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"Thanks for your interesting article. I think some points in this article should be considered. The paper provides MAILE primarily narrative and theoretical foundations, much of the corroborative evidence coming from studies on generic isometric or core stabilization exercises. Although the authors themselves point out that direct empirical proof of MAILE is limited, no randomized controlled trials are available to contrast it with other core stabilization protocols. It is difficult to determine whether MAILE has any real clinical advantage or if it is simply a re-packaging of what is currently done, thus, in the lack of such comparisons.
Additionally, besides subjective outcome measures like pain scales and questionnaires, objective physiological indicators like electromyography, motion analysis, or ultrasound imaging are desperately required in order to confirm that MAILE actually activates the assumed musculature as hypothesized.
Identification of predictors of successful response to MAILE is another area that would benefit from more light. While the correlations reported (e.g., aberrant movement patterns, postpartum status, or positive Trendelenburg sign) are logical, they appear more based on the overall rehabilitation literature rather than specifically proven for MAILE.
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Syed Y, Hassan MA, Kalayil RM, Othman OA, Mekkodathil A, El-Menyar A. Promising technique for managing nonspecific chronic low back pain using multi angular isometric lumbar exercise. World J Orthop 2025; 16(5): 104425 [DOI: 10.5312/wjo.v16.i5.104425]
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"AI is usefull a lot in many fields. ARLD is common in many countries with cirrhosis complication. The article with new idea has shown that using AI in ARLD management is very effective. Hopefully in the future many hospitals and medical centers will use AI in ARLD management to demonstrate effectiveness.
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Chen ML, Jiao Y, Fan YH, Liu YH. Artificial intelligence for early prediction of alcohol-related liver disease: Advances, challenges, and clinical applications. Artif Intell Gastroenterol 2025; 6(1): 107193 [DOI: 10.35712/aig.v6.i1.107193]
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"The benefits of PRF in regulating innate immunity and encouraging wound healing have been covered in this editorial. PRF is a possible treatment strategy for improved wound healing. It is a useful tool in therapeutic settings because of its ability to effectively promote tissue regeneration and modify innate immunity. PRF has the potential to greatly enhance patient outcomes and lessen the burden related to wound care as long as research into its processes and uses is conducted. The authors supported their manuscript by one figure and one table."
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Mohammadi S. Innate immunity and wound repair: The platelet-rich fibrin advantage. World J Biol Chem 2025; 16(2): 107195 [PMID: 40476259 DOI: 10.4331/wjbc.v16.i2.107195]
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"In this manuscript, the authors provided a lengthy conclusion. They found that, while CQ and HCQ have shown promise in the treatment of autoimmune diseases, there are several concerns and disputes surrounding their use. Although these drugs can help cure autoimmune illnesses, their use must be carefully considered in light of the benefits and drawbacks. The authors also stated that more study is needed to fully understand the therapeutic potential of CQ and HCQ in autoimmune diseases, maximize its use in clinical practice, and develop safer and more efficient treatments. In addition, the authors showed two nice figures."
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Al-Hamadani M, Darweesh M, Mohammadi S, Al-Harrasi A. Chloroquine and hydroxychloroquine: Immunomodulatory effects in autoimmune diseases. World J Biol Chem 2025; 16(2): 107042 [PMID: 40476257 DOI: 10.4331/wjbc.v16.i2.107042]
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"In an effort to transform the treatment of Parkinson's disease and enhance patient outcomes, this review addressed preclinical achievements, long-term safety issues, and ethical considerations while highlighting the importance of stem cell therapy in neuroregeneration.
Figures 1 and 2 are strong highlights in this manuscript, since Figure 1 depicts the classification of stem cells. As a result, this publication provided fundamental information regarding different types of stem cells and their applications in therapy."
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Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, Giakoumettis D. Stem cell therapy for Parkinson’s disease: A new hope for neural regeneration. World J Biol Chem 2025; 16(2): 106850 [PMID: 40476258 DOI: 10.4331/wjbc.v16.i2.106850]
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"In recent years, to enhance the diagnostic capability of colonoscopy in detecting polyps in the large intestine, tiny ones, various computer-aided detection (CADe) systems have been increasingly utilized to improve the diagnostic accuracy of colonoscopy. In the study in question, the authors investigated precisely this possibility of CADe by conducting a meta-analysis of five relevant studies involving 1,624 examinees.
They found that the adenoma missing rate was significantly lower in the group that underwent CADe compared to the group that underwent routine colonoscopy for small neoplasms. Interestingly, although the overall adenoma detection rate was not different between the two groups, it was higher in the group that underwent CADe during the first examination, suggesting that CADe significantly reduces the adenoma missing rate and polyp missing rate while improving the adenoma detection rate during the initial passage of the endoscope, thus demonstrating its potential to enhance the performance of colonoscopy.
In recent years, we have witnessed the explosive growth and integration of artificial intelligence (AI) into clinical practice. It has been increasingly incorporated into clinical practice as it improves the detection of small and advanced colonic adenomas. The existing data strongly support the clinical application of AI in colonoscopy, as it significantly improves the diagnostic accuracy of endoscopy while reducing the endoscopic workload.
However, over the next few years, the impact of AI applications is expected to be determined with precision, not only in the field of endoscopy but also in other areas of medical science, concerning not only gastroenterologists but also the effectiveness of daily therapeutic interventions."
