Publication Name	World Journal of Clinical Cases
Manuscript ID	107279
Country	Greece

Received	2025-03-20 10:46
Peer-Review Started	2025-03-20 10:46
To Make the First Decision
Return for Revision	2025-04-01 12:51
Revised	2025-04-03 10:57
Second Decision	2025-05-07 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-07 14:12
Articles in Press	2025-05-07 14:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-26 02:00
Publish the Manuscript Online	2025-06-04 07:41

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Minireviews
Article Title	Off-label use of treprostinil in adult patients in clinical cases
Manuscript Source	Invited Manuscript
All Author List	Christina Mouratidou, Efstathios T Pavlidis, Georgios Katsanos, Serafeim-Chrysovalantis Kotoulas, Georgios Tsoulfas, Eleni Mouloudi, Ioannis A Taitzoglou, Ioannis N Galanis and Theodoros E Pavlidis
Funding Agency and Grant Number
Corresponding Author	Theodoros E Pavlidis, MD, PhD, Professor, The 2nd Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Key Words	Treprostinil; Off-label use; Pulmonary hypertension; Digital ischemia; Chronic limb ischemia; Hepatic ischemia–reperfusion injury
Core Tip	Treprostinil is a synthetic prostacyclin analog with a stable structure that is currently used for the treatment of pulmonary arterial hypertension. By way of vasodilation and the inhibition of platelet aggregation, treprostinil increases the blood supply in pulmonary circulation and reduces the cardiac workload. In addition to its main indication, several positive reports of off-label treprostinil use in the adult population indicate its benefit in other clinical conditions. Hepatic ischemia–reperfusion injury, chronic limb ischemia, digital ischemia and group 3 and 4 pulmonary hypertension are currently under study as possible indications for treprostinil use outside its approved labeling.
Publish Date	2025-06-04 07:41
Citation	<p>Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Tsoulfas G, Mouloudi E, Taitzoglou IA, Galanis IN, Pavlidis TE. Off-label use of treprostinil in adult patients in clinical cases. <i>World J Clin Cases</i> 2025; 13(23): 107279</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i23/107279.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i23.107279

Full Article (PDF)	WJCC-13-107279-with-cover.pdf
Manuscript File	107279_Auto_Edited_061617.docx
Answering Reviewers	107279-answering-reviewers.pdf
Audio Core Tip	107279-audio.m4a
Conflict-of-Interest Disclosure Form	107279-conflict-of-interest-statement.pdf
Copyright License Agreement	107279-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	107279-non-native-speakers.pdf
Peer-review Report	107279-peer-reviews.pdf
Scientific Misconduct Check	107279-scientific-misconduct-check.png
Scientific Editor Work List	107279-scientific-editor-work-list.pdf
CrossCheck Report	107279-crosscheck-report.pdf