Publication Name	World Journal of Stem Cells
Manuscript ID	105394
Country	China

Received	2025-01-21 05:05
Peer-Review Started	2025-01-21 05:53
To Make the First Decision
Return for Revision	2025-02-19 07:16
Revised	2025-02-27 07:07
Second Decision	2025-04-14 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-15 08:20
Articles in Press	2025-04-15 08:20
Publication Fee Transferred	2025-03-01 05:43
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-05 11:10
Publish the Manuscript Online	2025-05-26 09:15

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Cell-free extracts from human fat tissue attenuate ischemic injury in cardiomyocytes in a murine model
Manuscript Source	Unsolicited Manuscript
All Author List	Tian-Yun Yang, Yi Sun, Wen-Jie Zhang, Chang-Qian Wang and Jin Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82200270 Vascular Disease Discipline Cluster SKQJS202402
Corresponding Author	Chang-Qian Wang, Professor, Department of Cardiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No. 280 Mohe Road, Baoshan District, Shanghai 200011, China. wangcqdr1218@163.com
Key Words	Ischemic heart disease; Myocardial infarction; Ischemia injury; Fat extract; Phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin signaling pathway
Core Tip	Fat extract derived from mesenchymal stem cell therapy demonstrates protective effects on cardiomyocytes under ischemic conditions by inhibiting cardiomyocyte apoptosis and improving left ventricular function. This protection is mediated through the activation of the phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin signaling pathway, suggesting fat extract as a potential new treatment for ischemic heart disease.
Publish Date	2025-05-26 09:15
Citation	<p>Yang TY, Sun Y, Zhang WJ, Wang CQ, Zhou J. Cell-free extracts from human fat tissue attenuate ischemic injury in cardiomyocytes in a murine model. <i>World J Stem Cells</i> 2025; 17(5): 105394</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i5/105394.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i5.105394

Full Article (PDF)	WJSC-17-105394-with-cover.pdf
The ARRIVE Guidelines	105394-The-ARRIVE-Guidelines.pdf
Manuscript File	105394_Auto_Edited_035550.docx
Answering Reviewers	105394-answering-reviewers.pdf
Audio Core Tip	105394-audio.mp3
Biostatistics Review Certificate	105394-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	105394-conflict-of-interest-statement.pdf
Copyright License Agreement	105394-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	105394-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	105394-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	105394-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	105394-non-native-speakers.pdf
Peer-review Report	105394-peer-reviews.pdf
Scientific Misconduct Check	105394-scientific-misconduct-check.png
Scientific Editor Work List	105394-scientific-editor-work-list.pdf
CrossCheck Report	105394-crosscheck-report.pdf