Publication Name	World Journal of Gastroenterology
Manuscript ID	104875
Country	China

Received	2025-01-05 14:25
Peer-Review Started	2025-01-05 14:26
To Make the First Decision
Return for Revision	2025-02-13 22:30
Revised	2025-02-24 13:43
Second Decision	2025-03-24 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-24 08:02
Articles in Press	2025-03-24 08:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-07 10:43
Publish the Manuscript Online	2025-04-18 07:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Basic Study
Article Title	Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Yu Wang, Fang Liu, Qi-Tong Wang, Shu-Zhu Li, Yu-Zhao Ye, Tao Chen and Ben-Chi Cai
Funding Agency and Grant Number	Funding Agency Grant Number Hainan Provincial Natural Science Foundation of China 823MS133 and 821QN0979
Corresponding Author	Ben-Chi Cai, Professor, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Medical University, No. 19 Xiuhua Road, Xiuying District, Haikou 570100, Hainan Province, China. caibenchi@hainmc.edu.cn
Key Words	Rhapontin; Gastrointestinal dysfunction; Parkinson’s disease; Nuclear factor erythroid 2-related factor 2; Gut-Brain axis; Oxidative stress; Neuroinflammation
Core Tip	The specific objectives of this study are to identify key molecular targets of rhapontin, evaluate its impact on gastrointestinal symptoms in Parkinson's disease, and investigate its anti-inflammatory effects mediated by nuclear factor erythroid 2-related factor 2 activation.
Publish Date	2025-04-18 07:43
Citation	<p>Wang XY, Liu F, Wang QT, Li SZ, Ye YZ, Chen T, Cai BC. Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice. <i>World J Gastroenterol</i> 2025; 31(15): 104875</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i15/104875.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i15.104875

Full Article (PDF)	WJG-31-104875-with-cover.pdf
The ARRIVE Guidelines	104875-The-ARRIVE-Guidelines.pdf
Manuscript File	104875_Auto_Edited_060528.docx
Answering Reviewers	104875-answering-reviewers.pdf
Audio Core Tip	104875-audio.mp3
Biostatistics Review Certificate	104875-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	104875-conflict-of-interest-statement.pdf
Copyright License Agreement	104875-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104875-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	104875-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	104875-non-native-speakers.pdf
Supplementary Material	104875-supplementary-material.pdf
Peer-review Report	104875-peer-reviews.pdf
Scientific Misconduct Check	104875-scientific-misconduct-check.png
Scientific Editor Work List	104875-scientific-editor-work-list.pdf
CrossCheck Report	104875-crosscheck-report.pdf