Publication Name	World Journal of Stem Cells
Manuscript ID	101891
Country	Italy

Received	2024-09-29 19:59
Peer-Review Started	2024-09-29 19:59
To Make the First Decision
Return for Revision	2025-02-10 08:39
Revised	2025-02-17 12:15
Second Decision	2025-03-17 00:10
Accepted by Journal Editor-in-Chief	2025-03-18 13:16
Accepted by Executive Editor-in-Chief	2025-03-21 10:39
Articles in Press	2025-03-21 10:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-03-25 19:06
Typeset the Manuscript	2025-04-11 06:06
Publish the Manuscript Online	2025-04-23 03:33

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Evaluating the efficacy of stem cells in treating severe dry eye disease
Manuscript Source	Invited Manuscript
All Author List	Lan-Xing Fu, Lucia Pelosini, Nick Kopsachilis, Roberta Foti, Fabiana D’Esposito, Mutali Musa, Alberto D’Amico, Daniele Tognetto, Caterina Gagliano and Marco Zeppieri
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Dry eye disease; Stem cell therapy; Mesenchymal stem cells; Corneal regeneration; Exosome; Cornea; Clinical trials
Core Tip	Stem cell treatment offers a potential regenerative strategy for addressing severe dry eye disease by restoring lacrimal gland function, regulating inflammation, and facilitating corneal restoration. This review incorporates current preclinical and clinical discoveries, contrasting various mesenchymal stem cell (MSC) sources and their modes of action. Notwithstanding promising outcomes, obstacles persist in enhancing MSC viability, standardizing administration techniques, and guaranteeing prolonged safety. More extensive randomized controlled studies are necessary to determine the effectiveness of MSC-based treatments in severe dry eye disease.
Publish Date	2025-04-23 03:33
Citation	<p>Fu LX, Pelosini L, Kopsachilis N, Foti R, D’Esposito F, Musa M, D’Amico A, Tognetto D, Gagliano C, Zeppieri M. Evaluating the efficacy of stem cells in treating severe dry eye disease. <i>World J Stem Cells</i> 2025; 17(4): 101891</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i4/101891.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i4.101891

Full Article (PDF)	WJSC-17-101891-with-cover.pdf
Manuscript File	101891_Auto_Edited_064335.docx
Answering Reviewers	101891-answering-reviewers.pdf
Audio Core Tip	101891-audio.mp3
Conflict-of-Interest Disclosure Form	101891-conflict-of-interest-statement.pdf
Copyright License Agreement	101891-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	101891-non-native-speakers.pdf
Peer-review Report	101891-peer-reviews.pdf
Journal Editor-in-Chief Review Report	101891-journal-editor-in-chief.pdf
Scientific Misconduct Check	101891-scientific-misconduct-check.png
Scientific Editor Work List	101891-scientific-editor-work-list.pdf
CrossCheck Report	101891-crosscheck-report.pdf