Publication Name	World Journal of Radiology
Manuscript ID	105722
Country	China

Received	2025-02-05 04:16
Peer-Review Started	2025-02-05 04:16
To Make the First Decision
Return for Revision	2025-02-24 08:18
Revised	2025-03-09 15:16
Second Decision	2025-03-25 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-25 07:18
Articles in Press	2025-03-25 07:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-03-27 04:43
Typeset the Manuscript	2025-04-21 03:28
Publish the Manuscript Online	2025-04-22 06:49

ISSN	1949-8470 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Clinical translation of ultra-high dose rate flash radiotherapy: Opportunities, challenges, and prospects
Manuscript Source	Invited Manuscript
All Author List	Xiang-Xiang Yang, Hui Luo, Jia-Jun Zhang, Hong Ge and Liang Ge
Funding Agency and Grant Number
Corresponding Author	Liang Ge, Assistant Professor, MD, PhD, Department of Medical Imaging, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfuqian Street, Zhengzhou 450001, Henan Province, China. zl13703920959@sina.com
Key Words	Ultra-high dose rate flash radiotherapy; Mechanism; Clinical translation; Radiation-induced damage to normal tissues; Prospects
Core Tip	Ultra-high dose rate flash radiotherapy (FLASH-RT) has garnered significant attention due to its unique high-efficiency and low-toxicity biological effects. With an increasing number of research teams entering this field, the number of related publications has grown exponentially. While the high-efficiency and low-toxicity characteristics of FLASH-RT have been extensively validated, it is equally crucial to objectively analyze relevant negative findings. This article systematically synthesizes published research data to elucidate the advance of FLASH-RT. These findings provide valuable references for designing future FLASH-RT preclinical experimental protocols and facilitating clinical translation.
Publish Date	2025-04-22 06:49
Citation	<p>Yang XX, Luo H, Zhang JJ, Ge H, Ge L. Clinical translation of ultra-high dose rate flash radiotherapy: Opportunities, challenges, and prospects. <i>World J Radiol</i> 2025; 17(4): 105722</p>
URL	https://www.wjgnet.com/1949-8470/full/v17/i4/105722.htm
DOI	https://dx.doi.org/10.4329/wjr.v17.i4.105722

Full Article (PDF)	WJR-17-105722-with-cover.pdf
Manuscript File	105722-Review-FilipodiaCL.docx
Answering Reviewers	105722-answering-reviewers.pdf
Audio Core Tip	105722-audio.mp3
Conflict-of-Interest Disclosure Form	105722-conflict-of-interest-statement.pdf
Copyright License Agreement	105722-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	105722-non-native-speakers.pdf
Peer-review Report	105722-peer-reviews.pdf
Scientific Misconduct Check	105722-scientific-misconduct-check.png
Scientific Editor Work List	105722-scientific-editor-work-list.pdf
CrossCheck Report	105722-crosscheck-report.pdf