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"Nanotechnology has evolved into a groundbreaking field, impacting everything from materials science to industrial applications. In medical science, nanomedicine using nanoparticles has led to the creation of new biomaterials suitable for diagnostic and therapeutic applications, particularly in CRC. Nanoscale delivery of anti-neoplastic drugs enables effective, precise administration of the correct doses to patients with CRC. Recent studies report on a variety of nano-biomaterials designed for controlled and targeted drug delivery to CRC, especially in immunotherapy, reprogramming the immunosuppressive tumor microenvironment and improving the effectiveness of immune checkpoint inhibitors. Most applications involving specialized "smart" nanoparticles for colorectal cancer are currently in the preclinical stage (laboratory and experimental animals) with promising results. Integrating Artificial Intelligence into nanomedicine accelerates the design of these platforms, bringing clinical trials in humans ever closer. As the authors point out, closer collaboration between different scientific disciplines and research groups is essential to integrate this technology into CRC treatment."
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Yang ZH, Huang QL, Luo L, Wu XX, Nie SW, Xu MM. Nanotechnology for drug delivery systems in colorectal cancer: Recent developments and future prospects. World J Gastroenterol 2026; 32(35): 121133 [DOI: 10.3748/wjg.121133]
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"This is a timely and relevant Letter to the Editor addressing an important aspect of antimicrobial stewardship in hospitalized patients with IBD. The distinction between antibiotic exposure prevalence and antibiotic consumption intensity is clinically meaningful, and the proposed shift toward indication-specific stewardship, de-escalation, and patient-level metrics such as days of therapy is appropriate and useful in clinical practice in the management of IBD patients. The manuscript is well structured, clearly and concise written, easy ro read, without spelling or grammar errors and provides a useful perspective on the findings of Zeng et al.
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Fiore M. Letter to the Editor: From antibiotic exposure to antibiotic intensity: Rethinking inpatient stewardship in inflammatory bowel disease. World J Gastroenterol 2026; 32(33): 118868 [DOI: 10.3748/wjg.118868]
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"In their interesting study, the authors utilized previous data showing that water temperature significantly affects gastrointestinal peristalsis. They found that low injected-water temperature during diagnostic endoscopic ultrasound with a mini-probe (mEUS) improves image quality, diagnostic accuracy, safety, and comfort during the examination compared with higher water temperatures. In more detail, cold water injection (6-10 °C) reduced gastrointestinal peristalsis and improved image quality of images. The authors concluded that cold-water injection enhances mEUS diagnostic and differential diagnostic value, especially for protuberant lesions, while helping select appropriate treatment strategies.
I believe that in the near future the technique should be applied more widely in specialized diagnostic centers. If these results are confirmed in other multicenter studies, then its application should be generalized. It is anticipated that mEUS using cold water would reduce the use of anticholinergic drugs and improve the diagnostic accuracy of mEUS, especially in cases of malignant tumors of the upper digestive tract.
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Mao XY, Ye MM, Yu XY, Liao JT, Hu Y, Guo M, Zeng B, Li J, Peng L, Hu WF, Liu H, Gong P, Long Y, Wang XY, Tian L. Cold water infusion enhances image quality in sedated miniprobe endoscopic ultrasonography: A prospective, multicenter, double-blind, randomized trial. World J Gastroenterol 2026; 32(34): 118510 [DOI: 10.3748/wjg.118510]
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"Endoscopic submucosal dissection (ESD) is considered the standard therapeutic approach for superficial esophageal carcinoma. Compared with surgery, ESD has advantages such as minimal trauma, rapid recovery, and fewer complications. However, owing to the narrowness of the esophagus, its thin wall, and the absence of a plasma layer, complications such as esophageal stenosis are prone to occur after the procedure. Previous studies have reported esophageal stenosis rates of 11%-20% following ESD. Lesions encompassing more than 3/4 of the circumferential area are among the high-risk factors for stenosis, with an incidence as high as 70% being observed. Moreover, complete circumferential lesion resection results in near-universal stricture formation (approximately 100% incidence) In clinical practice, body mass index (BMI) does not appear to affect the occurrence of postoperative esophageal ESD stenosis, nor does it comprehensively reflect patients' nutritional status. Sarcopenia is a progressive and generalized skeletal muscle disorder involving the accelerated loss of muscle mass and function (strength or performance). In recent years, this condition has evolved from simple muscle mass loss to a unique muscle disorder linked to the postoperative prognosis of various diseases. Sarcopenia (low muscle mass and strength) is an independent risk factor for esophageal stenosis (narrowing) after endoscopic submucosal dissection (ESD). Studies show that patients with sarcopenia have a significantly higher rate of post-ESD stricture (around 48%) compared to non-sarcopenic patients (about 22%). Poor tissue healing and lower systemic reserve drive this increased risk.Sarcopenia has been indicated to be related to the postoperative outcome of patients with various digestive tract diseases. However, no studies have investigated the association between sarcopenia and esophageal stenosis after endoscopic submucosal dissection (ESD). Patients with low skeletal muscle mass face a significantly higher rate of post-ESD stricture formation compared to non-sarcopenic patients, shifting focus toward holistic nutritional and functional pre-assessments. Please tell me the diagnostic criteria for sarcopenia. What percentage of the circumference was resected during the ESD, and how many months post-procedure did the stricture develop?
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Li WM, Liu B, Liu Q. Beyond local injury: Sarcopenia as a systemic host-related determinant of esophageal stenosis after endoscopic submucosal dissection. World J Gastroenterol 2026; 32(34): 118801 [DOI: 10.3748/wjg.118801]
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"1. Ethics
The study was approved by institutional review boards at four centers: Thomas Jefferson University, Johns Hopkins Medicine, National Cheng Kung University Hospital, and the University of Pennsylvania. It followed the Declaration of Helsinki and the Declaration of Istanbul. Written informed consent was obtained from all participants. Patients with a glomerular filtration rate below 30 ng/mL were excluded, as stated in the manuscript. The conflict-of-interest statement is complete. Four authors are shareholders of JBS Science Inc., and this is clearly disclosed.
2. Methods
The experimental design is reasonable and the procedures appear reproducible, but several details need attention.
2.1.Strengths
2.1.1. Urine was mixed with EDTA immediately after collection (final concentration 10–50 mmol/L) and stored at −80°C. Plasma was prepared by two-step centrifugation: 1300 × g for 20 min followed by 3000 × g for 10 min. These pre-analytical steps are described clearly.
2.1.2.DNA extraction followed a published method. Low-molecular-weight DNA (<1 kb) was size-selected with a 0.55× magnetic bead ratio.
2.1.3.UMI adapters were used for NGS library preparation, which should correct PCR errors. HBV genotyping and subgenotyping relied on 42 reference genomes.
2.2.Weaknesses
2.2.1.No tumor tissue mutational profile is available. As a result, the concordance between urine/plasma cfDNA and the tissue gold standard cannot be assessed.
2.2.2.The urine cfDNA isolation method may not recover fragments below 100 bp efficiently. Such short fragments are often enriched for tumor-derived variants. The authors acknowledge this limitation in the Discussion.
2.2.3. Plasma cfDNA was extracted with two different kits: Zymo Quick-cfDNA for Table 1, and a JBS in-house kit for the remaining samples. This inconsistency may introduce systematic bias.
2.2.4.Only four plasma samples were included in the HBV targeted NGS analysis. This small sample size limits the statistical power of the plasma-versus-urine trDNA fragment size comparison.
3. Results
The results appear credible. The main hypothesis is supported, but some conclusions rest on limited evidence.
3.1.Findings supported by the data
3.1.1.HBV transrenal DNA (trDNA) fragments were significantly shorter than human urine cfDNA and plasma HBV DNA (P < 0.001). Figures 2A–B support this finding.
3.1.2.In urine from HCC patients, the median HBV trDNA insert size was 100 bp. This was significantly shorter than in hepatitis (145 bp, P < 0.001) and cirrhosis (113 bp, P = 0.048). Figures 3A–D present these data clearly.
3.1.3.HCC-specific 5′ 4-mer end motifs, such as CCAA and GAGA, were 3–6 times more abundant in urine cfDNA from HCC patients than from non-HCC patients. No such difference was observed in plasma. This is one of the most novel findings in the study.
3.1.4.qPCR showed an overall urine–plasma mutation concordance of 78.3% (95% CI, 72.0–83.7%). Targeted NGS in HCC showed 97% concordance at the site level.