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Wang SY, Gao JC, Wu SD. Artificial intelligence for reducing missed detection of adenomas and polyps in colonoscopy: A systematic review and meta-analysis. World J Gastroenterol 2025; 31(21): 105753 [DOI: 10.3748/wjg.v31.i21.105753]
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"The healthy volunteers and the case groups should also be checked for conditions that would alter gut microbime including bacterial overgrowth syndrome. This is a large entity that consists of GI motility disorders, anatomical anomalies and so on. There are large body of evidence regarding the role of bacterial overgrowth syndrome in progression of chronic liver disease. The enterance of bacterial endotoxins through portal vein as a result of leaky gut is another important issue that should be addressed in the methodology."
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Ma C, Yang J, Fu XN, Luo JY, Liu P, Zeng XL, Li XY, Zhang SL, Zheng S. Microbial characteristics of gut microbiome dysbiosis in patients with chronic liver disease. World J Hepatol 2025; 17(5): 106124 [DOI: 10.4254/wjh.v17.i5.106124]
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"A well desined study in the field of biliary stricture management. Further researches are needed to identify if stent placemnet would have added value to biliary dilation alone. It seemes that percutaneous approach might be more feasible in proximal strictures than the distal ones. Moreover, in ishemia induced strictures, timely diagnosis and appropriate intervention might be a key preventive management."
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Trifonov S, Kovalenko Y, Gurmikov B, Varava A, Vodeiko V, Pakhtushkin E, Vishnevsky V, Zharikov Y. Reconstructive surgery and percutaneous balloon dilation for the treatment of benign biliary strictures: A retrospective study. World J Hepatol 2025; 17(5): 104646 [DOI: 10.4254/wjh.v17.i5.104646]
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"Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is an effective and minimally invasive alternative treatment for gastric outlet obstruction. Compared with conventional treatments such as duodenal stent placement and surgical gastrojejunostomy, EUS-GE has comparable technical and clinical success rates, with the advantages of longer patency, fewer adverse events, and lower reintervention rates. This technique is applicable not only to malignant obstruction, but also to complex pathologies such as benign lesions and afferent loop syndrome, and is a promising treatment that allows early recovery and resumption of oral intake, which is crucial for oncological patients. This review explained this point."
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Karagyozov PI, Kavrakov D, Shumka N. Endoscopic ultrasound-guided gastroenterostomy: The new standard treatment of gastric outlet obstruction. Artif Intell Gastrointest Endosc 2025; 6(2): 106600 [DOI: 10.37126/aige.v6.i2.106600]
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Zhong XY, Liang ZJ, Lan ML, Xu XG, Yuan L, Zeng JX. Acinar cystic transformation of the pancreas: A rare case report. World J Clin Cases 2025; 13(23): 107096 [DOI: 10.12998/wjcc.v13.i23.107096]
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Maity R, Rathna RB, Dhali A, Fernandes N, Biswas J, Kapoor GS, Dhali GK. Ulcerated benign jejunal gastrointestinal stromal tumor causing gastrointestinal bleeding: A case report. World J Clin Cases 2025; 12(23): 106140 [DOI: 10.12998/wjcc.v12.i23.106140]
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Cicek E, Karatepe YK, Kantarcı TR, Sahin TT. Demanding sleeve gastrectomy procedure in a patient with severe intraabdominal adhesions: A case report and review of the literature. World J Clin Cases 2025; 12(23): 104807 [DOI: 10.12998/wjcc.v12.i23.104807]
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Zhao KF, Xie CB, Wu Y. Prediction of the efficacy of first transarterial chemoembolization for advanced hepatocellular carcinoma via a clinical-radiomics model. World J Clin Cases 2025; 12(23): 101742 [DOI: 10.12998/wjcc.v12.i23.101742]
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"The article provides a valuable contribution to the field by offering a comprehensive and balanced review of the immunomodulatory effects of CQ and HCQ in autoimmune diseases. While it acknowledges the existence of certain problems, such as inter-individual variability in therapeutic response, it proposes potential solutions through further research and the development of personalized treatment approaches. It a useful resource for healthcare professionals and researchers involved in the management of autoimmune diseases.
Ethics:
The article does not directly provide an ethical approval form; however, it is a mini-review rather than an experimental study involving human or animal subjects.
Methods:
The article provides a comprehensive review of the immunomodulatory effects of chloroquine (CQ) and hydroxychloroquine (HCQ) in autoimmune diseases. It discusses the mechanisms of action, clinical applications, and safety considerations based on existing literature. As it is a review article, it does not present original experimental data. The methods used to compile and analyze the literature are not explicitly detailed, but the article follows a logical structure and cites relevant sources. The approach is reproducible by fellow researchers interested in conducting a similar literature review.
Results:
The results presented are based on existing research and clinical trials. The article summarizes the findings of previous studies, indicating that CQ and HCQ have immunomodulatory effects and clinical benefits in various autoimmune diseases. While the results are not original experimental data, they are true and authentic summaries of published research. The theory or hypothesis of the immunomodulatory effects of CQ and HCQ is well-validated by the cited literature.
Figures and tables:
The article includes a few figures and tables to illustrate key points. Figure 1 depicts the immunomodulatory effects of CQ and HCQ on various immune cells, and Figure 2 summarizes the clinical applications across autoimmune diseases. Table 1 lists clinically relevant drug interactions with CQ and HCQ. These figures and tables are well-constructed, annotated, and helpful in conveying the information clearly.
Biostatistics:
As the article is a review and does not present original research data, it does not include biostatistical data or line charts with data. Therefore, this aspect is not applicable to the evaluation.
