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4/16/2025 8:25:40 AM | Browse: 58 | Download: 72
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Received |
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2024-10-28 01:53 |
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Peer-Review Started |
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2024-11-07 00:39 |
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To Make the First Decision |
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Return for Revision |
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2025-01-08 12:39 |
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Revised |
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2025-01-21 23:14 |
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Second Decision |
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2025-02-21 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-02-21 09:58 |
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Articles in Press |
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2025-02-21 09:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-02-27 05:46 |
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Typeset the Manuscript |
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2025-03-25 01:04 |
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Publish the Manuscript Online |
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2025-04-16 05:36 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Cytoplasmic and nuclear programmed death-ligand 1 expression in peritumoral stromal cells in breast cancer: Prognostic and predictive value
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Evgeniya Yu Zubareva, Marina A Senchukova and Natalia V Saidler |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Russian Science Foundation |
23-25-00183 |
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| Corresponding Author |
Marina A Senchukova, MD, PhD, Professor, Department of Oncology, Orenburg State Medical University, 6 Sovetskaya Street, Orenburg 460000, Russia. masenchukova@yandex.com |
| Key Words |
Breast cancer; Programmed death-ligand 1; Regional metastasis; Tumor stroma |
| Core Tip |
Programmed death-ligand 1 expression was studied in breast cancer (BC) stromal cells via a new antibody against programmed cell death protein 1 ligand 1 (PDCD1 LG1). This study revealed that moderate and pronounced PDCD1 LG1 expression in polymorphic cell infiltrates and the presence of PDCD1 LG1 expression in the fibroblastic stroma are associated with unfavorable BC prognosis. In addition, a PDCD1 LG1+ lymphocyte score ≥ 3 in the absence of lymphovascular invasion is associated with a reduced risk of BC regional metastasis; in contrast, in the presence of LVI, it is associated with an increased risk of regional BC metastasis. |
| Publish Date |
2025-04-16 05:36 |
| Citation |
<p>Zubareva EY, Senchukova MA, Saidler NV. Cytoplasmic and nuclear programmed death-ligand 1 expression in peritumoral stromal cells in breast cancer: Prognostic and predictive value. <i>World J Exp Med</i> 2025; 15(2): 102761</p> |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i2/102761.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i2.102761 |
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