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1
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"It is a well conducted study with meaningful endpoints . As the authors have mentioned in their limitations , it will be interseting to see the correlation between BAL TGF levels and lung involvement, as per CT scan rather than chest x-ray . It will make an interesting future study ."
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Kandi PN, Iskandar MH, Putrawan HA, Mubin RH, Bakri S, Kasim H, Alimuddin S, Rusman RD, Seweng A. Bacterial load and transforming growth factor-beta: Predicting the extent of lung damage in pulmonary tuberculosis patients. World J Exp Med 2026; 16(3): 120424 [DOI: 10.5493/wjem.120424]
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2
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"The inflammatory microenvironment can promote tumor formation and stimulate tumor progression. In esophageal cancers, bacterial infection and neutrophilia can contribute to a poor prognosis. A large amount of evidences support the role of cyclooxygenase-2 (COX-2) in inflammation and oncogenesis. High expression of COX-2 is significantly associated with cell apoptosis, tumor occurrence, development and invasion . COX-2 inhibition has been shown to suppress tumor growth and lymph node metastasis , and, of importance, is an effective strategy for cancer treatment. Prostaglandin E2 (PGE2), a COX-2 product, can enhance angiogenesis and lymphangiogenesis during chronic inflammation and tumor progression. Therefore, the crucial role of COX-2 in tumor progression highlights the importance of discovering and identifying novel regulators of COX-2. In this study,authors combined streptavidin-agarose pulldown assay and mass spectrum identification criteria to pull down and discover several new COX-2 expression regulators in esophageal cells, and identified hnRNPA2/B1 (heterogeneous nuclear ribonucleoprotein A2/B1) as a specific COX-2 promoter binding protein. However, the precise mechanism of hnRNPA2/B1 involved in the regulation of COX-2 expression and esophageal cancer growth remains unknown.
hnRNPA2/B1 has been supposed to be overexpressed in a variety of cancers, including breast, pancreas, liver, and prostate cancer (Tauler et al., 2010, Torosyan et al., 2010, Katsimpoula et al., 2009, Turck et al., 2004). hnRNPA2/B1 is a protein which ubiquitously participates in RNA-binding and pre-RNA processing, and is involved in the regulation of cancer cell metabolism, migration, invasion, proliferation, survival, and apoptosis (Clower et al., 2010, Moran-Jones et al., 2009, Patry et al., 2003, He et al., 2005, He et al., 2009). It also plays an important role in epithelial–mesenchymal transition (Tauler et al., 2010). hnRNPA2/B1 is not the unique characteristic for esophageal cancer. However, whether hnRNPA2/B1 regulates esophageal cancer growth by modulating inflammatory mediator COX-2 expression in esophageal cancer cells is clear. Esophageal cancer includes both adenocarcinoma (ADC) and squamous cell carcinoma (SCC). While Barrett's esophageal cancer (ADC)caused by duodenal fluid reflux is believed to arise through that specific mechanism, does SCC caused by tobacco and alcohol arise via the same mechanism?
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Lu JQ, Fang XF, Guo XX, Liu M, Lin JH, Zheng HL, Zhong CM, Lin QY, Huang XY, Wang XZ, Tian H, Que JW, Chen FL, Zheng BY. Epitranscriptomic regulation of the COX-2/PGE2 axis by hnRNPA2B1 promotes esophageal squamous cell carcinoma progression. World J Gastroenterol 2026; 32(41): 121890 [DOI: 10.3748/wjg.121890]
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3
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"This is a well-written and presented rare case report on "Microscopic evaluation of giant peritoneal loose body. This manuscript gives additional new knowledge to the existing literature.
However, I believe that an adequate literature review has not been conducted. A similar case report was published by us in 2014 (Coskun A, Eliyatkın N, Yıldırım M, Top OE, Vardar E, Erkan N. Completely free and mobile intra-abdominal tumor. Surgery, 2014; 155(2): 350-352). I think that this manuscript is suitable and worth to be published in the World Journal of Gastrointestinal Surgery.
"
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Lou YM, Gao TZ, Zheng CZ, Yu H, Hong YY, Liu XS. Microscopic evaluation of giant peritoneal loose body: A case report. World J Gastrointest Surg 2026; 18(9): 121842 [DOI: 10.4240/wjgs.121842]
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4
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"Damage to the digestive tract caused by anticancer treatment (chemotherapy and radiotherapy) is quite significant, profoundly affecting patients' quality of life. In many cases, side effects are severe enough to require the assistance of a gastroenterologist for effective management—sometimes involving the administration of biological agents, such as in cases of colitis induced by immune checkpoint inhibitors. The gastroenterologist plays important role in diagnosing and assessing the severity of the underlying condition through endoscopic procedures and biopsies. I believe that collaboration between the oncologist and the gastroenterologist is absolutely essential today. However, this does not occur in routine clinical practice; consequently, gastroenterologists lack sufficient experience in this field."
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Nan YL, Sun TH, Ren KJ, Min TH, Ma YY, Xie X, Deng XY, Peng YC, Liu YY, Tong SY, Wang W, Dang CX, Zhang H. Cancer therapy-induced intestinal injury: Mechanisms, clinical manifestations, and management strategies. World J Gastroenterol 2026; 32(41): 120954 [DOI: 10.3748/wjg.120954]
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5
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"1. Evaluation of Objectivity, Credibility, and Scientific Quality
• Objectivity: The study is based on clear medical reasoning. The authors looked at how the disease starts: Crohn’s fistula begins on the inner lining of the bowel and cuts straight through the wall (transmural), whereas a common cryptoglandular fistula starts in the glands between the muscle layers. The two main MRI features checked—wall breakthrough and active inflammation/swelling of the rectum—are straightforward and practical. The doctors reviewing the MRI scans were also kept unaware of the patients’ medical records, which prevented personal bias.
• Credibility: The findings are trustworthy because the authors tested their method on a completely separate group of 168 patients from a second hospital. The model worked just as well in this second group, proving that the results were not just a lucky finding at one hospital. Checking patients from two different years (2021 vs. 2022) also confirmed that the tool remained consistent over time.
• Scientific Quality: The paper is well organized and deals with a major real-world problem: preventing doctors from performing the wrong surgery on an unsuspected Crohn's patient. The authors also made a smart choice to exclude patients with setons already in place, because setons create an artificial hole that could trick the scan.
2. Issues Successfully Resolved by the Authors
• Simple, Usable Signs: Instead of relying on complicated math scores or complex imaging formulas, the authors found two clear signs on standard MRI scans: transmural inflammation and active proctitis.
• High Accuracy: Using either of these two signs caught over 82% of Crohn’s cases (sensitivity) and correctly ruled out over 80% of routine fistula cases (specificity).
• Reliable Regardless of Past Care: These MRI signs worked well even if the patient had already undergone past surgery or was taking biologic medications like anti-TNF drugs.
3. Problems and Limitations That Still Exist
• No Routine Colonoscopy for the Control Group: Patients in the common fistula group did not all get a colonoscopy to confirm that their bowels were completely clear of Crohn's. Doctors ruled it out using only symptoms and blood tests. Because Crohn's disease can stay hidden in the bowel for months or years, a few of these patients might have actually had early Crohn's disease.
• Counting the Same Patient Twice: The authors counted 17 patients who returned to the hospital for failed treatments as brand-new cases. In statistics, counting the same person more than once can slightly skew the results.
• Specialist-Only Reviewers: The scans were read by two colorectal surgeons who each had over 10 years of experience reading pelvic MRIs. It is not yet clear if general radiologists or doctors at smaller community hospitals would get the same high accuracy without special training.
