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1
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"• This is very interesting paper about pancreatic cyst. Pancreatic cysts are diagnosed through imaging tests like CT, MRI, and endoscopic ultrasound (EUS). These tests help characterize the cyst's size, structure, and relationship to the pancreas. An EUS can also be used to collect fluid or tissue samples for lab analysis to check for cancer cells, while other factors like symptoms, patient history, and risk factors are also considered to make a final diagnosis. Fluid and tissue analysis: If a sample is collected through EUS-FNA, the fluid is analyzed for specific markers like carcinoembryonic antigen (CEA), which can help identify cancer. The diagnostic process involves a combination of medical history review, various imaging tests, and sometimes fluid analysis/biopsy to determine the cyst's type and its potential for malignancy.
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Shumka N, Karagyozov PI. Cystic tumors of the pancreas: Current perspectives on diagnosis and management. World J Gastroenterol 2025; 31(43): 111393 [DOI: 10.3748/wjg.v31.i43.111393]
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2
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"The article is well written and well conducted.
I particularly appreciated the discussion, which is rich and full of interesting comments.
Unfortunately, the study is retrospective. The addition of other parameters, such as the precence of left ventricular noncompaction and serum electrolyte values, would likely have further differentiated the two populations studied."
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Kaddoura R, Al-Tamimi H, Pieles GE. Racial disparities in electrical and structural cardiac adaptation among adolescent athletes: A systematic review and meta-analysis. World J Cardiol 2025; 17(11): 107835 [DOI: 10.4330/wjc.v17.i11.107835]
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3
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Park YE. Gastric Crohn’s disease presenting as a subepithelial tumor: A case report. World J Clin Cases 2025; 13(33): 113312 [DOI: 10.12998/wjcc.v13.i33.113312]
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4
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Bergeron E, Gologan A. Abdominal compartment syndrome with colonic hypoganglionosis and massive colonic distension in a young adult: A case report. World J Clin Cases 2025; 13(33): 112684 [DOI: 10.12998/wjcc.v13.i33.112684]
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5
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"1. Ethics
It is a review article thus ethics approval form is not required
2. Methods
As a narrative/invited review, the “methods” section is not a detailed primary experimental protocol. The paper describes construction methods of gastric organoids, modeling steps, mechanisms, limitations and future directions.
The methods are adequate in describing the topic and background rather than reporting new experimental workflows.
3. Results
The results are summary of published work rather than original data. The authors summaries how gastric organoids can model atrophic gastritis → intestinal metaplasia → dysplasia → gastric cancer, and discuss mechanisms and propose that gastric organoids are a “promising model” for the inflammation-cancer transition.
4. Figures and Tables
Figures shows the multiple schematic figures. Annotation/Quality of the figures is good and are schematic exhibiting the appropriateness for this study. The legends appear clear; axes/labels in the schematics are present. The paper has well-constructed and expressive figures and tables.
5. Biostatistics
This is a review paper, there is no new statistical analyses/biostatistical tables of primary data are needed.
6. References
Lis of references is current, appropriate and is reasonable in number (> 100)
7. Language
The language is clear, rationally concise, and generally well-written.
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Liu C, Wu CH, Jia YB, Qiu JX, Li XY, Ling JH. Gastric organoids: A promising model for studying “inflammation-cancer” transition in atrophic gastritis. World J Clin Oncol 2025; 16(11): 110453 [DOI: 10.5306/wjco.v16.i11.110453]
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6
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"It was with pleasure that I tracked the article quality of the following manuscript. Please see my comments below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The figures add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate/up-to-date
7 Language: This is a concise/well written editorial
8 Caveats or drawbacks: N/A "
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Zerem E, Zerem D, Vila Š, Bajgorić S. Ascites in acute pancreatitis: A window into disease severity. World J Gastroenterol 2025; 31(43): 112797 [DOI: 10.3748/wjg.v31.i43.112797]
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7
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"“Pyroptosis” is a term composed of the union of two separate ancient Greek words, namely “Πυρ” (Fire) and “Πτώσις” (fall), which together mean “fall of the fire” (reduction of inflammation). It is a lytic mechanism of programmed cell death that involves cleavage of proteins in the gasdermin D family. Its effects are mediated through nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3)/caspase-1 classical and caspase-4/5/11. The inflammatory process mediated by this mechanism appears to play a central role in the development and pathogenesis of IBD by destroying the intestinal epithelial barrier, leading to excessive inflammation and worsening the disease progression.
Targeting pyroptosis is a promising therapeutic approach for IBD. Recent data support the notion that inhibitors of inflammasomes, such as small-molecule biological agents, other biological agents, and drugs that specifically target NLRP3, caspases, or GSDMD, suppress inflammasome activation and inhibit membrane pore formation. However, the precise regulatory mechanisms and therapeutic effect of pharmacological targeting of inflammasomes in IBD are not fully understood.
Research on the specificity of pharmaceutical agents that may prove effective in treating the disease, the extent of drug side effects, and the potential for combination with other active pharmaceutical agents is a key goal for the near future.
