Publication Name	World Journal of Stem Cells
Manuscript ID	102923
Country	China

Received	2024-11-04 12:06
Peer-Review Started	2024-11-04 12:07
To Make the First Decision
Return for Revision	2025-02-10 08:42
Revised	2025-02-22 22:50
Second Decision	2025-03-21 03:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-21 10:23
Articles in Press	2025-03-21 10:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-03-27 05:00
Typeset the Manuscript	2025-04-11 06:07
Publish the Manuscript Online	2025-04-23 03:33

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Editorial
Article Title	Mechanisms and challenges of mesenchymal stem cells in the treatment of knee osteoarthritis
Manuscript Source	Invited Manuscript
All Author List	Jing-Shun Lu, Chen-Yu Song, Wen-Jing Cheng and Kai-Yang Wang
Funding Agency and Grant Number
Corresponding Author	Kai-Yang Wang, Assistant Professor, MD, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600 Yishan Road, Shanghai 200233, China. ortho_wang@163.com
Key Words	Mesenchymal stem cells; Knee osteoarthritis; Inflammation; Exosome; Biological materials
Core Tip	Mesenchymal stem cells (MSCs) exhibit remarkable efficacy in the field of regenerative medicine and are considered to be the key cells for the repair and regeneration of cartilage. In this paper, we explore the clinical application of MSCs in the treatment mechanism of osteoarthritis and address the challenges associated with MSC therapy.
Publish Date	2025-04-23 03:33
Citation	<p>Lu JS, Song CY, Cheng WJ, Wang KY. Mechanisms and challenges of mesenchymal stem cells in the treatment of knee osteoarthritis. <i>World J Stem Cells</i> 2025; 17(4): 102923</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i4/102923.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i4.102923

Full Article (PDF)	WJSC-17-102923-with-cover.pdf
Manuscript File	102923_Auto_Edited_064335.docx
Answering Reviewers	102923-answering-reviewers.pdf
Audio Core Tip	102923-audio.m4a
Conflict-of-Interest Disclosure Form	102923-conflict-of-interest-statement.pdf
Copyright License Agreement	102923-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	102923-non-native-speakers.pdf
Peer-review Report	102923-peer-reviews.pdf
Scientific Misconduct Check	102923-scientific-misconduct-check.png
Scientific Editor Work List	102923-scientific-editor-work-list.pdf
CrossCheck Report	102923-crosscheck-report.pdf