| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Antonija Duzel, Josipa Vlainic, Marko Antunovic, Dominik Malekinusic, Borna Vrdoljak, Mariam Samara, Slaven Gojkovic, Ivan Krezic, Tinka Vidovic, Zdenko Bilic, Mario Knezevic, Marko Sever, Nermin Lojo, Antonio Kokot, Marijan Kolovrat, Domagoj Drmic, Jaksa Vukojevic, Tamara Kralj, Katarina Kasnik, Marko Siroglavic, Sven Seiwerth and Predrag Sikiric |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Predrag Sikiric, MD, PhD, Professor, Department of Pharmacology, School of Medicine, University of Zagreb, Salata 11, Zagreb 10000, Croatia. sikiric@mef.hr |
| Key Words |
Ischemic colitis; Blood flow rescue; Collaterals; BPC 157; L-NAME; L-arginine; Oxidative stress; NO; Rats |
| Core Tip |
We rescued rat ischemic colitis. The gastric pentadecapeptide BPC 157, which has been used in clinical trials for ulcerative colitis, exerted rapid cytoprotective endothelium rescue against the disabled left colic artery and vein after blood deprivation via two ligations and during reperfusion (ligations removed). By bypassing obstructions, quickly rescuing blood supply, rapidly activating collaterals, and restoring arcade interconnections, as a new integrative beneficial effect, BPC 157 prevented the occurrence of pale lesions without mucosal folds and normalized the levels of NO and MDA, two oxidative stress markers, in tissues. BPC 157 showed effectiveness over the NO-system background, immobilized (L-NAME+L-arginine), (over)stimulated (L-arginine) or blocked (L-NAME). Likewise, later application of BPC 157 in a bath treatment to rats with pertinently obstructed vessels that underwent additional colon obstruction for three days produced a similar beneficial effect. |
| Publish Date |
2017-12-27 11:08 |
| Citation |
Duzel A, Vlainic J, Antunovic M, Malekinusic D, Vrdoljak B, Samara M, Gojkovic S, Krezic I, Vidovic T, Bilic Z, Knezevic M, Sever M, Lojo N, Kokot A, Kolovrat M, Drmic D, Vukojevic J, Kralj T, Kasnik K, Siroglavic M, Seiwerth S, Sikiric P. Stable gastric pentadecapeptide BPC 157 in treatment of colitis and ischemia and reperfusion in rats: New insights. World J Gastroenterol 2017; 23(48): 8465-8488 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i48/8465.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i48.8465 |
