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12/17/2025 7:16:34 AM | Browse: 23 | Download: 57
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Received |
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2025-06-20 01:53 |
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Peer-Review Started |
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2025-06-20 01:53 |
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First Decision by Editorial Office Director |
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2025-07-10 09:06 |
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Return for Revision |
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2025-07-10 09:06 |
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Revised |
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2025-07-20 09:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-20 02:57 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-20 07:17 |
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Articles in Press |
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2025-10-20 07:17 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-08 02:26 |
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Publish the Manuscript Online |
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2025-12-17 06:45 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Intertwined roles of microRNA-155 and metformin in osteoarthritis: Novel potential diagnostic, prognostic, and therapeutic modulators
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mantana Paisan, Konstantinos I Papadopoulos, Alexandra Papadopoulou, Weerapong Prasongchean and Phanphen Wattanaarsakit |
| Funding Agency and Grant Number |
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| Corresponding Author |
Konstantinos I Papadopoulos, MD, PhD, Department of R and D, THAI StemLife, 566/3 THAI StemLife Bldg, Soi Ramkhamhaeng 39 (Thepleela 1), Prachaouthit Road, Wangthonglang, Bangkok 10330, Thailand. kostas@thaistemlife.co.th |
| Key Words |
Osteoarthritis; MicroRNA-155; Metformin; Glucagon-like peptide 1; Renin-angiotensin aldosterone system; Cyclooxygenase 2; Adenosine monophosphate-activated protein kinase |
| Core Tip |
In osteoarthritis (OA) and its associated risk factors, elevated microRNA-155 (miR-155) regulates systemic and local joint inflammatory mediators, extracellular matrix degradation, and chondrocyte apoptosis, with context-dependent roles in cartilage repair. MiR-155 also shows promise as a diagnostic and prognostic biomarker. Metformin exerts cartilage-protective effects via adenosine monophosphate-activated protein kinase activation, nuclear factor kappa-B inhibition, and possible modulation of miR-155 expression. Combined miR-155-targeted strategies and metformin in OA could enhance anti-inflammation, cartilage-preservation, and joint regeneration through the development of innovative treatments, including novel articular delivery systems and cell-based therapies. Further research is needed to fully understand the molecular underpinnings of this relationship. |
| Publish Date |
2025-12-17 06:45 |
| Citation |
Paisan M, Papadopoulos KI, Papadopoulou A, Prasongchean W, Wattanaarsakit P. Intertwined roles of microRNA-155 and metformin in osteoarthritis: Novel potential diagnostic, prognostic, and therapeutic modulators. World J Orthop 2025; 16(12): 110992 |
| URL |
https://www.wjgnet.com/2218-5836/full/v16/i12/110992.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v16.i12.110992 |
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