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Dong WW, Liu T, He LX, He WT. Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach. World J Gastroenterol 2025; 31(43): 111358 [DOI: 10.3748/wjg.v31.i43.111358]
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8
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"This letter to the Editor just agrees with the authors of the original paper that BMI is associated with worse outcome in patients with acute liver injury. In this regard, all "scientific" information descries only "associations" with BMI and organ failure. However no studies indicate possible causes so science can advance towards possible treatments beyond weight loss."
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Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514 [PMID: 41256347 DOI: 10.12998/wjcc.v13.i32.113514]
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9
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"A concise, comprehensive, complex and well-structured manuscript. There are no grammatical/spelling errors throughout the manuscript and the topic debated is of a great interest due to the fact that AI technologies have a real potential to revolutionize liver lesion assessment in association with CEUS. Indeed, in order to obtain a valid implementation in clinical practice of AI technologies combined with CEUS, we need more large-scale prospective studies in the near future.
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Ciocalteu A, Urhut CM, Streba CT, Kamal A, Mamuleanu M, Sandulescu LD. Artificial intelligence in contrast enhanced ultrasound: A new era for liver lesion assessment. World J Gastroenterol 2025; 31(42): 112196 [PMID: 41278165 DOI: 10.3748/wjg.v31.i42.112196]
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10
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"1 Ethics: Not provided
2 Methods: The experimental method is effective and can be repeated by fellow researchers
3 Results The theory is validated
4 No figures or tables provided
5 Biostatistics: Not needed
6 References: The author scientifically and reasonably cite the latest references
7 Language: The language in article correctly, clearly and concisely expresses the information
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Sameer M, Muthu S, Vadranapu S. Prophylactic fixation in elderly fractures: Preventive breakthrough or unnecessary intervention? World J Orthop 2025; 16(11): 109855 [DOI: 10.5312/wjo.v16.i11.109855]
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11
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"In the recent years,the relationship between intestinal flora disorders and various diseasess,especially IBD,has become clear, and fecal transplantation , which aims to improve dysbiosis, has attracted attention.This study also reports on fecal transplantation for the purpose of correcting intestinal flora disorders in IBD,and further research and clinical application are expected in the furture."
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Zheng L, Duan SL, Wang K. Research progress concerning the involvement of the intestinal microbiota in the occurrence and development of inflammatory bowel disease. World J Gastroenterol 2025; 31(42): 113170 [PMID: 41278154 DOI: 10.3748/wjg.v31.i42.113170]
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"It was with pleasure that I reviewed the article quality of the following manuscript. Please see my comments below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The tables add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: References are appropriate/up to date
7 Language: This is a concise/well written manuscript
8 Caveats or drawbacks: None "
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Wang XY, An F, Wang BJ, Han WW. Hydrogen peroxide pathway in ulcerative colitis: Promises and challenges in translating novel pathogenesis to clinical practice. World J Gastroenterol 2025; 31(42): 112566 [PMID: 41278161 DOI: 10.3748/wjg.v31.i42.112566]
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"Overall Assessment
1. The letter clearly addresses the association between BMI and clinical outcomes in ALF, which is clinically relevant.
2. The format follows standard Letter to the Editor conventions, making it easy to read.
3. The discussion is well-supported by Krishnan et al.’s recent study and previous reports (Kanda et al., Rutherford et al.), with accurate citations.
Strengths
1. Highlights a growing concern—obesity and its impact on ALF outcomes.
2. Includes Japanese and U.S. data, showing differences in etiology (acetaminophen vs. non-acetaminophen causes).
3. Emphasizes vigilance for renal failure and hepatic encephalopathy in obese ALF patients.
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Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514 [PMID: 41256347 DOI: 10.12998/wjcc.v13.i32.113514]
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14
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Kim N, Lee H, Park D. Challenging diagnosis of groove pancreatitis with severe gastric outlet obstruction: A case report. World J Clin Cases 2025; 13(32): 111796 [PMID: 41256349 DOI: 10.12998/wjcc.v13.i32.111796]
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15
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Aisikaer A, Sun MM, Shen J. Positron emission tomography/computed tomography in risk-factor-negative young female with malignant pleural mesothelioma: A case report and review of literature. World J Clin Cases 2025; 13(32): 110897 [PMID: 41256342 DOI: 10.12998/wjcc.v13.i32.110897]
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Liu KT, Lee MH, Lin CH, Tsou YK, Sung KF, Wang SF, Wu CH, Liu NJ. Acute cholangitis due to common bile duct stones: Clinical outcomes in patients with and without concurrent acute pancreatitis. World J Clin Cases 2025; 13(32): 110553 [PMID: 41256350 DOI: 10.12998/wjcc.v13.i32.110553]
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391 [PMID: 41256348 DOI: 10.12998/wjcc.v13.i32.110391]
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"Has authors used low threshold for BMI in this study.This needs attention and could be bias.To apply this , international definition for obesity needs to be included.The study is read by clinicians all over world ans using nonstandardised definition needs to reconsider.
sing a standardized 3-port LC technique.
Using 3 port instead of 4 port in obesity raises alarm over safety keepi in view ergonomics
Intraoperative bile leak in your series seems to be heroic by using 3 port lap chole
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Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391 [PMID: 41256348 DOI: 10.12998/wjcc.v13.i32.110391]
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"This case report is highlighting low threshold of Malignancy in groove pancreatitis.A meticolous clinical approach is refeclting in this case.Imaging is well giving learning .
