Publication Name	World Journal of Stem Cells
Manuscript ID	103482
Country	China

Received	2024-11-21 12:22
Peer-Review Started	2024-11-21 12:22
To Make the First Decision
Return for Revision	2025-02-10 08:44
Revised	2025-02-23 16:38
Second Decision	2025-04-03 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-07 07:58
Articles in Press	2025-04-07 07:58
Publication Fee Transferred	2025-02-24 10:21
Edit the Manuscript by Language Editor	2025-04-08 09:42
Typeset the Manuscript	2025-04-14 02:23
Publish the Manuscript Online	2025-04-23 03:33

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	EZH2, via an association with KDM2B, modulates the osteogenic differentiation of root apical papillary stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Yue Xu, Yan-Tong Wang, Hao-Qing Yang, Yang-Yang Cao and Zhi-Peng Fan
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program 2022YFA1104401 Beijing Natural Science Foundation 7222075 CAMS Innovation Fund for Medical Sciences 2019RU020 Innovation Research Team Project of Beijing Stomatological Hospital CXTD202204
Corresponding Author	Zhi-Peng Fan, PhD, Professor, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University, No. 4 Tiantanxili, Dongcheng District, Beijing 100050, China. zpfan@ccmu.edu.cn
Key Words	Bioactive peptides; Bone tissue engineering; Enhancer of zeste homolog 2; Osteogenic; Apical papillary stem cell
Core Tip	Enhancing the osteogenic potential of stem cells is crucial for bone regeneration. This study reveals that overexpressing enhancer of zeste homolog 2 (EZH2), a key methyltransferase, promotes osteogenic differentiation in root apical papillary stem cells. EZH2 enhances osteogenesis by regulating related proteins and gene expression, both in vitro and in vivo. Furthermore, the interaction between EZH2 and lysine demethylase 2B inhibits this process, suggesting that disrupting this interaction with small-molecule peptides could improve apical papillary stem cell-based therapies for bone defects. This finding opens new avenues for optimizing stem cell-based treatments through targeted molecular modulation.
Publish Date	2025-04-23 03:33
Citation	<p>Xu HY, Wang YT, Yang HQ, Cao YY, Fan ZP. EZH2, via an association with KDM2B, modulates the osteogenic differentiation of root apical papillary stem cells. <i>World J Stem Cells</i> 2025; 17(4): 103482</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i4/103482.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i4.103482

Full Article (PDF)	WJSC-17-103482-with-cover.pdf
The ARRIVE Guidelines	103482-The-ARRIVE-Guidelines.pdf
Manuscript File	103482_Auto_Edited_015234.docx
Answering Reviewers	103482-answering-reviewers.pdf
Audio Core Tip	103482-audio.mp3
Biostatistics Review Certificate	103482-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103482-conflict-of-interest-statement.pdf
Copyright License Agreement	103482-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103482-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	103482-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	103482-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	103482-non-native-speakers.pdf
Supplementary Material	103482-supplementary-material.pdf
Peer-review Report	103482-peer-reviews.pdf
Scientific Misconduct Check	103482-scientific-misconduct-check.png
Scientific Editor Work List	103482-scientific-editor-work-list.pdf
CrossCheck Report	103482-crosscheck-report.pdf