Publication Name	World Journal of Gastroenterology
Manuscript ID	30970
Country	Ireland

Received	2016-10-25 09:05
Peer-Review Started	2016-10-28 17:14
To Make the First Decision	2017-03-03 10:08
Return for Revision	2017-03-06 17:18
Revised	2017-03-19 20:32
Second Decision	2017-04-11 17:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-04-12 18:12
Articles in Press	2017-04-12 18:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-27 11:01
Publish the Manuscript Online	2017-05-06 20:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Frontier
Article Title	BRAF inhibitor treatment of melanoma causing colonic polyps: An alternative hypothesis
Manuscript Source	Invited Manuscript
All Author List	Fergal C Kelleher, Grainne Callaghan, Catriona Gallagher and Hazel O’Sullivan
Funding Agency and Grant Number
Corresponding Author	Fergal Kelleher, MB, BCh, BAO, BMedSc, MSc, AFRCSI, FRCPI, MD, Department of Medical Oncology, Specialty Certification Medical Oncology Royal College of Physicians United Kingdom, European Certification in Medical Oncology, The Adelaide and Meath Hospital, Tallaght, 24 Dublin, Ireland. fergalkelleher@hotmail.com
Key Words	BRAF inhibitors; Malignant melanoma; Serrated polyps; Colonic polyps
Core Tip	In this article, we focus on BRAF inhibitors, and their relationship to colonic polyps. As is already known, colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due to parado­xical activation of the mitogen-activated protein-kinase pathway. In this article, we postulate a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps.
Publish Date	2017-05-06 20:30
Citation	Kelleher FC, Callaghan G, Gallagher C, O’Sullivan H. BRAF inhibitor treatment of melanoma causing colonic polyps: An alternative hypothesis. World J Gastroenterol 2017; 23(17): 3022-3029
URL	http://www.wjgnet.com/1007-9327/full/v23/i17/3022.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i17.3022

Full Article (PDF)	WJG-23-3022.pdf
Full Article (Word)	WJG-23-3022.doc
Manuscript File	30970-Review.docx
Answering Reviewers	30970-Answering reviewers .docx
Audio Core Tip	30970-Audio core tip
Conflict-of-Interest Disclosure Form	30970-Conflict-of-interest statement.pdf
Copyright License Agreement	30970-Copyright assignment.pdf
Peer-review Report	30970-Peer-review(s).pdf
Scientific Misconduct Check	30970-Scientific misconduct check.pdf
Scientific Editor Work List	30970-Scientific editor work list.pdf