3.2.Findings with limited evidential support
3.2.1.Positive concordance was only 23.7% by qPCR and 17.7% by NGS. Urine and plasma therefore capture the same tumor mutations quite differently. The authors attribute this to “biological variation,” but without tissue controls it is impossible to determine which source is closer to the true mutation status.
3.2.2.The proposed link between HBV trDNA size differences and HCC—increased tumor cell death or a predominance of clonally expanded HBV DNA—lacks direct experimental evidence. It remains an interpretive hypothesis.
4. Figures and Tables
The figures and tables are well prepared and clearly annotated.
4.1. Figure 1 gives a clear overview of the study design.
4.2. Figures 2A–B compare fragment sizes among HBV trDNA, urine cfDNA, and plasma HBV DNA. The data are easy to follow.
4.3. Figures 3A–D show HBV DNA insert size distributions and statistical results by disease group.
4.4.Figures 4A–B compare the frequencies of the top 10 5′ 4-mer end motifs in plasma and urine.
4.5.Table 1 summarizes qPCR mutation concordance data for 101 HCC patients. The information density is reasonable.
One suggestion: the VAF correlation in Supplementary Figure 2 (Pearson’s r = 0.966) is mentioned only in the text. These key correlation data should be included in a main figure or table.
5. Biostatistics
The statistical methods are mostly appropriate, but there are several weaknesses.
5.1 Appropriate choices
5.1.1.Student’s t-tests and one-way ANOVA were used for fragment size comparisons. These are suitable for group comparisons.
5.1.2. Cohen’s κ (0.565) and overall percent agreement were used for concordance analysis. This is an appropriate approach.
5.1.3.Pearson’s r (0.966) was used to assess VAF correlation. That is reasonable for continuous variables.
5.2 Problems and limitations
5.2.1.In Table 1, TP53 positive concordance was 0.0% (0/10). There was no overlap between urine and plasma among TP53 mutation-positive samples. This extreme result may reflect small sample size or a methodological problem, but the authors do not discuss it.
5.2.2.No correction for multiple comparisons was described. It is unclear whether post-hoc tests after ANOVA used Bonferroni or another adjustment.
5.2.3.The reporting of 95% confidence intervals is incomplete. In Table 1, some intervals have a lower bound of 0.0%, which indicates very unstable estimates. These should be interpreted cautiously.
5.2.4.The HBV targeted NGS analysis included only four plasma samples. No statistical rationale is provided for this subgroup analysis.
6. References
The references are generally appropriate and cover important work in the field. However, there are a few self-citation and recency issues.
6.1.Strengths
6.1.1.The citations include key trDNA literature: Chan et al. (2008) on EBV trDNA, Su et al. (2004) on urine DNA, and Markus et al. (2021) and van der Pol et al. (2023) on urine cfDNA fragmentomics.
6.1.2 .Jiang et al. (2015) on plasma DNA length changes in HCC is cited. This is directly relevant to the core findings.
6.1.3.Mouliere et al. (2021) on urine cfDNA in glioma is cited, which shows cross-cancer awareness.
6.2.Issues requiring attention
6.2.1.The DOI for reference [20] points to a paper on digoxin metabolism (Schmoldt A, Biochem Pharmacol 1975). It is unrelated to urine DNA extraction. This is a clear citation error and should be corrected to the intended reference.
6.2.2.The authors’ previous work on urine HBV DNA [29] (Jain et al., BMC Gastroenterol 2018) and HCC urine DNA biomarkers [6–7] is cited multiple times. Some self-citation is present, but it remains within a reasonable range.
6.2.3.Few references from 2026 are included. Given the September 2026 publication date, the recency of citations is acceptable.
7. Language
The writing is clear and professional overall. It follows standard academic conventions.
7.1.Good points:
7.1.1. The Abstract, Introduction, Methods, Results, and Discussion are logically organized.
7.1.2.Technical terms such as “transrenal DNA,” “cell-free DNA,” and “variant allele frequency” are used accurately.
7.1.3. Figure legends and table notes are complete enough to be understood independently.
7.2.Minor points:
7.2.1. Some long sentences could be split to improve readability. One example is the first paragraph of the Discussion.
7.2.2.In the Methods, the phrase “Patients with glomerular filtration rates < 30 ng/mL” contains a unit error. GFR should be expressed in mL/min/1.73 m², not ng/mL.
8. Caveats or Drawbacks
The authors acknowledge several limitations in the Discussion. The following is a combined assessment.
8.1.Limitations already identified
8.1.1. No tissue control is available. The true-positive rate of urine/plasma cfDNA mutation detection cannot be verified. This is the largest methodological gap in the study.
8.1.2. Most patients have early-stage disease. With a 10 ng DNA input, detection sensitivity may be affected.
8.1.3. Recovery of fragments below 100 bp is insufficient. This may underestimate the true detection rate of tumor-derived variants.
8.1.4. Standardization across laboratories is lacking. Differences in DNA isolation and sequencing methods limit generalizability.
8.1.5. The sample size is limited: four plasma samples in HBV targeted NGS, and 15 paired samples in HCC targeted NGS.
8.2.Limitations not adequately discussed
8.2.1. The generalizability of HBV as a transrenal DNA marker is not addressed. HBV DNA is used as a liver-derived trDNA marker, but it is unclear whether the approach applies to HBV-negative HCC patients. These patients account for a substantial proportion of HCC.
8.2.2. Renal function is not fully controlled. Patients with GFR <30 were excluded, but the authors did not analyze whether trDNA detection rates vary with renal function. Glomerular filtration directly affects transrenal DNA excretion.
8.2.3. The discrepancy between qPCR and NGS results is not explained. qPCR showed 78.3% overall concordance, whereas NGS showed 97% site-level concordance. The difference may be due to different units of analysis. The authors do not discuss this.
9.Overall Assessment
This is a well-designed, data-rich exploratory study. It provides valuable preliminary evidence for urine cfDNA in HCC liquid biopsy. The fragmentomics analysis, especially the 5′ 4-mer end motif differences, is the most innovative contribution. However, the lack of tissue controls and gold-standard validation is a major weakness. The conclusions should be regarded as proof-of-concept. They need to be confirmed in larger cohorts that include tissue controls."
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Kim AK, Lin SY, Liu HN, Jain S, Gade TP, Shieh FS, Hamilton J, Hann HW, Chang TT, Goryunov D, Wang Z, Su YH. Urinary cell-free DNA as a noninvasive liquid biopsy for hepatocellular carcinoma. World J Gastroenterol 2026; 32(33): 118587 [DOI: 10.3748/wjg.118587]
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"The authors developed and implemented a preoperative artificial intelligence-based model that combines and integrates clinical variables with MRI-derived features to predict the need for neoadjuvant chemoradiotherapy in SNCs staged as cT1-2N0 rectal cancer. This model was shown to be effective in identifying patients with cT1-2N0 rectal cancer who require neoadjuvant chemoradiotherapy, thereby increasing the proportion of patients who will benefit from neoadjuvant chemotherapy. Compared with radiologist evaluation of the same data, this model demonstrated greater reliability and clear advantages in clinical decision-making. One can comment on the results of this study by noting the need to verify the findings by other centers treating rectal cancer, and by considering the possibility of their widespread adoption and application. I believe that the results of such studies should be carefully evaluated by competent scientific bodies, which will make the necessary recommendations and prompts for further study and practical application of these findings."
