Publication Name	World Journal of Stem Cells
Manuscript ID	109283
Country	China

Received	2025-05-07 13:45
Peer-Review Started	2025-05-07 13:45
To Make the First Decision
Return for Revision	2025-05-17 08:35
Revised	2025-05-21 06:25
Second Decision	2025-06-12 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-12 09:14
Articles in Press	2025-06-12 09:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-13 02:54
Typeset the Manuscript	2025-06-17 08:35
Publish the Manuscript Online	2025-06-25 10:17

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Letter to the Editor
Article Title	Clarifying the role of exosomal miR-137-3p in endometrial regeneration: Mechanistic gaps and future directions
Manuscript Source	Unsolicited Manuscript
All Author List	Fang Lin, Yue Ding, Ke-Xin Ma and Xiao-Ting Liang
Funding Agency and Grant Number	Funding Agency Grant Number General Program of the Natural Science Foundation of Guangdong Province 2025A1515011163
Corresponding Author	Xiao-Ting Liang, MD, PhD, Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn
Key Words	Mesenchymal stem cells; Exosomal derived miR-137-3p; Ubiquitin protein ligase E3C; Signal transducer and activator of transcription 3; Endometrial repair; Hypoxia
Core Tip	This commentary examines the study by Zhang et al on exosomal miR-137-3p-mediated endometrial regeneration. While the proposed mechanism involving ubiquitin protein ligase E3C inhibition and signal transducer and activator of transcription 3 activation is compelling, several issues remain unresolved, including the unclear source of miR-137-3p, lack of exosome characterization, and absence of in vivo validation. We highlight the need for direct evidence of exosomal microRNA transfer, mechanistic exploration of signal transducer and activator of transcription 3 ubiquitination, and functional evaluation in animal models to substantiate the therapeutic relevance of this approach.
Publish Date	2025-06-25 10:17
Citation	<p>Lin F, Ding Y, Ma KX, Liang XT. Clarifying the role of exosomal miR-137-3p in endometrial regeneration: Mechanistic gaps and future directions. <i>World J Stem Cells</i> 2025; 17(6): 109283</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i6/109283.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i6.109283

Full Article (PDF)	WJSC-17-109283-with-cover.pdf
Manuscript File	109283_Auto_Edited_074506.docx
Answering Reviewers	109283-answering-reviewers.pdf
Audio Core Tip	109283-audio.aac
Conflict-of-Interest Disclosure Form	109283-conflict-of-interest-statement.pdf
Copyright License Agreement	109283-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	109283-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	109283-non-native-speakers.pdf
Peer-review Report	109283-peer-reviews.pdf
Scientific Misconduct Check	109283-scientific-misconduct-check.png
Scientific Editor Work List	109283-scientific-editor-work-list.pdf
CrossCheck Report	109283-crosscheck-report.pdf