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1
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"As regard ethics: The IRB is only from porta said university while sherbin central hospital is one of the units of National committee of control of viral hepatitis so all the data is belong to the national committee and need separate IRB
what the time of this study it is stated that it is prospective while those patients receive treatment since the national program since 2017 and the center is closed since 4 years or more so it is actually retrospective study on stored samples?????
Rational of the study:The SVR for DAAs even in cirrhotic HCV patients were 97% so research for predicting response as regard cost benefit at national program because the cost of generic drug cost about 10 dolars while these markers cost may exceed 1000 dollar's it is non practical for its use except from the research aspect.
Methods: the inclusion criteria for the patients is not mentioned :if it is naïve cirrhotic or experienced cirrhotic what the duration of treatment for each group.
- The method include major mistakes as the National protocol undergo PCR HCV at the start of treatment , at the end for treatment to define responder from non responders and after 6 month to define relapse from sustained virological response (SVR) so the definition of non responders in this study is not correct . the correct expression is SVR and relapsers so theses markers predict SVR not response to treatment"
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Abdelrazek MA, Elghwab AI, Tabll AA, Elsayed EH, El Behery M. Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals. World J Virol 2025; 14(2): 106479 [PMID: 40575636 DOI: 10.5501/wjv.v14.i2.106479]
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"This review explores whether robotic-assisted lymphadenectomy provides measurable advantages over laparoscopic approaches in the treatment of gastric cancer. While robotic gastrectomy appears to offer comparable oncologic outcomes in terms of lymph node retrieval and survival rates, it may confer technical benefits such as reduced blood loss, lower pancreatic fistula rates, and more precise dissection—particularly in challenging cases following neoadjuvant therapy or involving suprapancreatic nodes. However, robust evidence remains limited, and further randomized controlled trials—especially in Western populations with varied surgical expertise—are warranted to validate these findings."
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Marrelli D, Carbone L, Poto GE, Fusario D, Gjoka M, Andreucci E, Piccioni SA, Calomino N, Sandini M, Roviello F. Minimally invasive lymphadenectomy for gastric cancer: Could the robotic approach provide any benefits than laparoscopy? World J Gastrointest Oncol 2025; 17(6): 104015 [PMID: 40547156 DOI: 10.4251/wjgo.v17.i6.104015]
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"Based on the article, this study highlights the prognostic significance of preoperative biomarkers—specifically fibrinogen and neutrophil-to-lymphocyte ratio (F-NLR), alpha-fetoprotein (AFP), and prealbumin (PA)—in patients with primary liver cancer undergoing transarterial chemoembolization (TACE). The integrated model incorporating all three indicators showed strong predictive accuracy for patient outcomes, suggesting its potential utility for personalized risk stratification and treatment planning. However, to enhance clinical applicability, external validation in diverse cohorts and prospective trials would be beneficial."
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Liu QQ, Li YD, Chen JX, Zhang LL, Guan RC, Zhao W, Meng LY. Prognostic value of preoperative fibrinogen, neutrophil-to-lymphocyte ratio, serum alpha-fetoprotein, and prealbumin for patients with primary liver cancer undergoing transarterial chemoembolization. World J Gastrointest Oncol 2025; 17(6): 103198 [PMID: 40547171 DOI: 10.4251/wjgo.v17.i6.103198]
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"This study sheds light on the genetic predisposition to esophageal squamous cell carcinoma (ESCC) in the Chinese population by investigating activin A receptor type 1C (ACVR1C) polymorphisms. The findings suggest that certain SNPs may serve as potential biomarkers for early diagnosis and personalized treatment. However, integration of clinical features and treatment response data would further strengthen its translational relevance."
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Kumar S. Esophageal squamous cell carcinoma susceptibility of activin A receptor type 1C variants in Chinese population. World J Gastrointest Oncol 2025; 17(6): 102687 [PMID: 40547142 DOI: 10.4251/wjgo.v17.i6.102687]
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5
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"This article discusses recent advances in the integrated application of genetic and imaging techniques in esophageal squamous cell carcinoma and pancreatic cancer, highlighting the clinical potential of precision medicine. In particular, the identification of specific genetic polymorphisms and imaging biomarkers suggests meaningful implications for early diagnosis and individualized treatment strategies. Such a multidisciplinary approach could contribute to improved detection of high-risk patients and more personalized therapeutic interventions in the future."
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Zhang SK, Jiang L, Jiang CL, Cao Q, Chen YQ, Chi H. Unveiling genetic susceptibility in esophageal squamous cell carcinoma and revolutionizing pancreatic cancer diagnosis through imaging. World J Gastrointest Oncol 2025; 17(6): 102544 [PMID: 40547163 DOI: 10.4251/wjgo.v17.i6.102544]
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6
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"Based on the document, the study emphasizes the prognostic significance of preoperative inflammatory and nutritional biomarkers—such as neutrophil-to-lymphocyte ratio (NLR) and hemoglobin—in patients with colorectal cancer and peritoneal metastases. The development of a nomogram integrating these factors offers a practical tool for risk stratification and clinical decision-making, though external validation through larger, multicenter cohorts remains essential to confirm its broader utility."
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Cai Z, Dai WD, Cai XW. Prognostic impact of inflammatory and nutritional markers in colorectal cancer patients with peritoneal metastasis. World J Gastrointest Oncol 2025; 17(6): 100010 [PMID: 40547170 DOI: 10.4251/wjgo.v17.i6.100010]
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"The article was excellent and well-organized. MSC-derived extracellular vesicles (MSC-EVs) have emerged as a promising candidate across various medical fields, including tissue regeneration, biomarker development, and biomedical engineering. Therefore, a comprehensive review covering the applications of EVs in biomedicine, along with future perspectives, is essential for advancing our understanding and addressing current limitations in the field."