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Kang BY, Bai H, Ni K, Qiao YH, Li YL, Wang YQ, Wang Q, Zhu J, Li JP. Artificial intelligence-integrated multimodal data-assisted magnetic resonance imaging for neoadjuvant chemoradiotherapy decision-making in cT1-2N0 rectal cancer. World J Gastroenterol 2026; 32(33): 118584 [DOI: 10.3748/wjg.118584]
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Benea I, Fabbri N, Pesce A, Feo CV. Indocyanine green-guided laparoscopic completion cholecystectomy for stump syndrome: A case report. World J Clin Cases 2026; 14(23): 121732 [DOI: 10.12998/wjcc.121732]
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8
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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See KC. Performing medical thoracoscopy safely in the outpatient setting: A case report. World J Clin Cases 2026; 14(23): 121367 [DOI: 10.12998/wjcc.121367]
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"In this manuscript, authors stated ‘Has increased significantly’ which was a strong epidemiologic claim and needed supporting data and reference. They also wrote ‘Clinical significance of BMMs’. I think this statement was vague. More precise phrasing would be ‘To compare bone metabolic markers (BMMs) between patients with T2DM with and without OP and identify factors independently associated with OP’. In methods section, authors wrote ‘Using dual-energy X-ray absorptiometry as the gold standard’ which was also imprecise. DXA was the standard method for assessing bone mineral density and diagnosing osteoporosis, but ‘gold standard’ may depend on the diagnostic criteria used. Authors should state the specific diagnostic threshold and criteria. In presentation of the findings, authors wrote overloaded variables. It would be clearer to prioritize the clinically important findings; age, HbA1c, PTH, and β-CTX. The long list of nonsignificant variables added considerable clutter. They should be presented in tables. I also noted that authors used ‘OP comorbidity’ and ‘T2DM patients with comorbid OP’ terminology. I found them awkward. I recommend authors to prefer ‘osteoporosis in patients with T2DM’ or ‘coexisting osteoporosis’ phrases. Similarly, ‘risk determinants’ terminology implied causality. But, the study was observational. I recommend ‘independent factors associated with OP’ or ‘independent risk factors’ terms. In discussion and conclusion sections, authors stated that ‘PTH provides valuable guidance for OP diagnosis’ which overstated the findings presented in results section. An association didn’t establish diagnostic utility. Unless diagnostic performance was evaluated, authors should wrote that elevated PTH ‘may be associated with the presence of OP’. "
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Lu HL, Yu F, Zhou HF, Hu P, Gan SL. Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study. World J Diabetes 2026; 17(8): 123389 [DOI: 10.4239/wjd.123389]
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10
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"In this manuscript, authors addressed an important clinical problem. They presented a potentially useful physiologic approach. The findings presented in results were promising, but several methodological and wording issues should be addressed. Authors wrote ‘fever, mania, inflammation and depression caused by the imbalance of water and electrolytes’ statement. This phrase was erratic because they were not standard DKA related symptoms collectively attributable to fluid/electrolyte imbalance, and ‘mania’ and ‘depression’ were particularly inappropriate. Authors should consider focusing on dehydration, hemodynamic instability, electrolyte disturbances, and cerebral complications. In methodology, authors described two stage design, which was confusing. They called the second stage ‘embedded, comprehensive review’ and then stated ’we systematically retrieved’ and ‘conducted a systematic review’ was really redundant. They should clearly distinguish the prospective proof of concept study from the systematic review. As primary outcome, authors reported net fluid balance at three time points as ‘the primary outcome’. This was somewhat awkward. They should specify whether this was a repeated measures outcome or whether one time point was pre-specified as primary. Moreover, I noted that in results section that absolute differences in fluid balance were difficult to interpret without the corresponding group values and confidence intervals. Authors wrote ‘-1246.8 mL’ and they should make clear that this was the between group difference. As a systematic review, authors added useful context. However, systematic review’s relationship to the intervention study should be clearer. Also, ‘externality validation and generalization’ was sound as nonstandard wording. They should use ‘to assess the generalizability of the findings and contextualize the available evidence’. "
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Bo Y, Li HJ, Han ZZ, Tian LJ, Chen YF. Non-invasive haemodynamic monitoring to individualise fluid resuscitation in adult diabetic ketoacidosis: A randomized controlled pilot trial. World J Diabetes 2026; 17(8): 121563 [DOI: 10.4239/wjd.121563]
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"Overall, I think the study was strong, logical, and included a clear study question. Statistics were appropriate and findings were clinically important. Authors used generalized additive models, two-piecewise regression, subgroup analyses, and sensitivity analyses in the work. These approaches provided a well support for the reported nonlinear associations. In methods, authors explained ‘nonlinearity’ meant was unnecessary for a scientific paper and could be removed. Authors also wrote ‘Missing glycated HGB (HbA1c) data’ which was incorrect terminology. HbA1c is glycated hemoglobin, not “glycated HGB.” Also, authors should clarify why HbA1c was missing and whether it was the only variable imputed. In results section, authors wrote ‘RBC and white blood cell (WBC) counts’ after mentioning HCT/HGB/RBC. They should consider separating the associations like ‘higher HCT, HGB, RBC count, and WBC count’. Moreover, if the inflection point was approximately 45 cm², I advise authors to report confidence intervals clearly. This would make the threshold estimate more informative. In discussion and conclusion sections, ‘sensitive indicators of visceral fat burden’ statement overstated the evidence presented in this work. Authors showed association, not diagnostic sensitivity or predictive validity in the current study. ‘Potential markers of visceral adiposity’ would be more defensible. "
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Rao ZC, Xu CY, Hua LY, Fang ZR, Zhu CY, Zhang YM. Visceral fat area and red-blood-cell-related indices in adults with type 2 diabetes: Cross-sectional evidence of nonlinear associations. World J Diabetes 2026; 17(8): 121923 [DOI: 10.4239/wjd.121923]
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"Overall, I think the paper was clear and written on a clinically relevant question. The results of the study were specific and quantitatively supported, especially the correlations of HbA1c. In my opinion, the wording ‘may contribute to glycemic regulation and the pathophysiology’ was stronger than warranted by a cross sectional, observational correlation analysis. Authors may consider writing ‘may be associated with’ instead of implying causality. In methods, the statement ‘Demographics and clinical characteristics were briefly evaluated’ was vague and slightly awkward. I recommend authors to write ‘Demographic and clinical characteristics were assessed’. In results, the number of elements reported was substantial. For brevity, I recommend authors to prioritize the most clinically relevant findings and avoid listing every association. They belong to the tables. Conclusion of the study was appropriate since authors acknowledged the need for longitudinal studies and healthy controls. "
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Abdelbaset-Ismail A, Hui X, Lin Q, Gu C, Xu J, Watson S, Cai L, Tan Y, Wintergerst KA. Serum elemental profiles and their associations with glycemic control in pediatric type 1 and type 2 diabetes. World J Diabetes 2026; 17(8): 122649 [DOI: 10.4239/wjd.122649]
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13
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"This is very interesting paper about the relationship between urinaryD1AcSpm and cancer.. Urinary N1, N12-diacetylspermine (DiAcSpm or DAS) is a modified polyamine excreted in higher amounts during rapid cell turnover, serving as a potential non-invasive biomarker for gastrointestinal malignancies like gastric and colorectal (colon) cancer. Clinical Relevance and Findings Biomarker Potential: DiAcSpm levels are significantly elevated in the urine of patients with gastric and colorectal cancers compared to healthy individuals or those with benign gastrointestinal conditions. Diagnostic Value: It often shows higher sensitivity than traditional serum markers (such as CEA or CA19-9), particularly for detecting early-stage colorectal tumors. Combining DiAcSpm with conventional markers further increases detection sensitivity. Prognosis and Monitoring: Elevated levels can correlate with advanced tumor stages and distant metastasis (notably in gastric cancer), and studies show that urinary concentrations tend to decrease following successful chemotherapy.
The primary advantage of DiAcSpm measurement is that it is a non-invasive test utilizing urine. Because it does not require a blood draw, it imposes minimal physical burden, making it easier for patients to continue with regular cancer screenings. Furthermore, the use of a dedicated automated analyzer ensures rapid and highly reliable results. This allows for the reliable assessment of changes in urinary DiAcSpm levels over time in the same individual, offering potential utility for the continuous monitoring of cancer progression and treatment efficacy.
Research on the Utility of DiAcSpm: Potential Across Various Cancer Types
Multiple studies have reported that DiAcSpm may offer advantages over conventional tumor markers across a variety of cancer types.
Early Detection of Colorectal Cancer:
?
Lung Cancer (Non-Small Cell Lung Cancer contribute to the early detection of lung cancer.
Breast Cancer Screening:
Novel Marker for Pancreatic and Biliary Tract Cancers:
Please tell me what kinds of cancer is most sensitive for detection in DiAcSpm ?
Is this tumor marker test available at general clinics?
and Findings Biomarker Potential: DiAcSpm levels are significantly elevated in the urine of patients with gastric and colorectal cancers compared to healthy individuals or those with benign gastrointestinal conditions. Diagnostic Value: It often shows higher sensitivity than traditional serum markers (such as CEA or CA19-9), particularly for detecting early-stage colorectal tumors. Combining DiAcSpm with conventional markers further increases detection sensitivity. Prognosis and Monitoring: Elevated levels can correlate with advanced tumor stages and distant metastasis (notably in gastric cancer), and studies show that urinary concentrations tend to decrease following successful chemotherapy.
