Publication Name	World Journal of Gastroenterology
Manuscript ID	31173
Country	China

Received	2016-11-02 11:48
Peer-Review Started	2016-11-03 11:13
To Make the First Decision	2016-12-19 11:29
Return for Revision	2016-12-20 11:09
Revised	2017-01-11 19:23
Second Decision	2017-02-06 14:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-02-08 09:56
Articles in Press	2017-02-08 09:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-24 16:31
Publish the Manuscript Online	2017-05-06 20:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Review
Article Title	Macrophage inflammatory protein-2 as mediator of inflammation in acute liver injury
Manuscript Source	Unsolicited Manuscript
All Author List	Chao-Chao Qin, Yan-Ning Liu, Ying Hu, Ying Yang and Zhi Chen
Funding Agency and Grant Number	Funding Agency Grant Number State 12th 5-Year Plan S&T Projects of China 2012ZX10002007 National Natural Science Foundation of China 81272679 National Natural Science Foundation of China 81470851
Corresponding Author	Dr. Zhi Chen, Professor, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 866 Yuhong Road, Hangzhou 310003, Zhejiang Province, China. zjuchenzhi@zju.edu.cn
Key Words	Macrophage inflammatory protein-2; Liver injury; Polymorphonuclear neutrophils; Macrophages; Inflammation
Core Tip	Macrophage inflammatory protein (MIP)-2 is produced by a variety of cell types in response to infection or injury, and affects neutrophil recruitment and activation by binding to chemokine CXC receptor (CXCR)1 and CXCR2. MIP-2 plays a complex dual role in the development of liver diseases by mediating liver inflammation at a high concentration and promoting liver regeneration at a low concentration. Here, we review its physiological and pathological functions in various types of liver damage. Further understanding of the regulatory mechanisms of MIP-2 may be helpful to develop MIP-2-targeted therapeutic strategies.
Publish Date	2017-05-06 20:30
Citation	Qin CC, Liu YN, Hu Y, Yang Y, Chen Z. Macrophage inflammatory protein-2 as mediator of inflammation in acute liver injury. World J Gastroenterol 2017; 23(17): 3043-3052
URL	http://www.wjgnet.com/1007-9327/full/v23/i17/3043.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i17.3043

Full Article (PDF)	WJG-23-3043.pdf
Full Article (Word)	WJG-23-3043.doc
Manuscript File	31173-Review.doc
Answering Reviewers	31173-Answering reviewers.pdf
Audio Core Tip	31173-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31173-Conflict-of-interest statement.pdf
Copyright License Agreement	31173-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	31173-Language certificate.pdf
Peer-review Report	31173-Peer-review(s).pdf
Scientific Misconduct Check	31173-Scientific misconduct check.pdf
Scientific Editor Work List	31173-Scientific editor work list.pdf