• Overlap from Severe Infections: In severe ordinary fistulas, bad swelling and pus can spill over and irritate the rectal wall. This can sometimes look like Crohn’s inflammation on a scan, causing a false alarm.
4. Next Steps and How to Solve Remaining Problems
• Conducting Prospective Studies: The authors explicitly state that their findings need to be tested forward in time with prospective studies.
• Targeted Endoscopy Workups: The authors propose using these MRI findings as an early warning system: any patient showing these signs should immediately be sent for a full colonoscopy and tissue biopsy before undergoing surgery. Testing this exact workflow in future clinical trials will prove how many unnecessary operations can be prevented.
• Adding Advanced Scans and Stool Tests: Future research can combine these basic MRI signs with advanced MRI sequences (such as DWI or ADC scans) and stool tests (like fecal calprotectin) to tell the difference between temporary swelling and true Crohn's disease.
"
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Xu ZP, Li L, Sun GD, Wu YY, Cai EW, Wen K, Shao WJ, Chen YG. Magnetic resonance imaging predicts perianal fistula in Crohn’s disease. World J Gastroenterol 2026; 32(40): 116827 [DOI: 10.3748/wjg.116827]
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6
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"The title “Do they have a vested interest?” implies a conclusion of conflict or bias; the manuscript should use more neutral wording unless systematic evidence demonstrates that the guideline recommendations were actually influenced by financial interests.
The authors should clearly distinguish declared industry relationships from demonstrated industry influence on recommendations. A financial conflict of interest does not, by itself, establish that a guideline is biased.
Statements such as “these guidelines will always promote the hernia industry”, “guidelines are meaningless and industry-friendly,” and “industry funding may likely lead to less transparent clinical results” are overly categorical and should be supported by direct evidence or appropriately qualified.
The manuscript should provide a systematic assessment of the HerniaSurge panel's individual conflicts of interest, including the type, magnitude, timing, and relevance of each relationship, rather than making broad statements about “most panel members.”
The claim that industry funding was accepted for the guideline process should be documented with precise evidence, including the source and amount/type of funding, and clarification of whether industry had any role in evidence synthesis or recommendation formulation.
The article should more carefully distinguish guideline recommendations from the authors' interpretation of those recommendations. In particular, claims that the guidelines “promote” mesh or minimally invasive surgery require direct comparison with the actual guideline recommendations.
The discussion of mesh versus non-mesh repair is potentially unbalanced. The authors should acknowledge evidence supporting mesh repair, including recurrence reduction, while separately discussing chronic pain, mesh-related complications, and patient preferences.
The statement that “clear-cut, hard-core level 1 evidence for the best groin hernia technique is still elusive” should be clarified because evidence may support different techniques for different patient groups; absence of a single universally superior technique is not equivalent to absence of high-quality evidence.
The table comparing open, laparoscopic, and robotic repair is useful but oversimplified. Important outcomes such as recurrence, chronic pain, quality of life, complications, learning curve, and long-term follow-up should be supported by references.
The assertion that robotic repair has “no proven superiority in major clinical outcomes” should be referenced to contemporary comparative evidence and should distinguish lack of demonstrated superiority from evidence demonstrating equivalence.
The discussion of cost should incorporate healthcare-system differences and ideally include formal health-economic evidence rather than general statements about operative costs.
The manuscript would benefit from explicitly acknowledging limitations of its own methodology. It appears to be a narrative/opinion-based critique rather than a systematic review, yet some conclusions are presented as established facts.
Several quotations from Bendavid and other sources are rhetorically strong and may give the article an advocacy/opinion-piece character. The authors should ensure that these quotations are balanced by contemporary, objective evidence.
The authors should discuss the 2023 HerniaSurge update in greater detail, including how its methodology addressed conflicts of interest, evidence grading, patient preferences, and multidisciplinary participation.
Rather than concluding that current guidelines are “meaningless,” the authors could make a more scientifically defensible argument that guidelines should be continuously evaluated for transparency, independence, methodological rigor, and applicability to different patient populations.
Overall critique
The manuscript has a relevant and worthwhile subject, but its credibility would improve substantially with a more systematic and balanced evaluation of the HerniaSurge guidelines. The authors should replace allegations and categorical language with documented evidence, quantified conflict-of-interest analysis, transparent methodology, and appropriately cautious conclusions. The central argument—that guideline development should maximize independence, transparency, patient involvement, and rigorous evidence appraisal—is reasonable, but it should be separated clearly from claims that existing HerniaSurge recommendations are actually the product of industry influenc"
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Bhattacharya K. International guidelines for groin hernia management: Do they have a vested interest? World J Surg Proced 2026; 16(2): 124162 [DOI: 10.5412/wjsp.124162]
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7
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"This case report addresses a clinically relevant and technically challenging problem in the management of choledocholithiasis when conventional ERCP is not feasible.
The manuscript provides a detailed and reproducible description of the laparoscopic transcystic technique and intraoperative fluoroscopic guidance.
The patient's clinical presentation, imaging findings, operative procedure, and postoperative course are generally well documented.
The successful clearance of an 8-mm distal CBD stone demonstrates the technical feasibility of this approach in a carefully selected patient.
The case's novelty is potentially valuable, although the specific contribution should be better supported by a comprehensive review of existing literature.
The discussion appropriately considers alternative approaches, but several statements regarding safety, efficacy, cost-effectiveness, and superiority are stronger than can be supported by a single case.
The reported one-month follow-up is reassuring but insufficient to establish long-term biliary safety or recurrence outcomes.
Important details, including anticoagulation management, laboratory values, and the precise technique of papillary dilation, should be clarified.
The manuscript would benefit from improved adherence to case-report reporting standards and more cautious, evidence-based language throughout the Discussion and Conclusion.
Overall, the report has good clinical and technical value, but substantial revision is recommended to strengthen methodological rigor and ensure that conclusions remain proportionate to the evidence.
CRITICAL REVIEW COMMENTS :
Please moderate claims such as “safe,” “effective,” “least morbid,” and “most efficient,” as these cannot be established from a single case report; “technically feasible” would be more appropriate.
Please provide the actual laboratory values (bilirubin, AST/ALT, ALP/GGT, WBC, CRP, amylase/lipase and coagulation profile) rather than stating that routine investigations were normal.
The statement that the patient was “on anticoagulation” should be clarified, including the drug used, indication, perioperative interruption and resumption.
Please clarify whether the duodenal stricture was definitively diagnosed as benign/peptic, since biopsies were deferred and the stated etiology appears presumptive.
The terminology and technical details of ampullary balloon dilation/biliary sphincteroplasty should be described more precisely, including balloon position, diameter, pressure and duration.
Please distinguish clearly between technical infeasibility of ERCP and an absolute contraindication to ERCP.
The criteria stated for transcystic clearance (e.g., stones <10 mm and fewer than 10 stones) should be supported by appropriate references or presented as suggested selection criteria rather than definitive recommendations.
Table 1 should provide more consistent information regarding study populations, definitions of stone-clearance success, complications and follow-up, because the included studies are heterogeneous.
Please substantiate the claim that the specific use of an infant feeding tube is novel, preferably through a more comprehensive literature search.
The one-month follow-up should be acknowledged as a limitation, particularly regarding recurrent stones, biliary stricture and delayed complications.
Statements such as “essential reference for surgeons” should be removed or rephrased in neutral scientific language.
Consider adding a CARE-style timeline to make the sequence of diagnostic evaluation, failed ERCP access, surgery, stone clearance and follow-up clearer.
The conclusion should emphasize technical feasibility in a selected patient, rather than implying general safety or superiority over established alternatives."