The primary advantage of DiAcSpm measurement is that it is a non-invasive test utilizing urine. Because it does not require a blood draw, it imposes minimal physical burden, making it easier for patients to continue with regular cancer screenings. Furthermore, the use of a dedicated automated analyzer ensures rapid and highly reliable results. This allows for the reliable assessment of changes in urinary DiAcSpm levels over time in the same individual, offering potential utility for the continuous monitoring of cancer progression and treatment efficacy.
Research on the Utility of DiAcSpm: Potential Across Various Cancer Types
Multiple studies have reported that DiAcSpm may offer advantages over conventional tumor markers across a variety of cancer types.
Early Detection of Colorectal Cancer:
?
Lung Cancer (Non-Small Cell Lung Cancer contribute to the early detection of lung cancer.
Breast Cancer Screening:
Novel Marker for Pancreatic and Biliary Tract Cancers:
Please tell me what kinds of cancer is most sensitive for detection in DiAcSpm ?
Is this tumor marker test available at general clinics?
"
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Zheng HZ, Wang P, Zheng HJ, Wang ZQ, Li QX, Chen HW, Chen HQ, Lei QC. Urinary N1, N12-diacetylspermine as a potential tumor biomarker for gastric and colorectal cancer. World J Gastroenterol 2026; 32(33): 118185 [DOI: 10.3748/wjg.118185]
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14
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"This paper synthesizes evidence from multiple recent studies and clinical trials to provide a comprehensive overview of the current status and future directions of HER2-targeted therapy in urothelial carcinoma (UC). Building on perspectives previously articulated in the Centennial Special Column of the Chinese Medical Association （https://pubmed.ncbi.nlm.nih.gov/40443342/）—where I argued that “over the past half-century of global efforts against cancer, the vast majority of investigations in both basic tumor research and clinical practice have centered on the somatic mutation paradigm”—we propose a conceptual reframing. This paradigm underpins molecular classification, individualized precision medicine, gene therapies, neoantigen-based vaccines, and advances in sequencing technologies; even in the tumor microenvironment—including tumor immunity—the mechanistic explanations routinely converge on driver mutations in tumor or stromal cells. Yet, despite its dominance, the somatic mutation paradigm has not yielded broadly curative clinical interventions. HER2-targeted therapy exemplifies this paradigm in practice—but also exposes its fundamental limitations. When patients develop resistance or relapse, clinical responses typically focus on identifying next-generation inhibitors or combinatorial regimens, without adequately addressing the root cause: evolutionary adaptation of tumor cell populations under selective pressure. We contend that a paradigm shift is urgently needed—from viewing cancer solely as a collection of acquired mutations to recognizing it as a dynamic, ecosystem-level evolutionary process （https://loop.frontiersin.org/people/588275/bio）. Only such a foundational reorientation can unlock transformative progress in oncology research and therapy."
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Ismaili N. Emergence of human epidermal growth factor receptor 2 as a key biomarker and therapeutic target in advanced urothelial carcinoma. World J Clin Oncol 2026; 17(7): 116520 [DOI: 10.5306/wjco.116520]
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15
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"The current manuscript is focusing on major scientific and methodological issues. The central hypothesis is interesting, but several conclusions especially related to CCM3, PI3K–AKT, ferroptosis, and “neural damage preceding vascular damage” are currently stronger than the data support. The lead exposure dose is extremely high and its translational relevance needs to be addressed. However, the manuscript does not report actual water consumption or calculate daily lead intake (e.g., mg/kg/day) while the lead consumption corresponds to very high nominal lead concentration."
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Liang X, Yang LX, Tao T, Ding WJ, Tang XY, Shang ZB, Zhou H, He Y, Sun Y. Role of CCM3 in lead-induced neurological damage in diabetes. World J Diabetes 2026; 17(8): 113938 [DOI: 10.4239/wjd.113938]
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16
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"There is currently no optimal treatment for alcoholic liver disease. The authors used a C57 mouse model to determine whether saroglitazar could prevent or improve alcohol-induced liver injury.
Using a preventive study design, the authors demonstrated that the use of saroglitazar is associated with reduced plasma alanine aminotransferase and plasma ethanol levels and with increased plasma acetate levels compared to a vehicle.
Authors showed in therapeutic study model that saroglitazar reduced plasma alanine aminotransferase, aspartate aminotransferase and triglyceride levels; reduced plasma ethanol concentrations buth increased plasma acetate levels compared to a vehicle. Saroglitazar also reduced fat accumulation in the liver.
Saroglitazar is associated with altered alcohol metabolism, significantly improves plasma and liver biomarkers associated with alcoholic liver disease. These findings must be validated in further animal experiments and human studies.
1) The ethical approval form provided by the author meets the requirements
2) Experimental method is effective and can be repeated by other researchers
3) The results are authentic and excellent. The research is highly innovative; howerer hypothesis should first be validated in an animal model and then in humans.
4) The authors provided perfect tables.
5) Biostatistics is adequate.
6) References are carefully selected.
7) I am not qualified to assess the quality of the English, but I did not find any major errors in the manuscript.
8) I don't have any major caveats or drawbacks
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Giri SR, Bhoi B, Trivedi C, Rath A, Jadhav V, Palode S, Ranvir R, Patel A, Sundar R, Patel H, Jain MR. Saroglitazar ameliorates alcoholic liver disease and is associated with enhanced ethanol metabolism. World J Hepatol 2026; 18(7): 120153 [DOI: 10.4254/wjh.120153]
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17
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"This manuscript offers an insightful and well-structured comparative analysis of the prevention and management of metabolic dysfunction-associated steatotic liver disease (MASLD) between Egypt and China. Grounded in accurate epidemiological metrics and supported by a robust, contemporary reference list, the work objectively synthesizes macro-level data, viral hepatitis co-exposure profiles, and resource disparities to deliver valuable public health implications for developing nations. The scientific arguments are robust and the language is professional and polished. The reference list is up-to-date, and highly relevant. However, to further strengthen its future translational impact, the authors may benefit from incorporating real-world health economic evaluations and detailing specific, cost-effective frameworks for tiered primary care implementation."
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Liu XL, Fan JG. Letter to the Editor: Prevention and management of metabolic dysfunction-associated steatotic liver disease: Insights from Egypt and implications for China. World J Gastroenterol 2026; 32(32): 117644 [DOI: 10.3748/wjg.117644]
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"The manuscript is a valuable, well-written and multidisciplinary thinking. However, the authors should have explicitly defined its boundary conditions in the discussion, clarifying that biological scale acts as one intersecting element alongside host genetics, immune competence, and dynamic microenvironmental factors.
1. Ethics:Compliant / Not Applicable (Narrative Design).
2. Methods: Qualitative Literature Synthesis (No Primary Experiments).
3. Results:Valid Conceptual Model with Inherent Methodological Boundaries.
4. Figures and Tables: Does the author provide clear, well-annotated tables and visual aids?Clear, Structured, and Well-Organized.Detailed Assessment
5. Biostatistics: Does the author provide sound biostatistical data? Not Applicable.
6. References: Scientific, Reasonable, and Relevant.
7. Language: Does the language correctly, clearly, and concisely express the information?Evaluation: Clear, Academic, and Precise.
8. Caveats or Drawbacks: What are the main limitations, missing dimensions, and conceptual gaps?
Evaluation: SScope and Conceptual Boundaries
While the manuscript offers strong pedagogical utility, a critical peer analysis reveals major conceptual limitations:
A. Single-Axis OversimplificationThe primary limitation inherent to this article type is that conceptual and opinion frameworks are not falsifiable in the way empirical studies or biophysical models are. The "size as a central determinant" thesis—while intuitively appealing and supported by literature (e.g., pathogen size vs. phagocytic clearance, BMI-infection U-shaped curves)—risks oversimplifying multifactorial host-pathogen dynamics into a single organizing axis.
Real-world infection outcomes are heavily governed by confounding axes operating independently of scale, including host genetics, microbiome architecture, comorbidities, and socioeconomic factors.
B. Host-Side Vulnerability ExclusionsThe framework models the human host as a static, immunocompetent entity, omitting:
-Host Genetic Susceptibility: Receptor polymorphisms (e.g., CCR5, ACE2) and hereditary structural defects (e.g., ciliary dyskinesias, CFTR mutations) alter entry and clearance dynamics at the molecular level, independent of organism size.
-Host Frailty & Immunosuppression: States of compromised host immunity—such as primary immunodeficiencies, secondary immunosuppression (oncologic or biologic therapies), immunosenescence, or extreme age—functionally collapse specific cellular and humoraldefense tiers, invalidating standard physical barrier scaling.
