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4/16/2025 8:25:40 AM | Browse: 65 | Download: 53
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Received |
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2024-11-21 11:50 |
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Peer-Review Started |
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2024-11-25 01:01 |
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To Make the First Decision |
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Return for Revision |
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2025-02-28 06:49 |
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Revised |
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2025-03-10 05:06 |
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Second Decision |
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2025-03-21 03:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-03-21 11:51 |
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Articles in Press |
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2025-03-21 11:51 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-03-28 07:47 |
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Publish the Manuscript Online |
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2025-04-16 05:36 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Immunomodulatory effect of allium sativum in type 2 diabetes mellitus
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Elva Manuela Mejía Delgado, Juan Eduardo Quiroz-Aldave, María del Carmen Durand-Vásquez, Lea Noemí Aldave-Pita, Jenyfer María Fuentes-Mendoza, Luis Alberto Concepción-Urteaga, José Paz-Ibarra and Marcio José Concepción-Zavaleta |
| Funding Agency and Grant Number |
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| Corresponding Author |
Marcio José Concepción-Zavaleta, Carrera de Medicina Humana, Universidad Científica del Sur, 19 Panamericana Sur Km, Villa El Salvador, Lima 15067, Peru. mconcepcion@cientifica.edu.pe |
| Key Words |
Garlic; Phytotherapy; Anti-inflammatory agents; Antioxidants; Immunomodulating agents; Type 2 diabetes mellitus |
| Core Tip |
Allium sativum (garlic) demonstrates significant potential in managing type 2 diabetes mellitus through its immunomodulatory effects, primarily due to its organosulfur compounds like allicin. Preclinical and clinical studies suggest garlic improves metabolic control by reducing inflammation, oxidative stress, glucose levels, and insulin resistance, with benefits comparable to antidiabetic drugs. It may also positively impact complications such as metabolic-associated fatty liver disease, hypertension, nephropathy, and cardiovascular disease. However, more clinical trials are needed to confirm its therapeutic efficacy and optimize its use in type 2 diabetes mellitus treatment. Garlic offers promise as a natural adjunct to conventional diabetes management. |
| Publish Date |
2025-04-16 05:36 |
| Citation |
<p>Mejía Delgado EM, Quiroz-Aldave JE, Durand-Vásquez MDC, Aldave-Pita LN, Fuentes-Mendoza JM, Concepción-Urteaga LA, Paz-Ibarra J, Concepción-Zavaleta MJ. Immunomodulatory effect of allium sativum in type 2 diabetes mellitus. <i>World J Exp Med</i> 2025; 15(2): 103481</p> |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i2/103481.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i2.103481 |
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