Introduction is well evidence based.Case presentation is excellent.Discussion is robust with well coverage of latest updates in literaure.References are latest one
Overall, a case report giving good "Message to take home "
"
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Kim N, Lee H, Park D. Challenging diagnosis of groove pancreatitis with severe gastric outlet obstruction: A case report. World J Clin Cases 2025; 13(32): 111796 [PMID: 41256349 DOI: 10.12998/wjcc.v13.i32.111796]
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20
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"1. The review provides a thorough and well-organized synthesis of the complex interplay between MASLD and IBD, with a strong emphasis on the gut microbiota and the gut-liver axis. The topic is highly relevant, given the rising global prevalence of both MASLD and IBD, and the growing recognition of their co-occurrence. The review successfully highlights the shift from a purely metabolic understanding of MASLD to one that incorporates gut-derived inflammation and dysbiosis, which is a crucial contemporary concept.
2. References：The authors have done an excellent job integrating a vast body of literature, making the manuscript a valuable and up-to-date resource for researchers and clinicians.
3. Language：The manuscript is generally well-written in clear and accessible English, which facilitates the comprehension of complex pathophysiological concepts.
4. Figures and tables：A significant shortcoming is the lack of detailed, mechanistic figures. The existing two figures are overly simplistic and do not adequately illustrate the complex molecular and cellular pathways discussed in the text (e.g., the roles of TLRs, bile acid receptors FXR/TGR5, Th17/Treg imbalance, cytokine networks, and the impact of specific microbial metabolites). I strongly recommend the inclusion of at least one high-quality, multi-panel schematic diagram that visually integrates the key proposed mechanisms linking gut dysbiosis, intestinal barrier dysfunction, immune activation, and hepatic inflammation/fibrosis in the context of IBD-associated MASLD.
5. Caveats or drawbacks：
The manuscript contains several typographical and terminological errors that detract from its professionalism. For instance: On Page 4, the text reads "T17 cells play a key role..." This should be corrected to "Th17 cells..." as this is the standard nomenclature for T-helper 17 cells.
While the content is comprehensive, there is some repetition between sections, particularly regarding the description of gut dysbiosis and its consequences in both IBD and MASLD. The flow could be improved by more sharply differentiating the disease-specific mechanisms before synthesizing them into a unified model. The sections on "Eating Behaviour Patterns" and "Nutrition-Microbiota Axis," while interesting, feel somewhat distinct from the core mechanistic focus and could be more seamlessly integrated.
The treatment section briefly mentions probiotics, synbiotics, and cytokine inhibitors (IL-17/IL-23) but lacks depth in discussing the current evidence base, challenges, and future directions for these interventions.
The review excellently describes associations but could more explicitly acknowledge the challenges in establishing causality within the gut-liver axis in human studies.
In summary, this is a timely, informative, and largely well-executed review that makes a valuable contribution to the literature. Its primary strengths lie in its scholarly comprehensiveness and relevance.
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Sokal-Dembowska A, Ergan K, Jarmakiewicz-Czaja S. Role of gut microbiota in the development of metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease. World J Gastroenterol 2025; 31(40): 111375 [PMID: 41180986 DOI: 10.3748/wjg.v31.i40.111375]
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21
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"It is generally accepted that IBD results from the interaction of multiple environmental factors in genetically predisposed individuals, and that altered intestinal permeability is a key mechanism in the pathogenesis of the disease, as in many other digestive tract pathologies. Mitochondrial dysfunction in the intestinal mucosa is another mechanism involved in the pathogenesis of IBD.
In the reviewed study, the authors examined the factor GDF15, a member of the TGF-β superfamily, as a biomarker of mitochondrial dysfunction and a mediator of UPRmt. The researchers confirmed elevated circulating GDF15 levels in IBD patients compared with healthy controls and identified a novel molecular mechanism by which this cytokine disrupts the intestinal barrier. Therefore, successfully reducing GDF15 may constitute a therapeutic strategy to prevent intestinal barrier breakdown by reducing immune hyperactivation in the future.
All these basic research studies contribute decisively not only to elucidating the pathogenetic mechanisms of IBD but also to developing new therapeutic strategies that bring us closer to the day when we can achieve complete and sustained inhibition of IBD activity."