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Liu TM. Mesenchymal stem cell-derived extracellular vesicles: Pioneering the next generation of biomedical applications. World J Stem Cells 2025; 17(6): 108197 [DOI: 10.4252/wjsc.v17.i6.108197]
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8
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"Recent articles on the topic are fewer than expected. For example you could cite some of the following articles
https://pmc.ncbi.nlm.nih.gov/articles/PMC9120231/
Wang Y, Wei J, Zhang W, Doherty M, Zhang Y, Xie H, Li W, Wang N, Lei G, Zeng C. Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies. EBioMedicine. 2022 Jun;80:104055. doi: 10.1016/j.ebiom.2022.104055.
https://pubmed.ncbi.nlm.nih.gov/38352865/
Goudman L, Demuyser T, Pilitsis JG, Billot M, Roulaud M, Rigoard P, Moens M. Gut dysbiosis in patients with chronic pain: a systematic review and meta-analysis. Front Immunol. 2024 Jan 30;15:1342833. doi: 10.3389/fimmu.2024.1342833.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9895325/
https://pubmed.ncbi.nlm.nih.gov/29205415/"
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Tüsüz Önata E, Özdemir Ö. Microbiome, dysbiosis and use of probiotics in various diseases. World J Virol 2025; 14(2): 99574 [PMID: 40575647 DOI: 10.5501/wjv.v14.i2.99574]
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"Gastroparesis is a severe diabetic complication caused by progressively worsening intestinal neuropathy. Early detection is achieved through laboratory testing for delayed gastric emptying, mainly through annual real-time ultrasound. If the manometric study detects pyloric spasm, this should be treated endoscopically. If gastroparesis is detected by electrogastrographic body surface gastric mapping, it is treated with prokinetic drugs and careful management of diabetes mellitus. Early detection of the disease through blood or stool markers is not yet possible. Currently, the annual screening of patients who meet the criteria for potential disease appearance is the only way to achieve a successful and timely diagnosis. In cases of normal results, high-resolution intrapyloric-duodenal manometry or the EndoFLIP device should be used to check for pyloric spasm. Appropriate dietary interventions, prokinetic drugs, and blood sugar regulation follow this. However, both the diagnosis and treatment of the condition are not easy. The gastroenterologist should be well-informed about the diagnostic methodology and therapeutic interventions. Nevertheless, the future looks promising for emerging therapies aiming to treat the condition etiologically."
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Bortolotti M. Gastroparesis, a diabetic complication causing further, even serious, complications: How to prevent its worsening? World J Gastroenterol 2025; 31(23): 104932 [PMID: 40575340 DOI: 10.3748/wjg.v31.i23.104932]
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"The paper is interesting and well written. The information s correct and useful. It is an updated review. Probably, if the Authors have provided some images the comprehension of the issue would have been greater. A more detailed description of the haemodynamic problems for the presence of the sinus of Valsalva aneurysms would have increased the valute of the review."
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English K. Diagnosis and treatment options for sinus of Valsalva aneurysms: A narrative review. World J Cardiol 2025; 17(6): 102722 [PMID: 40575421 DOI: 10.4330/wjc.v17.i6.102722]
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"This is very interesting paper. I ask some questions to author.
1.A liver biopsy is required to diagnose NASH, but there are risks such as bleeding, so there are also noninvasive tests such as Fib-4 index, M2BPGi, and elastography. What combination would be best?
2.What are the reasons for the high incidence of NASH in developing countries?"
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Sato-Espinoza K, Valdivia-Herrera M, Chotiprasidhi P, Diaz-Ferrer J. Hepatocellular carcinoma in patients without cirrhosis. World J Gastroenterol 2025; 31(23): 107100 [PMID: 40575339 DOI: 10.3748/wjg.v31.i23.107100]
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"The study investigates phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high (MMR-deficient/MSI-H) colorectal carcinomas, a clinically relevant topic with clear translational implications. The retrospective design and focus on survival outcomes align with established research frameworks in oncology.
This study provides valuable insights into MMR-deficient/MSI-H colorectal cancer, but enhancements in ethical documentation, statistical rigor, and methodological transparency are needed to strengthen its credibility. Addressing these gaps will not only improve the manuscript’s scientific quality but also position the findings to influence clinical practice. The authors are encouraged to prioritize multivariable analysis, standardized reporting, and contemporary literature integration to maximize the study’s impact."
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Mehta A, Bansal D, Tripathi R, Anoop V. Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas. World J Clin Oncol 2025; 16(6): 104243 [DOI: 10.5306/wjco.v16.i6.104243]
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13
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"This is a very nice case that illustrates the Worldwide Problem that Medicine has with Bariatric Surgery when it is not properly indicated. The problem with obesity is that it has been tried to be solved with bariatric surgery alone. Obesity and overweight has caused a lot of health problems but most importantly are gastrointestinal symptomatology which is mostly attributed to a higher BMI. The solution to obesity is not surgery."
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Cass K, Leggett A, Gibson DG. Diagnostic dilemma of avoidant/restrictive food intake disorder after bariatric surgery: A case report and review of literature. World J Clin Cases 2025; 13(24): 106941 [DOI: 10.12998/wjcc.v13.i24.106941]
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"This study comparatively analyzed cancer incidence data between China and the global context in 2022, aiming to reveal disparities in cancer burden through multidimensional analysis of factors including gender, geographic distribution, and economic levels, while exploring risk factors associated with high-incidence cancer types. These findings provide a foundation for formulating targeted prevention and control strategies."
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Hu D, Yu J, Feng J, Liu P, Chen JM, Zhang HL. Comparison and trend analysis of cancer incidence in China and globally in 2022. World J Clin Oncol 2025; 16(6): 107016 [DOI: 10.5306/wjco.v16.i6.107016]
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"(1) The study adopted a retrospective cohort design with a sample size of 102 adult AML patients, which meets statistical requirements. However, the sample size may be insufficient for subgroup analyses (e.g., FAB-M2 subtype had only 44 cases) .
(2) While the study clearly reported negative results (e.g., no significant association between SOX11 expression and CR, OS/DFS), it lacked biological justification for the SOX11 high/low expression grouping criteria .
