Publication Name	World Journal of Experimental Medicine
Manuscript ID	100548
Country	India

Received	2024-08-21 02:08
Peer-Review Started	2024-09-04 14:04
To Make the First Decision
Return for Revision	2024-12-11 06:14
Revised	2024-12-19 10:17
Second Decision	2025-01-02 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-02 10:30
Articles in Press	2025-01-02 10:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-27 01:53
Publish the Manuscript Online	2025-04-16 05:36

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Developmental Biology
Manuscript Type	Basic Study
Article Title	MiRNA dysregulation in Duchenne muscular dystrophy comorbidities
Manuscript Source	Invited Manuscript
All Author List	Subhashree Sivakumar, Archana Rajavel, Venkataraman Viswanathan, Evangeline Ann Daniel, Prakash Gangadaran and NS Raja
Funding Agency and Grant Number
Corresponding Author	NS Raja, Assistant Professor, PhD, Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamil Nādu, India. rajan3@srmist.edu.in
Key Words	Duchenne muscular dystrophy; Dystrophin; MiRNA; Autism spectrum disorder; Phosphatase and tensin; Inflammatory response
Core Tip	This study presents a rare case of a ten-year-old boy with Duchenne muscular dystrophy (DMD) coexisting with autism spectrum disorder and epilepsy. By investigating the differential expression of miRNAs, we identified a significant downregulation of miR-132-3p in the DMD patient compared to the comorbid DMD case. This suggests that miR-132-3p downregulation may have contributed to accelerated muscle atrophy through failed silencing of the phosphatase and tensin homolog-mediated apoptotic pathway. Our findings emphasize the importance of studying such rare DMD comorbidities to enhance understanding of disease heterogeneity and improve diagnosis and treatment strategies.
Publish Date	2025-04-16 05:36
Citation	<p>Sivakumar S, Rajavel A, Viswanathan V, Daniel EA, Gangadaran P, Raja N. MiRNA dysregulation in Duchenne muscular dystrophy comorbidities. <i>World J Exp Med</i> 2025; 15(2): 100548</p>
URL	https://www.wjgnet.com/2220-315x/full/v15/i2/100548.htm
DOI	https://dx.doi.org/10.5493/wjem.v15.i2.100548

Full Article (PDF)	WJEM-15-100548-with-cover.pdf
Manuscript File	100548_Auto_Edited_023217.docx
Answering Reviewers	100548-answering-reviewers.pdf
Audio Core Tip	100548-audio.mp3
Biostatistics Review Certificate	100548-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	100548-conflict-of-interest-statement.pdf
Copyright License Agreement	100548-copyright-assignment.pdf
Institutional Review Board Approval Form or Document	100548-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	100548-non-native-speakers.pdf
Peer-review Report	100548-peer-reviews.pdf
Scientific Misconduct Check	100548-scientific-misconduct-check.png
Scientific Editor Work List	100548-scientific-editor-work-list.pdf
CrossCheck Report	100548-crosscheck-report.pdf