schematic exhibiting the appropriateness for this study. The legends appear clear; axes/labels in the schematics are present. The paper has well-constructed and expressive figures and tables.
5. Biostatistics
This is a review paper, there is no new statistical analyses/biostatistical tables of primary data are needed.
6. References
Lis of references is current, appropriate and is reasonable in number (> 100)
7. Language
The language is clear, rationally concise, and generally well-written.
"
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Liu C, Wu CH, Jia YB, Qiu JX, Li XY, Ling JH. Gastric organoids: A promising model for studying “inflammation-cancer” transition in atrophic gastritis. World J Clin Oncol 2025; 16(11): 110453 [PMID: 41355914 DOI: 10.5306/wjco.v16.i11.110453]
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28
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"It was with pleasure that I tracked the article quality of the following manuscript. Please see my comments below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The figures add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate/up-to-date
7 Language: This is a concise/well written editorial
8 Caveats or drawbacks: N/A "
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Zerem E, Zerem D, Vila Š, Bajgorić S. Ascites in acute pancreatitis: A window into disease severity. World J Gastroenterol 2025; 31(43): 112797 [PMID: 41358183 DOI: 10.3748/wjg.v31.i43.112797]
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29
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"“Pyroptosis” is a term composed of the union of two separate ancient Greek words, namely “Πυρ” (Fire) and “Πτώσις” (fall), which together mean “fall of the fire” (reduction of inflammation). It is a lytic mechanism of programmed cell death that involves cleavage of proteins in the gasdermin D family. Its effects are mediated through nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3)/caspase-1 classical and caspase-4/5/11. The inflammatory process mediated by this mechanism appears to play a central role in the development and pathogenesis of IBD by destroying the intestinal epithelial barrier, leading to excessive inflammation and worsening the disease progression.
Targeting pyroptosis is a promising therapeutic approach for IBD. Recent data support the notion that inhibitors of inflammasomes, such as small-molecule biological agents, other biological agents, and drugs that specifically target NLRP3, caspases, or GSDMD, suppress inflammasome activation and inhibit membrane pore formation. However, the precise regulatory mechanisms and therapeutic effect of pharmacological targeting of inflammasomes in IBD are not fully understood.
Research on the specificity of pharmaceutical agents that may prove effective in treating the disease, the extent of drug side effects, and the potential for combination with other active pharmaceutical agents is a key goal for the near future.
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Dong WW, Liu T, He LX, He WT. Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach. World J Gastroenterol 2025; 31(43): 111358 [PMID: 41358180 DOI: 10.3748/wjg.v31.i43.111358]
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30
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"This letter to the Editor just agrees with the authors of the original paper that BMI is associated with worse outcome in patients with acute liver injury. In this regard, all "scientific" information descries only "associations" with BMI and organ failure. However no studies indicate possible causes so science can advance towards possible treatments beyond weight loss."
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Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514 [PMID: 41256347 DOI: 10.12998/wjcc.v13.i32.113514]
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31
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"A concise, comprehensive, complex and well-structured manuscript. There are no grammatical/spelling errors throughout the manuscript and the topic debated is of a great interest due to the fact that AI technologies have a real potential to revolutionize liver lesion assessment in association with CEUS. Indeed, in order to obtain a valid implementation in clinical practice of AI technologies combined with CEUS, we need more large-scale prospective studies in the near future.
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Ciocalteu A, Urhut CM, Streba CT, Kamal A, Mamuleanu M, Sandulescu LD. Artificial intelligence in contrast enhanced ultrasound: A new era for liver lesion assessment. World J Gastroenterol 2025; 31(42): 112196 [PMID: 41278165 DOI: 10.3748/wjg.v31.i42.112196]
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32
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"1 Ethics: Not provided
2 Methods: The experimental method is effective and can be repeated by fellow researchers
3 Results The theory is validated
4 No figures or tables provided
5 Biostatistics: Not needed
6 References: The author scientifically and reasonably cite the latest references
7 Language: The language in article correctly, clearly and concisely expresses the information
"
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Sameer M, Muthu S, Vadranapu S. Prophylactic fixation in elderly fractures: Preventive breakthrough or unnecessary intervention? World J Orthop 2025; 16(11): 109855 [PMID: 41355824 DOI: 10.5312/wjo.v16.i11.109855]
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33
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"In the recent years,the relationship between intestinal flora disorders and various diseasess,especially IBD,has become clear, and fecal transplantation , which aims to improve dysbiosis, has attracted attention.This study also reports on fecal transplantation for the purpose of correcting intestinal flora disorders in IBD,and further research and clinical application are expected in the furture."