(3) Statistical analyses appropriately used Mann-Whitney tests and Kaplan-Meier survival methods for nonparametric data characteristics, but failed to implement multiple testing corrections (e.g., Bonferroni adjustment) .
(4) This work validated SOX11's association with FLT3-ITD mutations and FAB-M2 subtype in AML, proposing its potential as a stratification marker for high-risk patients. However, functional experiments (e.g., CRISPR knockout/overexpression) are required to verify SOX11's oncogenicity and synergistic effects with FLT3-ITD in AML pathogenesis .
Methodologically, the study demonstrated good standardization and result transparency, but was limited by sample size constraints and insufficient mechanistic exploration depth ."
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Abdel Aziz RS, Radwan EM, Fouad AM, Abdellateif MS, Elfishawi S. Clinical significance of the transcription factor (SOX11) expression in the bone marrow of acute myeloid leukemia patients. World J Clin Oncol 2025; 16(6): 107271 [DOI: 10.5306/wjco.v16.i6.107271]
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"(1) Objectivity and Credibility: The research design is rigorous and the data supports the conclusions, but confounding factor correction analysis needs to be added.
(2) Scientific Value: For the first time, a systematic comparison of the lymph node characteristics and survival associations of MMR-D/MSI-H and MMR-P/MSS CRC was made, providing new basis for immunotherapy stratification.
(3) Priority for Improvement: The results need to be verified through prospective cohort studies, and the clinical transformation pathways of LNY/LNR as prognostic markers need to be explored."
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Mehta A, Bansal D, Tripathi R, Anoop V. Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas. World J Clin Oncol 2025; 16(6): 104243 [DOI: 10.5306/wjco.v16.i6.104243]
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17
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"Objectivity: Moderate. The topic discussed in this study is actually a legacy topic, so the publication bias is obvious.
Credibility & Scientific quality: There are 2 papers included in this manuscript were reported on Pubpeer. Actually, there is one big problem for every meta-analysis article: There are too many fake papers published and indexed in various SciDatabases.
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Zheng XD, Li HY, Gao SY, Wang Q, Liu JB. High hypoxia inducible factor-1α expression is associated with reduced survival in patients with breast cancer: A meta-analysis. World J Clin Oncol 2025; 16(6): 105691 [DOI: 10.5306/wjco.v16.i6.105691]
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18
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Younus A, Liu Y, Connor EE, Wu ZY, Lee H, Fu ZY. Segmental atrophy of the liver: Review of a rare pseudotumor. World J Clin Cases 2025; 13(24): 107825 [DOI: 10.12998/wjcc.v13.i24.107825]
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19
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"The ethical approval meets requirements. The study obtained approval (CE24431B) from Taichung Veterans General Hospital. The methods are effective and can be repeated by fellow researchers. They conducted a robust retrospective cohort using the TriNetX database, which harmonizes EHR data across 80 U.S. healthcare organizations. Besides, the inclusion and exclusion criteria are clear. The results of this study are authentic, reliable and validate the initial hypothesis. The tables, graphs, and figures were constructed and annotated well. But one mistake was presented in Table 3. Gestational hypertension HR typo ("HR: 1.936(1.844,0.033)" – "0.033" likely should be "2.033"). The biostatistics data was generally right. However, more details of PSM and some sensitivity analyses (e.g., competing risks for mortality) are suggested to be added. Authors have cited key references to support the pathophysiological mechanisms and prior epidemiological relationship, as well as some recent references. I suggest adding recent reviews on PIH-related metabolic dysfunction. The language is generally clear, concise, and logically structed."
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Shih YH, Yang CY, Lung CC. Long-term risk of diabetes following hypertensive disorders of pregnancy: A retrospective cohort study. World J Diabetes 2025; 16(6): 105080 [PMID: 40548290 DOI: 10.4239/wjd.v16.i6.105080]
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"This was prospective study investigating factors that could potentially influence mesalamine adherence in patients with ulcerative colitis (UC), highlighting the impact of shared-decision-making on treatment outcomes. Basically, the results of the study indicate that when patients are involved in choosing their medication formulation, particularly granules, their adherence significantly improves, leading to better disease activity control. While acknowledging some limitations, such as reliance on self-reported adherence and potential participant dropout, the findings emphasize the importance of patient-centered care and accommodating individual preferences in long-term UC management. Ultimately, the study suggests that integrating shared-decision-making into routine gastroenterology practice might enhance adherence and overall outcomes.
Regarding specific aspects:
The ethical approval process appears to meet standard requirements based on the information provided. The study was reviewed and approved by the Ethics Committee of the North Rhine Chamber of Physicians, and registered on ClinicalTrials.gov. All study participants provided signed informed consent before study enrollment. Patient data were entered into an online electronic database using the double data entry method.
The experimental method is described with sufficient detail to assess its effectiveness and potential for reproducibility. Basically, this was a 12-month, prospective, multicenter, non-interventional cohort study conducted at 113 specialty gastroenterology practices in Germany. The study design allowed for the collection of real-world data without formal interventions, which is highlighted as a strength. Eligibility criteria were clearly defined, and the inclusion of patients initiating or re-initiating mesalamine treatment in routine practice across Germany enhances the real-world applicability of findings. Decisions about diagnostic procedures and treatment were made by the treating physician according to patients’ clinical needs and independently of the study, ensuring routine clinical practice was observed. Disease activity was assessed using the partial Mayo score, with scores ranging from 0 to 9. Patient knowledge of UC was assessed using a self-developed, patient-administered questionnaire with two parts: self-rating and nine yes/no questions grouped into poor, moderate, or good/very good categories.
Adherence was assessed using a self-developed, patient-administered questionnaire with a visual analogue scale (VAS). The reliance on a self-developed, self-reported VAS for adherence is noted as a potential limitation as it tends to overestimate adherence, though it is considered a simple and realistic measurement often used in practice. Patient involvement in treatment decision-making was not directly measured but inferred as a "proxy": instances where patients received their preferred mesalamine formulation were considered cases of shared decision-making. This is explicitly stated as an oversimplification and a limitation of the study.
