| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Saffron and Calculus bovis combination exerts anti-hepatic fibrotic effect in liver fibrosis rats via the mitogen-activated protein kinases pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sheng-Nan Sun, Kun Wang, Ya Xu, Fei Ye, Wei-Na Xia, Zhu-Wei Wang, Fang Liu, Zi-Xuan He, Meng Chen and Qing-Hong Du |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Tibetan Medicine Administration of Tibet Autonomous Region |
JJKT2020006 |
| Key Research and Development Project of Tibet Autonomous Region |
XZ202201ZY0019G |
| National Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project |
zyyzdxk-2023262 |
|
| Corresponding Author |
Qing-Hong Du, Associate Professor, Associate Research Scientist, PhD, Professor, Department of Pathology, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring East Road, Beijing 102488, China. qhdu2005@126.com |
| Key Words |
Liver fibrosis; Tibetan medicine; Saffron; Calculus bovis; Mitogen-activated protein kinases pathway |
| Core Tip |
Liver fibrosis, a health issue of global concern, lacks effective treatments. Using Tibetan medicine experience and network pharmacology, this study explored the potential mechanism of the saffron-Calculus bovis combination against liver fibrosis in rats. After CCl4 induction of rats, intragastric intervention was performed, followed by assessments of liver pathology, liver function, inflammation, and hepatic stellate cell activation. The results showed that the combination exerted more significant anti-fibrotic effects compared with single treatment, and it may act by regulating the mitogen-activated protein kinase pathway. |
| Publish Date |
2025-12-19 10:39 |
| Citation |
Sun SN, Wang K, Xu Y, Ye F, Xia WN, Wang ZW, Liu F, He ZX, Chen M, Du QH. Saffron and Calculus bovis combination exerts anti-hepatic fibrotic effect in liver fibrosis rats via the mitogen-activated protein kinases pathway. World J Gastroenterol 2025; 31(47): 113496 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i47/113496.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i47.113496 |