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Zheng L, Duan SL, Wang K. Research progress concerning the involvement of the intestinal microbiota in the occurrence and development of inflammatory bowel disease. World J Gastroenterol 2025; 31(42): 113170 [PMID: 41278154 DOI: 10.3748/wjg.v31.i42.113170]
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34
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"It was with pleasure that I reviewed the article quality of the following manuscript. Please see my comments below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The tables add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: References are appropriate/up to date
7 Language: This is a concise/well written manuscript
8 Caveats or drawbacks: None "
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Wang XY, An F, Wang BJ, Han WW. Hydrogen peroxide pathway in ulcerative colitis: Promises and challenges in translating novel pathogenesis to clinical practice. World J Gastroenterol 2025; 31(42): 112566 [PMID: 41278161 DOI: 10.3748/wjg.v31.i42.112566]
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35
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"Overall Assessment
1. The letter clearly addresses the association between BMI and clinical outcomes in ALF, which is clinically relevant.
2. The format follows standard Letter to the Editor conventions, making it easy to read.
3. The discussion is well-supported by Krishnan et al.’s recent study and previous reports (Kanda et al., Rutherford et al.), with accurate citations.
Strengths
1. Highlights a growing concern—obesity and its impact on ALF outcomes.
2. Includes Japanese and U.S. data, showing differences in etiology (acetaminophen vs. non-acetaminophen causes).
3. Emphasizes vigilance for renal failure and hepatic encephalopathy in obese ALF patients.
"
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Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514 [PMID: 41256347 DOI: 10.12998/wjcc.v13.i32.113514]
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36
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Kim N, Lee H, Park D. Challenging diagnosis of groove pancreatitis with severe gastric outlet obstruction: A case report. World J Clin Cases 2025; 13(32): 111796 [PMID: 41256349 DOI: 10.12998/wjcc.v13.i32.111796]
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37
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Aisikaer A, Sun MM, Shen J. Positron emission tomography/computed tomography in risk-factor-negative young female with malignant pleural mesothelioma: A case report and review of literature. World J Clin Cases 2025; 13(32): 110897 [PMID: 41256342 DOI: 10.12998/wjcc.v13.i32.110897]
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38
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Liu KT, Lee MH, Lin CH, Tsou YK, Sung KF, Wang SF, Wu CH, Liu NJ. Acute cholangitis due to common bile duct stones: Clinical outcomes in patients with and without concurrent acute pancreatitis. World J Clin Cases 2025; 13(32): 110553 [PMID: 41256350 DOI: 10.12998/wjcc.v13.i32.110553]
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39
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391 [PMID: 41256348 DOI: 10.12998/wjcc.v13.i32.110391]
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40
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"Has authors used low threshold for BMI in this study.This needs attention and could be bias.To apply this , international definition for obesity needs to be included.The study is read by clinicians all over world ans using nonstandardised definition needs to reconsider.
sing a standardized 3-port LC technique.
Using 3 port instead of 4 port in obesity raises alarm over safety keepi in view ergonomics
Intraoperative bile leak in your series seems to be heroic by using 3 port lap chole
"
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Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391 [PMID: 41256348 DOI: 10.12998/wjcc.v13.i32.110391]
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41
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"This case report is highlighting low threshold of Malignancy in groove pancreatitis.A meticolous clinical approach is refeclting in this case.Imaging is well giving learning .
