Publication Name	World Journal of Orthopedics
Manuscript ID	107575
Country	United Kingdom

Received	2025-03-26 04:24
Peer-Review Started	2025-03-26 04:24
To Make the First Decision
Return for Revision	2025-04-09 01:50
Revised	2025-04-18 10:26
Second Decision	2025-06-03 02:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-03 11:19
Articles in Press	2025-06-03 11:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-09 07:17
Publish the Manuscript Online	2025-07-17 08:43

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Defensive antibacterial coating in orthopaedic surgery: Current evidence and future direction
Manuscript Source	Invited Manuscript
All Author List	Richard Henry Randall Roberts, Charles Gamble and Ibrahim Malek
Funding Agency and Grant Number
Corresponding Author	Richard Henry Randall Roberts, Research Fellow, Department of Trauma and Orthopaedics, Wrexham Maelor Hospital, Croesnewydd Rd, Wrexham LL13 7TD, United Kingdom. richard.roberts@doctors.org.uk
Key Words	Hospital-acquired infections; Surgical site infections; Periprosthetic joint infections; Implant-related infections; Orthopaedic surgery; Antibiotic prophylaxis; Defensive antibacterial coating; Biofilm prevention; Revision arthroplasty; Patient outcomes
Core Tip	Orthopaedic implant-related infections, including prosthetic joint and osteosynthesis-associated infections, significantly burden healthcare systems clinically and economically. Defensive antibacterial coating (DAC®) hydrogel emerges as a promising bioresorbable adjunct to traditional prophylactic strategies, effectively reducing infection rates and antibiotic overuse in orthopaedic surgery. While robust evidence supports DAC® in revision arthroplasty and trauma surgery, further high-quality studies are needed to confirm its role in primary joint replacement and expand applications to diverse patient populations and anatomical sites.
Publish Date	2025-07-17 08:43
Citation	<p>Roberts RHR, Gamble C, Malek I. Defensive antibacterial coating in orthopaedic surgery: Current evidence and future direction. <i>World J Orthop</i> 2025; 16(7): 107575</p>
URL	https://www.wjgnet.com/2218-5836/full/v16/i7/107575.htm
DOI	https://dx.doi.org/10.5312/wjo.v16.i7.107575

Full Article (PDF)	WJO-16-107575-with-cover.pdf
Manuscript File	107575_Auto_Edited_055925.docx
Answering Reviewers	107575-answering-reviewers.pdf
Audio Core Tip	107575-audio.m4a
Conflict-of-Interest Disclosure Form	107575-conflict-of-interest-statement.pdf
Copyright License Agreement	107575-copyright-assignment.pdf
Peer-review Report	107575-peer-reviews.pdf
Scientific Editor Work List	107575-scientific-editor-work-list.pdf
CrossCheck Report	107575-crosscheck-report.pdf