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7/23/2025 7:29:59 AM | Browse: 20 | Download: 25
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Received |
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2024-12-19 10:18 |
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Peer-Review Started |
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2024-12-20 01:42 |
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To Make the First Decision |
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Return for Revision |
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2025-03-19 02:14 |
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Revised |
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2025-04-02 07:35 |
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Second Decision |
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2025-05-28 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-28 10:18 |
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Articles in Press |
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2025-05-28 10:18 |
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Publication Fee Transferred |
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2025-04-23 15:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-16 06:20 |
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Publish the Manuscript Online |
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2025-07-23 07:02 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Case Report |
| Article Title |
Hepatitis B virus and hepatitis D virus co-infection complicated by autoimmune hepatitis: Two case reports
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Dou, Xin-Yan Zhao, Zhuan-Guo Wang, Zhong-Hui Ning, Xiao-Zhong Wang and Feng Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Xinjiang “Tianshan Talents” Medical and Health High-Level Talent Training Program-Young and Middle-Aged Backbone Medical Talents |
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| Corresponding Author |
Feng Guo, Professor, Department of Hepatology, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, No. 116 Huanghe Road, Shayibak District, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. gf_sj@163.com |
| Key Words |
Hepatitis D virus; Hepatitis B virus; Autoimmune hepatitis; Liver biopsy; Pathology; Case report |
| Core Tip |
This study reports, for the first time, two patients with hepatitis D virus (HDV)-hepatitis B virus co-infection combined with autoimmune hepatitis (AIH) who were not treated with interferon and achieved serological conversion and histological remission with antiviral drugs (entecavir/tenofovir alafenamide) in combination with immunosuppression (prednisone + azathioprine). Patients with severe HDV-related liver disease should be routinely screened for autoantibodies to avoid exacerbation by interferon therapy. The combination therapy was effective in controlling HDV-hepatitis B virus co-infection associated AIH, suggesting that aberrant immunoregulation may be an important mechanism of HDV-induced AIH, providing new evidence for elucidating the pathogenesis of this complex disease, and emphasizing the necessity of immune mechanism research. |
| Publish Date |
2025-07-23 07:02 |
| Citation |
<p>Dou J, Zhao XY, Wang ZG, Ning ZH, Wang XZ, Guo F. Hepatitis B virus and hepatitis D virus co-infection complicated by autoimmune hepatitis: Two case reports. <i>World J Clin Cases</i> 2025; 13(26): 104421</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i26/104421.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i26.104421 |
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