Publication Name	World Journal of Orthopedics
Manuscript ID	107045
Country	China

Received	2025-03-14 06:29
Peer-Review Started	2025-03-14 06:29
To Make the First Decision
Return for Revision	2025-04-01 08:56
Revised	2025-04-14 12:29
Second Decision	2025-05-27 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-27 10:25
Articles in Press	2025-05-27 10:25
Publication Fee Transferred	2025-04-21 07:22
Edit the Manuscript by Language Editor	2025-05-28 04:34
Typeset the Manuscript	2025-07-10 07:35
Publish the Manuscript Online	2025-07-17 08:43

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	miR-365 promotes HOXA9-mediated differentiation of mesenchymal stem cells to nucleus pulposus cells by interacting with HIF-1α
Manuscript Source	Unsolicited Manuscript
All Author List	Zhong-Zheng Zhi, Tao Liu, Jian Kang, Fu-Chao Zhou, Xiao-Dong Liu and Zhi-Min He
Funding Agency and Grant Number	Funding Agency Grant Number Academic Subject Boosting Plan in Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine SY-XKZT-2019-3002 Academic Project from the Health Commission of Hongkou District, Shanghai 2202-25 clinical key specialty construction unit from the Health Commission of Hongkou District, Shanghai HKLCZD2024B03
Corresponding Author	Zhi-Min He, Department of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai Fourth People's Hospital, Shanghai 200434, China. zzz0327@tongji.edu.cn
Key Words	Degenerative disk disease; Nucleus pulposus cell; MiR-365; HOXA9; HIF-1α
Core Tip	This study investigates the role of miR-365 in promoting the differentiation of bone marrow mesenchymal stem cells (MSCs) into nucleus pulposus cells (NPCs) for degenerative disk disease (DDD) treatment. We reveal that miR-365 enhances MSC proliferation and inhibits apoptosis, while promoting NPC-related marker expression. Mechanistically, miR-365 targets HOXA9, which in turn regulates HIF-1α, Sox9, and Kdm6a. This finding highlights miR-365 as a potential therapeutic target for DDD, offering a novel strategy to address the loss of NPCs
Publish Date	2025-07-17 08:43
Citation	<p>Zhi ZZ, Liu T, Kang J, Zhou FC, Liu XD, He ZM. miR-365 promotes HOXA9-mediated differentiation of mesenchymal stem cells to nucleus pulposus cells by interacting with HIF-1α. <i>World J Orthop</i> 2025; 16(7): 107045</p>
URL	https://www.wjgnet.com/2218-5836/full/v16/i7/107045.htm
DOI	https://dx.doi.org/10.5312/wjo.v16.i7.107045

Full Article (PDF)	WJO-16-107045-with-cover.pdf
The ARRIVE Guidelines	107045-The-ARRIVE-Guidelines.pdf
Manuscript File	107045_Auto_Edited_015932.docx
Answering Reviewers	107045-answering-reviewers.pdf
Audio Core Tip	107045-audio.mp3
Biostatistics Review Certificate	107045-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	107045-conflict-of-interest-statement.pdf
Copyright License Agreement	107045-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	107045-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	107045-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	107045-non-native-speakers.pdf
Supplementary Material	107045-supplementary-material.pptx
Peer-review Report	107045-peer-reviews.pdf
Scientific Misconduct Check	107045-scientific-misconduct-check.png
Scientific Editor Work List	107045-scientific-editor-work-list.pdf
CrossCheck Report	107045-crosscheck-report.pdf