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5/16/2017 9:28:04 AM | Browse: 1133 | Download: 2122
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 29838
Country/Territory Australia
Received
2016-08-29 15:31
Peer-Review Started
2016-09-01 16:45
To Make the First Decision
2016-10-31 08:19
Return for Revision
2016-11-03 18:09
Revised
2016-12-01 09:03
Second Decision
2017-02-15 18:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-02 08:16
Articles in Press
2017-03-02 08:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-13 18:00
Publish the Manuscript Online
2017-05-16 06:56
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice
Manuscript Source Invited Manuscript
All Author List Mandy Heritage, Lesley Jaskowski, Kim Bridle, Catherine Campbell, David Briskey, Laurence Britton, Linda Fletcher, Luis Vitetta, V Nathan Subramaniam and Darrell Crawford
Funding Agency and Grant Number
Corresponding Author Dr. Kim Bridle, School of Medicine, The University of Queensland, Lower Lobby Level, Administration Building, Greenslopes Private Hospital, Newdegate Street, Brisbane 4120, Australia. k.bridle@uq.edu.au
Key Words Non-alcoholic fatty liver disease; hemo­chromatosis; iron overload; steatosis; high calorie diet
Core Tip The high prevalence of obesity and the metabolic syndrome suggests that many patients with liver disease of varying etiologies will have co-existent non-alcoholic fatty liver disease. Our model of co-toxic liver disease incorporates increased hepatic iron in combination with steatosis and was associated with necroinflammation and early hepatic fibrosis. Because of the beneficial effect of combination therapy, we believe vitamin E and curcumin should be investigated in other animal models of non-alcoholic steatohepatitis. Should beneficial effects be demonstrated, combination treatment with the development of appropriate dosing strategies could be rapidly moved to human studies allowing for an effective treatment strategy.
Publish Date 2017-05-16 06:56
Citation Heritage M, Jaskowski L, Bridle K, Campbell C, Briskey D, Britton L, Fletcher L, Vitetta L, Subramaniam VN, Crawford D. Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice. World J Gastrointest Pathophysiol 2017; 8(2): 67-76
URL http://www.wjgnet.com/2150-5330/full/v8/i2/67.htm
DOI http://dx.doi.org/10.4291/wjgp.v8.i2.67
Full Article (PDF) WJGP-8-67.pdf
Full Article (Word) WJGP-8-67.doc
Manuscript File 29838-Review.docx
Answering Reviewers 29838-Answering reviewers.pdf
Audio Core Tip 29838-Audio core tip.wav
Biostatistics Review Certificate 29838-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 29838-Conflict-of-interest statement.pdf
Copyright License Agreement 29838-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 29838-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 29838-Institutional review board statement.pdf
Supplementary Material 29838-Supplementary material.pdf
Peer-review Report 29838-Peer-review(s).pdf
Scientific Misconduct Check 29838-Scientific misconduct check.pdf
Scientific Editor Work List 29838-Scientific editor work list.pdf