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Ruiz-Malagón AJ, Herraiz-Vilela M, Serrano-Pino R, García-Ávila P, Díaz-Suárez L, Carmona-Segovia AD, Becerra-Munoz VM, Jiménez-Navarro M, Arranz-Salas I, López-Villodres JA, Fernández-Castañer A, Gutiérrez-Martínez F, Rodríguez-González FJ, Camargo-Camero R, Alcaín-Martínez G, Rodríguez-Díaz C, García-Fuentes E, Sánchez-Quintero MJ, López-Gómez C. Growth differentiation factor 15 alters intestinal barrier and increases permeability: A new molecular target in inflammatory bowel disease. World J Gastroenterol 2025; 31(41): 110955 [PMID: 41257277 DOI: 10.3748/wjg.v31.i41.110955]
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22
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"a fine-needle aspiration (FNA) biopsy, especially one guided by endoscopic ultrasound (EUS-FNA), is a valuable diagnostic tool for pancreatic tuberculosis. This procedure allows doctors to collect tissue samples to confirm the diagnosis by checking for characteristic signs like granulomas, caseous necrosis, and acid-fast bacilli (AFB) or by using polymerase chain reaction (PCR) to detect the DNA of Mycobacterium tuberculosis. EUS-FNA is especially useful because it can help differentiate pancreatic TB from pancreatic cancer, preventing unnecessary surgery. "
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Nima CL, Wang HG, Zhou Q. Pancreatic tuberculosis: A case report and review of literature. World J Gastroenterol 2025; 31(41): 110398 [PMID: 41257270 DOI: 10.3748/wjg.v31.i41.110398]
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23
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"In this mini-review, the authors described the current understanding of the pathogenesis, diagnosis, and management of hepatic hydrothorax. Despite the successes of modern hepatology, the presence of hepatic hydrothorax is associated with poor prognosis and high mortality. Most patients with hepatic hydrothorax are candidates for liver transplantation. In usual clinical practice, the key to the success of their management may be the stratification of the risk of an adverse outcome and the definition of individual therapeutic tactics. A pathogenetically based approach to the choice of pharmacotherapy, as well as optimization of minimally invasive treatment methods, will improve the quality of life and increase the survival rate of this category of patients. In general, the authors provided well-known information."
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Cilia BJ, Haridy J, Raj A, Hannah N. Hepatic hydrothorax as a manifestation of decompensated cirrhosis: An update on current management and future directions. World J Hepatol 2025; 17(10): 110412 [PMID: 41179726 DOI: 10.4254/wjh.v17.i10.110412]
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24
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"Dear Author
There are parameters like MELD score that show the severity of the disease. This important score was not addressed in the trial. Were the adherent and non-adherent groups had similar MELD scores? Sarcopenia as another important factor that influence cirrhosis out comes. This risk factor was not addressed in this trial. The nutritional status regarding the vitamins and protein intake are among the most important factors that influence cirrhosis out comes. In the future trials considering the variables that influence the patient outcomes should be considered. "
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Loschi TM, Baccan MDTA, Pereira EC, Dellabarba TDLC, Boteon APCS, Boteon YL. Telerehabilitation for frail cirrhotic patients awaiting liver transplant: A safe, effective strategy to improve outcomes. World J Hepatol 2025; 17(10): 110856 [PMID: 41179717 DOI: 10.4254/wjh.v17.i10.110856]
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25
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"Dear Author,
The patient had a history of cirrhosis of the liver based on abdominal CT scan. The data regarding the other causes of chronic hepatitis were not included in the draft. Although using herbal medicine could cause the fulminant hepatitis, yet it is a diagnosis of exclusion. In my opinion, the possibility of coexistence of auto immune hepatitis in this case needs more evaluation."
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Zhu XY, Zhao YT, Su CS, Yuan XD, Zhang SG, Nashan B. Acute liver failure caused by alkaloids from traditional Chinese medicine: A case report. World J Hepatol 2025; 17(10): 109575 [PMID: 41179722 DOI: 10.4254/wjh.v17.i10.109575]
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26
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"In recent years, artificial intelligence (AI) has brought about a real revolution in various fields of human activity, establishing itself as a pioneering innovation in modern medical science. In the field of gastroenterology, and in particular colonoscopy, it has contributed significantly by promoting key quality indicators, reducing the rate of human error, and improving the consistency of endoscopist decision-making with high reliability. Reduce human error and improve endoscopists' decision-making consistency in real time, ensuring higher reliability and standardization during the procedure. By optimizing the characterization of endoscopically detected lesions, supporting visual diagnosis, and predicting the depth of infiltration, AI can enable early diagnosis and prevention of colon cancer. The combination of AI with advanced imaging techniques improves the quality of gastroenterologists' training.
However, much remains to be clarified regarding the role of AI in upper and lower gastrointestinal endoscopy. I believe that the official gastroenterological societies of Europe, the USA, and Asia should immediately delve into studying and defining the possibilities, potential risks of the widespread application of the method, and define policies regarding quality assurance, clinician education, data protection, and liability, so that AI successfully complements human intelligence and experience. The innate tendency of people (in this case, endoscopists) to resist adopting these new technologies should not prevail. They can also help validate AI systems in real-world conditions by assessing their performance across a wide range of quality indicators.
I want to congratulate the authors for their excellent work in a promising field."
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Dimopoulou K, Spinou M, Ioannou A, Nakou E, Zormpas P, Tribonias G. Artificial intelligence in colonoscopy: Enhancing quality indicators for optimal patient outcomes. World J Gastroenterol 2025; 31(40): 111499 [PMID: 41180992 DOI: 10.3748/wjg.v31.i40.111499]
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27
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"This is very interesting paper.Higher serum gamma-glutamyl transpeptidase (γ-GTP) levels are associated with an increased risk of pancreatic cystic neoplasms (PCNs) and their malignant progression. However, γ-GTP is not a specific diagnostic marker for these conditions. Its elevation is more indicative of general liver or biliary dysfunction and oxidative stress. Recent large-scale studies have found that people with higher baseline serum γ-GTP levels have a significantly increased risk of being diagnosed with PCNs later on. This suggests γ-GTP could potentially serve as a biomarker for identifying high-risk individuals for surveillance."
