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5/24/2017 3:21:18 AM | Browse: 707 | Download: 1527
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Received |
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2016-09-24 14:20 |
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Peer-Review Started |
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2016-09-26 21:02 |
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To Make the First Decision |
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2016-10-20 08:47 |
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Return for Revision |
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2016-11-02 16:12 |
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Revised |
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2016-11-12 05:32 |
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Second Decision |
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2017-01-22 16:47 |
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Accepted by Journal Editor-in-Chief |
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2017-01-22 18:07 |
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Accepted by Company Editor-in-Chief |
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2017-02-13 12:13 |
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Articles in Press |
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2017-02-13 12:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-22 08:24 |
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Publish the Manuscript Online |
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2017-05-24 02:45 |
| ISSN |
2220-3176 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Antioxidant enzyme profile of two clinical isolates of Entamoeba histolytica varying in sensitivity to antiamoebic drugs
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lakshmi Rani Iyer, Neha Banyal, Shailendra Naik and Jaishree Paul |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Science and Technology, New Delhi, Government of India to Iyer LR |
WOS-A/LS-98/2007 |
| “Programme support on molecular parasitology”, Department of Biotechnology, New Delhi, India |
BT/01/CEIB/11/V/08 (to Paul J) |
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| Corresponding Author |
Dr. Jaishree Paul, School of Life Sciences, Jawaharlal Nehru University, New Mehrauli Road, New Delhi 110067, India. jpaul33@hotmail.com |
| Key Words |
Metronidazole; Entamoeba histolytica; Amoebiasis; Thioredoxin reductase; Isolates; Tolerance; Auranofin; Minimum inhibitory concentrations |
| Core Tip |
Due to overuse of the mainstay drug against amoebiasis in an endemic country like India, there are concerns regarding the development of resistance towards metronidazole by the parasite. When Entamoeba histolytica (E. histolytica) from stool samples of diarrheal patients were cultivated in xenic medium, two clinical isolates of E. histolytica showed differential tolerance to the commonly used drug metronidazole. A new drug Auranofin was found to be effective on the isolate with higher tolerance to metronidazole. This was shown by inhibition of the antioxidant enzyme thioredoxin reductase as monitored by mRNA expression of TrxR gene and its enzyme activy. |
| Publish Date |
2017-05-24 02:45 |
| Citation |
Iyer LR, Banyal N, Naik S, Paul J. Antioxidant enzyme profile of two clinical isolates of Entamoeba histolytica varying in sensitivity to antiamoebic drugs. World J Clin Infect Dis 2017; 7(2): 21-31 |
| URL |
http://www.wjgnet.com/2220-3176/full/v7/i2/21.htm |
| DOI |
http://dx.doi.org/10.5495/wjcid.v7.i2.21 |
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