Introduction is well evidence based.Case presentation is excellent.Discussion is robust with well coverage of latest updates in literaure.References are latest one
Overall, a case report giving good "Message to take home "
"
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Kim N, Lee H, Park D. Challenging diagnosis of groove pancreatitis with severe gastric outlet obstruction: A case report. World J Clin Cases 2025; 13(32): 111796 [PMID: 41256349 DOI: 10.12998/wjcc.v13.i32.111796]
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42
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"1. The review provides a thorough and well-organized synthesis of the complex interplay between MASLD and IBD, with a strong emphasis on the gut microbiota and the gut-liver axis. The topic is highly relevant, given the rising global prevalence of both MASLD and IBD, and the growing recognition of their co-occurrence. The review successfully highlights the shift from a purely metabolic understanding of MASLD to one that incorporates gut-derived inflammation and dysbiosis, which is a crucial contemporary concept.
2. References：The authors have done an excellent job integrating a vast body of literature, making the manuscript a valuable and up-to-date resource for researchers and clinicians.
3. Language：The manuscript is generally well-written in clear and accessible English, which facilitates the comprehension of complex pathophysiological concepts.
4. Figures and tables：A significant shortcoming is the lack of detailed, mechanistic figures. The existing two figures are overly simplistic and do not adequately illustrate the complex molecular and cellular pathways discussed in the text (e.g., the roles of TLRs, bile acid receptors FXR/TGR5, Th17/Treg imbalance, cytokine networks, and the impact of specific microbial metabolites). I strongly recommend the inclusion of at least one high-quality, multi-panel schematic diagram that visually integrates the key proposed mechanisms linking gut dysbiosis, intestinal barrier dysfunction, immune activation, and hepatic inflammation/fibrosis in the context of IBD-associated MASLD.
5. Caveats or drawbacks：
The manuscript contains several typographical and terminological errors that detract from its professionalism. For instance: On Page 4, the text reads "T17 cells play a key role..." This should be corrected to "Th17 cells..." as this is the standard nomenclature for T-helper 17 cells.
While the content is comprehensive, there is some repetition between sections, particularly regarding the description of gut dysbiosis and its consequences in both IBD and MASLD. The flow could be improved by more sharply differentiating the disease-specific mechanisms before synthesizing them into a unified model. The sections on "Eating Behaviour Patterns" and "Nutrition-Microbiota Axis," while interesting, feel somewhat distinct from the core mechanistic focus and could be more seamlessly integrated.
The treatment section briefly mentions probiotics, synbiotics, and cytokine inhibitors (IL-17/IL-23) but lacks depth in discussing the current evidence base, challenges, and future directions for these interventions.
The review excellently describes associations but could more explicitly acknowledge the challenges in establishing causality within the gut-liver axis in human studies.
In summary, this is a timely, informative, and largely well-executed review that makes a valuable contribution to the literature. Its primary strengths lie in its scholarly comprehensiveness and relevance.
"
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Sokal-Dembowska A, Ergan K, Jarmakiewicz-Czaja S. Role of gut microbiota in the development of metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease. World J Gastroenterol 2025; 31(40): 111375 [PMID: 41180986 DOI: 10.3748/wjg.v31.i40.111375]
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43
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"It is generally accepted that IBD results from the interaction of multiple environmental factors in genetically predisposed individuals, and that altered intestinal permeability is a key mechanism in the pathogenesis of the disease, as in many other digestive tract pathologies. Mitochondrial dysfunction in the intestinal mucosa is another mechanism involved in the pathogenesis of IBD.
In the reviewed study, the authors examined the factor GDF15, a member of the TGF-β superfamily, as a biomarker of mitochondrial dysfunction and a mediator of UPRmt. The researchers confirmed elevated circulating GDF15 levels in IBD patients compared with healthy controls and identified a novel molecular mechanism by which this cytokine disrupts the intestinal barrier. Therefore, successfully reducing GDF15 may constitute a therapeutic strategy to prevent intestinal barrier breakdown by reducing immune hyperactivation in the future.
All these basic research studies contribute decisively not only to elucidating the pathogenetic mechanisms of IBD but also to developing new therapeutic strategies that bring us closer to the day when we can achieve complete and sustained inhibition of IBD activity."