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Bhandarkar S, Dotor N, Bendapudi N, Kamat N, Parekh S, Vora S, Maydeo A. Transcystic laparoscopic common bile duct stone clearance facilitated by intraoperative fluoroscopy guided cholangiography: A case report. World J Surg Proced 2026; 16(2): 122292 [DOI: 10.5412/wjsp.122292]
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8
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"Patients with Crohn's disease frequently develop anal fistulas, and the presence of a fistula is often the initial sign leading to a diagnosis of Crohn's disease. Regarding the relationship between Crohn's disease and anal fistulas: High incidence of co-occurrence—approximately half of Crohn's disease patients exhibit painful, purulent anal lesions. Predominance in younger populations—onset often occurs in the teens and twenties, and the condition is characterized by being refractory to treatment. Differences from ordinary hemorrhoids—fistulas associated with Crohn's disease tend to involve complex inflammation; surgical treatment for standard fistulas often results in poor wound healing or the successive formation of new fistulas. MRI is highly useful for accurately mapping the course of complex anal fistulas (perianal fistulas) and the extent of abscesses associated with Crohn's disease, thereby aiding in the determination of treatment strategies. MRI reveals the following: Fistula tract course—where the tunnel-like opening begins and how it extends. Branching and secondary extensions—complex branching tunnels or deep tissue extensions. Presence of abscesses—locations and sizes of pus collections. Spatial relationship with sphincter muscles—the position of the lesion relative to the muscles that maintain anal closure (sphincters). Reasons for choosing MRI include: No radiation exposure—safe for repeated imaging and for young patients. High imaging resolution—the use of contrast agents allows for clearer visualization of inflammation and pus collections. Studies have shown that measuring changes in the 3D volume of perianal fistulas in Crohn's disease (CD) patients via MRI may serve as a useful imaging biomarker for predicting clinical outcomes. Specifically, it was found that a reduction of 16% or more in the volume of the active fistula component predicts clinical remission with high sensitivity and specificity. These findings were published in the *United European Gastroenterology Journal* on July 18, 2025. Based on the above, I believe that MRI analysis for anal fistulas is indeed useful, as the authors state.
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Xu ZP, Li L, Sun GD, Wu YY, Cai EW, Wen K, Shao WJ, Chen YG. Magnetic resonance imaging predicts perianal fistula in Crohn’s disease. World J Gastroenterol 2026; 32(40): 116827 [DOI: 10.3748/wjg.116827]
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9
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"This study demonstrated superiority of Infliximab at a dose of 5mg/Kg BW in patients with moderate to severe ulcerative colitis compared to 40-60 mg methypredizolone or 300-400mg hydrocortisone in divided doses. The authors demonstrated superiority of the biological agent in all parameters investigated compared to methylprednisolone and hydrocortisone.
In the study design, one could make the following observations
Methylprednisolone (up to 60mg, equivalent to 75 mg prednisolone) was used in the study. However, doses of prednisolone greater than 50- 60 mg have not been shown to increase the therapeutic effect.
Hydrocortisone, like other synthetic corticosteroids, has failed therapeutically in IBD and is not used.
These factors probably contributed to the difference in the results.
I am impressed by the long follow-up and the comparison of the two groups with these two regimens. Corticosteroids are not used as a maintenance treatment for IBD with the exception of budesonide (Cortiment tab 9mg) in some cases of ulcerative colitis.
In daily clinical practice, corticosteroids have proven their immediate and dramatic effect. For this reason, gastroenterologists widely use them in selected cases as a first-line treatment, and I strongly believe this reflects the view of most gastroenterologists involved in IBD treatment."
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Elsaadany HM, Abd El-Hamid B, Elewesy EA, Mansour MI, Abdelghany WM, Shoukeer MAH, Khalaf M, Eid SM, Almaghraby MT. Long-term comparative effectiveness of first-line infliximab vs corticosteroids in ulcerative colitis: Remission and colectomy risk. World J Gastroenterol 2026; 32(38): 121333 [DOI: 10.3748/wjg.121333]
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10
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"It is well prepared and written article.
The authors concluded that TGFβ2 may have differing effects on cancer cells and CAFs in the development of GC. TGFβ2 may promote cancer cell proliferation and invasion, but not in CAFs. High TGFβ2 levels on cancer cells and low levels of CAF or other factors may indicate a favorable prognosis for GC patients."
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Imanishi D, Nishikubo H, Ma D, Sano T, Fan C, Sakuma T, Yashiro M. Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma. World J Biol Chem 2026; 17(3): 121664 [PMID: 42707849 DOI: 10.4331/wjbc.121664]
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11
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"This manuscript is a review article with one figure and three tables. It is a nice review.
In this manuscript, the authors stated that calcification progresses from microcalcifications in the intima to more fragmented, sheet-like, or nodular deposits. Although widespread calcification frequently indicates stable plaque, some patterns, such as patchy calcification and eruptive calcified nodules, are associated with plaque susceptibility and thrombotic events. PCI in calcified lesions is technically difficult because calcium inhibits balloon expansion, stent delivery, and optimum stent deployment, increasing the risk of under-expansion and unfavorable results. Intracoronary imaging using intravascular ultrasound and optical coherence tomography allows for thorough calcium characterisation and guides lesion preparation. This study highlights the processes, prevalence, risk factors, clinical outcomes, and current treatment of calcified coronary artery disease."
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Ktenopoulos N, Apostolos A, Theodoropoulou T, Karakasis P, Iliakis P, Tsiamis N, Milaras N, Skalidis I, Evdaimon K, Sagris M, Drakopoulou M, Synetos A, Latsios G, Tsioufis K, Toutouzas K. Calcified coronary artery disease: Mechanisms, risk factors and clinical consequences. World J Biol Chem 2026; 17(3): 121278 [PMID: 42707870 DOI: 10.4331/wjbc.121278]
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12
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"This work confirms that RNAlater consistently enables high-quality RNA extraction from biopsies, addressing a gap in pancreas-specific evidence. Implementing this procedure may allow for more precise evaluation of graft injury, increase biomarker development, and facilitate high-quality biobanking of human pancreas samples for future investigations.
I have the following and important comment:
The title of the y axis of Figures 2 and 3 B should be RNA level, but not concentration. It have to be corrected and expressed per mg. What is mg? Isit protein or tissue.
This journal have to take care with units."
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Pook RR, Hearne A, Botting RA, Tingle SJ, Honkanen-Scott M, Shaw JAM, Ali S, Scott III WE. Improved stabilisation of human pancreas biopsies: Comparative evaluation of RNA preservation methods. World J Biol Chem 2026; 17(3): 121018 [PMID: 42707486 DOI: 10.4331/wjbc.121018]
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13
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"This evidence review addresses an important and evolving topic in gynecologic oncology and provides a useful overview of sentinel lymph node biopsy (SLNB) across cervical, endometrial, vulvar, and ovarian cancers. The discussion incorporates major studies including SENTICOL, SENTIX, FIRES, GROINS-V, SELLY, and SENTOV, and the summary table facilitates comparison of key evidence. The references are generally relevant and include recent publications.
As a review without patient recruitment or new experimental data, specific ethical approval and original biostatistical analysis are not applicable. However, the methodology of evidence identification could be described more clearly. Although PubMed was used, the search strategy, dates, eligibility criteria, and process for selecting studies are not provided, which limits reproducibility and raises the possibility of selection bias.
The conclusions are broadly consistent with the evidence presented, but some statements regarding SLNB as standard of care or its oncologic safety should be more carefully qualified according to cancer type, disease stage, patient selection, mapping technique, and maturity of survival evidence. The limitations of the review itself should also be explicitly acknowledged.