References:
The article cites numerous references that are scientifically and reasonably important in the field of autoimmune diseases and related to the immunomodulatory effects of CQ and HCQ. The references are recent and cover a broad range of relevant topics, indicating a thorough literature search. The author does not appear to self-cite excessively, omit critical references, or miscite sources.
Language:
The language in the article is correct, clear, and concise. It effectively conveys the information about the immunomodulatory effects of CQ and HCQ in autoimmune diseases. The article has no apparent grammatical or spelling mistakes.
Caveats or drawbacks:
The main caveats or drawbacks of the article are that it is a review and does not present original experimental data. Therefore, it does not provide new insights or results beyond what is already known from previous studies. Additionally, the article does not address potential biases in the cited literature or fully discuss limitations of the existing research on CQ and HCQ. The long-term side effects and the need for personalized treatment approaches are highlighted as important considerations but not fully explored.
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Al-Hamadani M, Darweesh M, Mohammadi S, Al-Harrasi A. Chloroquine and hydroxychloroquine: Immunomodulatory effects in autoimmune diseases. World J Biol Chem 2025; 16(2): 107042 [PMID: 40476257 DOI: 10.4331/wjbc.v16.i2.107042]
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"Traditional Chinese medicine (TCM) is used to treat a vast number of medical conditions with very satisfactory results. One of these therapeutic fields is chronic atrophic gastritis, in which the fungus Hericium erinaceus has been shown to improve clinical manifestations and histological findings. Its antimicrobial action against Helicobacter pylori and its anticancer action against gastric cancer is also interesting.
It is time for universities, large pharmaceutical companies, and health authorities in various countries to take seriously the clinical and laboratory results of Complementary and Alternative Treatments for multiple diseases and to allocate teaching hours and financial funding to investigate the combination of CAM with modern medicine in treating a bunch of benign and malignant conditions of the digestive system. Ultimately, doctors in developed countries should reconsider their skepticism about the efficacy of CAM, particularly traditional Chinese medicine. "
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Pellegrino R, Gravina AG. Potential of traditional Chinese medicine in gastrointestinal disorders: Hericium erinaceus in chronic atrophic gastritis. World J Gastroenterol 2025; 31(20): 106615 [DOI: 10.3748/wjg.v31.i20.106615]
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"The occurrence of acute kidney injury in liver cirrhosis patients is associated with poor short-term mortality. This review is devoted to the latest concepts in the field of pathophysiology, diagnosis and treatment of acute kidney injury in liver cirrhosis patients. This is a well-structured review based on the current understanding of this actual issue."
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Malakar S, Rungta S, Samanta A, Shamsul Hoda U, Mishra P, Pande G, Roy A, Giri S, Rai P, Mohindra S, Ghoshal UC. Understanding acute kidney injury in cirrhosis: Current perspective. World J Hepatol 2025; 17(5): 104724 [DOI: 10.4254/wjh.v17.i5.104724]
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"The article addresses the timely and pertinent subject of the potential of PRF in clinical applications related to wound healing and the immune response. The language used is clear and accessible, making complex biological concepts understandable to a wide readership. As an editorial, it effectively summarises key points without unnecessary elaboration, respecting the format's purpose.
While the editorial provides a succinct overview of the potential benefits of PRF in wound healing and immune response, incorporating recent research findings and a more detailed exploration of the underlying mechanisms would enhance it further."
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Mohammadi S. Innate immunity and wound repair: The platelet-rich fibrin advantage. World J Biol Chem 2025; 16(2): 107195 [PMID: 40476259 DOI: 10.4331/wjbc.v16.i2.107195]
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"This article addresses the important and timely topic of the immunomodulatory effects of chloroquine and hydroxychloroquine in autoimmune diseases. This topic remains highly relevant for clinical and research audiences alike. The review provides a comprehensive overview of various autoimmune conditions and the mechanisms through which these drugs exert their effects, offering readers a valuable summary of the current state of knowledge in this area. The article is organised coherently, progressing logically from drug mechanisms to clinical applications, which makes it easy for readers to understand.
However, while it discusses the immunomodulatory effects of these drugs, the article lacks a critical analysis of the results from the cited studies. There is little discussion of the strength of the evidence, the limitations of the studies, or the quality of the data presented.
Furthermore, while the article cites relevant literature, it does not include the most recent studies, particularly those published within the last year. Additionally, there is little discussion of conflicting evidence or ongoing debates in the field.
While the article briefly mentions the potential side effects of chloroquine and hydroxychloroquine, it does not address the controversies surrounding their use, such as the debate over their efficacy and safety profiles in different patient populations. Including a more in-depth discussion of the limitations, controversies and areas of uncertainty surrounding the use of these drugs in autoimmune diseases would provide a more balanced perspective."
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Al-Hamadani M, Darweesh M, Mohammadi S, Al-Harrasi A. Chloroquine and hydroxychloroquine: Immunomodulatory effects in autoimmune diseases. World J Biol Chem 2025; 16(2): 107042 [PMID: 40476257 DOI: 10.4331/wjbc.v16.i2.107042]
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"This mini-review is concise and well organised, providing a comprehensive overview of the topic. It effectively summarises the existing challenges and highlights the potential of stem cell therapy in Parkinson’s disease. To further enrich the article, it would be beneficial to include a comparative table summarising the different types of stem cells (e.g. ESCs, iPSCs and MSCs) and their respective advantages and disadvantages. Additionally, expanding upon novel technological advancements (e.g. CRISPR, organoids or biomaterials) would provide a forward-looking perspective that aligns with current research trends.