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Lee MW, Park JM, Cho IR, Chung KH, Kim BS, Choi JH, Paik WH, Ryu JK, Han K, Lee SH. Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study. World J Gastroenterol 2025; 31(40): 110932 [PMID: 41180989 DOI: 10.3748/wjg.v31.i40.110932]
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"Artificial intelligence has brought about a real revolution in various areas of human activities, including medical science. In recent years, AI has also emerged as a method to support the correct diagnosis and treatment of acute pancreatitis. Some elements of AI, such as machine learning, deep learning, natural language processing, and network pharmacology, seem to significantly facilitate diagnostic and therapeutic decisions in the treatment of patients with acute pancreatitis, through the analysis of clinical records, medical images, laboratory values, genomic data, and physiological signals in real time. AI functions as advanced decision support, enhancing clinical judgment with intelligence derived from diagnostic data, assessing risks to the patient from potential complications, and helping safely predict the disease. The authors also discuss future directions for AI development in the treatment of acute pancreatitis. As emphasized by the authors of this review, today's practical medicine often requires an interdisciplinary approach that integrates clinical experience, computational modeling, and ethical design. These largely theoretical data currently have limited application, especially in developing countries worldwide. For all health systems and in any country where AI is applied, its assistance should consist of improving decision-making through hybrid human-artificial intelligence models. The future looks excellent, although it causes concern and fear to the undersigned."
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Zhang XY, Hu MD, Maimaitijiang D, Wang T, Wang L. Artificial intelligence in pancreatitis: A narrative review on advancing precision diagnosis, prognosis, and therapeutic strategies. World J Gastroenterol 2025; 31(39): 110971 [PMID: 41180795 DOI: 10.3748/wjg.v31.i39.110971]
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29
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"This review explores the bidirectional regulation between the gut microbiome and the immune system within the colorectal cancer (CRC) microenvironment. It highlights how microbial metabolites and immune signaling pathways influence tumor progression, immune evasion, and therapeutic response. Key mechanisms include TLR4 and NLRP3 activation, SCFA modulation, and PD-1 pathway interactions. The authors discuss emerging interventions such as engineered probiotics, FMT, and metabolic vaccines targeting the microbiota-immune axis. Overall, the study provides a comprehensive framework for developing personalized CRC therapies through microbiome modulation."
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Liu XX, Yang B, Tang DX. Bidirectional regulation of the gut microbiome-immune axis in the immune microenvironment of colorectal cancer and targeted interventions. World J Gastrointest Oncol 2025; 17(10): 109503 [PMID: 41114103 DOI: 10.4251/wjgo.v17.i10.109503]
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30
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"This retrospective two-center study investigates ultrasound features of primary intestinal lymphoma in children and their correlation with prognosis. Twenty-eight pediatric cases were classified into focal segmental and extensive types based on sonographic findings. Extensive-type lymphoma was associated with significantly elevated LDH levels and poorer outcomes compared to the segmental type. Ultrasound classification and LDH levels showed strong prognostic relevance, while pathological type, age, and treatment modality did not. The study concludes that ultrasound is a valuable tool for diagnosis, classification, and prognosis prediction in pediatric intestinal lymphoma."
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Huang SF, Yang F, Chen WJ, Zhang XH. Ultrasound features of primary intestinal lymphoma in children and their correlation with prognosis: A two-center experiment. World J Gastrointest Oncol 2025; 17(10): 109450 [PMID: 41114090 DOI: 10.4251/wjgo.v17.i10.109450]
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31
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"This review highlights how lipid metabolic reprogramming drives colorectal cancer (CRC) progression, immune evasion, and therapy resistance. It discusses key alterations in fatty acid synthesis, oxidation, and cholesterol metabolism, as well as the impact of high-fat diets and gut microbiota on the tumor microenvironment. The authors emphasize the role of lipid metabolism in shaping immunosuppressive dynamics and promoting cancer stemness and metastasis. By identifying actionable lipid-related pathways and enzymes, the review proposes novel therapeutic strategies, including combinations with immunotherapy. Overall, it offers a comprehensive and timely framework for advancing precision oncology in CRC."
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Wang CD, Zhang BX, Song J. Lipid metabolic reprogramming in colorectal cancer: Insights to mechanisms and therapeutics. World J Gastrointest Oncol 2025; 17(10): 109398 [PMID: 41114120 DOI: 10.4251/wjgo.v17.i10.109398]
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"This multicenter retrospective study analyzed 189 colorectal cancer (CRC) patients admitted to intensive care units (ICUs) across 37 cancer-specialized hospitals in China. The 90-day mortality rate was relatively low at 12.2%, with elective surgery and conventional oxygen therapy associated with better outcomes. Chemotherapy history and unplanned ICU transfers were linked to higher mortality, while severity scores like SOFA and APACHE II showed only moderate predictive value. This study is commendable for its large-scale, multicenter design and its focus on a clinically important yet underexplored patient population. By identifying key prognostic factors and highlighting the limitations of current scoring systems, the authors provide valuable insights that can inform ICU admission decisions and personalized care strategies for CRC patients."