This is a clinically relevant and informative review with good educational value. Future updates would benefit from a more systematic literature-search methodology and incorporation of emerging prospective trial results and evolving international guidelines.
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Singh P. Sentinel lymph node biopsy in gynecologic cancers. World J Obstet Gynecol 2026; 15(2): 120261 [DOI: 10.5317/wjog.120261]
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14
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"This multicenter cross-sectional study addresses an important maternal and child health issue and provides useful evidence regarding breastfeeding techniques among primiparous mothers in Northeast Ethiopia. Ethical approval and informed consent are appropriately reported. The methodology is generally sound and reproducible, with systematic sampling, an adequate sample size, observational assessment of breastfeeding technique, and appropriate multivariable logistic regression. The tables and figures adequately present the main findings, and the references are generally relevant and reasonably current.
The principal limitation is the cross-sectional design, which permits identification of associations but not causal relationships. Therefore, terms such as “predictors” or “determinants” should be interpreted cautiously and preferably replaced by “associated factors.” The strong association between absence of breast problems and effective breastfeeding technique also requires cautious interpretation because the temporal relationship cannot be established. Facility-based recruitment from a limited geographic area, potential self-report and observer bias, and limited generalizability should also be recognized.
Overall, the article is scientifically credible and clinically relevant, with generally appropriate methods and statistical analysis. Future longitudinal or interventional studies would be valuable to determine whether structured breastfeeding education can causally improve breastfeeding technique and subsequent maternal and infant outcomes.
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Bogale M, Cherie N, Abeje G, Dagnew SB, Abate AW, Agidew MM. Breastfeeding techniques and associated factors among primiparous mothers: A multicenter health facility-based cross-sectional study in Northeast Ethiopia. World J Obstet Gynecol 2026; 15(2): 119451 [DOI: 10.5317/wjog.119451]
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15
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"This case report describes a rare and clinically important occurrence of ileosigmoid knotting with bowel gangrene and shock in a postpartum woman. The case has educational value because it highlights the diagnostic difficulty of acute abdominal conditions in the postpartum period and the importance of timely surgical intervention. The clinical course, operative findings, management, and follow-up are generally well documented, and written informed consent for publication is reported.
The major strength of the article is the direct operative confirmation of the diagnosis and the description of successful emergency surgical management. The figures, laboratory data, and discussion of previous literature support the clinical presentation. Formal biostatistical analysis is not applicable to a single case report.
Several issues, however, limit the scientific quality of the report. Most importantly, there appears to be an inconsistency in the classification of ileosigmoid knotting. Table 2 defines Type I as the ileum wrapping around the sigmoid colon and Type II as the sigmoid colon wrapping around the ileum, whereas the patient's condition is described as Type II despite the ileum reportedly twisting around the sigmoid colon. This should be clarified or corrected. In addition, the diagnosis of septic shock would be more convincing if supported by detailed objective parameters such as serum lactate, acid-base status, urine output, and evidence of organ dysfunction. The absence of CT imaging is appropriately explained by lack of availability but remains a diagnostic limitation.
The literature cited is generally relevant; however, because the article is presented as a case report and review of the literature, the method used to identify and select the reviewed literature could be described more clearly. The manuscript would also benefit from further language editing and more explicit acknowledgment of the limitations of drawing general conclusions from a single case.
Overall, the article provides a useful contribution concerning a rare postpartum surgical emergency, but greater consistency in disease classification, more precise documentation of shock, and cautious interpretation of conclusions would improve its scientific credibility. Future studies or case series should systematically document diagnostic, hemodynamic, operative, and outcome parameters to strengthen the evidence regarding ileosigmoid knotting in pregnancy and the postpartum period.
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Dereje WM, Zegeye ML, Wulolgn D, Tamene BA, Kassie MT. Ileosigmoid knotting causing gangrenous bowel obstruction in a postpartal mother presented with septic shock: A case report and review of literature. World J Obstet Gynecol 2026; 15(2): 118869 [DOI: 10.5317/wjog.118869]
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16
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"The article presents two interesting cases of patients with virus-related decompensated cirrhosis who were treated with TIPS and antiviral therapy and subsequently had favorable long-term outcomes. A major strength of the article is the more than 10-year follow-up period and the use of multiple assessment methods, including clinical, laboratory, hemodynamic, imaging, and histological parameters. The findings are particularly interesting, especially the normalization of portal pressure and the significant regression of liver fibrosis.
From a writing perspective, the article is well written, clear, and coherent, with a logical structure and appropriate medical terminology. The grammar and terminology are accurate, and the information is presented in a professional and easy-to-follow manner. Overall, I consider the article to be of good quality, addressing a relevant topic and presenting findings that deserve further investigation in larger studies.
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Tie J, Yuan XL, Niu J, Xu J, Shi YQ. Transjugular intrahepatic portosystemic shunt combined with viral suppression reverses decompensated cirrhosis: Two case reports. World J Gastroenterol 2026; 32(37): 120860 [DOI: 10.3748/wjg.120860]
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17
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"The conclusions are clinically relevant and highlight important dietary characteristics associated with glycemic control in patients with T2DM. However, the observed association between higher total energy intake and poor glycemic control should be interpreted cautiously, particularly given the cross-sectional nature of the analysis and the potential for reverse causality. The authors should further clarify the clinical implications of these findings and avoid overstating causality when discussing personalized dietary interventions."
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Tang YB, Du J, Zhou HP, Guo YM, Shen LS, Jiang XH, Huang S. Nutritional intake characteristics and glycemic control in patients with type 2 diabetes mellitus. World J Diabetes 2026; 17(9): 122163 [DOI: 10.4239/wjd.122163]
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18
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"The authors provide an interesting observation that elevated TNF-α levels may promote pancreatic islet β-cell apoptosis through the Bax/Bcl-2/caspase-3 pathway, with this process correlating with the severity of inflammation. However, the therapeutic implications of these findings remain insufficiently explored. The authors should further evaluate whether modulation of this pathway can attenuate β-cell apoptosis and improve glucose metabolism in acute pancreatitis-associated AGM.
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Qi FF, Zhang Y, Liu CQ, Chen HJ, Wang AF. Pancreatic injury and glucose metabolism dysfunction: The central role of inflammatory signaling and islet β-cell apoptosis. World J Diabetes 2026; 17(9): 117159 [DOI: 10.4239/wjd.117159]
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19
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"This is a methodologically sound, transparent, and clinically oriented retrospective cohort study that develops an interpretable machine-learning (ML) model for early (first-trimester) risk stratification of gestational diabetes mellitus (GDM). The authors compare eight ML algorithms under four class-imbalance handling strategies, report performance on an independent hold-out test set, and support interpretation with SHAP analysis and patient-level heatmaps. The study is well reported (STROBE statement), ethically complete, and internally consistent. Its principal contribution is the demonstration that routinely collected first-trimester clinical, ultrasound, and placental biomarkers can support a 'rule-out' (high negative predictive value, NPV 0.940) approach to GDM risk. The main limitations—single-center design, absence of external validation, heterogeneity of GDM diagnostic criteria, and test-set-based model selection—limit the generalizability and the strength of the causal/clinical claim. The study is a solid, incremental extension of the authors’ earlier logistic-regression work, but it does not deliver a new biological mechanism or a fully validated, practice-ready tool. Authors may add a head-to-head benchmark against a conventional multivariable logistic-regression model on the same cohort/features, and explicitly quantify the incremental AUC (ΔAUC), net reclassification improvement (NRI), and decision-curve net benefit over both no-screening and universal screening."