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Ruiz-Malagón AJ, Herraiz-Vilela M, Serrano-Pino R, García-Ávila P, Díaz-Suárez L, Carmona-Segovia AD, Becerra-Munoz VM, Jiménez-Navarro M, Arranz-Salas I, López-Villodres JA, Fernández-Castañer A, Gutiérrez-Martínez F, Rodríguez-González FJ, Camargo-Camero R, Alcaín-Martínez G, Rodríguez-Díaz C, García-Fuentes E, Sánchez-Quintero MJ, López-Gómez C. Growth differentiation factor 15 alters intestinal barrier and increases permeability: A new molecular target in inflammatory bowel disease. World J Gastroenterol 2025; 31(41): 110955 [PMID: 41257277 DOI: 10.3748/wjg.v31.i41.110955]
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44
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"a fine-needle aspiration (FNA) biopsy, especially one guided by endoscopic ultrasound (EUS-FNA), is a valuable diagnostic tool for pancreatic tuberculosis. This procedure allows doctors to collect tissue samples to confirm the diagnosis by checking for characteristic signs like granulomas, caseous necrosis, and acid-fast bacilli (AFB) or by using polymerase chain reaction (PCR) to detect the DNA of Mycobacterium tuberculosis. EUS-FNA is especially useful because it can help differentiate pancreatic TB from pancreatic cancer, preventing unnecessary surgery. "
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Nima CL, Wang HG, Zhou Q. Pancreatic tuberculosis: A case report and review of literature. World J Gastroenterol 2025; 31(41): 110398 [PMID: 41257270 DOI: 10.3748/wjg.v31.i41.110398]
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45
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"In this mini-review, the authors described the current understanding of the pathogenesis, diagnosis, and management of hepatic hydrothorax. Despite the successes of modern hepatology, the presence of hepatic hydrothorax is associated with poor prognosis and high mortality. Most patients with hepatic hydrothorax are candidates for liver transplantation. In usual clinical practice, the key to the success of their management may be the stratification of the risk of an adverse outcome and the definition of individual therapeutic tactics. A pathogenetically based approach to the choice of pharmacotherapy, as well as optimization of minimally invasive treatment methods, will improve the quality of life and increase the survival rate of this category of patients. In general, the authors provided well-known information."
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Cilia BJ, Haridy J, Raj A, Hannah N. Hepatic hydrothorax as a manifestation of decompensated cirrhosis: An update on current management and future directions. World J Hepatol 2025; 17(10): 110412 [PMID: 41179726 DOI: 10.4254/wjh.v17.i10.110412]
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46
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"Dear Author
There are parameters like MELD score that show the severity of the disease. This important score was not addressed in the trial. Were the adherent and non-adherent groups had similar MELD scores? Sarcopenia as another important factor that influence cirrhosis out comes. This risk factor was not addressed in this trial. The nutritional status regarding the vitamins and protein intake are among the most important factors that influence cirrhosis out comes. In the future trials considering the variables that influence the patient outcomes should be considered. "
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Loschi TM, Baccan MDTA, Pereira EC, Dellabarba TDLC, Boteon APCS, Boteon YL. Telerehabilitation for frail cirrhotic patients awaiting liver transplant: A safe, effective strategy to improve outcomes. World J Hepatol 2025; 17(10): 110856 [PMID: 41179717 DOI: 10.4254/wjh.v17.i10.110856]
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47
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"Dear Author,
The patient had a history of cirrhosis of the liver based on abdominal CT scan. The data regarding the other causes of chronic hepatitis were not included in the draft. Although using herbal medicine could cause the fulminant hepatitis, yet it is a diagnosis of exclusion. In my opinion, the possibility of coexistence of auto immune hepatitis in this case needs more evaluation."