Overall, this article meets BPG's quality standards and is a valuable contribution to the field of neurodegenerative medicine.
However, the existing figures are relatively few, lack quantitative detail, and are very simple. For instance, it would be highly beneficial to include a comparative table summarising the different stem cell types, their sources, differentiation capacities, and clinical readiness. I would recommend adding at least one comprehensive table summarising and comparing therapeutic options, mechanisms or clinical trial data."
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Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, Giakoumettis D. Stem cell therapy for Parkinson’s disease: A new hope for neural regeneration. World J Biol Chem 2025; 16(2): 106850 [PMID: 40476258 DOI: 10.4331/wjbc.v16.i2.106850]
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"This is very interesting paper. I ask some questions for author. In the past, surgical necrosectomy was performed for necrotizing pancreatitis, but this had a high incidence of complications. In recent years, endoscopic drainage has become more effective, but should it be performed after waiting four weeks until encapsulated necrosis (WON) occurs, or if MOF or infection is difficult to control, should it be ？"
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Zeng Y, Zhang JW, Yang J. Endoscopic management of infected necrotizing pancreatitis: Advancing through standardization. World J Gastroenterol 2025; 31(20): 107451 [DOI: 10.3748/wjg.v31.i20.107451]
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"The article is devoted to the search for new markers for the diagnosis of AMA-negative forms of primary biliary cholangitis (PBC), which is an important problem in hepatology. The authors of the study posit that the antibodies to RPL30 that were identified may serve as such a marker. The rationale behind the authors' decision to focus on the RPL30 protein, a constituent of the 60S ribosome subunit involved in protein synthesis, remains ambiguous. The impaired protein synthesis function of the liver in PBC occurs when a patient develops signs of progressive cholestasis involving hepatocytes, both in AMA-positive and AMA-negative patients. At the same time, in the early stages of PBC, cholangiocytes lining the small (intralobular, interlobular) bile ducts are primarily damaged. Therefore, the authors' rationale for determining antibodies to RPL30 remains ambiguous. Besidesr, the article does not provide a comprehensive analysis of the relationship between the detection of antibodies against RPL30 and the data on histological signs that confirm the presence of PBC.
The results obtained by the authors on the diagnostic value of antimitochondrial antibodies for the diagnosis of PBC are questionable..
The objective of the present study is to identify novel biomarkers that can facilitate the diagnosis of AMA-negative forms of PBC, a significant area of research in the field of hepatology. However, the motives behind this study remain unclear. What was the prerequisite for the study of antibodies to ribosomal protein L30? What role can ribosomal protein L30 play in the pathogenesis of PBC?"
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Zeng ZY, Huang ZX, Wang YR, Xie LK, Lin YP, Liang Y, Liu ZY, Li DL, Zhang XY. Anti-RPL30 as a novel biomarker for enhanced diagnosis of autoantibody-negative primary biliary cholangitis. World J Gastroenterol 2025; 31(20): 104891 [DOI: 10.3748/wjg.v31.i20.104891]
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"Neuroendocrine tumors of the rectum are a relatively rare malignancy that is often diagnosed during colonoscopy. In recent years, its incidence has been observed to be increasing. These small tumors can be removed endoscopically using modified endoscopic submucosal resection (mEMR) or endoscopic submucosal resection. In the annotated review article, the authors discuss the indications, methods, risks, and difficulties of their endoscopic removal and propose a therapeutic algorithm to assist in making correct treatment decisions. An essential part of treating these tumors is the accurate evaluation of their endoscopic characteristics and the demonstration by means of imaging methods of any lymph node metastases or distant metastases. Also, an essential part of the correct treatment of these tumors, which is usually neglected in everyday clinical practice, is the avoidance of taking a simple biopsy. EMR with submucosal dilatation should be preferred. Patient follow-up is an essential part of proper patient management. Finally, managing these patients by a team of specialists, which includes a gastroenterologist, oncologist, and pathologist with substantial experience in diagnosing and treating these neoplasms, represents an essential element regarding the best possible management of the patients. This article contributes substantially to enriching the knowledge of gastroenterologists and oncologists about diagnosing and managing rectal neuroendocrine tumors. "
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Liu JN, Chen H, Fang N. Current status of endoscopic resection for small rectal neuroendocrine tumors. World J Gastroenterol 2025; 31(19): 106814 [DOI: 10.3748/wjg.v31.i19.106814]
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"This is a well-written and presented rarely case report about Chronic abdominal pain caused by foreign bodies in the appendix .This manuscript gives additional new knowledge to the existing literature. This interesting and rare case report has certain guiding significance for clinicians.I think that this manuscript is worth to publication."
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Huang T, Li SK, Wang W, Zhang R. Chronic abdominal pain caused by foreign bodies in the appendix: A case report. World J Gastrointest Surg 2025; 17(5): 105423 [DOI: 10.4240/wjgs.v17.i5.105423]
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"This is very interesting paper. In the past, obesity was said to be bad for treatment, but the current data shows that a BMI of >35mg/dl is said to be associated with a good prognosis.
lenvatinib and camrelizumab were good effect for obesity patient with HCC and have not yet been observed with more commonly used immunotherapy treatments for hepatocellular carcinoma, such as nivolumab, pembrolizumab, or bevacizumab.
In the past, obesity was said to be bad for treatment, but the current data shows that a BMI of >35mg/dl is said to be associated with a good prognosis.
