Publication Name	World Journal of Gastroenterology
Manuscript ID	104397
Country	Italy

Received	2024-12-19 11:53
Peer-Review Started	2024-12-19 12:18
To Make the First Decision
Return for Revision	2025-01-22 04:42
Revised	2025-02-01 15:27
Second Decision	2025-03-20 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-21 00:59
Articles in Press	2025-03-21 00:59
Publication Fee Transferred	2025-02-19 14:43
Edit the Manuscript by Language Editor	2025-04-01 22:40
Typeset the Manuscript	2025-04-03 06:41
Publish the Manuscript Online	2025-04-11 02:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Guidelines
Article Title	Clinical settings in which human leukocyte antigens typing is still useful in the diagnosis of celiac disease
Manuscript Source	Unsolicited Manuscript
All Author List	Enrico Schirru, Rossano Rossino, Rita D Jores, Mara Corpino, Sandro Muntoni, Francesco Cucca and Mauro Congia
Funding Agency and Grant Number	Funding Agency Grant Number Fondazione di Sardegna No. 2020.2284
Corresponding Author	Mauro Congia, MD, Department of Pediatrics, Clinic of Pediatric and Rare Diseases, Microcitemico Pediatric Hospital, A.Cao, ASL8, Via Jenner Cagliari, Cagliari 09121, Sardegna, Italy. maurocongia1957@gmail.com
Key Words	Human leukocyte antigens; Celiac disease; Type 1 diabetes; Guidelines; Anti tissue transglutaminase type 2
Core Tip	This guide explains how to interpret human leukocyte antigens (HLA) genetics associated with celiac disease (CD) and the different clinical situations where HLA genotyping can be useful in the diagnosis of CD. It also provides a strategy based on HLA genotyping for monitoring CD patients at risk for the future development of type 1 diabetes (T1D). Only a subset of HLA genotypes linked to CD is associated with the development of T1D. Interestingly, some HLA genotypes that carry a high risk for CD may offer protection against T1D. Therefore, HLA genotyping in patients with CD could help in identify those at high risk for T1D, enabling proactive interventions and therapies to preserve beta-cell function.
Publish Date	2025-04-11 02:19
Citation	<p>Schirru E, Rossino R, Jores RD, Corpino M, Muntoni S, Cucca F, Congia M. Clinical settings in which human leukocyte antigens typing is still useful in the diagnosis of celiac disease. <i>World J Gastroenterol</i> 2025; 31(14): 104397</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i14/104397.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i14.104397

Full Article (PDF)	WJG-31-104397-with-cover.pdf
Manuscript File	104397_Auto_Edited_004703.docx
Answering Reviewers	104397-answering-reviewers.pdf
Audio Core Tip	104397-audio.m4a
Conflict-of-Interest Disclosure Form	104397-conflict-of-interest-statement.pdf
Copyright License Agreement	104397-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104397-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	104397-non-native-speakers.pdf
Peer-review Report	104397-peer-reviews.pdf
Scientific Misconduct Check	104397-scientific-misconduct-check.png
Scientific Editor Work List	104397-scientific-editor-work-list.pdf
CrossCheck Report	104397-crosscheck-report.png
CrossCheck Report	104397-crosscheck-report.pdf