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11/14/2017 11:53:32 AM | Browse: 627 | Download: 789
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Received |
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2017-08-05 05:07 |
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Peer-Review Started |
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2017-08-07 10:04 |
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To Make the First Decision |
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2017-08-30 02:42 |
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Return for Revision |
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2017-08-31 07:49 |
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Revised |
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2017-09-18 09:18 |
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Second Decision |
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2017-10-11 06:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-10-17 20:10 |
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Articles in Press |
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2017-10-17 20:10 |
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Publication Fee Transferred |
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2017-10-30 15:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-11-06 04:36 |
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Publish the Manuscript Online |
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2017-11-12 06:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Daniela Gabbia, Arianna Dalla Pozza, Laura Albertoni, Roberta Lazzari, Giorgia Zigiotto, Maria Carrara, Vincenzo Baldo, Tatjana Baldovin, Annarosa Floreani and Sara De Martin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant from the University of Padova |
CPDA138721/13 |
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| Corresponding Author |
Sara De Martin, PharmD, PhD, Assistant Professor, Department of Pharmaceutical and Pharmacological Sciences, University of Padova, L.go Meneghetti, 2, Padova 35131, Italy. sara.demartin@unipd.it |
| Key Words |
Cholestasis; CYP3A; Drug metabolism; Pregnane X receptor; Constitutive androstane receptor |
| Core Tip |
We demonstrated that early- and late-stage cholestasis affects CYP3A-mediated metabolism differently, probably as consequence of the different activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR). As a consequence, cholestatic patients may have an altered drug metabolism: in the early stage due to the induction of CYP3A enzymes; and in the late stage due to the high deposition of fibrotic liver and consequent hepatocyte loss. Secondly, since PXR activation is known to induce alternative hepatic export routes and detoxification enzymes, the induction of these cellular pathways with PXR and/or CAR agonists could be exploited as a therapeutic strategy for the management of cholestatic diseases. |
| Publish Date |
2017-11-12 06:39 |
| Citation |
Gabbia D, Dalla Pozza A, Albertoni L, Lazzari R, Zigiotto G, Carrara M, Baldo V, Baldovin T, Floreani A, De Martin S. pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis. World J Gastroenterol 2017; 23(42): 7519-7530 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i42/7519.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i42.7519 |
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