The authors provide information on the biostatistical methods used and present numerical results. The description of biostatistical methods and reported results appears to be correctly conducted.
The results are presented clearly, supporting the study's aims and partially validating its hypothesis. However, the authors acknowledge that if all lost-to-follow-up patients are assumed to have suboptimal adherence, the rates drop dramatically at Visit 3, aligning more with previous literature. This demonstrates authenticity in acknowledging potential biases.
Patient knowledge of UC (self-estimated or objectively measured) showed no significant association with adherence. Patients reporting good adherence experienced significant improvements in disease activity over 12 months. Patients who received their preferred formulation experienced continuous improvement in pMayo scores over 12 months.
The figures, tables, and the diagram are clear and provide important information.
The references provided suggest a reasonable approach to literature review on the subject., presenting relevant sources. There is no direct evidence to suggest self-citation, omission, mis-citation, or over-citation.
The language used in the article is generally clear, concise, and grammatically correct.
The study explicitly details its limitations in the "Strengths and limitations of the study" section.
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Kruis W, Jessen P, Morgenstern J, Reimers B, Müller-Grage N, Bokemeyer B. Shared decision-making improves adherence to mesalamine in ulcerative colitis: A prospective, multicenter, non-interventional cohort study in Germany. World J Gastroenterol 2025; 31(22): 101915 [PMID: 40539204 DOI: 10.3748/wjg.v31.i22.101915]
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"Authors studied a clinically important yet underexplored aspect of young-onset type 2 diabetes mellitus (T2DM): the association between vitamin D (VitD) status and apolipoprotein A1 (apoA1); a major component of HDL cholesterol with established cardioprotective properties. The study is one of the first to evaluate the relationship between VitD and apoA1 specifically in young-onset T2DM, a population at heightened risk for early cardiovascular morbidity and mortality. Since apoA1 plays a critical role in reverse cholesterol transport and HDL function, its association with VitD status provides a potential mechanistic link between VitD deficiency and increased cardiovascular risk in young-onset T2DM patients. However, the thresholds for “severe” VitD deficiency and the proportion of individuals in each deficiency category could be more clearly reported for better clinical applicability."
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Hu Y, Shao LN, Zheng J, Zhang XM, Song YX, Xing YB. Vitamin D deficiency is associated with apolipoprotein A1 levels in patients with young-onset type 2 diabetes mellitus. World J Diabetes 2025; 16(6): 105558 [PMID: 40548281 DOI: 10.4239/wjd.v16.i6.105558]
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22
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"Li et al's work is a narrative review article focusing on the emerging role of ferroptosis in the pathogenesis of diabetic cardiomyopathy (DCM) and its potential as a therapeutic target. Ferroptosis inhibitors (e.g., ferrostatin-1, liproxstatin-1, and iron chelators) have demonstrated protection against lipid ROS accumulation and reduction of cardiac injury and fibrosis in preclinical models. Ferroptosis is a cutting-edge area of research with growing relevance in diabetic complications. The review links molecular pathways (GPX4, ACSL4, iron metabolism) to clinical manifestations of DCM. Highlights ferroptosis inhibition as a potentially novel and actionable intervention for a currently untreatable condition. Justifies the need for alternative treatments beyond glycemic control in DCM. These agents are being explored for iron overload cardiomyopathies and may be repurposed or tailored for DCM."
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Li GZ, Liu JY, Zhou H. Ferroptosis: A novel therapeutic target for diabetic cardiomyopathy. World J Diabetes 2025; 16(6): 104665 [PMID: 40548263 DOI: 10.4239/wjd.v16.i6.104665]
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23
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"Authors studied an important limitation in diabetes management: the inadequacy of HbA1c in fully capturing glycemic control, particularly in patients with type 1 diabetes (T1D). The authors introduce and validate the Glycemia Risk Index (GRI) as a more holistic tool by integrating data from continuous glucose monitoring (CGM). Study results indicated that GRI showed strong inverse correlation with time in range (TIR) (r = -0.90) and positive correlations with time below range (TBR), time above range, and glycemic variability (CV)—metrics that HbA1c poorly reflects. Each 1% increase in TBR or CV substantially raises the GRI, highlighting its sensitivity to dangerous glycemic patterns that HbA1c alone would miss.
While the GRI is statistically elegant, its ease of use and interpretation by patients and non-specialist clinicians remain unexplored. User-friendliness is critical for widespread adoption."
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He BB, Liu ZZ, Xu RY, Fan L, Guo R, Deng C, Xie YT, Zhou ZG, Li X. Glycated hemoglobin is not enough: The role of glycemia risk index for glycemic control assessment in type 1 diabetes. World J Diabetes 2025; 16(6): 104024 [PMID: 40548262 DOI: 10.4239/wjd.v16.i6.104024]
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24
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"Authors studied an under-researched probiotic, Acetobacter pasteurianus, linking it with diabetes treatment via lipid metabolites, which is both innovative and timely given the rising interest in functional microbiota-derived therapeutics. The findings lay the groundwork for developing next-generation functional probiotics or postbiotics focused on metabolic diseases, particularly type 2 diabetes.
While CoQ9 and OA were identified as hypoglycemic agents in the work, their precise molecular mechanisms of action (e.g., insulin sensitization, beta-cell preservation, or anti-inflammatory effects) remain unexplored sufficiently. No adequate data on signaling pathways (e.g., AMPK, PI3K/Akt) is included, which would strengthen the findings.
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Xu WY, Zhou WT, Luo JZ, Jiang YY, Zhang K, Zhang SY, Liu PS, Wei HY, Huang YQ. Lipid metabolism of Acetobacter pasteurianus and its main components with hypoglycemic effects. World J Diabetes 2025; 16(6): 103370 [PMID: 40548275 DOI: 10.4239/wjd.v16.i6.103370]
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25
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"None
Please make a specific and meaningful evaluation on the objectivity, credibility and scientific quality of the article according to above listed criteria.