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Sierra L, Abu-Hammour MN, Chatterjee A, Simons-Linares CR. Obesity paradox role in the immunosuppressive treatment of hepatocellular carcinoma. World J Gastroenterol 2025; 31(19): 105617 [DOI: 10.3748/wjg.v31.i19.105617]
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"The authors claimed that helicobacter pylori infection could promote the progression of gastric cancer by regulating the expression of DMBT1, however,
The “tumor progression” involves multiple aspects. In this study, it was mainly investigated through in vitro “scratch, and Transwell assays”. It is too simple. Evidently, these approaches are insufficient to comprehensively address this complex issue. Another big concern is that, cancer is a complex system, not genetic disease. In fact, merely exploring the occurrence and development of cancer from the perspective of mutation/molecules pathway is insufficient to address the complex problems such as recurrence and resistance that arise in clinical practice."
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Zhou X, Wang LQ, Song S, Xu M, Li CP. Helicobacter pylori infection promotes the progression of gastric cancer by regulating the expression of DMBT1. World J Clin Oncol 2025; 16(5): 105322 [DOI: 10.5306/wjco.v16.i5.105322]
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"This study proposed that “HOXC6 may influence the cellular functions of BLCA by regulating the expression of the target gene TIMELESS,” yet no direct evidence was provided to substantiate this claim.
Another major concern is that cancer represents a complex system rather than merely a genetic disease. Indeed, focusing solely on mutations and molecular mechanisms to explore the occurrence and progression of cancer is insufficient to address the intricate challenges, such as recurrence and resistance, encountered in clinical practice.
Overall, this research is seriously lacking both in terms of its content and significance"
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Lu DJ, Wang HR, Xu YS, Huang HB, Zhong QG, Luo YN, Qi JF, Wu HC, Pei JY, Zhang K, Xu CX, Wang TX, Zhang W, Zhou YH, Huang ZG, Wang FB. Homeobox C6 plays an oncogenic role in bladder cancer. World J Clin Oncol 2025; 16(5): 103830 [DOI: 10.5306/wjco.v16.i5.103830]
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"This systematic review highlighted the growing role of hydroxyapatite, β-tricalcium phosphate, and fibrin-based products in bone regeneration. However, this article contains few diagrams and the references are quite outdated. Although this literature provides a detailed account of the application of synthetic biomaterials combined with fibrin derivatives in bone regeneration medicine, there is still a significant lack of research at the molecular level."
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Pagani BT, Rosso MPO, Moscatel MBM, Trazzi BFM, da Cunha MR, Issa JPM, Buchaim DV, Buchaim RL. Update on synthetic biomaterials combined with fibrin derivatives for regenerative medicine: Applications in bone defect treatment: Systematic review. World J Orthop 2025; 16(5): 106181 [DOI: 10.5312/wjo.v16.i5.106181]
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"This review is rich in illustrations and graphics, with appropriate methods and reliable results. Therefore, this article is highly scientific and innovative. The author elaborated in detail on the formation mechanism and progress of neutrophil extracellular traps in common osteoarticular diseases. However, the mechanism of interaction between neutrophil extracellular traps and other cells in osteoarticular diseases has not been fully elucidated, and this should be a direction for future research."
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Sun GJ, Xu F, Jiao XY, Yin Y. Advances in research of neutrophil extracellular trap formation in osteoarticular diseases. World J Orthop 2025; 16(5): 106377 [DOI: 10.5312/wjo.v16.i5.106377]
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"In this manuscript, the authors analyzed the prevalence and incidence of ulcerative colitis and Crohn's disease using large medical record databases from three regions: Hong Kong, Japan, and the United States. In the results, substantial differences were identified among regions in absolute prevalence/incidence, temporal trends, and disease characteristics. Although the authors discussed various potential factors contributing to these differences, it is difficult to accept several explanations, such as the difference in NO2 exposure leading to the different prevalence and incidence of Crohn's disease between Japan and the USA. NO2 exposure at the time point may not differ between Japan and the USA with the magnitude reflected in the different prevalence/incidence of Crohn's disease. It would be ideal for the authors to include a discussion that proposes possible solutions to reduce the prevalence and incidence of inflammatory bowel diseases in each society."
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Zhang Y, Chung H, Fang QW, Xu YR, Zhang YJ, Nakajo K, Wong ICK, Leung WK, Qiu H, Li X. Current and forecasted 10-year prevalence and incidence of inflammatory bowel disease in Hong Kong, Japan, and the United States. World J Gastroenterol 2025; 31(18): 105472 [DOI: 10.3748/wjg.v31.i18.105472]
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"This manuscript employs a bibliometric analysis to map the field of spondylolisthesis research. Using the Web of Science database, the authors identified 1831 relevant articles. The study reveals a dramatic increase in publications post-2010, with the United States leading in contributions. The University of California, San Francisco, emerges as the most prolific institution. Spine is identified as the top journal publishing in this area. Keyword analysis highlights themes in clinical presentation, diagnosis, and treatment. The authors conclude that this work provides a methodological framework to synthesize historical and current trends in spondylolisthesis studies, but the authors acknowledge limitations due to dependence on the web of science collection database."
