| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Retrospective Study |
| Article Title |
Sex-related differences in patients with chronic hepatitis C infection treated with direct-acting antiviral drugs
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Krystyna Dobrowolska, Dorota Zarębska-Michaluk, Malgorzata Pawłowska, Magdalena Tudrujek-Zdunek, Beata Lorenc, Hanna Berak, Ewa Janczewska, Włodzimierz Mazur, Justyna Janocha-Litwin, Jakub Klapaczyński, Marek Sitko, Dorota Dybowska, Anna Parfieniuk-Kowerda, Anna Piekarska, Jerzy Jaroszewicz and Robert Flisiak |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Dorota Zarębska-Michaluk, PhD, Professor, Department of Infectious Diseases and Allergology, Jan Kochanowski University, Żeromskiego 5, Kielce 25-369, Poland. dorota1010@tlen.pl |
| Key Words |
Women; Hepatitis C virus; Direct-acting antivirals; Menopause; Chronic hepatitis C |
| Core Tip |
Sex is the factor influencing the risk of hepatitis C virus infection and the natural course of the disease. An analysis of nearly 19000 patients treated with direct-acting antivirals for chronic hepatitis C according to sex and reproductive status documented that regardless of age, women have lower body mass index, less frequent infection with genotype 3, less frequent co-infections with hepatitis B and human immunodeficiency viruses, and less advanced liver disease. Antiviral treatment is more effective in women than in men, irrespective of age, but postmenopausal women have relatively the lowest effectiveness and the highest incidence of adverse events. |
| Publish Date |
2025-06-26 07:27 |
| Citation |
<p>Dobrowolska K, Zarębska-Michaluk D, Pawłowska M, Tudrujek-Zdunek M, Lorenc B, Berak H, Janczewska E, Mazur W, Janocha-Litwin J, Klapaczyński J, Sitko M, Dybowska D, Parfieniuk-Kowerda A, Piekarska A, Jaroszewicz J, Flisiak R. Sex-related differences in patients with chronic hepatitis C infection treated with direct-acting antiviral drugs. <i>World J Hepatol</i> 2025; 17(6): 105899</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i6/105899.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i6.105899 |