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Hung SM, Chen CP, Sun FJ, Chen YY, Wang LK, Chen CY. Early risk stratification of gestational diabetes using interpretable machine learning with first-trimester screening parameters. World J Diabetes 2026; 17(9): 123276 [DOI: 10.4239/wjd.123276]
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20
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"This paper evaluates the status of artificial intelligence (AI) implementation in the field of gastrointestinal endoscopy across six defined domains: evidence maturity, regulatory and healthcare system approval processes, clinical adoption status, potential for workflow integration (practicality), governance and monitoring, and generalizability. Computer-aided detection (CADe) for colonoscopy is classified as "Tier 1," while computer-aided diagnosis (CADx) for optical polyp characterization falls under "Tier 2." Also classified as "Tier 2" are second-observer systems for the upper gastrointestinal tract, AI-assisted procedural quality control systems, reading support tools for capsule endoscopy, and *Helicobacter pylori* infection prediction using endoscopic images. Cholangioscopy AI, therapeutic endoscopy assistance, and pancreatic lesion analysis using endoscopic ultrasound (EUS) are positioned at "Tier 3." The framework and checklist presented in this paper are noteworthy for enabling researchers designing trials, regulatory bodies evaluating submissions, and endoscopy departments deciding on implementation to apply these criteria in practice."
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Boppana SH, Chandrashekar A, Sunkesula V. From hype to clinical translation: A tiered, readiness-based framework for artificial intelligence in gastrointestinal endoscopy. Artif Intell Gastrointest Endosc 2026; 7(2): 121109 [DOI: 10.37126/aige.121109]
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21
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"Lee HY et al. presented an interesting case of an extensive multiple calcinosis in seronegative limited cutaneous scleroderma (CREST variant). The paper is written according to CARE criteria. The text is fluent and easy understandable. The figures are clearly visible and correctly marked. English is used according to scientific standards. Such unusual disease presentation is very important for everyday clinical practice. "
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Lee HY, Lee SK, Kim H, Kang SW. Extensive multiple calcinosis cutis in seronegative limited cutaneous scleroderma (CREST variant): A case report. World J Clin Cases 2026; 14(25): 123670 [DOI: 10.12998/wjcc.123670]
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22
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"The authors presented an interesting case of disseminated Cryptococcus infection (central nervous system and skin) in HIV-negative patient. The paper is written according to CARE criteria. The text is fluent and easy understandable. The figures are clearly visible and correctly marked. English is used according to scientific standards. Such unusual disease presentation is very important for everyday clinical practice. "
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Walia H, Mehta H, Rahi S, Singh I, McKee PH. Beyond the usual suspects - disseminated cryptococcosis presenting as molluscoid skin lesions: A case report. World J Clin Cases 2026; 14(25): 119033 [DOI: 10.12998/wjcc.119033]
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23
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"This is a nice, short review of the von Hippel-Lindau (VHL) protein by Kanno H and Nakahara K. Figure 1 summarizes the article content with impressive data. The authors concluded that VHL is a multifaceted regulator of neuronal differentiation and regeneration whose activity is heavily environment-dependent. Under normal oxygen conditions, VHL promotes neuronal development by suppressing JAK2/STAT and Notch signaling and activating proneural bHLH factors. In hypoxic settings, HIF-1α stabilization enhances glial differentiation and NSC survival and migration. The BC-box motif in VHL serves as a portable neural induction module, and the Daam2-VHL-Nedd4 axis promotes oligodendrocyte development and remyelination. Together, these pathways make VHL a promising target for regenerative therapeutics in neurodegenerative diseases, CNS injury, and demyelinating disorders."
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Kanno H, Nakahara K. Regenerative potential of von Hippel-Lindau tumor suppressor protein. World J Biol Chem 2026; 17(3): 119936 [PMID: 42707860 DOI: 10.4331/wjbc.119936]
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24
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"The manuscript explains good scientific quality, novelty, innovation, and clinical significance.
It provides a timely and well-structured synthesis of the emerging gut–ocular axis, integrating immunological, metabolic, neuroimmune, and barrier mechanisms across several ocular diseases.
Its inclusion of a transparent literature-search methodology, an evidence hierarchy, clinical-trial findings, and translational research priorities strengthen its value.
The review appropriately recognizes that most mechanistic evidence comes from animal models, while human evidence is largely observational, heterogeneous, and vulnerable to dietary, geographic, medication-related, and methodological confounding.
Clinical evidence for probiotics, dietary interventions, and fecal microbiota transplantation remains sparse and is insufficient to guide routine ophthalmic practice.
Accordingly, therapeutic claims should remain cautious and emphasize biological plausibility rather than proven clinical efficacy.
Overall, the manuscript offers a useful and clinically relevant overview, provided that the gut–ocular axis is presented as an emerging hypothesis requiring validation through prospective studies and adequately powered randomized controlled trials."
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Paul RS, Samanta A. Gut-ocular axis: An emerging strategy to treat ocular diseases. World J Clin Cases 2026; 14(25): 124172 [DOI: 10.12998/wjcc.124172]
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25
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"The manuscript shown moderate scientific quality and significance.
Its use of a large national cohort and propensity-score matching provides value; however, its retrospective design, residual confounding, use of prescription records, and broad two-year outcome window limit causal interpretation.
The research topic has moderate novelty, while the study’s creativity and methodological innovation are limited because it applies established database and propensity-matching methods to a previously studied clinical association.
Overall, the conclusions are generally supported when interpreted cautiously, although further prospective research using clinically defined postoperative intervals, morphine-milligram equivalents, and actual medication use is warranted."
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Wu KA, Mai E, Warburton CS, Dhanjani S, Choudhury A, Docters F, Wong L, Prabhat A, Raza M, Maayan O, Song J, Shatkin M, Moucha CS, Hayden BL. Obesity and postoperative opioid utilization after total knee arthroplasty: A propensity-matched analysis. World J Clin Cases 2026; 14(25): 125054 [DOI: 10.12998/wjcc.125054]
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26
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"This review summarizes how gastric cancer spreads to the peritoneum by integrating key mechanisms such as genetic mutations, EMT activation, ECM remodeling, hypoxia-driven signaling, anoikis resistance, and immunosuppressive microenvironment interactions. It explains how tumor cells detach, survive, adhere, invade, proliferate, and induce angiogenesis within the peritoneal cavity, highlighting the coordinated roles of stromal cells, immune cells, and metabolic reprogramming. Overall, it provides a clear molecular framework that identifies promising biomarkers and therapeutic targets for improving early diagnosis and treatment of peritoneal metastasis."
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Yan HQ, Lai QQ, Huang MW, Wang TA, Wu LC, Qin YZ. Advances in molecular mechanism of gastric cancer peritoneal metastasis. World J Gastrointest Oncol 2026; 18(8): 121799 [DOI: 10.4251/wjgo.v18.i8.121799]
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27
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"This review explains the need for liquid biopsy in CRC screening, summarizes key circulating biomarkers and how they complement each other, and highlights that multi‑analyte panels can improve early detection accuracy despite challenges in standardization and validation. Liquid biopsy ultimately offers a pathway toward earlier and more precise CRC diagnosis."
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Bai XZ, Bao SCL, Zhang XQ, Yang ZN. Liquid biopsies in colorectal cancer screening and diagnosis. World J Gastrointest Oncol 2026; 18(8): 120332 [DOI: 10.4251/wjgo.120332]
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28
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"The study shows that MCM10 overexpression is strongly associated with aggressive HCC and poor prognosis. It provides consistent mechanistic evidence that MCM10 promotes tumor growth through cyclin D1–CDK4/6 activation across cell, animal, and patient samples. Overall, it highlights MCM10 combined with cyclin D1 as a meaningful biomarker pair for HCC progression."