Please make a specific and meaningful evaluation on the objectivity, credibility and scientific quality of the article according to above listed criteria
Please make a specific and meaningful evaluation on the objectivity, credibility and scientific quality of the article according to above listed criteria"
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Sun M, Yu J, Zhou JW, Ye M, Ye F, Ding M. Can ChatGPT and DeepSeek help cancer patients: A comparative study of artificial intelligence models in clinical decision support. Artif Intell Cancer 2025; 6(1): 106356 [DOI: 10.35713/aic.v6.i1.106356]
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26
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"Thanks for your interesting article. I think some points in this article should be considered. The paper provides MAILE primarily narrative and theoretical foundations, much of the corroborative evidence coming from studies on generic isometric or core stabilization exercises. Although the authors themselves point out that direct empirical proof of MAILE is limited, no randomized controlled trials are available to contrast it with other core stabilization protocols. It is difficult to determine whether MAILE has any real clinical advantage or if it is simply a re-packaging of what is currently done, thus, in the lack of such comparisons.
Additionally, besides subjective outcome measures like pain scales and questionnaires, objective physiological indicators like electromyography, motion analysis, or ultrasound imaging are desperately required in order to confirm that MAILE actually activates the assumed musculature as hypothesized.
Identification of predictors of successful response to MAILE is another area that would benefit from more light. While the correlations reported (e.g., aberrant movement patterns, postpartum status, or positive Trendelenburg sign) are logical, they appear more based on the overall rehabilitation literature rather than specifically proven for MAILE.
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Syed Y, Hassan MA, Kalayil RM, Othman OA, Mekkodathil A, El-Menyar A. Promising technique for managing nonspecific chronic low back pain using multi angular isometric lumbar exercise. World J Orthop 2025; 16(5): 104425 [PMID: 40496263 DOI: 10.5312/wjo.v16.i5.104425]
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27
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"AI is usefull a lot in many fields. ARLD is common in many countries with cirrhosis complication. The article with new idea has shown that using AI in ARLD management is very effective. Hopefully in the future many hospitals and medical centers will use AI in ARLD management to demonstrate effectiveness.
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Chen ML, Jiao Y, Fan YH, Liu YH. Artificial intelligence for early prediction of alcohol-related liver disease: Advances, challenges, and clinical applications. Artif Intell Gastroenterol 2025; 6(1): 107193 [DOI: 10.35712/aig.v6.i1.107193]
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"The benefits of PRF in regulating innate immunity and encouraging wound healing have been covered in this editorial. PRF is a possible treatment strategy for improved wound healing. It is a useful tool in therapeutic settings because of its ability to effectively promote tissue regeneration and modify innate immunity. PRF has the potential to greatly enhance patient outcomes and lessen the burden related to wound care as long as research into its processes and uses is conducted. The authors supported their manuscript by one figure and one table."
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Mohammadi S. Innate immunity and wound repair: The platelet-rich fibrin advantage. World J Biol Chem 2025; 16(2): 107195 [PMID: 40476259 DOI: 10.4331/wjbc.v16.i2.107195]
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29
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"In this manuscript, the authors provided a lengthy conclusion. They found that, while CQ and HCQ have shown promise in the treatment of autoimmune diseases, there are several concerns and disputes surrounding their use. Although these drugs can help cure autoimmune illnesses, their use must be carefully considered in light of the benefits and drawbacks. The authors also stated that more study is needed to fully understand the therapeutic potential of CQ and HCQ in autoimmune diseases, maximize its use in clinical practice, and develop safer and more efficient treatments. In addition, the authors showed two nice figures."
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Al-Hamadani M, Darweesh M, Mohammadi S, Al-Harrasi A. Chloroquine and hydroxychloroquine: Immunomodulatory effects in autoimmune diseases. World J Biol Chem 2025; 16(2): 107042 [PMID: 40476257 DOI: 10.4331/wjbc.v16.i2.107042]
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30
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"In an effort to transform the treatment of Parkinson's disease and enhance patient outcomes, this review addressed preclinical achievements, long-term safety issues, and ethical considerations while highlighting the importance of stem cell therapy in neuroregeneration.
Figures 1 and 2 are strong highlights in this manuscript, since Figure 1 depicts the classification of stem cells. As a result, this publication provided fundamental information regarding different types of stem cells and their applications in therapy."
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Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, Giakoumettis D. Stem cell therapy for Parkinson’s disease: A new hope for neural regeneration. World J Biol Chem 2025; 16(2): 106850 [PMID: 40476258 DOI: 10.4331/wjbc.v16.i2.106850]
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"In recent years, to enhance the diagnostic capability of colonoscopy in detecting polyps in the large intestine, tiny ones, various computer-aided detection (CADe) systems have been increasingly utilized to improve the diagnostic accuracy of colonoscopy. In the study in question, the authors investigated precisely this possibility of CADe by conducting a meta-analysis of five relevant studies involving 1,624 examinees.
They found that the adenoma missing rate was significantly lower in the group that underwent CADe compared to the group that underwent routine colonoscopy for small neoplasms. Interestingly, although the overall adenoma detection rate was not different between the two groups, it was higher in the group that underwent CADe during the first examination, suggesting that CADe significantly reduces the adenoma missing rate and polyp missing rate while improving the adenoma detection rate during the initial passage of the endoscope, thus demonstrating its potential to enhance the performance of colonoscopy.
In recent years, we have witnessed the explosive growth and integration of artificial intelligence (AI) into clinical practice. It has been increasingly incorporated into clinical practice as it improves the detection of small and advanced colonic adenomas. The existing data strongly support the clinical application of AI in colonoscopy, as it significantly improves the diagnostic accuracy of endoscopy while reducing the endoscopic workload.
However, over the next few years, the impact of AI applications is expected to be determined with precision, not only in the field of endoscopy but also in other areas of medical science, concerning not only gastroenterologists but also the effectiveness of daily therapeutic interventions."