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Dong Q, Xia R, Xing XZ, Wang CS, Ma G, Wang HZ, Zhu B, Zhao JH, Zhou DM, Zhang L, Huang MG, Quan RX, Ye Y, Zhang GX, Jiang ZY, Huang B, Xu SL, Xiao Y, Zhang LL, Lin RY, Ma SL, Qiu YA, Zheng Z, Sun N, Xian LW, Li J, Zhang M, Guo ZJ, Tao Y, Zhou XZ, Chen W, Wang DX, Chi JY, Wang DH, Liu KZ. Intensive care unit outcomes and prognostic factors of colorectal cancer. World J Gastrointest Oncol 2025; 17(10): 108539 [PMID: 41114115 DOI: 10.4251/wjgo.v17.i10.108539]
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33
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"This review highlights the link between ulcerative colitis (UC) and colitis-associated colorectal cancer (caCRC), emphasizing how chronic inflammation drives cancer development. It outlines key molecular pathways, immune responses, and microbiota changes involved in this process, and discusses current strategies for surveillance, chemoprevention, and surgical management. The authors advocate for precision medicine approaches to improve early detection and personalized care. The manuscript is commendable for its comprehensive integration of molecular and clinical insights. By combining updated surveillance guidelines with emerging biomarker research, it offers a forward-thinking framework that can guide more effective prevention and treatment strategies for caCRC in UC patients."
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Catalano M, Mini E, Nobili S, Vascotto IA, Ravizza D, Amorosi A, Tonelli F, Roviello F, Roviello G, Nesi G. Ulcerative colitis and colorectal cancer: Pathogenic insights and precision strategies for prevention and treatment. World J Gastrointest Oncol 2025; 17(10): 108514 [PMID: 41114102 DOI: 10.4251/wjgo.v17.i10.108514]
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34
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides perfect images which is good quality and easily understandable plus interesting findings.
5 Biostatistics: Not applicable
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Wang WQ, Yang JP, Dong JW, Chen YB. Misdiagnosis of Crohn’s disease as appendicitis: A case report. World J Gastrointest Surg 2025; 17(9): 108348 [PMID: 41024824 DOI: 10.4240/wjgs.v17.i9.108348]
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35
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides good images which is good quality and easily understandable. Can be better figures intra-operative
5 Biostatistics: Not applicable
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Zhang J, Sun S, Zheng S, Ma YY, Chen G. Gastric adenomyoma in children: A case report. World J Gastrointest Surg 2025; 17(9): 107297 [PMID: 41024786 DOI: 10.4240/wjgs.v17.i9.107297]
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36
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides perfect images which is good quality and easily understandable.
5 Biostatistics: Not applicable
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Moon YJ, Lee SH. Inferior mesenteric arteriovenous fistula: Two case reports. World J Gastrointest Surg 2025; 17(9): 107139 [PMID: 41024812 DOI: 10.4240/wjgs.v17.i9.107139]
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37
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides good images which is good quality and easily understandable. need arrow in intra-operative image
5 Biostatistics: Not applicable
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Ahunayizhi A, Zhang XL, Chen Q, Wang H, Ding G, Akumuo S, Wang XX, Ruan XJ. Laparoscopic management of gallstones in a duplicate gallbladder with double cystic ducts: A case report. World J Gastrointest Surg 2025; 17(9): 110796 [PMID: 41024794 DOI: 10.4240/wjgs.v17.i9.110796]
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38
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides not medical photograph especially resected specimens photo.
5 Biostatistics: Not applicable
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Guo Q, Lu HY, Lyu H, Tian H, Zhao Q, Zheng YC. Complete appendiceal intussusception and appendiceal mucinous tumor: A case report and review of literature. World J Gastrointest Surg 2025; 17(9): 109320 [PMID: 41024822 DOI: 10.4240/wjgs.v17.i9.109320]
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39
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"This is a very interesting analysis and "observational" association between BMI and ALF. This work supports the knowledge about obesity and the worldwide problem it represents as a health problem. With all due respect, this work lacks further analysis (hypothesis) on how this increased BMI contributes to organ failure. Further analysis should focus not only on organ (liver in this case) failure but on gastrointestinal symptomatology (effects) in general."
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Krishnan A, Khan S, Gips J, Alqahtani SA, Vaidya D, Liu YS, Kim A, Su A, Gurakar A, Hamilton JP, Woreta TA. Body mass index and its association with clinical outcomes in acute liver failure. World J Clin Cases 2025; 13(30): 109212 [PMID: 41113074 DOI: 10.12998/wjcc.v13.i30.109212]
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40
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"1 Ethics: Ethical approval is stated as obtained from a relevant committee, meeting requirements.
2 Methods: Experimental methods (cell culture, molecular/functional assays, microscopy) are standard, well-described, and repeatable via established protocols/citations.
3 Results: Results are authentic (consistent dose-effects, clear molecular data). The hypothesis that Prdx1 inhibits CRC via pyroptosis is partially validated (robust in vitro support, but lacks in vivo/clinical evidence for universal significance). Notably, the loading control (β-actin) appears uneven between N17 and T17 samples, which may raise minor concerns about sample loading consistency. While the study uses three cell lines to validate findings—enhancing data volume and credibility—it would further strengthen translational relevance if the authors validated Prdx1’s effects using patient-derived organoids (PDOs), which better recapitulate in vivo tumor biology.