C. Pathogen-Side Exclusions & Static Assumptions
-Atypical Infectious Agents: Sub-viral and non-cellular entities, notably prions (misfolded proteins) and viroids, are excluded from the main comparative framework.
-Polymicrobial Complexity: The review evaluates host-pathogen interactions through an isolated single-pathogen lens, bypassing the clinical realities of co-infections, superinfections, and polymicrobial biofilm synergy.
-Static vs. Dynamic Realities: Assigning static average dimensions to pathogens simplifies dynamic biological shifts, such as fungal dimorphism (yeast-to-hyphae transitions), bacterial filamentation, and transient morphologic adaptations during tissue invasion "
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Pati BK, Panda PK. Body size and infection: An immunological balancing act. World J Immunol 2026; 16(2): 114815 [DOI: 10.5411/wji.v16.i2.114815]
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"The incidence of intraoperative biliary injury during laparoscopic cholecystectomy (LC) is reported to be approximately 0.6%, and cases involving proximal bile duct or hepatic artery injury require appropriate management. Detailed evaluation confirmed a disconnection between the left and right bile ducts as well as a concomitant injury to the right hepatic artery; based on the Strasberg classification, this case was diagnosed as Class E4. Although the authors considered performing a right hepatectomy—given the potential for sequelae such as right hepatic lobe abscess, recurrent cholangitis, and bile duct stenosis—biliary reconstruction was performed instead due to the patient's general condition. The patient subsequently died of postoperative sepsis; what was the status of the right hepatic abscess on the postoperative CT scan? Please also describe in detail the reasons why a hepatectomy was not performed. Unlike hepatic parenchymal cells, which receive a dual blood supply from the portal vein and the hepatic artery, the bile ducts are nourished primarily by the choledochal plexus, which is formed around the arteries. Therefore, ensuring arterial blood flow to the bile ducts is crucial for preventing postoperative biliary complications. Past reports indicate that severing the hepatic artery can lead to ischemia at the biliary reconstruction site, resulting in anastomotic leakage or biliary stenosis; these complications can trigger recurrent cholangitis and potentially progress from hepatic abscess to liver failure. Furthermore, as hepatectomy is a surgical procedure that carries a risk of operative mortality, it should not be selected lightly. When hepatectomy is indicated, the decision must be carefully weighed—taking into account factors such as hepatic functional reserve and anatomical details—and the procedure should be performed at a specialized facility. The case presented involved extensive tissue damage; please discuss methods to prevent bile duct and arterial injuries in such cases.
"
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Stelzl A, El-Mahrouk M, Stiegler P, Wagner M, Sucher R. Biliary sunrise - bile color as visible sign for hepatic ischemia after iatrogenic partial liver de-arterialization: A case report. World J Gastroenterol 2026; 32(31): 122449 [DOI: 10.3748/wjg.122449]
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"With interest I reviewed the article quality of the following editorial. Please see below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The included table adds to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate/up-to-date
7 Language: This is a detailed editorial which is well structured
8 Caveats or drawbacks: None "
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Papadakos SP, Katsaros I, Liatsou E, Argyrou A, Schizas D. Reflux self-medication and limited healthcare consultation: Systemic inadequacies in Barrett’s esophagus screening, surveillance, and management. World J Gastroenterol 2026; 32(31): 117258 [DOI: 10.3748/wjg.117258]
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied"
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Hagerman-Sucar G, Vázquez-Nicolás DA, Quiñones-Corona V, Olaya-Herrera M, Rodríguez Reyes A, Furuzawa-Carballeda J, Aguilar-León D, Torres-Villalobos G. Acute tension gastrothorax post hiatal hernia repair and Nissen fundoplication: A case report. World J Clin Cases 2026; 14(22): 121141 [DOI: 10.12998/wjcc.121141]
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied"
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Mirghani HO, Alanazi GO. Irritable bowel syndrome and colon cancer: A meta-analysis. World J Clin Cases 2026; 14(22): 121062 [DOI: 10.12998/wjcc.121062]
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied"
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Nguyen HN. Laparoscopic repair of a rare Morgagni hernia: A case report. World J Clin Cases 2026; 14(22): 120306 [DOI: 10.12998/wjcc.120306]
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"It is widely accepted that the predominant type of gastroesophageal reflux disease is non-erosive reflux, a situation that significantly affects patients' quality of life. It is so named because, on classical endoscopy, it is difficult to detect the small changes that occur in the esophageal mucosa as a result of reflux. In recent years, advances in endoscopic technology have made it possible to detect small changes in the esophageal mucosa of these patients. These developments have significantly improved the diagnostic accuracy of endoscopy. Recent advances in endoscopic imaging capabilities to detect subtle microstructural changes in patients with non-erosive reflux are of great help in assessing patients' actual condition and planning the most appropriate treatment. However, numerous questions arise regarding the diagnostic application of advanced techniques in daily clinical practice (especially when patients' symptoms are typical of reflux), or to what extent the detection of endoscopic findings other than the presence of Barrett's esophagus would modify treatment. Perhaps the emerging capabilities of artificial intelligence for automated analysis of imaging data can help in this regard, as can the development of integrated diagnostic strategies that combine symptom questionnaires, endoscopic methods, functional measures, and clinical biomarkers to enhance the management of non-erosive reflux, as mentioned by the authors. Finding and adopting adequate alternative ways to diagnose NERD are very important parameters for these patients."
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Zhang WT, Xu M, Zheng Y, Wu J, Zheng YJ, Wei J, Kang T, Jiang J, Cheng Y. Endoscopic diagnosis of non-erosive reflux disease. World J Gastroenterol 2026; 32(30): 119177 [DOI: 10.3748/wjg.119177]
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"This is well-written and presented an extremely rare case report.on "Gastrojejunal fistula".Most of Gastrojejunal fistula are secondary, resulting from other abdominal diseases such as peptic ulcer disease, malignancy, or prior surgery. Congenital Gastrojejunal fistula presented by the authors is an extremely rare case report. This a rare case report has certain guiding significance for clinicians.
I think that this manuscript is suitable and worth to be published in the World Journal of Gastrointestinal Surgery. "
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Chen XR, Guo HY, Liang R, Zhang CY, Yuan XB, Wang XF. Congenital gastrojejunal fistula in an asymptomatic adult: A case report. World J Gastrointest Surg 2026; 18(7): 120053 [DOI: 10.4240/wjgs.120053]
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"Summary
In this study, pulsed-wave spectral Doppler ultrasonography was used to measure ophthalmic artery hemodynamic parameters in second-trimester pregnant women. The primary objective was to assess whether these variables could predict the subsequent development of pregnancy-induced hypertension and identify patients at increased risk for preeclampsia. The results demonstrated that an elevated peak ratio was strongly associated with the later onset of preeclampsia, suggesting its potential value of prediction.
Strengths and Limitations
A notable strength of this study is its clear clinical relevance. However, in addition to the limitations acknowledged by the authors, several other issues must be mentioned:
(1) The term "hypertensive disorder" should be further specified—for example, as "pregnancy-induced hypertension" or "hypertensive disorders of pregnancy"—to enhance clarity in context.
(2) The classification of the second trimester as "17–23 weeks of gestation" is inaccurate. According to current obstetrical standards, the second trimester spans from 14 weeks to 27 weeks and 6 days of gestation.
(3) The "Core tip" section does not meet the journal's required criteria, and key contents have missed.
(4) In Figures 1 and 2, the ophthalmic arteries are not properly visualized. In both cases, the insonation angle between the sampling line and the ophthalmic artery exceeds the authors addressed threshold (<20°)(although <60°allowed for some peripheral vessels), and the placement of the angle correction line(orientation) is incorrect. Given that pulsed-wave Doppler-derived hemodynamic values are highly dependent on the aforementioned technical factors, non-standard protocols may compromise the accuracy of the measurements. Consequently, the issues evident in these figures undermine the robustness and validity of the study's results and conclusions. It is worth noting that proper visualization of the ophthalmic artery and adjustment of the insonation angle to within 20°are not technically challenging to achieve.
