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9/23/2025 7:03:21 AM | Browse: 427 | Download: 110
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Received |
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2025-06-30 04:25 |
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Peer-Review Started |
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2025-06-30 04:26 |
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To Make the First Decision |
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Return for Revision |
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2025-07-07 02:22 |
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Revised |
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2025-07-14 23:02 |
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Second Decision |
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2025-08-21 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-21 05:42 |
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Articles in Press |
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2025-08-21 05:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-11 01:03 |
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Publish the Manuscript Online |
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2025-09-23 06:49 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Emerging multifaceted roles of the microbiome in cancer susceptibility
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hang Chang, Jesus Perez-Losada and Jian-Hua Mao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The United States Department of Defense Breast Cancer Research Program |
BC190820 |
| the National Institutes of Health |
R01ES031322 |
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| Corresponding Author |
Jian-Hua Mao, Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, United States. jhmao@lbl.gov |
| Key Words |
Cancer susceptibility; Genetic variants; Genome-wide association study; Missing heritability; Microbiome; Microbiome-wide association study |
| Core Tip |
Understanding individual susceptibility to cancer is critical for effective prevention and treatment strategies. While genetic studies have identified numerous cancer-susceptibility genes, much of the heritable risk remains unexplained. Emerging evidence indicates the microbiome as a key contributor to this "missing heritability". Microbiomes influence cancer risk through immune modulation, metabolic activity, and interaction with environmental exposures. This review discusses the complex gene-microbiome-environment interplay in cancer susceptibility and emphasizes the value of integrative models and tools, such as collaborative cross mice and artificial intelligence, for uncovering microbial determinants of cancer risk. |
| Publish Date |
2025-09-23 06:49 |
| Citation |
<p>Chang H, Perez-Losada J, Mao JH. Emerging multifaceted roles of the microbiome in cancer susceptibility. <i>World J Clin Oncol</i> 2025; 16(9): 111379</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i9/111379.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i9.111379 |
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