Publication Name	World Journal of Experimental Medicine
Manuscript ID	102969
Country	India

Received	2024-11-05 02:18
Peer-Review Started	2024-11-13 02:23
To Make the First Decision
Return for Revision	2025-02-20 04:00
Revised	2025-03-03 04:15
Second Decision	2025-04-01 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-01 10:39
Articles in Press	2025-04-01 10:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-08 00:49
Publish the Manuscript Online	2025-04-16 05:36

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Review
Article Title	Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions
Manuscript Source	Invited Manuscript
All Author List	Naveen Jeyaraman, Madhan Jeyaraman, Priya Dhanpal, Swaminathan Ramasubramanian, Arulkumar Nallakumarasamy, Sathish Muthu, Gabriel Silva Santos, Lucas Furtado da Fonseca and José Fábio Lana
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, Assistant Professor, MD, PhD, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Gut microbiome; Pain management; Orthopaedics; Gut-brain axis; Probiotics; Inflammation
Core Tip	Modulating the gut microbiome may offer novel pain management strategies for orthopaedic conditions by reducing inflammation and influencing pain pathways through the gut-brain axis. Probiotics, prebiotics, dietary adjustments, and faecal microbiome transplantation show potential in controlling pain and limiting opioid dependence, though personalized approaches are crucial due to microbiome variability and the need for clinical validation.
Publish Date	2025-04-16 05:36
Citation	<p>Jeyaraman N, Jeyaraman M, Dhanpal P, Ramasubramanian S, Nallakumarasamy A, Muthu S, Santos GS, da Fonseca LF, Lana JF. Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions. <i>World J Exp Med</i> 2025; 15(2): 102969</p>
URL	https://www.wjgnet.com/2220-315x/full/v15/i2/102969.htm
DOI	https://dx.doi.org/10.5493/wjem.v15.i2.102969

Full Article (PDF)	WJEM-15-102969-with-cover.pdf
Manuscript File	102969_Auto_Edited_004939.docx
Answering Reviewers	102969-answering-reviewers.pdf
Audio Core Tip	102969-audio.opus
Conflict-of-Interest Disclosure Form	102969-conflict-of-interest-statement.pdf
Copyright License Agreement	102969-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	102969-non-native-speakers.pdf
Peer-review Report	102969-peer-reviews.pdf
Scientific Misconduct Check	102969-scientific-misconduct-check.png
Scientific Editor Work List	102969-scientific-editor-work-list.pdf
CrossCheck Report	102969-crosscheck-report.pdf