Publication Name	World Journal of Diabetes
Manuscript ID	103468
Country	China

Received	2024-11-21 11:19
Peer-Review Started	2024-11-26 06:07
To Make the First Decision
Return for Revision	2025-02-18 08:16
Revised	2025-03-21 01:38
Second Decision	2025-05-21 03:02
Accepted by Journal Editor-in-Chief	2025-05-27 08:23
Accepted by Executive Editor-in-Chief	2025-06-03 08:57
Articles in Press	2025-06-03 08:57
Publication Fee Transferred	2025-03-22 16:14
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-03 06:52
Publish the Manuscript Online	2025-07-15 08:26

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Case Control Study
Article Title	Detect the disrupted brain structural connectivity in type 2 diabetes mellitus patients without cognitive impairment
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Fan Li, Yue Wei, Ming-Rui Li, Zhi-Zhong Sun, Wei-Yan Xie, Qian-Fan Li, Chen-Hui xie, Jing-Yi Xiang, Xin Tan, Shi-Jun Qiu and Yi Liang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82104698 National Natural Science Foundation of China 82330058 National Natural Science Foundation of China 32200923
Corresponding Author	Yi Liang, MD, PhD, Department of Radiology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, detailed address, Guangzhou 510405, Guangdong Province, China. lysogood@126.com
Key Words	Type 2 diabetes mellitus; White matter; Diffusion tensor imaging; Cognitive impairment; Graph theoretical analysis
Core Tip	This study sheds light on the early-stage cognitive decline in type 2 diabetes mellitus (T2DM) by identifying disrupted brain connectivity and developing a classification model with a promising accuracy of 92.5%. Deep subcortical nuclei showed increased connectivity with the frontal lobe in T2DM patients without cognitive impairment. The diabetic brain exhibited measurable characteristics before patients presented with detectable cognitive impairments. The high-accuracy models demonstrate the potential of diffusion tensor imaging-based biomarkers for detecting preclinical cognitive decline and monitoring disease progression.
Publish Date	2025-07-15 08:26
Citation	<p>Li YF, Wei Y, Li MR, Sun ZZ, Xie WY, Li QF, xie CH, Xiang JY, Tan X, Qiu SJ, Liang Y. Detect the disrupted brain structural connectivity in type 2 diabetes mellitus patients without cognitive impairment. <i>World J Diabetes</i> 2025; 16(7): 103468</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i7/103468.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i7.103468

Full Article (PDF)	WJD-16-103468-with-cover.pdf
STROBE Statement	103468-STROBE-statement.pdf
Manuscript File	103468_Auto_Edited_102541.docx
Answering Reviewers	103468-answering-reviewers.pdf
Audio Core Tip	103468-audio.mp3
Biostatistics Review Certificate	103468-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103468-conflict-of-interest-statement.pdf
Copyright License Agreement	103468-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103468-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	103468-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	103468-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	103468-non-native-speakers.pdf
Supplementary Material	103468-supplementary-material.pdf
Peer-review Report	103468-peer-reviews.pdf
Journal Editor-in-Chief Review Report	103468-journal-editor-in-chief.pdf
Scientific Misconduct Check	103468-scientific-misconduct-check.png
Scientific Editor Work List	103468-scientific-editor-work-list.pdf
CrossCheck Report	103468-crosscheck-report.pdf