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Xu JN, Li Y, Zhao TX, Wu WY, Yang XW, Zhang HW, Chen Q, Xia C, Zhang J. Mapping the field of spondylolisthesis: A bibliometric analysis. World J Clin Cases 2025; 13(22): 99221 [DOI: 10.12998/wjcc.v13.i22.99221]
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"This editorial critically analyzes a study by Maranhão et al. investigating pleural adenosine deaminase (P-ADA) as a biomarker for inflammatory pleural effusions. The editorial highlights the clinical relevance of the study, which established a cutoff value for P-ADA to differentiate between inflammatory and non-inflammatory pleural effusions. It emphasizes the study's novelty in providing a standardized P-ADA threshold in a Brazilian population, addressing inconsistencies found in previous studies. The editorial further explores the pathophysiological mechanisms underlying elevated P-ADA, linking it to purinergic signaling pathways and immune cell activation. The editorial acknowledges that using P-ADA leads to early diagnosis, improved treatment stratification and reduction in cost. The limitation is that the cutoff value requires validation across diverse population and the data is retrospective. Overall, the editorial positions P-ADA as a non-invasive, cost-effective biomarker with potential to streamline diagnostics, particularly in resource-limited settings, and calls for future research to prioritize global validation and explore integration with other biomarkers."
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Shi DD, Tian J, Ding J. Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation. World J Clin Cases 2025; 13(22): 106925 [DOI: 10.12998/wjcc.v13.i22.106925]
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Tasneem AA, Luck NH, Mubarak M. Mediastinal lymphadenopathy: Causes, symptoms and factors predicting good yield of endoscopic ultrasound-guided biopsy. World J Clin Cases 2025; 13(22): 105596 [DOI: 10.12998/wjcc.v13.i22.105596]
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Kucukakcali Z, Akbulut S. Role of immature granulocyte and blood biomarkers in predicting perforated acute appendicitis using machine learning model. World J Clin Cases 2025; 13(22): 104379 [DOI: 10.12998/wjcc.v13.i22.104379]
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34
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Abdishakur AE, Ahmed MAA. Adult ileo cecal intussusception as a manifestation of colon carcinoma: A case report. World J Clin Cases 2025; 13(22): 104352 [DOI: 10.12998/wjcc.v13.i22.104352]
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35
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Inoue Y, Yata Y, Yokota Y, Li ZL, Kawabata K. Acute pancreatitis after total aortic arch replacement leading to walled-off necrosis: A case report and review of literature. World J Clin Cases 2025; 13(22): 104165 [DOI: 10.12998/wjcc.v13.i22.104165]
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36
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"This manuscript describes a rare case of walled-off necrosis (WON) after acute pancreatitis following total aortic arch replacement in a 67-year-old man. The case was successfully managed with the endoscopic ultrasound (EUS)-guided drainage of the peripancreatic fluid collection (PFC). The manuscript underscores the feasibility and safety of this endoscopic intervention in this clinical scenario, even though large prospective studies are certainly needed to draw conclusions in this direction."
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Inoue Y, Yata Y, Yokota Y, Li ZL, Kawabata K. Acute pancreatitis after total aortic arch replacement leading to walled-off necrosis: A case report and review of literature. World J Clin Cases 2025; 13(22): 104165 [DOI: 10.12998/wjcc.v13.i22.104165]
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37
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"The authors conducted a single-centre retrospective study involving nearly 400 patients with ulcerative colitis and approximately 300 patients with Crohn’s disease, compared with 100 controls. The sample was subsequently resampled using propensity score matching to homogenise the cohorts. The authors assessed 17 serum biomarkers, both as individual and composite markers, evaluating their association with endoscopic activity (measured using the Mayo score for ulcerative colitis and the SES-CD for Crohn’s disease), and constructed a predictive nomogram based on the biomarkers that demonstrated predictive value as independent variables. A subgroup of 100 patients was subsequently re-evaluated to verify the consistency of the analyses with the ensuing endoscopic response. The study has several strengths: a large sample size filtered through propensity score matching; the biomarkers evaluated by the authors are readily available in any laboratory; and the endoscopic outcome is highly relevant, as opposed to surrogate laboratory (e.g. faecal calprotectin) or clinical (e.g. partial Mayo score or HBI) outcomes. The analyses demonstrated a very high AUC for ulcerative colitis (0.93) and a fair AUC for Crohn’s disease (0.78). Nonetheless, several limitations emerged: the single-centre design undermines generalisability, the retrospective nature compromises data robustness, external validity is lacking, follow-up was limited to 14 weeks, and therapeutic heterogeneity was not thoroughly accounted for."
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Liu X, Pan LX, Pei JX, Pu T, Wen HT, Zhao Y. Role of serological biomarkers in evaluating and predicting endoscopic activity in inflammatory bowel disease. World J Gastroenterol 2025; 31(18): 104206 [DOI: 10.3748/wjg.v31.i18.104206]
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38
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"In abstract , it is 5 % of intussusceptions , whereas in in Introduction , it is 6%,which is correct.
After Physical examination , t of the should be capital.
what is 8.5 g/DL.
What surgical resection was done ?
Various treatment options should have been described
References are outdated
There was room for improvement in this case , enhancing its credibility.Literature should have been searched.
Reviewers and editors should have reviewed literature to improve quality of case report for readers"
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Abdishakur AE, Ahmed MAA. Adult ileo cecal intussusception as a manifestation of colon carcinoma: A case report. World J Clin Cases 2025; 13(22): 104352 [DOI: 10.12998/wjcc.v13.i22.104352]
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39
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"This editorial provides a comprehensive interpretation of Maranhão et al. 's study, which establishes a pleural adenosine deaminase (P-ADA) cutoff for inflammatory pleural effusions. The authors successfully highlight the clinical utility of P-ADA in differentiating inflammatory from non-inflammatory effusions and connect this biomarker to broader pathophysiological processes involving purinergic signaling and ADA2 isoforms.
