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4/24/2026 5:54:48 AM | Browse: 79 | Download: 114
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Received |
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2025-12-30 06:09 |
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Peer-Review Started |
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2025-12-30 06:10 |
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First Decision by Editorial Office Director |
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2026-01-07 10:28 |
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Return for Revision |
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2026-01-07 10:28 |
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Revised |
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2026-01-13 12:22 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-05 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-05 08:51 |
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Articles in Press |
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2026-02-05 08:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-15 02:05 |
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Publish the Manuscript Online |
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2026-04-24 05:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Editorial |
| Article Title |
From local eradication to immune priming: Paradigm shift of hyperthermic intraperitoneal chemotherapy in gastric cancer therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chun-Xiao Ni and Jia-Ju Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Fund of Tai’an Science and Technology Agency |
No. 2019NS180 |
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| Corresponding Author |
Jia-Ju Xu, MD, Department of Medical Oncology, Tai’an City Central Hospital, No. 29 Longtan Road, Tai’an 271000, Shandong Province, China. jiajuxu1101@163.com |
| Key Words |
Gastric cancer; Hyperthermic intraperitoneal chemotherapy; Tumor immune microenvironment; Immunogenic cell death; Immune checkpoint inhibitors |
| Core Tip |
Postoperative hyperthermic intraperitoneal chemotherapy should be reconceptualized as an immunogenic primer that activates systemic anti-tumor immunity, rather than be viewed merely as a local cytoreductive treatment. This repositions hyperthermic intraperitoneal chemotherapy as a strategic foundation for synergistic combination with immune-checkpoint inhibitors. Consequently, future research should prioritize the definition of optimal synergistic sequences and the identification of predictive biomarkers to pave the way for this precision immunotherapy strategy. |
| Publish Date |
2026-04-24 05:43 |
| Citation |
Ni CX, Xu JJ. From local eradication to immune priming: Paradigm shift of hyperthermic intraperitoneal chemotherapy in gastric cancer therapy. World J Gastroenterol 2026; 32(17): 118346 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i17/118346.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i17.118346 |
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