4 Figures and tables: Figures are well-constructed with clear annotations, and tables present data effectively. However, most images rely heavily on black-and-white visuals, which could be aesthetically enhanced (e.g., using color coding for different groups or molecular targets) to improve readability and visual communication of key results.
5 Biostatistics: Statistical analyses are appropriately applied, with accurate p-values and data visualization (error bars, sample sizes).
6 References: Citations include key recent works on pyroptosis, inflammasomes, and CRC; citations are scientific, relevant, and not overly self-referential.
7 Language: Language is clear, concise, and grammatically correct.
8 Caveats or drawbacks: Animal-level experimental validation is insufficient; currently, only tumor size is assessed. Supplementing with detection of relevant proteins (e.g., NLRP3, GSDMD, caspase-1) or gene expression in tumor tissues from animal models would more be much better.
In summary, this study is well-conducted, utilizing paired tumor and adjacent non-tumor tissues from 20 patients, which enhances its clinical relevance. To further extend the current findings, it would be valuable for the authors to employ clinical specimens for establishing patient-derived organoids (PDOs) or patient-derived xenograft (PDX) models in future work, thereby validating the results in an in vivo context. Additionally, given the involvement of immunogenic cell death (ICD) discussed in the study, subsequent research could also explore the efficacy and underlying mechanisms related to tumor immunity.
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He Y, Liu J, Zhou N, Xie LX, Jiang YF, Chen CL. Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells. World J Gastroenterol 2025; 31(36): 111557 [PMID: 41025079 DOI: 10.3748/wjg.v31.i36.111557]
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41
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"This large-scale, 20-year retrospective study by Huang et al. is a significant achievement, successfully establishing the first genome-wide polygenic risk score (PRS) for diabetic retinopathy (DR) in a Taiwanese Han population. The study's key contribution is demonstrating that a high PRS is strongly associated not just with DR incidence, but more critically, with disease severity requiring interventions like laser treatment or surgery. This suggests the PRS could be a valuable tool for identifying patients needing more intensive monitoring.
Despite these strengths, the study highlights a crucial unresolved issue: the clinical utility of the PRS beyond existing risk factors. The central question remaining is whether this genetic information provides actionable predictive power over and above standard clinical data such as HbA1c and diabetes duration. Furthermore, the findings' generalizability to other ethnicities is yet to be determined, as the study was confined to a specific Asian population.
Therefore, the essential next step is to conduct prospective validation studies aimed at creating an integrated risk model. Such a model would combine the PRS with established clinical variables to definitively quantify its added value in personalizing DR screening strategies and improving patient outcomes."
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Huang YC, Liao WL, Lin HJ, Huang YT, Chang YW, Yang JS, Weng AL, Tsai FJ. Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study. World J Diabetes 2025; 16(10): 110138 [PMID: 41113490 DOI: 10.4239/wjd.v16.i10.110138]
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42
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"This is a thoughtful and well-executed study that provides a valuable, quantitative analysis of the interplay between type 2 diabetes (T2D), dry eye syndrome (DES), and corneal neuropathy. A significant strength of this paper lies in its robust methodology, which combines standardized subjective questionnaires (SPEED) with objective clinical measures (NIBUT, SIt) and advanced imaging through corneal confocal microscopy.
Despite these strengths, the study's contributions are constrained by limitations inherent in its design, which the authors commendably acknowledge. The primary issue is the retrospective, single-center nature of the research and the relatively small sample size of the DES group (n=27). This framework, while excellent for identifying strong associations, cannot establish causality. A critical unanswered question remains: does poor glycemic control directly cause corneal neuropathy which then leads to DES, or do these pathologies develop in parallel? The cross-sectional data cannot delineate this temporal sequence. Another unresolved problem is the potential confounding influence of systemic diabetic peripheral neuropathy. The study does not differentiate whether the observed corneal neuropathy is an isolated ocular pathology or a manifestation of a wider systemic nerve degeneration. This distinction is vital, as it carries different implications for both prognosis and treatment.
To build upon this solid foundation, the next logical step would be to conduct a large-scale, prospective, multicenter cohort study. Following patients over several years would allow for the establishment of a causal sequence between fluctuations in glycemic control, the onset and progression of corneal nerve damage, and the emergence of clinical DES. Such a study should also incorporate comprehensive neurological examinations to contextualize the corneal findings within the patient's overall systemic neuropathy status. Further investigation into the underlying biological mechanisms, perhaps by analyzing inflammatory biomarkers in the tear film of these patients, could also illuminate the pathway from hyperglycemia to nerve damage, potentially revealing new therapeutic targets beyond blood sugar management."
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Han WT, Zhao J, Feng WL, Ma WT. Type 2 diabetes complicated by dry eye syndrome: Analysis of dry eye symptoms, corneal neuropathy, and influencing factors. World J Diabetes 2025; 16(10): 109080 [PMID: 41113480 DOI: 10.4239/wjd.v16.i10.109080]
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43
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"In the 1970s and 1980s, vagotomy was widely used for duodenal ulcers. However, with the widespread use of PPIs and high rates of recurrence, vagotomy soon fell out of favor. However, it has now been reported that patients who have undergone vagotomy have a lower incidence of Parkinson's disease, based on the brain-gut axis. The authors report a high incidence of IBD 10 years after vagotomy. I believe this paper is an excellent theoretical explanation of the relationship between vagotomy and organs such as gut flora."
