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8/24/2017 8:52:28 AM | Browse: 540 | Download: 1382
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Received |
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2017-01-12 08:56 |
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Peer-Review Started |
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2017-01-16 08:39 |
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To Make the First Decision |
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2017-04-17 09:24 |
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Return for Revision |
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2017-04-17 15:27 |
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Revised |
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2017-06-22 15:27 |
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Second Decision |
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2017-07-18 09:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-07-24 05:07 |
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Articles in Press |
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2017-07-24 05:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-08-18 07:57 |
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Publish the Manuscript Online |
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2017-08-24 04:57 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Danielle R Bruns, Alexander R Ghincea, Christian V Ghincea, Yasu-Taka Azuma, Peter A Watson, Michael V Autieri and Lori A Walker |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Colorado-Denver Center for Women’s Health Research |
To Walker LA |
| NIH NHLBI |
HL007822-19 (to Bruns DR) |
| NIH NHLBI |
HL117724 (to Autieri MV) |
| NIH NHLBI |
HL115575 (to Autieri MV) |
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| Corresponding Author |
Lori A Walker, PhD, Division of Cardiology, Department of Medicine, University of Colorado-Denver, 12700 E. 19th Ave, Aurora, CO 80045, United States. lori.walker@ucdenver.edu |
| Key Words |
Cardiac dysfunction; Sex differences; Heart failure; Interleukin-19 |
| Core Tip |
Heart failure (HF) is a sexually dimorphic disease. In a female-dominant model of HF, the do-minant negative cyclic AMP response-element binding protein (dnCREB) mouse, female mice show accelerated cardiac morbidity and mortality alongside downregulated interleukin-19 (IL-19) expression, while male mice maintain IL-19 expression and are protected against cardiac dysfunction. We generated a novel double transgenic mouse with dnCREB and IL-19 knockout to test the hypothesis that IL-19 is cardioprotective. We show accelerated cardiac morbidity only in male mice, supporting the hypothesis that IL-19 is a sex-specific cardioprotective cytokine. |
| Publish Date |
2017-08-24 04:57 |
| Citation |
Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA. Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. World J Cardiol 2017; 9(8): 673-684 |
| URL |
http://www.wjgnet.com/1949-8462/full/v9/i8/673.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v9.i8.673 |
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