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Dhiman R, Nayyar N, Takkar P, Sood D, Shukla A. Predictive value of second-trimester ophthalmic artery Doppler for identifying women at risk for preeclampsia. World J Radiol 2026; 18(7): 120995 [PMID: 42534172 DOI: 10.4329/wjr.120995]
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied"
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Karam K, Charro K, Kechaou D, Abarah W, Rakotobe J, Locher C. Rectal mantle cell lymphoma endoscopically mimicking ulcerative proctitis: A case report. World J Clin Cases 2026; 14(21): 120444 [DOI: 10.12998/wjcc.120444]
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"This study analyzed 97 HCC patients and confirmed that PIV demonstrates higher survival predictive power than ALBI or MELD-Na, establishing it as an independent prognostic factor. Patients with high-PIV showed a median survival of 5 months, while those with low-PIV had a median survival of 30 months, demonstrating a significant difference. Along with ECOG, PIV emerged as the most powerful risk indicator, highlighting the prognostic value of inflammation-based biomarkers."
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Karatlı S, Yazılıtaş D, Kaya S, İmamoğlu Gİ, Çelik S, Uyar GC. Prognostic value of pan-immune-inflammation index in hepatocellular carcinoma compared with albumin-bilirubin and model for end-stage liver disease sodium. World J Gastrointest Oncol 2026; 18(7): 121250 [DOI: 10.4251/wjgo.v18.i7.121250]
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"This paper integrated the evaluation of considerations regarding 97 items concerning herbal medicine treatments used in colorectal cancer, comprehensively analyzing the reporting, methodology, and evidence levels. Regarding the explanation of the law of moderation, the herbal law indicates the effects on ORR and KPS improvement. However, since there is methodological margin in most SRs, relatively rational conclusions do not exist, and this paper proposes the value of considerate, high-quality RCTs and SRs."
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Wang HP, Qin XY, Xu BW, Lu TC, Gao RK, Lin M, Li J. Chinese herbal medicine for colorectal cancer: An overview of systematic reviews and evidence map. World J Gastrointest Oncol 2026; 18(7): 120031 [DOI: 10.4251/wjgo.120031]
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"This study developed a diagnostic scoring model to predict liver metastasis in elderly patients with lung and colorectal cancer by combining four seromarkers—ST2, PIVKA-II, CEA, and CA125—with a history of fatty liver. The combination of the four markers demonstrated the highest sensitivity and specificity, and effectively predicts the likelihood of liver metastasis by classifying patients into low, medium, and high-risk groups based on their total score (0–12 points)."
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Cheng Y, Sun YS, He YM. ST2, PIVKA-II, CEA, CA125 and their combinations in elderly liver metastases cancers: Development of a diagnostic scoring model. World J Gastrointest Oncol 2026; 18(7): 118940 [DOI: 10.4251/wjgo.v18.i7.118940]
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"The greatest strength of this paper is that it is the first to integrate the PS-1/β-catenin/p-PTEN axis into a single invasion regulatory network. It identified a novel mechanism in which PS-1 stabilizes β-catenin and induces p-PTEN to promote gastric cancer invasion, and enhanced the reliability of the results through a multi-layered approach encompassing clinical, cell, and animal experiments. Furthermore, it expanded the potential for developing therapeutic targets by suggesting that the co-high expression of the three molecules can serve as a prognostic indicator."
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Xiao S, Song DD, Yu YP, Xu XZ, Tang JF, Zhou CF. Novel regulatory network of PS-1/β-catenin/p-PTEN axis in gastric cancer invasion. World J Gastrointest Oncol 2026; 18(7): 118256 [DOI: 10.4251/wjgo.v18.i7.118256]
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"The strength of this case report lies in the successful completion of curative treatment even in the extremely rare scenario of ruptured liver cancer and colon invasion. After stabilization via early TAE, R0 resection was achieved through simultaneous hepatectomy and colon resection, followed by effective suppression of micrometastasis through multidisciplinary treatment utilizing TACE, lenvatinib, and tislizumab. As a result, an outstanding long-term outcome of 42 months of disease-free survival was achieved."
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Yang CW, Zhang RX, Zheng XL, Zhu L, Zheng Z, Wu XH. Long-term survival after combined hepatectomy and colectomy for ruptured combined hepatocellular-cholangiocarcinoma with direct colonic invasion: A case report. World J Gastrointest Oncol 2026; 18(7): 118212 [DOI: 10.4251/wjgo.118212]
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"The authors investigated outpatient visit frequency in 800 patients with overlapping non-erosive reflux disease and epigastric pain syndrome and reported that frequent gastroenterology attendance was associated with disease chronicity, psychological distress, demographic characteristics, and complex medication patterns, whereas conventional measures of gastrointestinal symptom severity were not independently associated with visit frequency. However, frequent healthcare use should not automatically be interpreted as a direct surrogate for disease severity, treatment failure, or refractory acid-mediated disease. Repeated consultations may reflect interactions among symptom perception, illness-related concerns, psychological distress, previous treatment experience, healthcare accessibility, and clinician prescribing behaviour. I think that the principal clinical implication of this study is the need to move from repeated symptom-directed escalation toward multidimensional assessment of patients with overlapping upper gastrointestinal syndromes."
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Lv M, Liu X, Huang KY, Xu LS, Che H, Yao MX, Wang FY. Outpatient visit frequency in patients with overlapping non-erosive reflux disease and epigastric pain syndrome: A multicenter study. World J Gastroenterol 2026; 32(28): 119326 [DOI: 10.3748/wjg.119326]
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"A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can accommodate the magnetic ring , and the inner fixing ring can fix the inverted intestinal tissue ; the outer shell can be combined to enclose an annular space, and the magnetic ring and the intestinal tissue can be accommodated in the annular space. The magnetic anastomotic ring of the present invention can significantly shorten the anastomosis time and simplify the operation of the operation. It is particularly suitable for scenes such as rapid treatment of war trauma and laparoscopic intestinal anastomosis. It uses the magnetic squeezing principle for anastomosis, improves the anastomosis quality, shortens the anastomosis time, and improves the patient's prognosis.
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can accommodate the magnetic ring , and the inner fixing ring can fix the inverted intestinal tissue ; the outer shell can be combined to enclose an annular space, and the magnetic ring and the intestinal tissue can be accommodated in the annular space. The magnetic anastomotic ring of the present invention can significantly shorten the anastomosis time and simplify the operation of the operation. It is particularly suitable for scenes such as rapid treatment of war trauma and laparoscopic intestinal anastomosis. It uses the magnetic squeezing principle for anastomosis, improves the anastomosis quality, shortens the anastomosis time, and improves the patient's prognosis.
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can accommodate the magnetic ring , and the inner fixing ring can fix the inverted intestinal tissue ; the outer shell can be combined to enclose an annular space, and the magnetic ring and the intestinal tissue can be accommodated in the annular space. The magnetic anastomotic ring of the present invention can significantly shorten the anastomosis time and simplify the operation of the operation. It is particularly suitable for scenes such as rapid treatment of war trauma and laparoscopic intestinal anastomosis. It uses the magnetic squeezing principle for anastomosis, improves the anastomosis quality, shortens the anastomosis time, and improves the patient's prognosis.
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can accommodate the magnetic ring , and the inner fixing ring can fix the inverted intestinal tissue ; the outer shell can be combined to enclose an annular space, and the magnetic ring and the intestinal tissue can be accommodated in the annular space. The magnetic anastomotic ring of the present invention can significantly shorten the anastomosis time and simplify the operation of the operation. It is particularly suitable for scenes such as rapid treatment of war trauma and laparoscopic intestinal anastomosis. It uses the magnetic squeezing principle for anastomosis, improves the anastomosis quality, shortens the anastomosis time, and improves the patient's prognosis.
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can accommodate the magnetic ring , and the inner fixing ring can fix the inverted intestinal tissue ; the outer shell can be combined to enclose an annular space, and the magnetic ring and the intestinal tissue can be accommodated in the annular space. The magnetic anastomotic ring of the present invention can significantly shorten the anastomosis time and simplify the operation of the operation. It is particularly suitable for scenes such as rapid treatment of war trauma and laparoscopic intestinal anastomosis. It uses the magnetic squeezing principle for anastomosis, improves the anastomosis quality, shortens the anastomosis time, and improves the patient's prognosis.
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
The magnetic squeezing anastomosis technology is mainly applied to various open-abdominal operations such as postoperative biliary tract stenosis treatment, coronary bypass, esophageal stenosis treatment, vascular anastomosis, gastrointestinal anastomosis and the like and minimally invasive operations at present. Compared with the traditional titanium nail anastomat, the magnetic ring anastomosis technology has the advantages that bleeding does not occur in the operation, the magnetic ring falls off in a few days after the operation, no foreign matters remain at the wound healing position, the wound healing is more ideal, and the operation is not easy to infect after the operation, so that the magnetic ring anastomosis technology becomes an ideal choice for operations such as stomach and intestine.
