ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Permissions |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury
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Manuscript Source |
Invited Manuscript |
All Author List |
Mitsuhiko Abe, Takafumi Yoshida, Jun Akiba, Yu Ikezono, Fumitaka Wada, Atsutaka Masuda, Takahiko Sakaue, Toshimitsu Tanaka, Hideki Iwamoto, Toru Nakamura, Michio Sata, Hironori Koga, Akihiko Yoshimura and Takuji Torimura |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
JSPS Grant-in-Aid for Scientific Research (C) |
16K09385 |
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Corresponding Author |
Takafumi Yoshida, MD, PhD, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume Clinical Pharmacology Clinic.67 Asahi-Machi, Kurume 830-0011, Japan. tayoshi@med.kurume-u.ac.jp |
Key Words |
Hepatocellular carcinoma; Ductular reaction; Signal transducer and activator of transcription 3; Yes-associated protein; Sex determining region Y-box9; Transdifferentiation |
Core Tip |
Cell transdifferentiation has been identified as one of the crucial sources of organ regeneration. In liver regeneration, both mature hepatocytes and cholangiocytes have been shown to transdiffrentiate to each other to maintain hepatic homeostasis. Although STAT3 has been also shown to be implicated in cellular differentiation, the differentiative role of STAT3 in liver regeneration remains unknown. In this study, we found that hepatic-STAT3 deficiency promoted biliary ductular proliferation with upregulation of YAP/SOX9, crucial regulators of transdifferentiation, in liver injury of mice. This work suggests that STAT3 determines liver cell fate regulating YAP/SOX9 in liver regeneration. |
Publish Date |
2017-09-28 10:01 |
Citation |
Abe M, Yoshida T, Akiba J, Ikezono Y, Wada F, Masuda A, Sakaue T, Tanaka T, Iwamoto H, Nakamura T, Sata M, Koga H, Yoshimura A, Torimura T. STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury. World J Gastroenterol 2017; 23(37): 6833-6844 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i37/6833.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i37.6833 |