| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Strain- and sex-dependent variability in hepatic microcirculation and liver function in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bing Wang, Yuan Li, Qin Ouyang, Meng-Ting Xu, Ying-Yu Wang, Sun-Jing Fu, Wei-Qi Liu, Xue-Ting Liu, Hao Ling, Xu Zhang, Rui-Juan Xiu and Ming-Ming Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Municipal Natural Science Foundation |
No. 7212068 |
| National Natural Science Foundation of China |
No. 81900747 |
|
| Corresponding Author |
Ming-Ming Liu, Associate Professor, PhD, Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 5 Dong Dan Third Alley, Dongcheng District, Beijing 100005, China. mingmingliu@imc.pumc.edu.cn |
| Key Words |
Hepatic microhemodynamics; Sex differences; Mouse strains; Biological oscillators; Hepatic microcirculation |
| Core Tip |
This study reveals significant strain and sex-dependent variations in hepatic microcirculation among murine, highlighting the implications for liver health. Male mice exhibited higher microvascular perfusion and erythrocyte concentration, while sex-specific differences in endothelial function were indicated across strains. Cluster of differentiation 31 expression linked to microvascular density varied by sex, suggesting a role in hepatic microhemodynamics. These findings suggest the necessity of integrating genetic and sex factors into the understanding of liver physiology and pathology, potentially guiding personalized therapeutic strategies. |
| Publish Date |
2025-04-18 07:43 |
| Citation |
<p>Wang B, Li Y, Ouyang Q, Xu MT, Wang YY, Fu SJ, Liu WQ, Liu XT, Ling H, Zhang X, Xiu RJ, Liu MM. Strain- and sex-dependent variability in hepatic microcirculation and liver function in mice. <i>World J Gastroenterol</i> 2025; 31(15): 101058</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i15/101058.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i15.101058 |
