Publication Name	World Journal of Nephrology
Manuscript ID	33527
Country	Italy

Received	2017-02-14 08:29
Peer-Review Started	2017-02-14 18:22
To Make the First Decision	2017-04-14 10:32
Return for Revision	2017-04-19 17:36
Revised	2017-04-21 16:55
Second Decision	2017-04-23 18:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-05 18:32
Articles in Press	2017-05-05 18:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-29 01:03
Publish the Manuscript Online	2017-06-30 06:51

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Causal relationship between hypoalbuminemia and acute kidney injury
Manuscript Source	Invited Manuscript
All Author List	Christian J Wiedermann, Wolfgang Wiedermann and Michael Joannidis
Funding Agency and Grant Number
Corresponding Author	Christian J Wiedermann, MD, Department of Research, College of Health Professions Claudiana, Lorenz-Böhler-Street 13, 39100 Bolzano, Italy. christian.wiedermann@claudiana.bz.it
Key Words	Acute kidney injury; Acute renal failure; Hypoalbuminemia; Mortality; Prevention
Core Tip	The relationship between hypoalbuminemia and acute kidney injury (AKI)-related morbidity/mortality is now confirmed. This association is consistently evident in a wealth of observational studies conducted across a wide range of clinical settings, and suggests a causal link. Prospective studies adequately powered to assess severe AKI, mortality and causality are needed, as is evaluation of the trigger and appropriate target serum levels and albumin dose necessary to confer renal protection. Basic research is also warranted to define the mechanisms through which albumin affords nephroprotection. Serum albumin should be measured to identify patients with increased AKI risk who may benefit from treatment correcting underlying hypoalbuminemia.
Publish Date	2017-06-30 06:51
Citation	Wiedermann CJ, Wiedermann W, Joannidis M. Causal rela¬tionship between hypoalbuminemia and acute kidney injury. World J Nephrol 2017; 6(4): 176-187
URL	http://www.wjgnet.com/2220-6124/full/v6/i4/176.htm
DOI	http://dx.doi.org/10.5527/wjn.v6.i4.176

Full Article (PDF)	WJN-6-176.pdf
Full Article (Word)	WJN-6-176.doc
Manuscript File	33527-Review.docx
Answering Reviewers	33527-Answering reviewers.pdf
Audio Core Tip	33527-Audio core tip.wma
Conflict-of-Interest Disclosure Form	33527-Conflict-of-interest statement.pdf
Copyright License Agreement	33527-Copyright assignment.pdf
Peer-review Report	33527-Peer-review(s).pdf
Scientific Misconduct Check	33527-Scientific misconduct check.pdf
Scientific Editor Work List	33527-Scientific editor work list.pdf