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Chen YR, Wang G, He LJ, Ye HW, Wang LF, Zou DD, Wang MQ, Xie HW, Zhu SL, Wang XY. MCM10 promotes hepatocellular carcinoma progression through cyclin D1 regulation. World J Gastrointest Oncol 2026; 18(8): 119834 [DOI: 10.4251/wjgo.119834]
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29
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"The article clearly identifies a novel RHEB-CSF1R interaction as a driver of EMT in pancreatic cancer and supports this with coherent molecular, autophagy‑related, and functional evidence. It integrates in‑vitro and in‑vivo data to demonstrate mechanistic consistency across experimental models. Overall, the study provides a concise and compelling mechanistic framework that strengthens the biological relevance of targeting this pathway."
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Xing YR, Wang SF, Dai JJ, Xu XG, Mao WJ. Unlocking the metastatic switch: The RHEB-CSF1R complex ignites epithelial-mesenchymal transition in pancreatic cancer by autophagy. World J Gastrointest Oncol 2026; 18(8): 119680 [DOI: 10.4251/wjgo.v18.i8.119680]
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30
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"The case report clearly presents a rare CRC brain‑only metastasis with well‑documented imaging and pathology. It concisely describes coordinated multidisciplinary management across neurosurgery, oncology, and colorectal surgery. The discussion effectively contextualizes the case within existing literature, highlighting its clinical relevance. Overall, the report provides a clear and informative example of how early symptom recognition can guide timely multidisciplinary intervention."
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Xu JL, Ge ZW, Wu CW, Wang YH, Mao JD. Multidisciplinary care for colorectal cancer brain metastases with headache as initial symptom: A case report and literature review. World J Gastrointest Oncol 2026; 18(8): 119679 [DOI: 10.4251/wjgo.119679]
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31
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"This meta‑analysis is clearly structured, follows PRISMA standards, and uses high‑quality retrospective studies to synthesize evidence on NLR and malignant IPMN. The statistical method, including subgroup and leave‑one‑out sensitivity analyses, are rigorous and transparently reported. Overall, the article provides a coherent, well‑supported conclusion that elevated NLR is an adjunctive marker for malignant IPMN."
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Dong WW, Zhou LL, Yang DJ, Lu HM. Association between preoperative neutrophil-to-lymphocyte ratio and malignant intraductal papillary mucinous neoplasms: A systematic review and meta-analysis. World J Gastrointest Oncol 2026; 18(8): 119432 [DOI: 10.4251/wjgo.119432]
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32
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"The study clearly demonstrates that Streptococcus anginosus is most abundant in gastrointestinal tumors and rigorously links its load to inflammation, invasion depth, and tumor progression using both human samples and a controlled rat model. It integrates molecular, immunologic, and pathological data to show consistent pro‑tumorigenic effects, including elevated IL‑6/TNF‑α and increased immune‑cell infiltration. Overall, it provides strong, multi‑layered evidence that S. anginosus is a meaningful microbial driver and potential therapeutic target in gastric cancer."
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Huang DB, Chen BS, Wang AP, Hu XZ, Xu YJ. Polymerase chain reaction detection of Streptococcus anginosus in digestive diseases and its immunomodulation in rat gastric cancer model. World J Gastrointest Oncol 2026; 18(8): 119026 [DOI: 10.4251/wjgo.119026]
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33
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"The editorial clearly highlights how patient‑derived organoids overcome the limitations of traditional models and better preserve patient‑specific biology. It synthesizes recent mechanistic and translational findings into a coherent narrative that clarifies their relevance to gastric intestinal metaplasia. It also provides forward‑looking insight by emphasizing organoid‑based drug screening as a promising direction for future therapeutic development."
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Deng JY, Du HB, Zao XB. Patient-derived organoids: A new platform for mechanism research and drug development of gastric intestinal metaplasia. World J Gastrointest Oncol 2026; 18(8): 118750 [DOI: 10.4251/wjgo.v18.i8.118750]
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34
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"The study clearly states its clinical question, applies a structured comparative design with balanced baseline characteristics, and reports statistically consistent advantages of amlodipine without added toxicity. Safety outcomes are systematically presented using CTCAE criteria, and the authors transparently acknowledge methodological limitations. Overall, the article demonstrates clarity, methodological rigor, and responsible scientific reporting."
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Lou HC, Liu XH, Jin P, Wang JM, Liu B. Interaction between calcium channel blockers and capecitabine in colorectal cancer patients with hypertension. World J Gastrointest Oncol 2026; 18(8): 118698 [DOI: 10.4251/wjgo.118698]
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35
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"This is very interesting paper. While TIPS (Transjugular Intrahepatic Portosystemic Shunt) is dramatically effective in treating refractory ascites and esophageal varices caused by portal hypertension, a post-procedural decline in liver function—either temporary or long-term—is the more common outcome. However, under specific conditions or when complications are successfully managed, there are cases where the patient's overall condition and certain indicators of hepatic reserve appear to "improve." It is important to note that since the fundamental nature of TIPS is to bypass the liver, the procedure does not actually rejuvenate the hepatocytes themselves; rather, improvements in liver function markers and overall condition occur through the following mechanisms: Improvement in renal function and metabolism through the reduction or discontinuation of diuretics—Background: Cases involving the use of high-dose diuretics to control refractory ascites prior to the procedure, leading to dehydration, electrolyte imbalances, and impaired renal function (hepatorenal syndrome). Improvement: Once TIPS resolves the ascites, diuretic dosages can be significantly reduced or discontinued. This allows renal function to recover and improves systemic metabolic status, thereby indirectly reducing the burden on the liver and leading to improvements in blood test results (such as albumin levels). Recovery from liver failure by preventing gastrointestinal bleeding—Background: Cases where recurrent bleeding from esophageal or gastric varices causes chronic anemia and hypotension, resulting in insufficient oxygen supply to the liver and a marked decline in liver function. TIPS lowers portal pressure and completely controls bleeding, stabilizing oxygen supply to the liver. As anemia resolves, impaired hepatic reserve may recover to its baseline level. Dramatic improvement in nutritional status (amelioration of sarcopenia)—Background: Cases where abdominal distension due to massive ascites prevents adequate food intake, leading to severe malnutrition and loss of muscle mass (sarcopenia). Improvement: In such cases, the resolution of ascites enables increased food intake. Although the efficiency of amino acid metabolism decreases because a portion of portal blood flow bypasses the liver, there are cases where serum albumin levels rise and liver function (synthetic capacity) tends to improve over the long term due to increased total caloric and protein intake. I ask question for author. For which types of cases does TIPS yield favorable results?
"
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Tie J, Yuan XL, Niu J, Xu J, Shi YQ. Transjugular intrahepatic portosystemic shunt combined with viral suppression reverses decompensated cirrhosis: Two case reports. World J Gastroenterol 2026; 32(37): 120860 [DOI: 10.3748/wjg.120860]
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36
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"A really strange letter to the editor. This kind of article should not have any abstract nor separate conclusions. The references to histone metylation are nonsense. In all, the authors tried to do a soundful review and get a meaningless small review which does not get any interest for readers."
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Raikou VD, Gavriil S. Letter to the Editor: Finerenone and proteinuria in diabetic kidney disease. World J Nephrol 2026; 15(3): 121881 [PMID: 42625991 DOI: 10.5527/wjn.121881]
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37
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"This narrative review provides a comprehensive, well-structured, and clinically relevant overview of the imaging features of appendiceal mucinous epithelial neoplasms. The article successfully integrates pathological classification with the corresponding findings on ultrasound, CT, and MRI, offering a clear understanding of the role of imaging in diagnosis, characterization, staging, and assessment of peritoneal involvement.
