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9/7/2017 6:18:45 AM | Browse: 507 | Download: 919
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Received |
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2017-01-05 09:56 |
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Peer-Review Started |
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2017-01-07 08:41 |
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To Make the First Decision |
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2017-04-17 15:53 |
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Return for Revision |
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2017-04-20 15:28 |
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Revised |
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2017-04-29 00:45 |
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Second Decision |
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2017-05-17 09:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-05-24 01:03 |
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Articles in Press |
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2017-05-24 01:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-08-25 08:04 |
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Publish the Manuscript Online |
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2017-09-07 02:39 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Natalia Laufer, Diego Ojeda, María Laura Polo, Ana Martinez, Héctor Pérez, Gabriela Turk, Pedro Cahn, Norberto Walter Zwirner and Jorge Quarleri |
| Funding Agency and Grant Number |
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| Corresponding Author |
Natalia Laufer, MD, PhD, Investigador Asistente – CONICET, Instituto Investigaciones Biomédicas en Retrovirus y SIDA INBIRS, Universidad de Buenos Aires. Paraguay 2155 Piso 11, Buenos Aires C1121ABG, Argentina. nlaufer@fmed.uba.ar |
| Key Words |
CD4+ T cell; Human immunodeficiency virus/hepatitis C virus-coinfection; Fibrosis; Biomarker; Natural killer cells |
| Core Tip |
Approximately 2.3 million individuals with human immunodeficiency virus are coinfected with hepatitis C virus (HCV). The high cost of HCV treatment restricts its use. It is crucial to identify patients with advanced liver fibrosis with an urgent need of treatment. The aim of this study was to identify natural killer (NK) phenotypes as a biomarker for liver fibrosis. We observed that those subjects with higher fibrosis are those with lower percentage of NK cells and also with lower LTCD4+ count. These constitute two simple parameters that might be performed in a routine laboratory test and used in clinical practice as biomarkers for liver fibrosis. |
| Publish Date |
2017-09-07 02:39 |
| Citation |
Laufer N, Ojeda D, Polo ML, Martinez A, Pérez H, Turk G, Cahn P, Zwirner NW, Quarleri J. CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients. World J Hepatol 2017; 9(25): 1073-1080 |
| URL |
http://www.wjgnet.com/1948-5182/full/v9/i25/1073.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v9.i25.1073 |
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