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4/21/2026 1:29:17 PM | Browse: 54 | Download: 86
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Received |
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2025-11-18 07:03 |
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2025-11-18 09:04 |
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2025-12-03 10:03 |
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Second Decision by Editor |
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2026-02-05 02:37 |
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2026-02-05 07:36 |
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Articles in Press |
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2026-02-05 07:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-10 06:22 |
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Publish the Manuscript Online |
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2026-04-21 08:57 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Monocyte reprogramming and trained immunity: Linking metabolism to inflammation in non-alcoholic fatty liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Stanislav Kotlyarov |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Russian Scientific Foundation |
No. 25-25-01166 |
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| Corresponding Author |
Stanislav Kotlyarov, PhD, Department of Nurse, Ryazan State Medical University, Russian Federation, Ryazan, Vysokovoltnaya, 9, Ryazan 390005, Russia. skmr1@yandex.ru |
| Key Words |
Non-alcoholic fatty liver disease; Innate immune system; Immunometabolism; Metabolic reprogramming; Priming; Trained immunity; Monocytes |
| Core Tip |
Non-alcoholic fatty liver disease is a systemic immunometabolic disorder. Chronic exposure to metabolic factors such as lipotoxicity and hyperglycemia induces long-term functional reprogramming of innate immunity, underlying phenomena like priming and trained immunity. The resulting hyperactive pro-inflammatory phenotype of monocytes and macrophages serves as a key mechanism linking obesity, insulin resistance, and chronic liver inflammation, opening new avenues for therapeutic intervention. |
| Publish Date |
2026-04-21 08:57 |
| Citation |
Kotlyarov S. Monocyte reprogramming and trained immunity: Linking metabolism to inflammation in non-alcoholic fatty liver disease. World J Hepatol 2026; 18(4): 116689 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i4/116689.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i4.116689 |
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