| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Sex-based differences in hepatitis delta virus infection: Insights from the Italian PITER hepatitis delta virus cohort
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Barbara Coco, Maria Giovanna Quaranta, Maria Elena Tosti, Luigina Ferrigno, Giuseppina Brancaccio, Alessia Ciancio, Carmine Coppola, Vincenzo Messina, Ivan Gentile, Ernesto Claar, Filomena Morisco, Teresa Santantonio, Mauro Viganò, Irene Cacciola, Maurizio Pompili, Francesco Paolo Russo, Antonio Izzi, Grazia A Niro, Nicola Coppola, Alessandro Soria, Alessandro Federico, Giulia Morsica, Massimo Puoti, Erica Villa, Pietro Lampertico, Giovanni Battista Gaeta, Loreta A Kondili, Maurizia R Brunetto and PITER Collaborating Investigators |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Investigator Sponsored Research Grant from Gilead Sciences |
No. IN-IT-980-6816 |
| Fondazione Italiana per la Ricerca sul Cancro (AIRC) |
No. IG 2020 ID 24858 |
|
| Corresponding Author |
Loreta A Kondili, MD, PhD, Professor, Senior Researcher, National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Lazio, Italy. loreta.kondili@iss.it |
| Key Words |
Hepatitis delta virus; Chronic hepatitis delta virus infection; Cirrhosis; Sex differences; Migrant |
| Core Tip |
This multi-centre study analyzed 513 patients with chronic hepatitis delta virus (HDV) infection, enrolled across 58 Italian liver clinics regardless of treatment eligibility. The study population reflects the current HDV epidemiology in Italy, including a high proportion of migrant women. Key sex-based differences emerged: Men had a greater burden of metabolic comorbidities and hepatocellular carcinoma, while women, particularly those born abroad, were more likely to develop cirrhosis not only after menopause, as seen in other liver diseases, but also at significantly younger ages, including before 40. Tailored care for young migrant women and cofactor-guided management for men may improve outcomes promoting equity. |
| Publish Date |
2025-12-19 10:39 |
| Citation |
Coco B, Quaranta MG, Tosti ME, Ferrigno L, Brancaccio G, Ciancio A, Coppola C, Messina V, Gentile I, Claar E, Morisco F, Santantonio T, Viganò M, Cacciola I, Pompili M, Russo FP, Izzi A, Niro GA, Coppola N, Soria A, Federico A, Morsica G, Puoti M, Villa E, Lampertico P, Gaeta GB, Kondili LA, Brunetto MR, Collaborating Investigators P. Sex-based differences in hepatitis delta virus infection: Insights from the Italian PITER hepatitis delta virus cohort. World J Gastroenterol 2025; 31(47): 111637 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i47/111637.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i47.111637 |