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Wang SY, Gao JC, Wu SD. Artificial intelligence for reducing missed detection of adenomas and polyps in colonoscopy: A systematic review and meta-analysis. World J Gastroenterol 2025; 31(21): 105753 [PMID: 40538513 DOI: 10.3748/wjg.v31.i21.105753]
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"The healthy volunteers and the case groups should also be checked for conditions that would alter gut microbime including bacterial overgrowth syndrome. This is a large entity that consists of GI motility disorders, anatomical anomalies and so on. There are large body of evidence regarding the role of bacterial overgrowth syndrome in progression of chronic liver disease. The enterance of bacterial endotoxins through portal vein as a result of leaky gut is another important issue that should be addressed in the methodology."
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Ma C, Yang J, Fu XN, Luo JY, Liu P, Zeng XL, Li XY, Zhang SL, Zheng S. Microbial characteristics of gut microbiome dysbiosis in patients with chronic liver disease. World J Hepatol 2025; 17(5): 106124 [PMID: 40501476 DOI: 10.4254/wjh.v17.i5.106124]
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33
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"A well desined study in the field of biliary stricture management. Further researches are needed to identify if stent placemnet would have added value to biliary dilation alone. It seemes that percutaneous approach might be more feasible in proximal strictures than the distal ones. Moreover, in ishemia induced strictures, timely diagnosis and appropriate intervention might be a key preventive management."
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Trifonov S, Kovalenko Y, Gurmikov B, Varava A, Vodeiko V, Pakhtushkin E, Vishnevsky V, Zharikov Y. Reconstructive surgery and percutaneous balloon dilation for the treatment of benign biliary strictures: A retrospective study. World J Hepatol 2025; 17(5): 104646 [PMID: 40501473 DOI: 10.4254/wjh.v17.i5.104646]
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34
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"Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is an effective and minimally invasive alternative treatment for gastric outlet obstruction. Compared with conventional treatments such as duodenal stent placement and surgical gastrojejunostomy, EUS-GE has comparable technical and clinical success rates, with the advantages of longer patency, fewer adverse events, and lower reintervention rates. This technique is applicable not only to malignant obstruction, but also to complex pathologies such as benign lesions and afferent loop syndrome, and is a promising treatment that allows early recovery and resumption of oral intake, which is crucial for oncological patients. This review explained this point."
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Karagyozov PI, Kavrakov D, Shumka N. Endoscopic ultrasound-guided gastroenterostomy: The new standard treatment of gastric outlet obstruction. Artif Intell Gastrointest Endosc 2025; 6(2): 106600 [DOI: 10.37126/aige.v6.i2.106600]
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35
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Zhong XY, Liang ZJ, Lan ML, Xu XG, Yuan L, Zeng JX. Acinar cystic transformation of the pancreas: A rare case report. World J Clin Cases 2025; 13(23): 107096 [DOI: 10.12998/wjcc.v13.i23.107096]
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36
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Maity R, Rathna RB, Dhali A, Fernandes N, Biswas J, Kapoor GS, Dhali GK. Ulcerated benign jejunal gastrointestinal stromal tumor causing gastrointestinal bleeding: A case report. World J Clin Cases 2025; 12(23): 106140 [DOI: 10.12998/wjcc.v12.i23.106140]
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37
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Cicek E, Karatepe YK, Kantarcı TR, Sahin TT. Demanding sleeve gastrectomy procedure in a patient with severe intraabdominal adhesions: A case report and review of the literature. World J Clin Cases 2025; 12(23): 104807 [DOI: 10.12998/wjcc.v12.i23.104807]
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38
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Zhao KF, Xie CB, Wu Y. Prediction of the efficacy of first transarterial chemoembolization for advanced hepatocellular carcinoma via a clinical-radiomics model. World J Clin Cases 2025; 12(23): 101742 [DOI: 10.12998/wjcc.v12.i23.101742]
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39
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"The article provides a valuable contribution to the field by offering a comprehensive and balanced review of the immunomodulatory effects of CQ and HCQ in autoimmune diseases. While it acknowledges the existence of certain problems, such as inter-individual variability in therapeutic response, it proposes potential solutions through further research and the development of personalized treatment approaches. It a useful resource for healthcare professionals and researchers involved in the management of autoimmune diseases.
Ethics:
The article does not directly provide an ethical approval form; however, it is a mini-review rather than an experimental study involving human or animal subjects.
Methods:
The article provides a comprehensive review of the immunomodulatory effects of chloroquine (CQ) and hydroxychloroquine (HCQ) in autoimmune diseases. It discusses the mechanisms of action, clinical applications, and safety considerations based on existing literature. As it is a review article, it does not present original experimental data. The methods used to compile and analyze the literature are not explicitly detailed, but the article follows a logical structure and cites relevant sources. The approach is reproducible by fellow researchers interested in conducting a similar literature review.
Results:
The results presented are based on existing research and clinical trials. The article summarizes the findings of previous studies, indicating that CQ and HCQ have immunomodulatory effects and clinical benefits in various autoimmune diseases. While the results are not original experimental data, they are true and authentic summaries of published research. The theory or hypothesis of the immunomodulatory effects of CQ and HCQ is well-validated by the cited literature.
Figures and tables:
The article includes a few figures and tables to illustrate key points. Figure 1 depicts the immunomodulatory effects of CQ and HCQ on various immune cells, and Figure 2 summarizes the clinical applications across autoimmune diseases. Table 1 lists clinically relevant drug interactions with CQ and HCQ. These figures and tables are well-constructed, annotated, and helpful in conveying the information clearly.
Biostatistics:
As the article is a review and does not present original research data, it does not include biostatistical data or line charts with data. Therefore, this aspect is not applicable to the evaluation.
References:
The article cites numerous references that are scientifically and reasonably important in the field of autoimmune diseases and related to the immunomodulatory effects of CQ and HCQ. The references are recent and cover a broad range of relevant topics, indicating a thorough literature search. The author does not appear to self-cite excessively, omit critical references, or miscite sources.
