Publication Name	World Journal of Stem Cells
Manuscript ID	106520
Country	China

Received	2025-02-28 15:03
Peer-Review Started	2025-03-03 00:07
To Make the First Decision
Return for Revision	2025-03-27 10:37
Revised	2025-04-02 14:23
Second Decision	2025-05-30 02:35
Accepted by Journal Editor-in-Chief	2025-06-01 06:29
Accepted by Executive Editor-in-Chief	2025-06-03 09:14
Articles in Press	2025-06-03 09:14
Publication Fee Transferred	2025-04-03 05:24
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-08 06:18
Publish the Manuscript Online	2025-06-25 10:17

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	MiR-126 regulates the effect of mesenchymal stem cell vascular repair on carotid atherosclerosis through MAPK/ERK signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Qiu Ye, Xiao-Hu Meng, Xin Fang, Han-Yi Liu and Hassan Hamisi Mwindadi
Funding Agency and Grant Number	Funding Agency Grant Number Hangzhou Bio-Medicine and Health Industry Development Support Science and Technology Project 2022WJC005, 2024WJC105
Corresponding Author	Xiao-Hu Meng, Department of Vascular Surgery, The First People’s Hospital of Hangzhou Affiliated to Westlake University, No. 261 Huansha Road, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. 1193970654@qq.com
Key Words	Mesenchymal stem cells; Carotid atherosclerosis; MiR-126; Mitogen-activated protein kinases/extracellular signal-regulated kinase signaling pathway; Angiogenesis; Endothelial differentiation; Vascular repair
Core Tip	Carotid atherosclerosis is closely linked to endothelial dysfunction, a relationship validated in rat models. As traditional drugs fall short in curing the disease and surgery carries risks, researchers are exploring gene-based therapies. MiR-126 emerges as a potential therapeutic factor. Experiments show it promotes mesenchymal stem cell differentiation into endothelial cells. Molecularly, miR-126 synergizes with the mitogen-activated protein kinases/extracellular signal-regulated kinase pathway. By modulating this pathway, miR-126 suppresses atherosclerotic lesion progression and shows promise in enhancing vascular health. These findings underscore the potential of miR-126 mimics in treating carotid atherosclerosis, laying a foundation for clinical translation.
Publish Date	2025-06-25 10:17
Citation	<p>Ye ZQ, Meng XH, Fang X, Liu HY, Mwindadi HH. MiR-126 regulates the effect of mesenchymal stem cell vascular repair on carotid atherosclerosis through MAPK/ERK signaling pathway. <i>World J Stem Cells</i> 2025; 17(6): 106520</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i6/106520.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i6.106520

Full Article (PDF)	WJSC-17-106520-with-cover.pdf
The ARRIVE Guidelines	106520-The-ARRIVE-Guidelines.pdf
Manuscript File	106520_Auto_Edited_110705.docx
Answering Reviewers	106520-answering-reviewers.pdf
Audio Core Tip	106520-audio.wav
Biostatistics Review Certificate	106520-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	106520-conflict-of-interest-statement.pdf
Copyright License Agreement	106520-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106520-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	106520-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	106520-non-native-speakers.pdf
Peer-review Report	106520-peer-reviews.pdf
Journal Editor-in-Chief Review Report	106520-journal-editor-in-chief.pdf
Scientific Misconduct Check	106520-scientific-misconduct-check.png
Scientific Editor Work List	106520-scientific-editor-work-list.pdf
CrossCheck Report	106520-crosscheck-report.pdf