Publication Name	World Journal of Stem Cells
Manuscript ID	32849
Country	India

Received	2017-01-29 18:29
Peer-Review Started	2017-02-02 22:24
To Make the First Decision	2017-03-27 12:02
Return for Revision	2017-03-28 17:55
Revised	2017-05-22 06:50
Second Decision	2017-06-15 06:17
Accepted by Journal Editor-in-Chief	2017-06-15 08:22
Accepted by Company Editor-in-Chief	2017-06-20 01:56
Articles in Press	2017-06-20 01:56
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-07-06 02:59
Typeset the Manuscript	2017-08-18 07:56
Publish the Manuscript Online	2017-08-24 02:02

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance
Manuscript Source	Invited Manuscript
All Author List	Minal Garg
Funding Agency and Grant Number
Corresponding Author	Dr. Minal Garg, Assistant Professor, Department of Biochemistry, University of Lucknow, University Road, Lucknow 226007, India. garg_minal@lkouniv.ac.in
Key Words	Epithelial-mesenchymal transition; Anticancer therapies; Cancer stem cells; Molecular pathogenesis; Tumor relapse
Core Tip	Frequently observed reason for the failure in the treatment of malignant carcinomas is the biological programming of epithelial cells called epithelial-mesenchymal transition (EMT). It confers cancer cells, an ability to lose epithelial traits; gain mesenchymal traits; acquire stem-like properties; disseminate and colonize to distant organ sites and show elevated resistance to cancer therapies. Partial elimination of cancer stem cells and their propagation into secondary tumors post-treatment are the limitations associated with currently available standard of care including radio/chemotherapies, surgical resection or combination of these. Differentiation-based therapeutic strategies utilize the variable and regulatory powers of EMT program, lead to successful eradication of stem-like population of cancer cells by reverting the EMT phenotype and may hold great promise in improving the clinical outcomes.
Publish Date	2017-08-24 02:02
Citation	Garg M. Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance. World J Stem Cells 2017; 9(8): 118-126
URL	http://www.wjgnet.com/1948-0210/full/v9/i8/118.htm
DOI	http://dx.doi.org/10.4252/wjsc.v9.i8.118

Full Article (PDF)	WJSC-9-118.pdf
Full Article (Word)	WJSC-9-118.doc
Manuscript File	32849-Review.docx
Answering Reviewers	32849-Answering reviewers.pdf
Audio Core Tip	32849-Audio core tip.wma
Conflict-of-Interest Disclosure Form	32849-Conflict-of-interest statement.pdf
Copyright License Agreement	32849-Copyright assignment.pdf
Peer-review Report	32849-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	32849-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	32849-Scientific misconduct check.pdf
Scientific Editor Work List	32849-Scientific editor work list.pdf