The manuscript is clearly written and easy to follow. The figures are of good quality, informative, and appropriately selected to illustrate the main imaging patterns across the spectrum of appendiceal mucinous neoplasms. The tables are concise and practical, particularly the summary of differential diagnoses, which may be useful in routine clinical practice. The references are relevant and include recent literature in the field.
A particular strength of the review is its practical approach, combining morphological imaging features with clinically important aspects such as pseudomyxoma peritonei, assessment of disease burden, and the complementary roles of CT and MRI. The discussion of emerging applications of radiomics and artificial intelligence also adds a contemporary perspective and highlights promising directions for future research.
This is a valuable and educational review that provides a clear synthesis of current knowledge and may serve as a useful reference for radiologists, gastroenterologists, surgeons, and other clinicians involved in the multidisciplinary management of patients with appendiceal mucinous neoplasms.
"
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Morelli C, Villanova I, Lorusso G, Cozzi M, Greco S, Calbi R, Maggialetti N, Calabrese A. Imaging of appendiceal mucinous epithelial neoplasms: A narrative review. World J Gastroenterol 2026; 32(37): 120384 [DOI: 10.3748/wjg.120384]
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38
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"This study addresses a relevant and timely question regarding the potential of endocytoscopy to provide real-time optical assessment of histological inflammatory activity in ulcerative colitis. The development of a structured endocytoscopic scoring system, the use of blinded histopathological assessment, and the evaluation of interobserver agreement are important methodological strengths. The reported diagnostic performance of ECSS is encouraging, particularly for the more stringent definition of histological inactivity.
The findings should be considered in the context of the study design. The proposed ECSS cut-off was derived and evaluated in the same relatively small, single-center cohort of 72 patients, and further validation in independent populations would be useful. In addition, patients with Mayo endoscopic score 3 were not included and most patients had minimal or no endoscopic activity, which may inluence the applicability of the findings across the full spectrum of ulcerative colitis severity. The potential role of endocytoscopy in reducing the need for biopsies or in predicting the risk of clinical recurrence is particularly interesting, and represents an important area for further longitudinal investigation.
The manuscript is a scientifically interesting proof-of-concept study with promising results and potential clinical relevance. Its principal value lies in proposing a structured approach for real-time optical prediction of histological activity in ulcerative colitis. Larger prospective multicenter studies, external validation of the ECSS threshold, standardized image acquisition, and longitudinal outcome assessment would be valuable to further establish the clinical applicability of this approach.
"
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Li M, Lou XY, Liu ZC, Peng B, Huang Y, Guo Q. Endocytoscopy for histological evaluation of inflammation in ulcerative colitis. World J Gastroenterol 2026; 32(37): 119611 [DOI: 10.3748/wjg.119611]
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39
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"This is a well-designed single-center retrospective study which confirms the prognostic value of admission Pulse Pressure(PP) for early risk stratification in patients with TBI. The finding that PP 41-60 mmHg may represent an optimal hemodynamic window-warrants prospective validation. The admission PP might vary with different measurement method, and other markers such as the injury mode presented on CT scans, and the dynamic changes inclusive of the PP after initial resuscitation treatment in ER might be of better for the single admission PP measurement in this manuscript. "
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Ahmed K, El-Menyar A, Asim M, Al Jogol H, Taha I, Kanbar A, Younis B, Rizoli S, Al-Thani H. Prognostic utility of on-admission pulse pressure in hospitalized patients with traumatic brain injury. World J Crit Care Med 2026; 15(3): 115627 [PMID: 42707857 DOI: 10.5492/wjccm.115627]
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40
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"This is a high-quality narrative review that innovatively reintegrates venous physiology into bedside hemodynamic assessment. The AVPG framework has some clinical teaching and practical value. The article is well-structured and well referenced. But the potential selection bias was inherent to narrative reviews, furthermore,the relationship between MAP-CVP as a surrogate and true organ-level perfusion gradients requires further elucidation."
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Kataria S, Vinjamuri S, Juneja D, Goel S. Venous dimension of shock: Integrating arterial inflow and venous back-pressure in hemodynamic assessment. World J Crit Care Med 2026; 15(3): 122632 [PMID: 42707869 DOI: 10.5492/wjccm.122632]
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41
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"The decision of performing renal artery stenting for the treatment of atherosclerotic renal artery stenosis is very controversial in clinical grounds. This review offer important information about cummulated evidence in this field. A pitfall is that the design of the table is not friendly to read and too much information is included in the last row.
"
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Warfield AE, Morris CS, Bhave AD, Scriver GM, Massouh A, Kallen J, Solomon RT, Majdalany BS. Renal artery stenting for atherosclerotic renal artery stenosis: A review of contemporary data. World J Nephrol 2026; 15(3): 124524 [PMID: 42626292 DOI: 10.5527/wjn.124524]
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42
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"The authors have writen a very good mini review with clear objective and adequate evaluation of evidence. Conclusions are very clear. May be a figure would have improved the article. In the same way, a table comparing the different criteria suggested for diagnosing contrast associated acute kidney failure would had been helpful. "
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Trombara F, Cosentino N, Pontone G, Marenzi G. Renal replacement therapies in the prevention of contrast-induced acute kidney injury. World J Nephrol 2026; 15(3): 119548 [PMID: 42625961 DOI: 10.5527/wjn.v15.i3.119548]
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43
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"This manuscript is well-written and informative, offering adequate textual content and appropriate citation support. The content appears authentic and adequate, and the figures, tables, and references are sufficient and relevant to the topic(narrative mini-review). Nevertheless, several limitations should be addressed to improve the overall quality, as outlined below.
1. Title: The current title does not fully reflect the scope of the manuscript. While the title suggests a focused introduction to vascular complications, the content actually covers a broader range of topics, including diagnosis, treatment, and management of vascular complications in percutaneous biliary interventions. Revising the title to better align with the comprehensive nature of the content (narrative mini-review) is recommended.
2. Abstract: The phrase “for both benign or malignant biliary strictures” should be revised to “for both benign and malignant biliary strictures or obstruction” for greater accuracy and clarity.
3. Abstract and Vascular Complications section: The statement “reduced serum hemoglobin levels” is insufficiently specific. It should be expanded to “reduced hemoglobin levels, reduced blood volume, and/or hypotension” to more comprehensively describe the clinical manifestations."
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Acquafredda F, Vizzuso A, Grigoriadis S, Di Giovanni G, Renzulli M, Giampalma E, Paraskevopoulos I, Spiliopoulos S, Inchingolo R. Vascular complications in percutaneous biliary interventions. World J Radiol 2026; 18(8): 119018 [PMID: 42676980 DOI: 10.4329/wjr.119018]
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44
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"
Recent data support the view that the intestinal flora may, through its connection with the environment, host metabolism, and systemic health, be related to aging and age-related diseases. The intestinal flora influences metabolic reprogramming, immune regulation, and neuroinflammation through the gut-liver axis (a metabolic conduit) and the gut-brain axis (a neuroimmune communication pathway), with neuroinflammation acting as an integral hub. Dysbiosis, characterized by gut microbial imbalance and subsequent multisystem disorders, is a key mechanism underlying aging and the pathogenesis of related diseases. This comprehensive review highlights, among others, the potential of Traditional Chinese Medicine to regulate intestinal microflora. Classical theories of Traditional Chinese Medicine provide examples of how these interventions regulate microbiome function and contribute to host homeostasis, thereby addressing the systemic nature of aging.