Strengths:
The article clearly emphasizes the practical implications of Maranhão et al. 's findings, especially in resource-limited settings where non-invasive, cost-effective biomarkers are highly needed.
The connection between P-ADA levels and immune modulation through ADA2 isoforms in macrophages and lymphocytes adds valuable biological context.
The editorial effectively highlights the need for global validation studies and standardization of P-ADA cutoffs, a crucial message for the field.
Suggestions for Improvement:
Add a paragraph critically discussing P-ADA's diagnostic overlap with malignant and parapneumonic effusions.
Include practical suggestions for standardizing P-ADA testing across different regions and populations.
Expand on the possible role of P-ADA within multi-marker panels and its integration into current diagnostic workflows.
"
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Shi DD, Tian J, Ding J. Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation. World J Clin Cases 2025; 13(22): 106925 [DOI: 10.12998/wjcc.v13.i22.106925]
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40
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"It was with pleasure that I reviewed the article quality of the following manuscript.
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The figures/tables add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate/up-to-date
7 Language: This is a concise/well written manuscript
8 Caveats or drawbacks: None"
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Dong ZY, Zhu HB. Idiopathic retroperitoneal fibrosis arising from peritoneal space: A case report and review of literature. World J Gastroenterol 2025; 31(18): 105443 [DOI: 10.3748/wjg.v31.i18.105443]
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41
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"Full laparoscopic ALPPS for CRLM is safe and feasible, with the potential for reduced morbidity and mortality. However, due to the technical complexity of this procedure, it cannot be guaranteed that each center can perform successfully and safely. It requires surgeons to be highly experienced with laparoscopic hepatectomy.
What level of laparoscopic hepatectomy skills are required? For example, how many laparoscopic hepatectomy cases?
"
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Zheng ZY, Zhang L, Li WL, Dong SY, Song JL, Zhang DW, Huang XM, Pan WD. Laparoscopic associating liver partition and portal vein ligation for staged hepatectomy for colorectal liver metastases: A single-center experience. World J Gastroenterol 2025; 31(18): 105530 [DOI: 10.3748/wjg.v31.i18.105530]
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42
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"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this paper is of high value because the research methods used to confirm the original hypotheses regarding the topic, as well as the results, analysis methods, and evaluation methods, all appear to be valid."
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Guo X, Guo L, Lu QZ, Xie H, Chen J, Su WL, Tian Y, Li XH, Miao HL, Zhang Y, Yang Y, Liao C, Deng JY, Yang YH, Tang CL, Liu HJ. Effect of electroacupuncture combined with Tuina therapy on gut microbiota in patients with knee osteoarthritis. World J Gastroenterol 2025; 31(18): 105495 [DOI: 10.3748/wjg.v31.i18.105495]
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43
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"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this paper is of high value because the research methods used to confirm the original hypotheses regarding the topic, as well as the results, analysis methods, and evaluation methods, all appear to be valid."
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Kamimura K, Terai S. Importance of understanding a diagnostic-treatment algorithm for primary hyperparathyroidism-induced acute pancreatitis during pregnancy. World J Gastroenterol 2025; 31(18): 105866 [DOI: 10.3748/wjg.v31.i18.105866]
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44
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"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this paper is of high value because the research methods used to confirm the original hypotheses regarding the topic, as well as the results, analysis methods, and evaluation methods, all appear to be valid."
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Zhang Y, Chung H, Fang QW, Xu YR, Zhang YJ, Nakajo K, Wong ICK, Leung WK, Qiu H, Li X. Current and forecasted 10-year prevalence and incidence of inflammatory bowel disease in Hong Kong, Japan, and the United States. World J Gastroenterol 2025; 31(18): 105472 [DOI: 10.3748/wjg.v31.i18.105472]
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45
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"The authors conducted a systematic review and meta-analysis to compare the clinical outcomes and safety of TAVR and SAVR in patients with severe AS. The methodology follows PRISMA guidelines, and both inclusion criteria and outcome assessment are clearly defined and presented. Multiple reviewers were involved in data extraction procedure eliminating the risk of selection bias. The authors used the Cochrane Collaboration Tool for assessing the risk of bias in the included studies. However, there are concerns regarding the blinding of participants in some studies which could have led to performance bias.
Statistical methods were appropriately applied making the study reproducible by other researchers. TAVR was associated with significantly lower risk of short-term mortality (1-year-mortality) and reduced complications like AKI, major bleeding and new-onset AF, while it was associated with higher rates of long-term mortality (5-year-mortality), permanent pacemaker implantation and major vascular complications compared to SAVR. The results are strongly supported by tables and forest plots. However, the interpretation of this difference in long-term and short-term mortality rates could be discussed further and explain possible factors. The statistical analysis was conducted using Review Manager which is a well-established software in the field.
References are current and relevant including major clinical trials and systematic reviews. The authors avoid excessive self-citation and provide a solid foundation of current literature. The language used in this manuscript is generally clear but some sentences are overly complex and could be simplified for better understanding. This study has several limitations which are appropriately presented and discussed in the relevant section of this manuscript. However, a major caveat regarding this study is that the analysis did not include several patient-specific factors which could have influenced both selection of treatment and outcomes.
