| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Study of the relationship between iron metabolism disorders and sepsis-associated liver injury: A prospective observational study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tian-Wei Wang, Lu-Lu Zhou, Jing Yuan, Wen-Xin Zhou, Hao-Ran Wang, Ting-Ting Yu, Ji-Chao Zhai, Cheng-Bin Tang, Wei Jiang, Jiang-Quan Yu, Rui-Qiang Zheng, Hai-Long Yu and Jun Shao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Foundation of Jiangsu Province |
BK20221280 |
| National Natural Science Foundation of China |
82371336 |
| Chinese Postdoctoral Science Foundation |
2022M711426 |
| Special Fund for Social Key Research and Development Plan of Yangzhou City |
YZ2022097 |
| Yangzhou Municipal Science and Technology Bureau |
YZ2024091 |
| Yangzhou Municipal Science and Technology Bureau |
YZ2022098 |
|
| Corresponding Author |
Jun Shao, Associate Chief Physician, Department of Center for Cardiac Macrovascular Disease, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, No. 98 Nantong Road West, Guangling District, Yangzhou 225001, Jiangsu Province, China. sjun1982@163.com |
| Key Words |
Sepsis; Liver injury; Iron metabolism; Biomarkers; Serum iron; Total iron-binding capacity |
| Core Tip |
Sepsis-associated liver injury (SALI) refers to secondary liver function impairment caused by sepsis, the SALI patients often have worse clinical outcomes. Recent evidence has suggested that iron metabolism plays a significant role in the adverse processes of sepsis and sepsis-induced organ damage. Our research indicates that iron metabolism disorders are closely related to the occurrence and development of SALI and that serum iron and total iron-binding capacity can serve as potential predictive indicators for SALI. These findings provide valuable information for further exploration of the mechanisms underlying the occurrence of SALI and the development of new treatment strategies. |
| Publish Date |
2025-04-11 02:19 |
| Citation |
<p>Wang TW, Zhou LL, Yuan J, Zhou WX, Wang HR, Yu TT, Zhai JC, Tang CB, Jiang W, Yu JQ, Zheng RQ, Yu HL, Shao J. Study of the relationship between iron metabolism disorders and sepsis-associated liver injury: A prospective observational study. <i>World J Gastroenterol</i> 2025; 31(14): 104584</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i14/104584.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i14.104584 |