Language:
The language in the article is correct, clear, and concise. It effectively conveys the information about the immunomodulatory effects of CQ and HCQ in autoimmune diseases. The article has no apparent grammatical or spelling mistakes.
Caveats or drawbacks:
The main caveats or drawbacks of the article are that it is a review and does not present original experimental data. Therefore, it does not provide new insights or results beyond what is already known from previous studies. Additionally, the article does not address potential biases in the cited literature or fully discuss limitations of the existing research on CQ and HCQ. The long-term side effects and the need for personalized treatment approaches are highlighted as important considerations but not fully explored.
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Al-Hamadani M, Darweesh M, Mohammadi S, Al-Harrasi A. Chloroquine and hydroxychloroquine: Immunomodulatory effects in autoimmune diseases. World J Biol Chem 2025; 16(2): 107042 [PMID: 40476257 DOI: 10.4331/wjbc.v16.i2.107042]
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40
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"Traditional Chinese medicine (TCM) is used to treat a vast number of medical conditions with very satisfactory results. One of these therapeutic fields is chronic atrophic gastritis, in which the fungus Hericium erinaceus has been shown to improve clinical manifestations and histological findings. Its antimicrobial action against Helicobacter pylori and its anticancer action against gastric cancer is also interesting.
It is time for universities, large pharmaceutical companies, and health authorities in various countries to take seriously the clinical and laboratory results of Complementary and Alternative Treatments for multiple diseases and to allocate teaching hours and financial funding to investigate the combination of CAM with modern medicine in treating a bunch of benign and malignant conditions of the digestive system. Ultimately, doctors in developed countries should reconsider their skepticism about the efficacy of CAM, particularly traditional Chinese medicine. "
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Pellegrino R, Gravina AG. Potential of traditional Chinese medicine in gastrointestinal disorders: Hericium erinaceus in chronic atrophic gastritis. World J Gastroenterol 2025; 31(20): 106615 [PMID: 40495939 DOI: 10.3748/wjg.v31.i20.106615]
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41
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"The occurrence of acute kidney injury in liver cirrhosis patients is associated with poor short-term mortality. This review is devoted to the latest concepts in the field of pathophysiology, diagnosis and treatment of acute kidney injury in liver cirrhosis patients. This is a well-structured review based on the current understanding of this actual issue."
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Malakar S, Rungta S, Samanta A, Shamsul Hoda U, Mishra P, Pande G, Roy A, Giri S, Rai P, Mohindra S, Ghoshal UC. Understanding acute kidney injury in cirrhosis: Current perspective. World J Hepatol 2025; 17(5): 104724 [PMID: 40501465 DOI: 10.4254/wjh.v17.i5.104724]
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"The article addresses the timely and pertinent subject of the potential of PRF in clinical applications related to wound healing and the immune response. The language used is clear and accessible, making complex biological concepts understandable to a wide readership. As an editorial, it effectively summarises key points without unnecessary elaboration, respecting the format's purpose.
While the editorial provides a succinct overview of the potential benefits of PRF in wound healing and immune response, incorporating recent research findings and a more detailed exploration of the underlying mechanisms would enhance it further."
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Mohammadi S. Innate immunity and wound repair: The platelet-rich fibrin advantage. World J Biol Chem 2025; 16(2): 107195 [PMID: 40476259 DOI: 10.4331/wjbc.v16.i2.107195]
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43
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"This article addresses the important and timely topic of the immunomodulatory effects of chloroquine and hydroxychloroquine in autoimmune diseases. This topic remains highly relevant for clinical and research audiences alike. The review provides a comprehensive overview of various autoimmune conditions and the mechanisms through which these drugs exert their effects, offering readers a valuable summary of the current state of knowledge in this area. The article is organised coherently, progressing logically from drug mechanisms to clinical applications, which makes it easy for readers to understand.
However, while it discusses the immunomodulatory effects of these drugs, the article lacks a critical analysis of the results from the cited studies. There is little discussion of the strength of the evidence, the limitations of the studies, or the quality of the data presented.
Furthermore, while the article cites relevant literature, it does not include the most recent studies, particularly those published within the last year. Additionally, there is little discussion of conflicting evidence or ongoing debates in the field.
While the article briefly mentions the potential side effects of chloroquine and hydroxychloroquine, it does not address the controversies surrounding their use, such as the debate over their efficacy and safety profiles in different patient populations. Including a more in-depth discussion of the limitations, controversies and areas of uncertainty surrounding the use of these drugs in autoimmune diseases would provide a more balanced perspective."
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Al-Hamadani M, Darweesh M, Mohammadi S, Al-Harrasi A. Chloroquine and hydroxychloroquine: Immunomodulatory effects in autoimmune diseases. World J Biol Chem 2025; 16(2): 107042 [PMID: 40476257 DOI: 10.4331/wjbc.v16.i2.107042]
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44
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"This mini-review is concise and well organised, providing a comprehensive overview of the topic. It effectively summarises the existing challenges and highlights the potential of stem cell therapy in Parkinson’s disease. To further enrich the article, it would be beneficial to include a comparative table summarising the different types of stem cells (e.g. ESCs, iPSCs and MSCs) and their respective advantages and disadvantages. Additionally, expanding upon novel technological advancements (e.g. CRISPR, organoids or biomaterials) would provide a forward-looking perspective that aligns with current research trends.
Overall, this article meets BPG's quality standards and is a valuable contribution to the field of neurodegenerative medicine.
However, the existing figures are relatively few, lack quantitative detail, and are very simple. For instance, it would be highly beneficial to include a comparative table summarising the different stem cell types, their sources, differentiation capacities, and clinical readiness. I would recommend adding at least one comprehensive table summarising and comparing therapeutic options, mechanisms or clinical trial data."
