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1/27/2026 10:16:33 AM | Browse: 0 | Download: 0
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Received |
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2025-09-08 05:37 |
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Peer-Review Started |
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2025-09-08 05:37 |
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First Decision by Editorial Office Director |
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2025-09-30 08:06 |
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Return for Revision |
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2025-09-30 08:06 |
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Revised |
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2025-10-10 11:50 |
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Publication Fee Transferred |
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2025-10-18 08:01 |
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Second Decision by Editor |
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2025-11-25 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-26 03:26 |
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Articles in Press |
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2025-11-26 03:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-13 03:44 |
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Publish the Manuscript Online |
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2026-01-27 10:12 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Transforming growth factor beta reduces proprotein convertase subtilisin/kexin type 9 in the supernatant of hepatic stellate cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jan Bundschuh, Maximilian Neumann, Sebastian Zimny, Marlen Spirk and Christa Buechler |
| Funding Agency and Grant Number |
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| Corresponding Author |
Christa Buechler, Associate Professor, PhD, Senior Researcher, Department of Internal Medicine I, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, Regensburg 93053, Bavaria, Germany. christa.buechler@klinik.uni-regensburg.de |
| Key Words |
Hepatic stellate cells; Kupffer cells; Leptin; Lipopolysaccharide; Transforming growth factor beta; Proprotein convertase subtilisin/kexin type 9; Liver X receptor |
| Core Tip |
This study showed that primary hepatic stellate cells and the LX-2 cell line secrete proprotein convertase subtilisin/kexin type 9 (PCSK9). Levels of PCSK9 in the medium of LX-2 cells were found to be reduced by interleukin-6, chemerin-156, and transforming growth factor beta, and increased by lipopolysaccharide. The liver X receptor agonist lowered PCSK9 levels in the cell medium. As transforming growth factor beta is a fibrotic cytokine and activation of the liver X receptor exerts antifibrotic effects, PCSK9 levels in the cell medium cannot be used as a marker of activated hepatic stellate cells. |
| Publish Date |
2026-01-27 10:12 |
| Citation |
Bundschuh J, Neumann M, Zimny S, Spirk M, Buechler C. Transforming growth factor beta reduces proprotein convertase subtilisin/kexin type 9 in the supernatant of hepatic stellate cells. World J Hepatol 2026; 18(1): 113896 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i1/113896.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i1.113896 |
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