At present, the magnetic ring anastomosis technology and the magnetic ring anastomosis device are researched, developed and designed at home and abroad.
Magnetic compression anastomosis is a third type of anastomosis differing from suture anastomosis and stapled anastomosis. With the development of magnamosis, to meet the usage requirements for different situations, diversified magnetic ring designs are necessary. The deformable self-assembling magnetic anastomosis ring (DSAMAR) is a new combined-type magnetic ring design.
Authors investigate the anastomosis effects of combined-type and whole-type magnetic rings for gastroenterostomy in a beagle model. From the point of operative time ,survival rate and incidence of postoperative complication, DSAMAR is similar to whole type magnetic rings. I ask question for authors.Please compare between DSAMAR and whole type magnetic rings from the point of the time magnets release days, the burst pressure of anastomose (mmHg) and circumference of the anastomosis (mm)
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Zhang MM, Xu SQ, Wu HX, Ren HL, Wan JH, Zhong QY, Chen MY, Zhang QF, Gong RM, Yusif-Zada K, Badarch BI, Shi AH, Lyu Y, Liu XM, Yan XP. Comparison of the anastomotic effects of combined-type and whole-type magnetic rings for gastrointestinal anastomosis in beagles. World J Gastroenterol 2026; 32(28): 118067 [DOI: 10.3748/wjg.118067]
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"This Letter to the Editor highlights the importance of monitoring ocular health as a warning sign for leukemia in pediatric patients. It is a concise yet well-written paper, accompanied by a figure summarizing the clinical, diagnostic, and therapeutic flowchart. The references are very recent and in a sufficient number. In my opinion could be very useful for other clinicians to discover promptly leukemia. "
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Ghosh D. Letter to the Editor: Eye as a window to disease burden in pediatric acute leukemia. World J Exp Med 2026; 16(2): 119334 [PMID: 42394785 DOI: 10.5493/wjem.v16.i2.119334]
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"In this manuscript, the authors concluded that phytosterols are a compelling example of multifunctional dietary bioactives with established cardiometabolic utility and prospective, albeit emerging, applications beyond lipid lowering. The authors have illustrated two figures and one table to explain their review, but Figure 1 seems unclear. The explanation of future perspectives is a good point."
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Mohamed D, Ramadan AA, Mabrok HB, Hamed I. Phytosterols in human health: Biochemical mechanisms of action and disease-modulating effects. World J Biol Chem 2026; 17(2): 121685 [PMID: 42273523 DOI: 10.4331/wjbc.v17.i2.121685]
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"The authors reported that measured cell recovery probabilities, phenotype misclassification rates, locus- and cell-type-specific dropout and stutter models, quantified contamination and drop-in rates, validated minimum cell counts for consensus formation, and specified database-upload requirements should all be required for casework submission. It should also demand a clear separation of sub-source reporting and activity-level assertions. If such prerequisites are met, single-cell typing can supplement, rather than replace, bulk STR analysis and probabilistic genotyping in a small but significant number of high-value forensic instances.
The manuscript is just a review, and it is so interesting."
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Evangelou K, Angeli P, Polydorou A, Petropoulou T. Single-cell deoxyribonucleic acid typing for forensic mixtures and trace evidence: Opportunities, validation requirements, and reporting limits. World J Biol Chem 2026; 17(2): 121467 [PMID: 42273528 DOI: 10.4331/wjbc.v17.i2.121467]
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38
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"The review clarified the HBV reactivation process. Following treatment for HBV-related HCC, the effect of immune-based methods and the antivirals lamivudine, entecavir, tenofovir alafenamide, and tenofovir disoproxil fumarate on reactivation was investigated. This review suggests comparing the genome/proteome of blood from overt and relapsed HCC-related chronic HBV patients. This facilitates recognizing the lingering genetic/epigenetic profiles of HBV-resistant variants, allowing for more precise selection of the optimal antiviral treatment and eliminating the potential of viral reactivation."
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Abdulrahman MS, Aboelmagd O, Zhang Y, Zaky S, Johar D. Precore/core mutation relatedness to viral reactivation in patients undergoing targeted therapy for hepatitis B virus-related hepatocellular carcinoma. World J Biol Chem 2026; 17(2): 120297 [PMID: 42273524 DOI: 10.4331/wjbc.v17.i2.120297]
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39
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"The text is an excellently written mini-review that does not need methods or results. Figure 1 illustrates the significance of TREM2-induced activation of pancreatic macrophages in obesity and its metabolic implications. However, at least one more figure is necessary to demonstrate TREM2 ligand identification and signal transduction. All references are essential, and the language is appropriate.
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Zhang AY, Xie CY, Song X, Guo ZH, Shi YR, Wang SY, Yang GH, Liu Y, Xu TC. Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk: Key regulator of obesity pathophysiology and metabolic dysregulation. World J Biol Chem 2026; 17(2): 118705 [PMID: 42273525 DOI: 10.4331/wjbc.v17.i2.118705]
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40
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Awadallah M, Ton L, Thoguluva Chandrasekar V, Yap JEL, Vega KJ. Ascending colon toothpick impaction identified during screening colonoscopy: A case report. World J Clin Cases 2026; 14(19): 121345 [DOI: 10.12998/wjcc.121345]
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41
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"The authors Sharma and Patial, in their study entitled “Protective effects of kaempferol against diet-induced metabolic disorder," which was published in the World Journal of Hepatology 2026, 18(6) [1], stressed the findings of Nair et al. that kaempferol is a significant medication for diet-induced obesity and hepatic steatosis in mice[2]. This interesting study is limited in its experimental findings and focuses specifically on a diet that is restricted to Indian people. The title of the study and the abstract did not mention that this study is an experimental study or mini-review or a letter to the editor. The selection of C57BL/6 mice as an experimental model for studying the effect of kaempferol on hepatic lipids is misleading because this strain of animal is resistant to the medications, has a tendency to drink alcoholic beverages and is susceptible to morphine addiction. The authors did not mention the constituents of the Indian diet or the differences in the prevalence of MASLD between Indian people and people in other countries to claim that the Indian diet is the pathological cause for MASLD. The pharmacokinetics of kaempferol indicate that this natural antioxidant needs specific formulation to produce its effect, and there is no evidence that kaempferol reduces hepatic lipids. These points need to be considered in assessing the article to avoid many pitfalls that limit the importance of the study.
References
[1] Sharma V, Patial V. Protective effects of kempferol against diet-induced metabolic disorder World J Hepatol 2026; 18 (6)
[2] Nair B, Gopalakrishna R, Nath LR. Kaempferol attenuates diet-induced obesity and hepatic steatosis in C57BL/6J mice fed an Indian diet mimicking regimen. World J Hepatol 2026; 18: 115659
Dr. Marwan S. Al-Nimer
Emeritus Professor
Department of Clinical Pharmacology and Therapeutics
College of Medicine, University of Diyala, 32001 Baqubah, Iraq
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Sharma V, Patial V. Protective effects of kaempferol against diet-induced metabolic disorders. World J Hepatol 2026; 18(6): 120789 [DOI: 10.4254/wjh.120789]
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42
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"Dear Authors,
This study develops a rat model of chronic radiation proctitis using single-dose irradiation and follows disease progression with serial endoscopy, histopathology, fibrosis assessment, VEGF staining, and cytoskeletal protein analysis. The results suggest that 20–35 Gy induces persistent mucosal injury, telangiectasia, fibrosis, and chronic rectal damage, whereas lower doses allow recovery. The longitudinal endoscopic monitoring and blinded scoring increase the credibility of the model. Future studies may strengthen these findings by including fractionated irradiation protocols, validating the model in independent cohorts, and clarifying whether early α-tubulin loss is a causal mechanism or a predictive marker of chronic radiation injury."
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Chang Y, Sun R, Juan W, Xu Z, Xu HY, Zen K, Xuan J. Establishment of a standardized rat model of chronic radiation proctitis and preliminary evaluation of its association with tubulin. World J Gastroenterol 2026; 32(26): 118923 [DOI: 10.3748/wjg.v32.i26.118923]
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43
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"Dear Authors,
This study investigates CDK5 expression in gastric neuroendocrine carcinoma through immunohistochemical evaluation, survival analysis, and functional cell-line experiments. The association of high CDK5 expression with advanced tumor features, higher Ki-67 index, poorer survival, and independent adverse prognostic value suggests a possible role of CDK5 in aggressive GNEC biology. The blinded pathological assessment and multivariable analysis enhance the credibility of the results. The conclusions could be further strengthened by validation in larger multicenter cohorts and by additional pathway-level studies explaining the biological basis of CDK5 activity, particularly the different effects observed in knockdown and overexpression experiments. These future approaches may clarify whether CDK5 serves only as a prognostic marker or may also represent a therapeutic target in GNEC."