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Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, Giakoumettis D. Stem cell therapy for Parkinson’s disease: A new hope for neural regeneration. World J Biol Chem 2025; 16(2): 106850 [PMID: 40476258 DOI: 10.4331/wjbc.v16.i2.106850]
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45
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"This is very interesting paper. I ask some questions for author. In the past, surgical necrosectomy was performed for necrotizing pancreatitis, but this had a high incidence of complications. In recent years, endoscopic drainage has become more effective, but should it be performed after waiting four weeks until encapsulated necrosis (WON) occurs, or if MOF or infection is difficult to control, should it be ？"
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Zeng Y, Zhang JW, Yang J. Endoscopic management of infected necrotizing pancreatitis: Advancing through standardization. World J Gastroenterol 2025; 31(20): 107451 [PMID: 40495946 DOI: 10.3748/wjg.v31.i20.107451]
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46
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"The article is devoted to the search for new markers for the diagnosis of AMA-negative forms of primary biliary cholangitis (PBC), which is an important problem in hepatology. The authors of the study posit that the antibodies to RPL30 that were identified may serve as such a marker. The rationale behind the authors' decision to focus on the RPL30 protein, a constituent of the 60S ribosome subunit involved in protein synthesis, remains ambiguous. The impaired protein synthesis function of the liver in PBC occurs when a patient develops signs of progressive cholestasis involving hepatocytes, both in AMA-positive and AMA-negative patients. At the same time, in the early stages of PBC, cholangiocytes lining the small (intralobular, interlobular) bile ducts are primarily damaged. Therefore, the authors' rationale for determining antibodies to RPL30 remains ambiguous. Besidesr, the article does not provide a comprehensive analysis of the relationship between the detection of antibodies against RPL30 and the data on histological signs that confirm the presence of PBC.
The results obtained by the authors on the diagnostic value of antimitochondrial antibodies for the diagnosis of PBC are questionable..
The objective of the present study is to identify novel biomarkers that can facilitate the diagnosis of AMA-negative forms of PBC, a significant area of research in the field of hepatology. However, the motives behind this study remain unclear. What was the prerequisite for the study of antibodies to ribosomal protein L30? What role can ribosomal protein L30 play in the pathogenesis of PBC?"
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Zeng ZY, Huang ZX, Wang YR, Xie LK, Lin YP, Liang Y, Liu ZY, Li DL, Zhang XY. Anti-RPL30 as a novel biomarker for enhanced diagnosis of autoantibody-negative primary biliary cholangitis. World J Gastroenterol 2025; 31(20): 104891 [PMID: 40495948 DOI: 10.3748/wjg.v31.i20.104891]
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"Neuroendocrine tumors of the rectum are a relatively rare malignancy that is often diagnosed during colonoscopy. In recent years, its incidence has been observed to be increasing. These small tumors can be removed endoscopically using modified endoscopic submucosal resection (mEMR) or endoscopic submucosal resection. In the annotated review article, the authors discuss the indications, methods, risks, and difficulties of their endoscopic removal and propose a therapeutic algorithm to assist in making correct treatment decisions. An essential part of treating these tumors is the accurate evaluation of their endoscopic characteristics and the demonstration by means of imaging methods of any lymph node metastases or distant metastases. Also, an essential part of the correct treatment of these tumors, which is usually neglected in everyday clinical practice, is the avoidance of taking a simple biopsy. EMR with submucosal dilatation should be preferred. Patient follow-up is an essential part of proper patient management. Finally, managing these patients by a team of specialists, which includes a gastroenterologist, oncologist, and pathologist with substantial experience in diagnosing and treating these neoplasms, represents an essential element regarding the best possible management of the patients. This article contributes substantially to enriching the knowledge of gastroenterologists and oncologists about diagnosing and managing rectal neuroendocrine tumors. "
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Liu JN, Chen H, Fang N. Current status of endoscopic resection for small rectal neuroendocrine tumors. World J Gastroenterol 2025; 31(19): 106814 [PMID: 40497093 DOI: 10.3748/wjg.v31.i19.106814]
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48
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"This is a well-written and presented rarely case report about Chronic abdominal pain caused by foreign bodies in the appendix .This manuscript gives additional new knowledge to the existing literature. This interesting and rare case report has certain guiding significance for clinicians.I think that this manuscript is worth to publication."
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Huang T, Li SK, Wang W, Zhang R. Chronic abdominal pain caused by foreign bodies in the appendix: A case report. World J Gastrointest Surg 2025; 17(5): 105423 [PMID: 40502514 DOI: 10.4240/wjgs.v17.i5.105423]
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49
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"This is very interesting paper. In the past, obesity was said to be bad for treatment, but the current data shows that a BMI of >35mg/dl is said to be associated with a good prognosis.
lenvatinib and camrelizumab were good effect for obesity patient with HCC and have not yet been observed with more commonly used immunotherapy treatments for hepatocellular carcinoma, such as nivolumab, pembrolizumab, or bevacizumab.
In the past, obesity was said to be bad for treatment, but the current data shows that a BMI of >35mg/dl is said to be associated with a good prognosis.
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Sierra L, Abu-Hammour MN, Chatterjee A, Simons-Linares CR. Obesity paradox role in the immunosuppressive treatment of hepatocellular carcinoma. World J Gastroenterol 2025; 31(19): 105617 [PMID: 40497086 DOI: 10.3748/wjg.v31.i19.105617]
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50
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"The authors claimed that helicobacter pylori infection could promote the progression of gastric cancer by regulating the expression of DMBT1, however,
The “tumor progression” involves multiple aspects. In this study, it was mainly investigated through in vitro “scratch, and Transwell assays”. It is too simple. Evidently, these approaches are insufficient to comprehensively address this complex issue. Another big concern is that, cancer is a complex system, not genetic disease. In fact, merely exploring the occurrence and development of cancer from the perspective of mutation/molecules pathway is insufficient to address the complex problems such as recurrence and resistance that arise in clinical practice."
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Zhou X, Wang LQ, Song S, Xu M, Li CP. Helicobacter pylori infection promotes the progression of gastric cancer by regulating the expression of DMBT1. World J Clin Oncol 2025; 16(5): 105322 [PMID: 40503422 DOI: 10.5306/wjco.v16.i5.105322]
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