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Zhu XY, Zhao YT, Su CS, Yuan XD, Zhang SG, Nashan B. Acute liver failure caused by alkaloids from traditional Chinese medicine: A case report. World J Hepatol 2025; 17(10): 109575 [PMID: 41179722 DOI: 10.4254/wjh.v17.i10.109575]
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48
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"In recent years, artificial intelligence (AI) has brought about a real revolution in various fields of human activity, establishing itself as a pioneering innovation in modern medical science. In the field of gastroenterology, and in particular colonoscopy, it has contributed significantly by promoting key quality indicators, reducing the rate of human error, and improving the consistency of endoscopist decision-making with high reliability. Reduce human error and improve endoscopists' decision-making consistency in real time, ensuring higher reliability and standardization during the procedure. By optimizing the characterization of endoscopically detected lesions, supporting visual diagnosis, and predicting the depth of infiltration, AI can enable early diagnosis and prevention of colon cancer. The combination of AI with advanced imaging techniques improves the quality of gastroenterologists' training.
However, much remains to be clarified regarding the role of AI in upper and lower gastrointestinal endoscopy. I believe that the official gastroenterological societies of Europe, the USA, and Asia should immediately delve into studying and defining the possibilities, potential risks of the widespread application of the method, and define policies regarding quality assurance, clinician education, data protection, and liability, so that AI successfully complements human intelligence and experience. The innate tendency of people (in this case, endoscopists) to resist adopting these new technologies should not prevail. They can also help validate AI systems in real-world conditions by assessing their performance across a wide range of quality indicators.
I want to congratulate the authors for their excellent work in a promising field."
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Dimopoulou K, Spinou M, Ioannou A, Nakou E, Zormpas P, Tribonias G. Artificial intelligence in colonoscopy: Enhancing quality indicators for optimal patient outcomes. World J Gastroenterol 2025; 31(40): 111499 [PMID: 41180992 DOI: 10.3748/wjg.v31.i40.111499]
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49
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"This is very interesting paper.Higher serum gamma-glutamyl transpeptidase (γ-GTP) levels are associated with an increased risk of pancreatic cystic neoplasms (PCNs) and their malignant progression. However, γ-GTP is not a specific diagnostic marker for these conditions. Its elevation is more indicative of general liver or biliary dysfunction and oxidative stress. Recent large-scale studies have found that people with higher baseline serum γ-GTP levels have a significantly increased risk of being diagnosed with PCNs later on. This suggests γ-GTP could potentially serve as a biomarker for identifying high-risk individuals for surveillance."
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Lee MW, Park JM, Cho IR, Chung KH, Kim BS, Choi JH, Paik WH, Ryu JK, Han K, Lee SH. Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study. World J Gastroenterol 2025; 31(40): 110932 [PMID: 41180989 DOI: 10.3748/wjg.v31.i40.110932]
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50
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"Artificial intelligence has brought about a real revolution in various areas of human activities, including medical science. In recent years, AI has also emerged as a method to support the correct diagnosis and treatment of acute pancreatitis. Some elements of AI, such as machine learning, deep learning, natural language processing, and network pharmacology, seem to significantly facilitate diagnostic and therapeutic decisions in the treatment of patients with acute pancreatitis, through the analysis of clinical records, medical images, laboratory values, genomic data, and physiological signals in real time. AI functions as advanced decision support, enhancing clinical judgment with intelligence derived from diagnostic data, assessing risks to the patient from potential complications, and helping safely predict the disease. The authors also discuss future directions for AI development in the treatment of acute pancreatitis. As emphasized by the authors of this review, today's practical medicine often requires an interdisciplinary approach that integrates clinical experience, computational modeling, and ethical design. These largely theoretical data currently have limited application, especially in developing countries worldwide. For all health systems and in any country where AI is applied, its assistance should consist of improving decision-making through hybrid human-artificial intelligence models. The future looks excellent, although it causes concern and fear to the undersigned."
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Zhang XY, Hu MD, Maimaitijiang D, Wang T, Wang L. Artificial intelligence in pancreatitis: A narrative review on advancing precision diagnosis, prognosis, and therapeutic strategies. World J Gastroenterol 2025; 31(39): 110971 [PMID: 41180795 DOI: 10.3748/wjg.v31.i39.110971]
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