"
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Moradi I, Mustafa MS, Sardar Sheikh J, Shojai Rahnama B, Fredericks M, Kumar Yennam A, Arain M, Saha U, Richard Ma A, Nagendran A, Bin Omer M, Armaghan M, Jaimes DCC, Avinash Bojanki NLSV, Shafique MA. Comparative effectiveness of transcatheter vs surgical aortic valve replacement: A systematic review and meta-analysis. World J Cardiol 2025; 17(4): 104168 [PMID: 40308627 DOI: 10.4330/wjc.v17.i4.104168]
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46
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Chen LQ, Wu CY, Wu SJ, Ye K. Laparoscopic surgical approaches for various locations of gastrointestinal stromal tumours. World J Clin Cases 2025; 13(21): 105559 [DOI: 10.12998/wjcc.v13.i21.105559]
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47
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"In this editorial, the authors discussed an article reporting the significance of the triglyceride-glucose (TyG) index in predicting prognosis and response to immunotherapy. Unfortunately, it is difficult to assess the study’s significance, as the editorial does not provide actual probability for each comparison. Furthermore, the manuscript lacks clarity, as it contains numerous contradictory statements.
In the sections titled “The TyG Index as a Prognostic Factor in GC” and “Exploring the Relationship Between TyG and Immunotherapy Response”, the authors emphasize that a higher TyG index is associated with better outcomes and an improved response to immunotherapy. However, in the subsequent section “Mechanisms Linking TyG to Cancer Progression and Immune Function”, they state that a high TyG index may promote tumor cell proliferation, inhibit apoptosis, and reduce the response rate to immunotherapy.
The authors should revise the manuscript to resolve these inconsistencies and improve overall clarity."
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Zhao CF, Liu XL, Wu NB, Xu ZF. Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research. World J Gastroenterol 2025; 31(17): 104794 [DOI: 10.3748/wjg.v31.i17.104794]
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48
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"Helicobacter pylori is still a significant health problem in developed and developing countries. Its presence is associated with several important consequences. Its eradication is, therefore, an essential objective in cases where its presence has been demonstrated. It is well known that inhibiting gastric acid secretion is necessary for the combination of antibiotics used for its eradication to be effective. In recent years, a new drug with a strong antisecretory effect has been introduced into our pharmaceutical quiver, Vonoprazan (VPZ), which is a member of the potassium competitive acid blockers. In the commented study (Ozercan M et al., Vonoprazan and proton pump inhibitors: which is superior for Helicobacter pylori eradication? World J Gastroenterol 2025; 31(17): 103156), the authors commented on the safety and efficacy of VPZ with the safety and effectiveness of proton pump inhibitors (PPIs), in the eradication of Helicobacter pylori. By reviewing the relevant studies, they found that VPZ administration had a higher rate of efficacy and a lower rate of side effects compared to PPIs. They concluded that despite its higher cost, VPZ is an economically and medically superior therapeutic strategy compared to PPIs. Helicobacter pylori eradication therapy may be a significant problem in daily clinical practice in some proportion of patients, particularly in patients over 60 years of age, for whom the avoidance of the side effects of treatment should be a key objective. This task could be achieved by using fewer antibiotics combined with VPZ, e.g. only amoxicillin plus VPZ which is an important alternative therapy shortly.
The paper by Ozercan M et al. is a comprehensive but clear review of the data on the usefulness of VPZ in the treatment of Helicobacter pylori infection, providing clear guidelines for the use of the drug in daily clinical practice. "
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Ozercan M, Tawheed A, Ismail A, Amer MS, El-Kassas M. Vonoprazan and proton pump inhibitors: Which is superior for Helicobacter pylori eradication? World J Gastroenterol 2025; 31(17): 103156 [DOI: 10.3748/wjg.v31.i17.103156]
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49
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"This is the first United Kingdom study to report the frequency of death in patients presenting with paracetamol overdose-related acute hepatic failure.Paracetamol overdose (POD) is the most common cause of acute hepatic failure (AHF) in the United Kingdom. Without urgent orthotopic liver transplant (OLT), mortality is high. Indeed, Paracetamol overdose (POD) is the most common cause of acute hepatic failure (AHF) in the United Kingdom. Without urgent orthotopic liver transplant (OLT), mortality is high.
This is an 18-year single-centre retrospective cohort study based in a national liver transplant centre. 524 participants were identified from a departmental database and included if they had AHF from suspected POD and received a psychiatric assessment for OLT.Among 524 patients undergoing psychiatric assessment for OLT, there were 102 in-episode deaths (19.5%). This indicates a need for ongoing assessor training and support, and (inter) national comparisons of practice"
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Impey ORE, Baker JD, Smyth RS, Potts SG. Death after psychiatric contraindications to urgent liver transplant for paracetamol overdose. World J Transplant 2025; 15(3): 101865 [DOI: 10.5500/wjt.v15.i3.101865]
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50
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"Paediatric liver transplantation (PLT) is a life-saving procedure for children with advanced liver disease or hepatoblastoma. The number of available grafts is limited in relation to the number of children on PLT waiting list. One of the limitations is the donor obesity. Donors’ obesity is strongly associated with hepatic steatosis which can affect graft function by impairing microcirculation and maximizing the potential of ischemia-reperfusion injury. This important study faces this problem and offers a possible solution. New strategies to optimize the grafts before PLT such as normothermic regional perfusion and ex vivo liver perfusion can potentially mitigate the risk of using grafts from obese donors.The study in particular treats new strategies to optimize the grafts before PLT such as normothermic regional perfusion and ex vivo liver perfusion can potentially mitigate the risk of using grafts from obese donors.
"
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Alnagar A, Amgad A, Grammatikopoulos T, Kyrana E. Impact of donor obesity on paediatric liver transplantation; current evidence and potentials for graft pool expansion. World J Transplant 2025; 15(3): 103015 [DOI: 10.5500/wjt.v15.i3.103015]
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