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da Silva ACA, Severo JS, dos Santos BLB, Soares HS, Martins JA, Lima RSP, Gadelha KKL, Torres-Leal FL, Correia-de-Sá P, Magalhães PJC, Santos AA, da Silva MTB. Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease. World J Gastroenterol 2025; 31(38): 111252 [PMID: 41112001 DOI: 10.3748/wjg.v31.i38.111252]
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44
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"This retrospective cohort study from Johns Hopkins University provides important evidence linking body mass index (BMI) to adverse outcomes in acute liver failure (ALF). Analyzing 196 patients over two decades, the authors found that both overweight and obesity independently doubled the risk of death or liver transplantation. Given the rarity of ALF, this well-characterized cohort and rigorous statistical analysis make the findings clinically meaningful.
The study’s strengths include clear case definition using AASLD criteria, comprehensive data collection, and appropriate use of multivariable Cox regression and Kaplan–Meier analysis. The results are consistent with prior evidence from the Acute Liver Failure Study Group, reinforcing obesity as a significant prognostic factor. Importantly, overweight and obese patients showed higher rates of advanced hepatic encephalopathy and renal dysfunction, emphasizing the metabolic and inflammatory burden in this population.
However, BMI alone may not accurately represent metabolic health. Future studies incorporating waist circumference, hepatic fat indices, or noninvasive imaging markers could improve risk stratification. Moreover, temporal changes in critical care and transplant practices warrant consideration across the 20-year study period.
Overall, this well-designed and clinically valuable study strengthens the link between metabolic dysfunction and ALF outcomes. Incorporating BMI or related measures into existing prognostic models could further refine risk prediction and guide early intervention."
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Krishnan A, Khan S, Gips J, Alqahtani SA, Vaidya D, Liu YS, Kim A, Su A, Gurakar A, Hamilton JP, Woreta TA. Body mass index and its association with clinical outcomes in acute liver failure. World J Clin Cases 2025; 13(30): 109212 [PMID: 41113074 DOI: 10.12998/wjcc.v13.i30.109212]
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45
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"This article offers an in-depth overview of current adjuvant strategies and their challenges in treating HCC. The authors note that China represents nearly half of global HCC cases. Despite surgical resection, recurrence rates remain high and five-year survival rates low. The article reviews nine adjuvant approaches, but their effectiveness is still uncertain.
While the review is concise, it would benefit from clearer organization—such as using subsections for each therapy focusing on efficacy, challenges, and prospects for future research. Including a comparative table summarizing the therapies could also enhance understanding. The review lacks a critical evaluation of the referenced studies. Expanding on emerging therapies, their mechanisms, and potential advantages would strengthen the analysis. Additionally, incorporating data from other regions would offer a more comprehensive perspective on global HCC management.
"
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Liu F, Zhang J, Li K. Postoperative adjuvant management in hepatocellular carcinoma: A review of therapeutic efficacy and prognostic outcomes. World J Hepatol 2025; 17(9): 107631 [PMID: 41024879 DOI: 10.4254/wjh.v17.i9.107631]
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46
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Barbosa OA. Small bowel ulcers and bleeding: An overlooked yet critical clinical challenge. World J Clin Cases 2025; 13(30): 109445 [PMID: 41113072 DOI: 10.12998/wjcc.v13.i30.109445]
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47
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Curto A, Iamello RG, Lynch EN, Galli A. Advancing the management of primary biliary cholangitis: From pathogenesis to emerging therapies. World J Clin Cases 2025; 13(30): 109028 [PMID: 41113084 DOI: 10.12998/wjcc.v13.i30.109028]
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48
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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O’Neill RS, Goh LH, Lee C, Jia K, Feller R. Endoscopic management of intragastric balloon related gastric outlet obstruction: A case report and review of literature. World J Clin Cases 2025; 13(30): 108934 [PMID: 41113070 DOI: 10.12998/wjcc.v13.i30.108934]
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49
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Alsulaimi MS, Memon MY, Alyabary IM, Almotairi E, Sulaiman T, Shamsan AN, Mubarak M. Ileocecal basidiobolomycosis mimicking malignancy successfully treated without surgery: A case report. World J Clin Cases 2025; 13(30): 108566 [PMID: 41113071 DOI: 10.12998/wjcc.v13.i30.108566]
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50
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"The manuscript offers practical, clinically relevant findings on lymph node metastasis patterns that can inform surgical planning and pathological sampling; its statistical approach (Cox regression, Kaplan‑Meier) and tumor‑location–specific lymph node recommendations are clear strengths. However, the lack of survival analysis by Siewert classification, uncertain sample size and power for subgroup analyses, and inadequate adjustment for confounders (surgical technique, adjuvant therapy) limit interpretability. I view the results as hypothesis‑generating and recommend multicenter prospective validation with multivariable adjustment and larger cohorts."
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Liu HM, Zhang X, Huang HY, Sun JM, Tong QD. Comparative impact of antiviral therapies on postoperative recurrence risk in patients with hepatitis B virus-related hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(9): 106297 [PMID: 40977657 DOI: 10.4251/wjgo.v17.i9.106297]
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