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12/18/2025 5:54:20 AM | Browse: 15 | Download: 59
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Received |
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2025-04-21 04:40 |
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Peer-Review Started |
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2025-04-21 04:40 |
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First Decision by Editorial Office Director |
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2025-05-12 03:45 |
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Return for Revision |
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2025-05-12 03:45 |
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Revised |
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2025-06-09 01:01 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-10 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-10 08:09 |
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Articles in Press |
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2025-12-10 08:09 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-15 15:13 |
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Publish the Manuscript Online |
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2025-12-18 05:53 |
| ISSN |
2308-3840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Reevaluating aminosalicylates role in maintaining remission in ulcerative colitis: Systematic review and meta-analysis in the era of biologics
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Themba Mudege and Jonathan Soldera |
| Funding Agency and Grant Number |
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| Corresponding Author |
Jonathan Soldera, PhD, Professor, Department of Gastroenterology, University of South Wales, Llantwit Road, Pontypridd, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com |
| Key Words |
Colitis ulcerative; Mesalamine; Remission induction; Biological therapy; Sulfasalazine |
| Core Tip |
Oral 5-aminosalicylic acid (5-ASA) has long been a cornerstone treatment for maintaining remission in ulcerative colitis (UC). This systematic review and meta-analysis of 44 randomized controlled trials, involving nearly 10000 patients, demonstrates that 5-ASA is significantly more effective than placebo in sustaining remission in quiescent UC, with a favorable safety profile. Despite the emergence of advanced therapies such as biologics and small molecules, 5-ASA remains a viable and cost-effective option. These findings underscore the enduring relevance of 5-ASA and highlight the need for tailored therapeutic approaches in the modern management of UC. |
| Publish Date |
2025-12-18 05:53 |
| Citation |
Mudege T, Soldera J. Reevaluating aminosalicylates role in maintaining remission in ulcerative colitis: Systematic review and meta-analysis in the era of biologics. World J Meta-Anal 2025; 13(4): 108681 |
| URL |
https://www.wjgnet.com/2308-3840/full/v13/i4/108681.htm |
| DOI |
https://dx.doi.org/10.13105/wjma.v13.i4.108681 |
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