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Sun YQ, Su J, Ye KN, Chen QX, Kang EZ, Lv CB, Lian MQ, Zeng WM, Zhang YB, Cai LS. High cyclin-dependent kinase 5 expression promotes tumor progression in gastric neuroendocrine carcinoma. World J Gastroenterol 2026; 32(26): 119574 [DOI: 10.3748/wjg.v32.i26.119574]
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44
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"Fragos et al. presented a case on CSS with hypothyroidism and dyslipidemia. Such a rare case is very important for clinical practice. The case report is presented according to CHECK criteria, thoroughly and well-documented. The content is easily readable and clear, English is correct. The discussion is fruitful, the conclusions have arisen from the presented text. The future perspective are presented. The references are updated.
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Fragos MN, Toulia I, Grammatikopoulou MG, Savvidou P, Taiganidis I, Zissiadis P, Antachopoulos C, Goulis DG, Tsiroukidou K. De novo ARID1A Coffin-Siris syndrome with hypothyroidism and dyslipidemia: A case report and literature review. World J Clin Cases 2026; 14(19): 120716 [DOI: 10.12998/wjcc.120716]
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45
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"This retrospective study addresses a clinically relevant question—whether long-term outcomes after endoscopic strictuotomy for small bowel strictures differ by etiology and whether a simple biomarker can aid risk stratification. The scientific quality is above average, with several methodological strengths, though important limitations temper the conclusions.
1. The study fully meets ethical standards, with IRB approval and informed consent documented. The methodology is clearly described and reproducible, including well-defined eligibility criteria, a patient flowchart, and detailed procedural specifications. However, key unresolved issues weaken internal validity: the lack of standardized post-procedural medical therapy (especially biologics in Crohn's patients) introduces a major confounder; strictures were classified as fibrosis-dominant based on imaging and endoscopy alone without histopathological confirmation; and reintervention decisions relied on symptom recurrence rather than a validated scoring system, introducing subjectivity.
2. The results are authentic and statistically robust. Tables and figures are well-constructed, though endoscopic images could benefit from annotations. Statistical methods are rigorous: a parsimonious multivariable Cox model avoided overfitting, maximally selected log-rank statistics objectively determined the NLR cutoff, and collinearity was properly managed. Nonetheless, gaps remain—no formal power calculation, no sensitivity analyses, and no interaction test between etiology and NLR to assess whether the biomarker's prognostic value differs between groups.
3. References are comprehensive, current, and relevant.
4. The authors have honestly acknowledged several limitations, including the single-center design, modest sample size, residual confounding, and subjective outcome definition. However, other critical issues remain unresolved: heterogeneity within the non-Crohn's group (radiation, NSAID, ischemic, CMUSE) is unexplored; histopathological fibrosis confirmation is lacking; post-procedural medical protocols are not standardized; and only baseline NLR was assessed.
To address these gaps, future studies should incorporate objective fibrosis assessment (EUS, CLE, or STAR histopathological scoring), enroll larger cohorts for subgroup analyses and interaction testing, use validated symptom scores for reintervention definition, and measure NLR longitudinally. A formal sample size calculation based on the effect sizes observed here would strengthen future prospective, multicenter study designs.
In summary, this study makes a valuable contribution by providing etiology-stratified outcome data and identifying NLR as a practical prognostic marker. The findings suggest that non-Crohn's patients with low NLR are the best candidates for endoscopic strictuotomy, while Crohn's patients with elevated NLR may need intensified medical therapy or earlier surgery. Despite its limitations, the study is methodologically sound and advances the field. "
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Lai WC, Feng XM, Huang ZH, Jiang ZM, Sun T, Yin X, Zhang L, Ning SB, Li BR. Balloon-assisted endoscopic stricturotomy for small bowel fibrostenotic strictures: A comparison of Crohn’s disease-related and non-Crohn’s disease strictures. World J Gastroenterol 2026; 32(26): 118889 [DOI: 10.3748/wjg.118889]
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46
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"Colorectal cancer (CRC) is currently one of the most important causes of morbidity and mortality in all parts of the world. It is very important that the shift in its occurrence to younger ages concerns not only developed but also developing countries. According to other epidemiological data, the incidence of this neoplasm is expected to increase over the next two decades despite the availability of the most effective treatment methods. Preventive screening of the asymptomatic population, aimed at early detection, remains the cornerstone of efforts to increase five-year survival rates. Although in all developed countries preventive screening programs are implemented with varying effectiveness, mainly through colonoscopy, the situation is different in developing countries. The limited resources available for health promotion, socioeconomic disparities, and other factors necessitate the development of a cost-effective screening program tailored to these specific conditions. In these countries, priority should be given to primary screening methods, such as fecal hemoglobin detection, which, if positive, should be followed by colonoscopy. The identification of high-risk groups for mandatory colonoscopy is imperative, in combination with efforts to reduce the influence of other environmental factors (mainly dietary) on carcinogenesis. The review by Wu et al. emphasizes the need to develop optimized risk-stratification algorithms in these countries, as an adaptive, organized screening framework can deliver optimal population-level benefits while increasing residents' willingness to undergo colonoscopy."
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Wu YP, Chen M, Wang L. Current colorectal cancer screening in developing countries: Identifying optimal approaches. World J Gastroenterol 2026; 32(26): 118151 [DOI: 10.3748/wjg.118151]
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47
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"This is a well-written and prezented rarely case report about " Pancreatic Schwannoma". Schwannoma can occur anywhere in the body. Pancreatic schwannoma (PS) is an extremly rare mesenchymal tumor.
Technological advancements in cross-sectional imaging such as ultrasonography (USG), computed tomography (CT), and magnetic resonance imaging (MRI), and their increased use have made incidental pancreatic tumors more frequently detectable.
Pancreatic schwannoma is one of these tumors and should be considered in the differential diagnosis.
This manuscript gives additional new knowledge to the existing literature. I think that this manuscript is suitable and worth to be published in the World Journal of Gastrointestinal Surgery."
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Xu SM, Qiu LY. Incidental schwannoma of the pancreatic tail mimicking a solid pseudopapillary tumor: A case report. World J Gastrointest Surg 2026; 18(6): 119246 [DOI: 10.4240/wjgs.119246]
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48
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"This paper explains the immune evasion mechanisms of gastric cancer by integrating spatial structure, metabolic reorganization, microbial interactions, and molecular subtypes. By synthesizing cutting-edge insights derived from spatial transcriptomics, single-cell data, and clinical trials, it presents a comprehensive framework advancing toward ecosystem-level precision immuno-oncology and the development of next-generation biomarkers."
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Yao ZY, Ma LJ, Han ZX, Ji GJ. Evolving landscape of the gastric cancer immune microenvironment: From spatial architecture to precision biomarkers. World J Gastrointest Oncol 2026; 18(6): 119114 [DOI: 10.4251/wjgo.v18.i6.119114]
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49
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"This study presents clinically significant and clear evidence by analyzing 38 cases of non-R0 resected rectal neuroendocrine tumors through long-term follow-up. The consistent absence of residual tumor cells after salvage surgery and during the follow-up period supports the conclusion that salvage surgery may be unnecessary. This study supports conservative treatment by integrating pathological findings, treatment outcomes, and the context of clinical guidelines."
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Lin SY, Li ZH, Xu GL, Weng J, Bai KH. Is salvage surgery necessary for non-R0 endoscopic resection of small rectal neuroendocrine tumors? World J Gastrointest Oncol 2026; 18(6): 118531 [DOI: 10.4251/wjgo.v18.i6.118531]
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50
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"This paper comprehensively presents longitudinal, mechanistic, and immunological evidence to re-establish CD24 as a dynamic regulator of liver cancer development rather than a static biomarker. By integrating animal models, human cohorts, immune checkpoint biology, and spatial single-cell analysis, it provides a comprehensive framework highlighting the diagnostic potential and therapeutic importance of CD24 for hepatocellular carcinoma."
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Ren LN, Liu C, Jin CQ, Zhang XH. From association to intervention: Rethinking CD24’s causal role in hepatocellular carcinogenesis. World J Gastrointest Oncol 2026; 18(6): 117434 [DOI: 10.4251/wjgo.v18.i6.117434]
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