The impact of environmental factors on microbiome aging represents a critical and cost-effective public health intervention. Applying polyomics, network pharmacology, and artificial intelligence technologies will accelerate the transition to clinical translation. By integrating traditional wisdom with modern scientific approaches, the development of precise, personalized microecological interventions may offer opportunities to address the challenges of an aging global population.
Current interventions include nutritional modulation, development of next-generation Probiotics and Prebiotics, use of Postbiotics, Fecal Microbiome Transplantation from young or healthy donors to older people, and drug repurposing.
Future Directions and perspectives include precision microbiome medicine with personalized gut mapping, engineered Live Biotherapeutic Products, multi-omics and artificial intelligence, and, finally, targeting gut-brain immune cells. For the latter, specialized gut immune cells (e.g., dendritic cells) can migrate directly to the brain and affect neuroinflammation. Developing therapies that "train" these cells in the gut to become anti-inflammatory before they travel to the central nervous system could be a radical therapeutic avenue. The future looks promising.
"
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Hou ZW, Zhang P, Chen C. Gut microbiota-multi-organ axis and neuroinflammatory network: A potential integrative hub in aging and age-related diseases. World J Gastroenterol 2026; 32(36): 119520 [DOI: 10.3748/wjg.119520]
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45
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"This is an excellent review with an interest objective that have very good figures and a progresive development of facts that allowed a good understanding of this complex field. It could be really helpful for researchers and even for clinicians although, from a clinical point of view, currently there is no evidence of clinical helpfulness about microRNA for predicting or diagnosing diabetic nephropathy. "
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Sharma VK, Beg MMA, Singh S, Singh SK, Shrivastav D. SLC30A8 (ZnT8) at the crossroads of epigenetics and microRNA regulation in type 2 diabetes and nephropathy. World J Nephrol 2026; 15(3): 122565 [PMID: 42626274 DOI: 10.5527/wjn.122565]
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46
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"The manuscript gives interesting results although it have some pitfalls. The beginning is a bit strange since it sounds like the start of a letter to the editor and the background is hard to understand since it signal an article that is not really related to the objective (even more, it is repeteadly referenced along the text). Conclusions are extremely long and not related to the article. "
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Mpisa S, Soldera J. From kidney to liver: Are sodium–glucose cotransporter-2 inhibitors emerging as metabolic disease modifiers? World J Nephrol 2026; 15(3): 121652 [PMID: 42626005 DOI: 10.5527/wjn.121652]
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47
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"This is very interesting paper about the relationship between mental health and Inflammatory bowel diseases (IBDs), such as ulcerative colitis
and Crohn’s disease. These diseases are chronic immune-mediated diseases
that cause inflammation throughout the gastrointestinal
tract. Nearly 1 in 100 Americans are diagnosed IBD.
Although IBD is a gastrointestinal disease, it can have a
profound impact on a patient’s emotional health. Studies
have found a higher prevalence of psychiatric comorbidities,
such as anxiety and depression, among patients with IBD.
Compared with similar healthy individuals, patients with IBD
were found to have 3 to 5 times higher risk of developing
anxiety disorders and 2 to 4 times higher risk of developing
depression disorders in their lifetime. These psychiatric
comorbidities can have significant implications for IBD
patients, with evidence supporting an association between
psychiatric state and IBD disease course, such as patients
with more depressive symptoms presenting with greater in
flammation due to stressors. Depressive symptoms are also
associated with IBD relapse and shorter periods of remission
Studies have found a higher risk of comorbid anxiety and depression among patients with inflammatory bowel disease (IBD)
compared with healthy individuals. If left untreated, comorbid depression and anxiety in patients with IBD can lead to poorer health outcomes
and an increased healthcare utilization. The goal of this work was to develop a consensus statement to begin to address patient and provider
needs and responsibilities related to screening and treatment of depression and anxiety symptoms among patients with IBD. Mental healthcare and support for IBD patients is critical; the statements included in this article represent practical considerations
for IBD healthcare professionals in addressing key issues on provider awareness, knowledge and behaviors, screening and treatment resources,
and patient education.
patients with IBD may experience symptoms of anxiety and depression as the disease progresses. These symptoms can occur not only during active disease phases but also during periods of remission. The following approaches are considered effective for improving the mental health of IBD patients:
Importance of mental health care: Mental health care is crucial, as IBD patients often carry a heavier burden of stress and anxiety than is commonly realized.
Improving gut health: Restoring the balance of gut microbiota may help alleviate symptoms of depression.
Mindfulness: Evidence suggests that meditation and other mindfulness-based techniques can help relieve stress and anxiety in IBD patients.
I think that a combination of these methods is recommended for managing mental well-being in IBD patients. I agree to your paper.
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Gao X, Xiao P, Di JQ, Jiao Y, Liu Q. Beyond inflammation control: Rethinking fatigue as a multidimensional target in Crohn’s disease management. World J Gastroenterol 2026; 32(36): 118624 [DOI: 10.3748/wjg.118624]
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48
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"It is a short but intensive review about Donor medicine. I cannot agree with the title: An emerging field in nephrology, since transplantation start by kidney living donors near eighty years ago. I do not support the final recommendation, there is no place for a medical especiality based only on the small number of this kind of donors, but the need for specific training on this issue is warranted.
"
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Abbasi MT, Prasad GVR. Donor medicine: An emerging field in nephrology. World J Nephrol 2026; 15(3): 121522 [PMID: 42626248 DOI: 10.5527/wjn.121522]
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49
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"Although the sample is big and the data have some interest, the format of letter to editor make difficult to correctly assess the presented results. The discussion and conclusions are written in a telegraphic way that made it hard to understand. In fact, I think that it should had not been published."
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Feyissa GD. Letter to the Editor: Enhancing renin-angiotensin-aldosterone system inhibitors utilization through patiromer adherence - real-world insights for nephrology practice. World J Nephrol 2026; 15(3): 119286 [PMID: 42626019 DOI: 10.5527/wjn.119286]
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50
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"The article addresses a clinically relevant and insufficiently clarified question, namely whether Clostridioides difficile colonization is associated with subsequent IBD activity. A major strength of the study is its prospective design, with the inclusion of patients in remission, which allows for longitudinal assessment of the development of IBD flares and evaluation of whether these are preceded by C. difficile colonization. Furthermore, the distinction between colonization and infection is an important aspect of the study. The authors define CDC as a positive culture and GDH test in the presence of a negative toxin test, whereas CDI requires both clinical criteria and a positive toxin test. Another strength is the repeated collection of stool samples from patients with IBD and the relatively long follow-up period of approximately 420 days, which increases the likelihood of identifying colonization and subsequent episodes of CDI. In addition, the inclusion of both clinical and biochemical parameters to assess IBD activity represents another methodological strength.
From a writing and presentation standpoint, the article is clearly and logically structured, the methods are described in sufficient detail to allow the study protocol to be understood and reproduced, and the findings are appropriately discussed in the context of the existing literature. The authors address both the clinical implications of their findings and the limitations of the study, which gives the manuscript a balanced and objective perspective.
"
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Morado-Aramburo O, Ochoa-Hein E, Pérez-Gutiérrez MT, Sánchez-Cruz MN, Bobadilla-del-Valle M, Yamamoto-Furusho JK, Ponce-de-Leon A, Sifuentes-Osornio J. Association between Clostridioides difficile colonization and inflammatory bowel disease activity in outpatients with remission. World J Gastroenterol 2026; 32(35): 118677 [DOI: 10.3748/wjg.118677]
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